Abstract: A container for housing a fluid therapeutic composition includes a rigid housing, a collapsible bag and a seal. The housing has an opening and an interior surface. The interior surface forms a cavity having a volume. The bag is disposed in the housing and is expandable to contact the interior surface of the housing and occupy the entire volume of the cavity when filled with the fluid therapeutic composition. The bag has an opening that is fixed in proximity to the opening of the housing. The seal is configured to prevent air from entering the bag via the bag opening and to prevent air from entering the cavity of the housing via the housing opening.

Abstract: The invention relates to compounds and methods for the prevention and/or treatment of infection after stroke.

Abstract: An ampoule made of plasties material, for liquid or suspension pharmaceuticals, has a reservoir linked to a removable head by a channel in a neck portion. The channel has a trap, thus located between its reservoir and the head, in the form of an elongated restriction and/or a bend to trap liquid or suspension which may settle during storage, and prevent either reaching the head.

Abstract: This invention relates to compositions and methods for treating GC-responsive conditions and for reducing and preventing side-effects of GC treatment in patients.

Abstract: A medical connector for use with one or more medical implements. In some embodiments, the connector minimizes or eliminates the retrograde flow of fluid into the connector from one end or port upon the disconnection of a medical implement from the other end or port. In some embodiments, the connector generates a positive flow of fluid out of the connector from one end or port when a medical implement is disconnected from the other end or port.

Abstract: Provided a port member for an infusion solution bag that is capable of suppressing occurrence of gaps or wrinkles in a sealed portion in a manufacturing process, and preventing damages to resin sheets of a bag body during storage or transportation. A port member for an infusion solution bag includes a tubular body portion having one end sealed by a plug member structured to enable a hollow needle to be pierced into the plug member, and a tubular to-be-sealed portion continuously formed with an other end of the body portion and having an inner space communicated with the inside of the body portion, the to-be-sealed portion being held between and sealed to end portions of resin sheets overlapped together to form a bag body having an inner space for accommodation of at least a medicine, in which the to-be-sealed portion thus sealed has a radially flattened shape.

Abstract: A flow-through fluid reservoir includes a body with a first fluid port, a member movable within the body by an actuator to increase or decrease a volume of a chamber defined by a sidewall of the body. The actuator has a second fluid port. Movable member has a fluid path therethrough such that fluid ports are in fluid communication irrespective of the position of the movable member or the volume of chamber. A shaped slot on the shell of the actuator and a projection on the body cooperate to constrain relative movement of the body and actuator along a path corresponding to the shaped slot. The slot advantageously may include a stop intermediate therealong. A canted aspect of the slot may be used to initiate relative movement of the member within body. The body includes an end wall through which the first fluid port communicates. A shroud is defined by a coaxial extension of the sidewall beyond the end wall to surround the first fluid port, and gripping elements may be provided on the shroud.

Abstract: An infusion bag according to one exemplary embodiment includes a body having an interior space for holding a fluid. The interior space is defined by a pair of side walls and an inner wall and an opposite bottom wall. The inner wall extends across the body from one side wall to the other side wall such that a first angle ?1 is formed between a first end of the inner wall and one side wall and a second angle ?2 is formed between a second end of the inner wall and the other side wall. The first angle is different from the second angle. The bag also includes a needleless port that is in fluid communication with the interior and is configured to sealingly mate with an external device. The needleless port is disposed in an upper corner of the body.

Abstract: The present disclosure relates to clamps for controlling the flow of liquid through a fluid circuit. More particularly, the present disclosure relates to flow control clamps that can be substantially irreversibly secured in a closed position, thereby discouraging reopening of the flow path of the tube.

Abstract: An IV product comprises a flexible fluid bag and a container housing for supporting and protecting the fluid bag. The IV product may include an information element such as a bar code, RFID or the like which provides information. The IV product may also include a mechanism for expelling fluid from the fluid bag, such as an inflatable bellows. In one embodiment, the IV product may be mated to a docking station or receptacle. One or more elements may be provided for aligning and connecting the IV product to establish a fluid connection with the fluid bag.

Abstract: A system for removing or tranferring a pharmaceutical product from a reservoir including an ampoule with a moveable piston therein and an adaptor which includes, generally along a longitudinal axis, a reservoir connector and an ampoule connector for coupling to the ampoule, wherein the ampoule connector includes at least one locking mechanism which, in a side wall, includes a resilient element generally corresponding to a portion of the side wall which extends along the periphery thereof and, at opposing ends, merges with the side wall.

Abstract: An oral syringe of the type having a syringe barrel terminating in a syringe neck with a blunt orificed end is combined with a medication bottle provided with a self resealing elastomeric closure designed for admitting the syringe neck into the bottle while maintaining a sufficient liquid tight seal against the syringe neck to allow a dose of medication to be drawn from the bottle in an inverted condition of the bottle without significant leakage, the closure resealing itself upon withdrawal of the syringe neck.

Abstract: The present disclosure provides for an airless intravenous (IV) bag which contains a specialized device, referred to herein as the airless intravasculature infusion device (AIVID). The AIVID allows one to view the amount of fluid in the IV bag but substantially decreases or completely prohibits the risk of an inadvertent air infusion into a patient.

Abstract: A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Abstract: This document provides connectors such as a connector for enabling fluid transfer between a first fluid container and a second fluid container, which connector comprises a first component that is arranged to be connected to a first fluid container and a second component that is arranged to be connected to a second fluid container. The first component can be non-rotatably connected to the second component before a second fluid container is connected to the second component and/or before a first fluid container is connected to the first component. The connector can comprise a locking and rotation-enabling element that is arranged to be activated once a second fluid container has been connected to the second component, and/or once a first fluid container has been connected to the first component, which locking and rotation-enabling element enables the first component and the second component to rotate freely with respect to one another.

Abstract: An apparatus for collecting and salvaging blood includes: a first chamber with a below atmosphere internal pressure for continuous collection of blood through an inlet port; a second chamber for receiving blood from the first chamber through a connection channel; a channel valve manually controllable to close the connection channel; and a control for simultaneously controlling the channel valve and the internal pressure of the second chamber between an internal pressure corresponding to the internal pressure of the first chamber and ambient air pressure, wherein the control is arranged to provide an internal pressure corresponding to the internal pressure of the first chamber to the second chamber through a passageway separated from the connection channel for providing blood from the first chamber to the second chamber.

Abstract: This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy utilizing a GCR antagonist, such as ORG 34517. The rapid, sensitive, and inexpensive test can be used to determine patients who have non-normal cortisol production or disordered circadian rhythms as a method for selecting subjects for GCR antagonist therapy for whom it is likely to have beneficial and/or therapeutic effects, and can also be used to monitor changes in cortisol levels in response to treatment.

Abstract: Disclosed is a fluid transfer system for transferring a substance from one vessel to another vessel while avoiding leakage of liquid and gas contaminants. The transfer system includes a needle safe design that is facilitated by a housing that shrouds a tip of a fluid transfer cannula such that the cannula tip is not exposed for inadvertent puncture. This feature may also be enhanced by use of a blunt tipped cannula. The fluid transfer system permits multiple access by enabling the easy swabbing of a septum prior to use.

Abstract: A communicating member for a medical container contains a plate member 4 having a first opening 5 and a second opening 6, a first connection port 15 including the first opening 5, a plug 9 that obturates the first opening 5 and a first approximately cylindrical member 19 that is in communication with the first opening 5, a second connection port 16 including the second opening 6 and a barrier member 13 that obturates the second opening 6, and a continuous wall 17 disposed on the plate member 4 on the first approximately cylindrical member 19 side and disposed upright on the plate member 4 such that the continuous wall 17 encloses the first opening 5 and the second opening 6 when the plate member is viewed from above; and the first approximately cylindrical member 19 is provided with a first communication part 20 that has an opening on the second opening 6 side.

Abstract: An improved propellant pillow and method for filling a propellant chamber of an implantable pump with propellant through the use of such an improved propellant pillow are disclosed. The propellant pillow includes an improved design that prevents the damage of such during evacuating and filling procedures.

Abstract: An object is to provide a communicating needle of simple construction which is attached to a medical infusion bag to connect two or more containers in fluid communication with each other. The communicating needle for connecting two or more containers to communicate includes a tip having an outlet opening formed thereon and a seal member integrally formed with the communicating needle to seal the outlet opening. The seal member readily comes off the communicating needle when acted upon by an external force, causing the outlet opening to open. The communicating needle may be covered by a seal body.

Abstract: The present invention refers to a tubing set (126) suitable for use in co-operation with a machine (100) for carrying out a hemodialysis treatment of a patient's blood. The tubing set comprises: a blood out-tube (102) for supplying the blood from the patient to a filter (106) of said machine; a blood in-tube (114) for supplying the blood from the filter back to the patient; and a substitution tube (116) connected to one of said blood in-tube or blood out-tube suitable for providing a substitution fluid in the patient's blood. According to the invention, the substitution tube comprises an insert (30) for the infusion of drugs. The invention further refers to the insert and to a vial (34) suitable to co-operate with the insert. The invention finally refers to a method for delivering drugs.

Abstract: The invention relates to a medicament container, comprising a cavity at least partially defined by a container wall comprising a soft, flexible inner layer consisting of a soft material and a rigid outer layer consisting of a rigid material, wherein the layers are arranged as a one-piece part by two component injection moulding.

Abstract: The invention relates to a closing cap for containers that are filled with medical liquids. The closing cap includes removal and injection sites. The removal site has a first opening for removing the medical liquid and is obturated by a first pierceable self-sealing membrane. The injection site includes a second opening for injecting an additive and is obturated by a second pierceable self-sealing membrane. The first and second membranes are configured differently.

Abstract: Disclosed is a dispensing system a dispenser having a first chamber containing a first material and a second chamber containing a second material. The dispenser is configured to selectively retract one of the chambers at least partially within the other to transition the dispenser between an extended position and a compact position. The first chamber includes an open top end that is, before use, covered with a first breakable membrane. A breaker ring, at least initially covered with a second breakable membrane, is configured to break the breakable membranes when the dispenser is transitioned between an extended position and a compact position. In the compact position, with the membranes broken, the first material and second material are free to form a mixture that can be dispensed via an opening in the dispenser's openable tip.

Abstract: A fluid delivery device includes a compressible sleeve configured to hold a fluid-holding container such as an ampoule or capsule. The sleeve is compressible so as to be able to shatter the container under user-applied force to release the contents of the container for application to a desired location. The sleeve is constructed from at least two independent and separate walls. The independence of the walls improves the resistance of the sleeve to accidental puncturing by the frangible container while not significantly impacting the force required to shatter the container.

Abstract: The present invention relates to a bung (20) for drug containing cartridges (10) for use in drug delivery devices wherein the bung (20) has a distal end face (22), a proximal end face (24) and a lateral area (26), wherein the bung (20) comprises at least two different materials, a first material (30) covering the whole lateral area (26) of the bung (20) and a second material (32) which is at least partly arranged inside the bung (20), wherein the first material (30) has a larger compressibility than the second material (32) and wherein the whole lateral area (26) has a flat surface. Furthermore, it relates to a cartridge (10) and to a drug delivery device comprising a bung (20) as claimed.

Abstract: An indwelling needle assembly includes a stylet having a sharp needlepoint at an end thereof, a stylet hub secured to a base end of the stylet, a hollow outer needle in which the stylet is inserted, an outer needle hub secured to a base end of the outer needle, an opening formed at the base end or at a side of the outer needle hub to communicate with the inner cavity of the outer needle, a seal fitted onto the outer needle hub and in which a hole or slit is provided for insertion of the stylet therein, the hole or slit being formed to become closed when the inserted stylet is extracted, an operating part installed on the outer needle hub to move the stylet and outer needle along the longitudinal direction when the stylet is inserted into the outer needle, and a movement suppresser for stopping or suppressing moving the stylet relative to the seal when the operating part is operated.

Abstract: In general, the disclosure is directed toward releasing material within a medical device via an optical feedthrough. A system for releasing material with a medical device comprises a cup that holds a material, wherein the cup includes a discharge port, a seal disc that seals the material within the cup, an optical feedthrough assembly coupled to the cup, a shell that defines a chamber within a medical device, wherein the optical feedthrough assembly is coupled to the shell, and a radiant energy source that shines a beam through the optical feedthrough assembly to puncture the seal disc to allow the material to enter the chamber via the discharge port.

Abstract: A flexible container for storing a liquid medicament and a device for the automated release of the liquid medicament from the flexible container are disclosed. The flexible container includes a wall and an access opening. The wall of the flexible container comprises two sheets of flexible material sealed together such that a storage volume intended to contain the liquid medicament is defined. The access opening provides a fluid connection to a conduit system in fluid connection with the storage volume via a fluid channel arranged between the storage volume and the access opening, wherein the fluid channel is formed by a cavity arranged on at least one of the two sheets.

Abstract: A system for removing or transferring a pharmaceutical product from a reservoir including an ampoule with a moveable piston therein and an adaptor which includes, generally along a longitudinal axis, a reservoir connector and an ampoule connector for coupling to the ampoule, wherein the ampoule connector includes at least one locking mechanism which, in a side wall, includes a resilient element generally corresponding to a portion of the side wall which extends along the periphery thereof and, at opposing ends, merges with the side wall.

Abstract: The invention relates to a kit for parenteral administration of drugs, particularly a kit for the infusion of those medicaments dissolved in solvents that extract toxic components from PVC, which is also suitable for the infusion of highly active medicaments, said kit ensuring a safe administration both for the patient and for healthcare staff.

Abstract: A package including a vessel made of cyclic olefin polymer (COP) resin, a CVD coating on a vessel, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.

Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.

Abstract: The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.

Abstract: The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.

Abstract: A holding device for a container having a closure system to be pierced by a spike includes a base, a shield, and a mounting unit supporting the base. The base includes an elongate body having opposed first and second ends and an elongate body extending therebetween. The base body defines an elongate open spike cavity extending between opposing ends thereof. The channel receives an elongate spike therein so that a free end of the spike extends beyond the base body from the channel. The shield includes first and second opposed open ends and an elongate cylindrical wall extending therebetween. The shield is telescopically mounted over the base so as to be movable between a first position wherein an inserted spike is clear of inserted container cap and a second position wherein the spike pierces through the septum of the container cap at the intended location.

Abstract: A cartridge is engageable with a medical device, the cartridge comprising an ordered arrangement of N electrical components (540) each with different respective values of an electrical property, and an ordered arrangement of N conductors (522, 524, 526) operably coupled to the ordered arrangement of the N electrical components.

Abstract: A connector for packings containing medical liquids, particularly infusion, transfusion or enteral bags, comprises a connecting part (1) for accommodating a spike for drawing out the liquid and comprises a closure part (3) that closes the passage (2) inside the connecting part (1). The connecting part (1) has an elastically deformable pinching off part (4) provided in the form of a tubular section with a non-circular cross-section. A base part (5), which widens on both sides is adjoined to said pinching off part (4) and can be integrated in the packing. During manufacturing, the packing is filled with liquid via the connecting part. After filling, the pinching off part is pressed together whereby preventing liquid from escaping. Afterwards, the closure part is placed onto the connecting part. The manufacturing of the packing is simplified by virtue of the fact that an additional tube for connecting the connector and packing is rendered unnecessary.

Abstract: An apparatus is disclosed that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.

Abstract: A single-use indicator is provided and is particularly well suited for use with a surgical catheter device. The indicator includes an absorbent filament or wick which is placed in a transparent or translucent indicator lumen of a multi-lumen catheter. The lumen is provided with at least one side port. When the catheter is inserted into a blood vessel, blood enters the indicator lumen through the side port and is absorbed by the filament, thus turning the filament red or purple in color. When the instrument is removed from the blood vessel, the stained filament is clearly visible as an indicator that the instrument has been used. Because the filament is trapped inside a lumen of a relatively long catheter, it is difficult or impossible to remove it during a remanufacturing process.

Abstract: Device (5) for filtering blood including a filter unit (7) having a blood filter, an inlet (8) for blood to be filtered and being connectable to an artery of a patient and a blood outlet (9) for filtered blood and being connectable to a vein of the patient, and having a filtrate container (6,14), that encloses the filter unit (7), for receiving filtrate (12) passing through the blood filter during a filtering process and that the filtrate container (6,14) is a closed container, which in a filled state is arranged to establish a counter-pressure over the blood filter, whereby the filtering process is interrupted. The invention also concerns a system including the above device.

Abstract: The present invention consists of a blood reservoir that incorporates a separate chamber designed to trap condensing water vapor. The blood chamber and the vapor trap are in fluid communication along their top assuring that vacuum applied to the top of the vapor trap is equally applied to the blood chamber. The combination is also structured to prevent condensate water accumulating in the vapor trap chamber from overflowing into the blood chamber as well as provide a structure that allows the end user to empty the water in the vapor trap chamber.

Abstract: Ambulatory infusion pumps, pump assemblies, cartridges, baseplates, cannulas, insertion tools, and related components as well as combinations thereof and related methods.

Abstract: A blood tube system for extracorporeal uses, such as dialysis devices, wherein an arterial expansion chamber including a lower region for receiving blood, in which a blood inlet channel terminates, and from which a blood outlet channel extends, and an upper region for receiving air, where a venting channel provided with a venting valve extends from the upper region. The blood tube system includes a central region of the expansion chamber which has considerably reduced cross-sectional dimensions, the blood level being adjustable by means of the venting valve in such a manner that blood/air contact takes place in the central region. The amounts of heparin and EPO needed for a dialysis treatment can thereby be reduced.

Abstract: The invention relates to a container (5) for receiving at least one non-sterile vessel (1, 1?), in particular a pierceable ampoule with a pierceable rubber stopper (3), containing a removable substance (2, 2?), and for introducing the at least one vessel (1, 1?) into a sterile region (I), said container comprising at least two interconnectable parts (6, 7) which, in their interconnected state, are designed to receive the at least one vessel (1, 1?), one container part (7) including at least one means (11, 11?) for removing the respective substance (2, 2?) from the at least one vessel (1, 1?). To create such a container (5) which can be produced at low costs and is easy to handle, said container parts (6, 7) are surrounded by a removable envelope (10) which consists of at least two parts (8, 9).

Abstract: A fluid containment and dispensing system includes a sealed, variable-volume containment device having a movable plunger slidably mounted within a barrel, and a sealing head having a seal insert retained thereon. A seal arrangement includes a self-resealing cross-slit opening, an internal sealing ring for engaging a corresponding coupling of a compatible device, and a raised peripheral seal ring for sealing engagement with a closure lid.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: Systems and devices are provided to facilitate safe handling and injection of medicaments contained in vials. A vial handling system has at least one vial gripping member to hold a vial, and a filler pin movable relative to the vial gripping member for piercing a membrane seal on the vial. At least one window is provided in the vial handling system to permit access to remove a cap on the vial, while preventing needle access to the membrane seal through the window. In some embodiments, the vial contents are removed through a male end connector portion of a unique connector pair. A female end connector portion has a female socket with an inner fluid tube in fluid communication with a body of a syringe, while the male end connector portion has an engaging end dimensioned to fit within the female socket and securely overlap the inner fluid tube.

Abstract: An arrangement in connection with the handling of patient fluids, comprising a suction canister open at one end, a cover for closing the suction canister, a suction bag fastened to the cover, and an underpressure apparatus for applying underpressure to a space between the suction canister and the suction bag. The arrangement further comprises fastening means for keeping the suction bag narrowed in such a manner that the width and length of the suction bag are at least along part of the suction bag smaller than when the suction bag is opened, and the fastening means are arranged to release the suction bag to be opened into the suction canister under the action of the underpressure when the cover is closed.