Abstract: Compositions of proteins having free thiols, and methods of making and using such compositions, are described.

Abstract: A portable blood storage device includes an outer housing an inner housing. The outer housing defines the structure of the blood storage device. The inner housing is located within the outer housing and has an interior cavity for storing collected blood and/or blood components. The inner housing has an open top to allow access to the interior cavity. The storage device also has an inlet duct and a return duct located within the interior cavity. The inlet duct is fluidly connectable to a cooling device and brings conditioned air into the storage device when fluidly connected to the cooling device. The return duct is also fluidly connectable to the cooling device and returns exhaust air to the cooling device when fluidly connected.

Abstract: The present disclosure is generally directed to an embolic material which, in some embodiments, may be in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material may further comprise a therapeutic agent, such as doxorubicin.

Abstract: A container for accommodating different injection medicines comprises a first vessel, a second vessel and a partition disk. First vessel is an integral hollow cylinder sandwiched between a pair of intercommunicatable top surface and bottom surface. Second vessel of integral hollow cylinder includes a first holding compartment therein encompassed by an open top surface, a closed bottom surface and a sidewall. Partition disk is padded under the bottom of the first vessel. Partition disk and lower section of first vessel are inserted into upper section of second vessel. Thereby, different injections can be temporarily held in separated compartments respectively without intermixing. When injection administration is required, blending procedure is well hermetically finished in the vial without any syringe needle. Thereby, not only entire blending procedure meets aseptic requirement, but also accidence for the healthcare personnel being pierced by such syringe needle is completely eliminated.

Abstract: Chlorine and Hydrogen Peroxide Medical Therapies including Ear Dropper Multiple Vile Medicine Mixing Cool Mist Vaporizer with detachable Inhalation Hose and Facemask Double Density Air Filter, 3-Speed Motor with On/Off Switch, Home and Hospital Models with Atomizer and an Orifice for attachment to and Oxygen Tank, Pre-Wrapped Bandages, Gauze Stick-On Strips or Squares or Strip-less Gauze Pads with Liquid or Gel, Chlorine or Hydrogen Peroxide also, Lotions for Skin Infections and Cancers, Chemical Injections and Patient Baths, and Wellness Therapies

Abstract: An apparatus is disclosed that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.

Abstract: A cartridge insertion assembly including apparatus with a pathway formed therein, a cartridge insertable into the pathway, the cartridge including a cartridge coupling element connectable to an activation mechanism disposed in the apparatus operative to cause a substance contained in the cartridge to be metered out of the cartridge, and a door pivoted to the apparatus that includes a door coupling element arranged with respect to the cartridge such that when the door is in a fully closed position, the door coupling element couples the cartridge coupling element with a coupling element of the activation mechanism.

Abstract: Provided herein are stable co-formulations of immunoglobulin and hyaluronidase that are stable to storage in liquid form at room temperature for at least 6 months and at standard refrigerator temperatures for 1-2 years. Such co-formulations can be used in methods of treating IG-treatable diseases or conditions by subcutaneous administration.

Abstract: A port assembly includes a valve housing with an inlet opening, a valve disposed in the valve housing to control access through the inlet opening, and a base having an outlet opening that is initially occluded by a membrane. A pivot is disposed within the base and has a cutting surface disposed within the base, the cutting surface rupturing the membrane at least in part as the pivot is pivoted about an axis between first and second positions. The port assembly may be used in a fluid container that includes a receptacle for retaining a fluid, and at least one conduit in communication with the receptacle. The at least one conduit is defined, at least in part, by the port assembly.

Abstract: The present invention relates to a liquid pharmaceutical composition comprising a granulocyte colony stimulating factor polypeptide conjugated with a polymer, the composition having a pH value in the range of 4.5 to 5.5. The composition further comprises a surfactant and optionally one or more other pharmaceutically acceptable excipients. Further, the composition of the invention is free from tartaric acid or salts thereof and from succinic acid and salts thereof as buffering agents and does not contain amino acids as stabilizer. The composition has a good storage stability and is especially useful for the prophylaxis and treatment of disorders and medical indications where granulocyte colony stimulating factor preparations are considered as useful remedies.

Abstract: Disclosed is L-glucose monohydrate and compositions thereof. Also disclosed are methods for making L-glucose monohydrate and compositions thereof. Further disclosed are methods for colonic cleansing using L-sugars, such as L-glucose monohydrate, and compositions and kits useful for colonic cleansing.

Abstract: Compositions and methods for modifying biologically active substances to achieve multi-day delivery of such substances, particularly through oral or parenteral administration, are disclosed. The compositions include the biologically active substance conjugated to a carrier having a suitably long half life, typically more than one day, wherein the conjugate optionally contains a spacer linking the carrier to the biologically active substance. Pharmaceutical formulations of the conjugates are also disclosed, as are methods of extending delivery of a single dose of a biologically active substance for more than one day.

Abstract: The present invention relates to the use, as active ingredient, of a 1-N-(halo-3-pyridylmethyl)-N-methylamino-1-alkylamino-2-nitroethylene derivative for preparing a veterinary pharmaceutical composition for topical use in the treatment of external parasites, in particular fleas, in domestic animals, in particular in dogs and cats, intended to be applied at least every 2 weeks.

Abstract: Improved fluid delivery devices and systems are disclosed, including drug delivery devices and systems, and methods that permit, inter alia, the rapid sequential delivery of two or more fluids to a single external fluid flow or intravenous line.

Abstract: The invention relates to a process for producing polyethylene aseptic squeezable pouches. The invention also covers said pouches and their use for medical packaging applications.

Abstract: Vacuum break vial assembly and method for reducing the incidence of nosocomial infections, comprising a vial stopper having an apertured needle sheath, and a hole in the bottom of the vial fitted with a single or multi-part bladder-retaining plug/vent assembly. The vial has an aluminum cap holding a plastic flip-off top, removal of which permits access by hypodermic needle through the stopper into the needle sheath. No pre-pressurization of the vial by ambient contaminated air via the hypodermic can occur. Rather, the needle is inserted in the vial through the stopper and the medicinal fluid withdrawn. Air is inlet via a vent into the collapsed bladder secured in the bottom of the vial and the bladder expands to permit withdrawal of fluid into the hypodermic without vacuum lock. No air having pathogen vectors is introduced into the vial medicinal fluid, as the bladder isolates volume-compensating air from the medicinal fluid.

Abstract: An aqueous composition comprising a therapeutic protein further characterized in that (i) the pH of the composition is adjusted to be between about 5.9 and 6.3, preferably about 6.1; (ii) the composition comprises at least one displaced buffer having a pKa within 1 to 3 pH units of the pH of the composition; (iv) the osmolarity of the composition is between 150-500 mOsm/L.

Abstract: The invention relates to a label, to the use of a raised structural feature, to an injection device, and to a method for producing a label. The label (10) comprises a flexible support layer (12) which, on one face (18), is provided at least partially with at least one raised structural element (20), wherein the structural element (20) is designed in such a way that, when the label is applied to the container (40), the raised structural element (20) is directed away from the container (40), and the structural element (20) is able to establish a form-fit connection with another structural element (67).

Abstract: A pharmaceutical composition for the acute and/or chronic treatment or prevention of osteoarticular diseases includes an adequate pharmaceutical carrier or diluent, a polysaccharide and/or a glycosaminoglycan, an anti-inflammatory agent and stem cells.

Abstract: Hexaamminecobalt(III) chloride, also called Cohex, reduces the extent of viral infection, including difficult to treat infections caused by Ebola virus and HIV. Disclosed are methods for treating a viral infection, comprising administering to a patient a cobalt(III) hexammine compound in an amount effective to reduce an extent of a viral infection. Also disclosed are kits for delivery of a cobalt(III) hexammine compound by injection.

Abstract: A novel anti-human tenascin ST2146 monoclonal antibody is described endowed with high affinity with the native antigen and high tumor selectivity. The cST2146 hybridoma is stably producing the antibody in high density culture conditions and is suitable for the industrial development of ST2146-based products. ST2146 exhibits properties exploitable for both therapeutic and diagnostic applications.

Abstract: A flexible multi-chamber container for preparation of medical mixed solutions includes at least three chambers separated from each other by leaktight seams. The chambers are designated to be filled with different solutions and are separated from each other by leaktight seams. At least a part of the first leaktight seam is provided with a separation zone to be opened for fluid transfer from the first chamber into the second chamber. At least a part of the second leaktight seam is provided with a separation zone to be opened for fluid transfer from the second chamber into the third chamber. The leaktight seams are arranged and the separation zones are formed such that, in use of the container for preparation of the medical mixed solution, the first separation and second separation zones are opened in a sequential order. The first zone is opened before the second separation zone is opened. Thus, the components are mixed one after another in a predetermined sequential order.

Abstract: The invention relates to a tamperproof seal for a container or a syringe, with a lockable conical adapter which is sealed in a sterile manner by means of a rubber stopper and is protected by a safety sleeve, wherein the safety sleeve, which is pushed non-releasably onto the conical adapter lock, comprises a retaining part, a break-off part and a break-off zone located between said parts. The break-off part encloses the rubber stopper without radical contact. It has a retaining pin, the free end of which rests axially on the rubber stopper—when the tamperproof seal is fitted, and it has at least two open apertures. The length of the break-off part corresponds to at least twice the length of the internal thread of the conical adapter lock. The present invention produces a tamperproof seal which ensures safe handling of the combination comprising the container or syringe and tamperproof seal.

Abstract: In a drug container filled with a liquid drug, bubbles are formed during prolonged storage even in the case where the liquid drug is filled in a gas-free state after removing dissolved gas. With the container here, bubbles formed in the container during storage are removed and the formation of bubbles in the container is inhibited or prevented. A drug container, in which a liquid drug is enclosed, includes at least in part a resin member coming into contact with the liquid drug and a pressurizing member removable from the drug container, by which the liquid drug is maintained in a pressurized state, with the liquid drug being in a substantially bubble-free state.

Abstract: A test for diagnostic tests, particularly for testing blood prior to a transfusion is disclosed. The test element includes at least two test units for carrying out at least two tests. The test element is provided with a fixing means for fixing the test element.

Abstract: In a peritoneal dialysis embodiment of the present invention, spent dialysate from the patient's peritoneal cavity passes, along a patient loop, through a dialyzer having a membrane that separates waste components from the spent dialysate, wherein the patient loop returns fresh dialysate to the patient's peritoneal cavity. The waste components are carried away in a second regeneration loop to a regeneration unit or sorbent cartridge, which absorbs the waste components. The regeneration unit removes undesirable components in the dialysate that were removed from the patient loop by the dialyzer, for example, excess water (ultrafiltrate or UF), toxins and metabolic wastes. Desirable components can be added to the dialysate by the system, such as glucose and electrolytes. The additives assist in maintaining the proper osmotic gradients in the patient to perform dialysis and provide the necessary compounds to the patient.

Abstract: Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

Abstract: The invention relates generally to a sample vial adaptor for interfacing a sample vial with the sample port of a diagnostic instrument, in particular a sample vial containing a patient body fluid sample with the sample port and sample pathway of a multi-use diagnostic instrument. Embodiments of the sample vial adaptor according to the invention generally include a short exterior vent tube having one end in communication with a chamber having a vent, an interior collection tube that is longer than the short exterior vent tube, axially positioned in the lumen of the short exterior vent tube and extending to a capillary outlet that is located on the portion of the inner collection tube that is outside of the short exterior vent tube and outside the vented chamber.

Abstract: A stable packaged bicarbonate solution for use in dialysis treatment and for treating anemia, iron deficiency, or reducing the required dose of recombinant erythropoietin to treat anemia includes a bicarbonate solution into which ferric pyrophosphate is dissolved. The amount of ferric pyrophosphate dissolved in the bicarbonate solution is sufficient to provide a therapeutic effect for the treatment of anemia, iron deficiency or to reduce dose of recombinant erythropoietin needed to treat anemia when the bicarbonate solution is combined with other dialysis components to form a dialysate used for dialyzing a patient. The ferric pyrophosphate is stabilized in the bicarbonate solution by holding the solution in a polyolefin container or container liner, such as a high density polyethylene container or liner.

Abstract: The present invention is directed to aqueous based formulations of water-soluble prodrugs of propofol. The formulations comprise in aqueous medium an effective amount of the water-soluble prodrug of propofol in the absence of an antioxidant. The formulations are particularly useful as intravenous injections. The formulations preferably are buffered to a pH suitable for minimizing degradation of the prodrug during storage. The formulations can be prepared without the use of harmful co-solvents or surfactants and are stable at room temperature over extended periods of time.

Abstract: A medical device, for example a stent, has a surface which in use contacts body tissue, wherein said surface has on it a biocompatible coating layer comprising a polymer having covalently bound allyl-terminated pendent groups, said pendent groups comprising a moiety selected from -0-CH2—CH?CH2—S—CH2—CH?CH2—S(=0)-CH2—CH?CH2—Se—CH2—CH?CH2 and —Se (=0 J-CH2—CH?CH2. This surface has good biocompatibility and can bind strongly to a metallic surface. The polymer may be made from an electropolymerisable monomer, e.g. a pyrrole.

Abstract: The present invention is directed to pharmaceutical compositions comprising melphalan and a cyclodextrin derivative, and methods of making and using the same.

Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture.

Abstract: A container for a vial of radiopharmaceutical, made of polymethyl methacrylate consists of a receptacle, with a cavity capable of containing the vial of radiopharmaceutical, and of a lid screwed onto the receptacle for closing the container, said lid presenting a central through-hole. A set, in combination with this container with the vial of radiopharmaceutical, consisting of a bottle of saline solution and two infusion catheters, enhances the radioprotection during the infusion of a radiopharmaceutical in an infusion operation.

Abstract: Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed.

Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample and mesenchymal stem cells from bone reaming material. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.

Abstract: An aqueous or powder composition includes anti-gram-negative antibiotic or salt thereof being present at an amount ranging from about 100 mg/ml to about 200 mg/ml. Another aqueous or powder composition includes anti-gram-positive antibiotic or salt thereof being present at a concentration ranging from about 0.6 to about 0.9 of the water solubility limit, at 25° C. and 1.0 atmosphere, of the anti-gram-positive antibiotic or salt thereof. Other embodiments include unit doses, kits, and methods.

Abstract: A pharmaceutical product includes a container. The container, in turn, includes a receptacle having a wall including a layer of nickel or nickel alloy, the layer facing an interior of the receptacle. The product also includes a halogenated anesthetic selected from the group consisting of sevoflurane, desflurane, isoflurane, enflurane, methoxyflurane and halothane disposed within the container.

Abstract: Moderate moisture levels, such as greater than 3% but no greater than 7%, may be beneficial for solid formulations of certain prostacyclin analogs. Accordingly, a solid formulation containing a prostacyclin analog may be packaged inside a pharmaceutical packaging with such amount of a desiccant or a drying agent that after the storage the solid formulation may have a moderate level of moisture in it.

Abstract: A connector for connecting a container with a fluid preparation device for preparing a fluid, in particular a container with a concentrate for the preparation of dialysis fluid, as well as the combination of the connector, the corresponding container and the fluid preparation device. In order to simplify the handling during both the manufacturing process of such containers and the connection of such containers to the fluid preparation devices, the connector connects a first and second fluid line of the container with a third and fourth fluid line of the fluid preparation device with two laterally spaced-apart mounting elements which each incorporate one of two orifices terminating the first and second fluid lines.

Abstract: A sealing element is suggested, in particular one for closing primary packaging for medications, that has at least two parts, which touch each other at least in some areas. This is characterized in that steam-permeable channels are provided for sterilization of the contact surfaces. In addition, a method is suggested for manufacturing a syringe system with a sealing element. This is characterized by the steps—preliminary assembly of the sealing element, —sterilization of the sealing element, —final assembly of the sealing element.

Abstract: Methods and apparatus for collecting blood samples in vacuum sample tubes are disclosed. The samples, including the initial blood sample, are substantially free of excess air.

Abstract: The present invention relates to a packaging kit used for the stabilization of sirolimus particles wherein the packaging kit is in the form of a vacuum sealed impermeable container. It further relates to a method for stabilization of sirolimus particles as well as composition comprising the particles.

Abstract: The invention relates to a parison for producing a receptacle used for holding liquids for medical applications, especially for holding infusion solutions or enteral nutrient solutions. The invention further relates to a method for producing such receptacles as well as such a receptacle. The parison according to the invention comprises a neck part (1) with an opening (1A), a wall part (2), and a bottom part (3) and is characterized in that one end of a section (5B) of an annular suspension device for suspending the receptacle is molded onto the underside of the bottom part (3). The free end of said section (5B) can be connected to the underside of the bottom part (3) such that the section (5B) is deformed and the annular suspension device is formed. First, the parison is produced, whereupon the receptacle is formed from the parison by means of a drawing and blow molding process. Preferably, the parison is produced in an injection molding process.

Abstract: The injection-moulded multilayer transparent plastic container (1) exhibits air and water barrier properties, and has at least one barrier layer (CL) comprising a fluoropolymer. Preferably, said fluoropolymer is a homo or copolymer of polychlorotrifluoroethylene (PCTFE).

Abstract: A single-use, blow-molded container for medical or pharmaceutical media is presented. The container comprises a flexible storage portion connected to one end a dispensing portion and a cap connected to the other end of the dispensing portion, wherein the cap is separated from the dispensing portion to create an outlet opening so that the medical media can be expelled from the flexible storage portion. One improvement comprises at least one barrier member disposed on the dispensing portion, wherein the barrier member is sized and dimensioned to limit the insertion of the dispensing member into a patient's nostril. Another improvement comprises an orifice controlling the pattern and direction of the medical media as it exits the ampoule container and wherein the orifice is spaced apart from the outlet opening.

Abstract: The invention relates to a liquid pharmaceutical composition comprising a pegylated IFN-? (PEG-IFN-?), an excipient, a surfactant and a buffer wherein said excipient is a polyol, wherein said surfactant is a non-ionic surfactant and wherein said buffer is a sodium acetate buffer.

Abstract: A multi-layered plastic body for containing, storing or conducting a medical, diagnostic, pharmaceutical, cosmetic or other product, the plastic body including a first layer made of a stress fracture resistant plastic material, and at least a second layer adjacent to the first layer and made of a plastic material exhibiting a lower resistance to stress fractures than the first plastic material. The invention encompasses a suitable method of making the body.

Abstract: An enteral feeding device, includes a system for delivering liquid nutrients to an enteral feeding tube. The device includes: (a) a container, having first, second and third openings; (b) a tip configured to be coupled to the container, the tip having an opening in fluid communication with the first opening of the container, the second opening of the container configured such that nutrient can be delivered to the second opening and the third opening configured to receive nutrient or to allow gas expelled from the patient (e.g., through burping) to flow there through.

Abstract: A vial enshrouded or contained in a protective covering which prevents emission of radiation form the vial contents, shielding the environment and personnel from irradiation. The vial optionally has a V-shaped bottom to allow withdrawal of a maximal amount of the fluid without inverting the vial. The vial is equipped with a vial access adapter having a fluid withdrawal spike which extends in to the V-shaped bottom. The vial access adapter may be vented or non-vented.