Patents Represented by Attorney Casimir Jones, S.C.
  • Patent number: 8347924
    Abstract: The invention relates to a main valve for a fuel pump nozzle, the main valve comprising a shut-off body for closing a fuel line and a displacement space that is configured to avoid undesirable pressure surges during closing of the main valve. The invention further relates to a fuel pump nozzle comprising a main valve according to the invention.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: January 8, 2013
    Assignee: Elaflex Hiby Tanktechnick GmbH & Co.
    Inventor: Heinz-Ulrich Meyer
  • Patent number: 8341117
    Abstract: Provided herein are data management systems and methods for storing, cataloging, and protecting data on a computer using software and a portable data storage device. The technology can back up, manage, and protect data for any operating or file system by checking files for block-level or byte-level changes and storing only new data. By storing only new data and cataloging information within a comprehensive backup archive composed of these blocks, the size of each backup is minimized.
    Type: Grant
    Filed: November 18, 2008
    Date of Patent: December 25, 2012
    Assignee: Arkeia Software, Inc.
    Inventors: Tamir Ram, Lawrence Hiroshi Kubo
  • Patent number: 8338569
    Abstract: Fibroblast growth factor receptor (FGFR) extracellular domain (ECD) acidic region muteins that have been engineered to exhibit decreased tissue binding by increasing the number of acidic amino acid residues within the D1-D2 linker region are provided. Polynucleotides encoding FGFR ECD acidic region muteins are also provided. Methods of making FGFR ECD acidic region muteins, and methods of using such molecules to treat proliferative disorders, including cancers, disorders of angiogenesis, and macular degeneration, are also provided.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: December 25, 2012
    Assignee: Five Prime Therapeutics, Inc.
    Inventors: Shannon Marshall, Deborah H. Charych, Ali Sadra
  • Patent number: 8337813
    Abstract: The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: December 25, 2012
    Assignee: Northwestern University
    Inventors: Elise A. Schultz Sikma, Mohammad Aslam, Vinayak P. Dravid, Thomas J. Meade, Bradley D. Ulrich
  • Patent number: 8334272
    Abstract: The present invention provides methods for increasing the transfer of nucleic acids into cells. In particular, the present invention provides for the use of inhibitors of HDAC6, a cytoplasmic histone deacetylase present in mammalian cells by, for example, small molecules or siRNA treatment, in increasing gene transfer and/or expression in cells in vitro and in vivo for research and gene therapy applications.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: December 18, 2012
    Assignee: Northwestern University
    Inventors: David A. Dean, Robert Christopher Geiger
  • Patent number: 8329887
    Abstract: The present invention relates generally to methods, compositions and kits for synthesizing sense RNA molecules from one or more RNA molecules of interest in a sample. In exemplary embodiments, the methods use a terminal tagging oligoribonucleotide (rTTO) to join a DNA sequence tag to the 3?-termini of first-strand cDNA molecules. The use of an rTTO comprising ribonucleotides results in decreased oligonucleotide-derived background synthesis of RNA in the absence of sample RNA and, surprisingly and unexpectedly, also results in significantly increased yields of sense RNA molecules that exhibit sequences that are substantially identical to those of the RNA molecules of interest in the sample. The sense RNA molecules also have an RNA sequence tag on their 5?-termini that is useful for fixing the lengths of sense RNA molecules that are synthesized in a second or subsequent round.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: December 11, 2012
    Assignee: Cellscript, Inc.
    Inventors: Gary Dahl, Roy Rabindranauth Sooknanan
  • Patent number: 8323914
    Abstract: The present invention relates to analyte detection test systems, including test systems for the oral detection of analytes in saliva. The present invention also provides compositions and methods for storing multiple assay tests and compositions and methods for measuring the concentration of analytes in a sample.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: December 4, 2012
    Assignee: N2itive1 Innovations
    Inventors: Anthony Toranto, Evan Singer, Brett Miller
  • Patent number: 8323926
    Abstract: The present invention relates to a novel H. polymorpha gene regulating Unfolded Protein Response (UPR) and a method for improving the efficiency of secretory expression of a recombinant protein using the same, more particularly, a method for improving the efficiency of secretory expression of a recombinant protein by identifying, modifying, and optimizing the HpHAC1 gene, which encodes a key transcription regulatory factor of the UPR mechanism in H. polymorpha, and a regulatory mechanism mediated by the gene. According to the present invention, the secretory expression system of H. polymorpha can be used for the mass-production of secretory proteins for industrial and medical applications, thereby producing a large amount of the proteins at low cost. Accordingly, the method is employed in the production of the proteins for industrial and medical use, so as to reduce economic burden for a patient, and contribute to the improvement in the welfare of all mankind.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: December 4, 2012
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyun Ah Kang, Hye-Yun Moon, Doo-Byoung Oh, Sang Ki Rhee
  • Patent number: 8318688
    Abstract: The present invention relates to compositions and methods for altering (e.g., enhancing) RNAi. In particular, the present invention provides systems and methods for identifying regulators of RNAi. For example, the present invention provides RNAi regulators (e.g., HPS1 and HPS4) and methods of altering (e.g., inhibiting) these regulators in order to alter (e.g., enhance) RNAi. The present invention also provides methods of identifying inhibitors (e.g., small molecule, nucleic acid (e.g., siRNA), and antibody) of RNAi regulators and methods of using the same (e.g., to enhance RNAi). Compositions and methods of the present invention find use in research (e.g., functional genomics), therapeutic (e.g., drug discovery and delivery) and clinical applications.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: November 27, 2012
    Assignee: Northwestern University
    Inventors: Richard William Carthew, Young Sik Lee, Dinari Harris
  • Patent number: 8318475
    Abstract: The present invention relates to compositions comprising yeast cells and/or yeast cell components and methods for producing and utilizing the same. In particular, the invention provides novel yeast comprising altered cell wall structure (e.g., clay and/or clay component(s) integrated (e.g., interlaced) into cell wall(s) and/or cell wall(s) comprising altered glucan:mannan ratio), methods of producing the same, compositions comprising and/or derived from the same, and methods of using the same (e.g., to sequester and/or adsorb bacteria and toxins). Compositions and methods of the invention find use in a variety of applications including dietary (e.g., admixing with feedstuffs or otherwise feeding to animals), therapeutic, prophylactic (e.g. admixing with bedding sources and/or other materials that come into contact with animals, usage during food and beverage processing and manufacture, and usage during filtration of liquids) as well as research applications.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: November 27, 2012
    Assignee: Alltech, Inc.
    Inventors: Alexandros Yiannikouris, Ursula Anne Thielen
  • Patent number: 8317264
    Abstract: The invention relates to a seat for a means of transport, having a supporting structure (1, 2, 3, 4), on which seating surface (5) and backrest (6) are mounted, and having a seat crossbeam (3, 4) of hollow design. The invention provides for the cavity of the seat crossbeam (3, 4) to contain electrical and/or electronic components (7).
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: November 27, 2012
    Assignee: Lufthansa Technick AG
    Inventors: Harald Merensky, Stefan Kahabka, Andrew Muirhead
  • Patent number: 8313941
    Abstract: Microfluidic devices having active features such as valves, peristaltic pumps, and mixing portions are fabricated to have a thin elastomeric membrane over the active features. The active features are activated by a tactile actuator external to the membrane, for example, a commercial Braille display. The display may be computer controlled, for example by simple text editor software, to activate individual Braille protrusions or a plurality of protrusions to actuate the active portions of the microfluidic device. Integral devices can incorporate the tactile actuators in a single device, but still external to the membrane.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: November 20, 2012
    Assignee: The Regents of The University of Michigan
    Inventors: Shuichi Takayama, Xiaoyue Zhu, Wei Gu, Gary Daniel Smith, Yunseok Heo, Brenda S. Cho, Nobuyuki Futai
  • Patent number: 8298760
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: October 30, 2012
    Assignee: Ibis Bioscience, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • Patent number: 8298801
    Abstract: The present invention is directed toward the delivery of toxic agents to pathogenic cells, particularly cancer cells. In some embodiments, the toxic agent is a human ribonuclease or similar agent that is toxic to cells.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: October 30, 2012
    Assignee: Quintessence Biosciences, Inc.
    Inventors: John A. Kink, Laura E. Strong, Mark N. Shahan
  • Patent number: 8296661
    Abstract: The present invention provides methods for integrating the peer review process with other applications and facilitating peer review using a user interface linked to a peer review application having knowledge base information and defined rules for: accepting a paper for peer review, assigning the paper to one or more of a defined set of reviewers for review, providing to the reviewers one or more criteria to be used for reviewing and evaluating each paper for enabling each reviewer to create a peer review result, and processing all peer review results for any paper to produce a peer review report. Access to these systems and methods may be provided, for example, on a stand-alone computer or over the Internet, World Wide Web, or an intranet.
    Type: Grant
    Filed: September 14, 2009
    Date of Patent: October 23, 2012
    Assignee: iParadigms, LLC
    Inventors: John M. Barrie, Colin C. Sherman
  • Patent number: 8293776
    Abstract: The present invention provides compositions and methods for treating inflammatory conditions (e.g., of the bowel). In particular, the present invention provides methods of treating (e.g., therapeutically and/or prophylactically treating) inflammatory conditions (e.g., of the bowel), compositions useful for such methods (e.g., antagonists and/or inhibitors of angiotensin II (AngII) receptor Type 1a (AT1a)), and methods of identifying, characterizing and/or optimizing such compositions. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine) and research applications.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: October 23, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: Daniel H. Teitelbaum, Hollis Showalter, Scott Larsen, Peter Lucas, Hiroyuki Koga
  • Patent number: 8288093
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof. The present invention further relates to methods and devices for the separation of nucleic acid molecules based on charge. The present invention also provides methods for the detection of non-target cleavage products via the formation of a complete and activated protein binding region. The invention further provides sensitive and specific methods for the detection of human cytomegalovirus nucleic acid in a sample.
    Type: Grant
    Filed: April 8, 2008
    Date of Patent: October 16, 2012
    Assignee: Third Wave Technologies, Inc.
    Inventors: Jeff G. Hall, Victor I. Lyamichev, Andrea L. Mast, Mary Ann D. Brow
  • Patent number: 8288523
    Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.
    Type: Grant
    Filed: March 7, 2007
    Date of Patent: October 16, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Rangarajan Sampath, Thomas A. Hall, David J. Ecker, Lawrence Blyn
  • Patent number: 8278367
    Abstract: A subject-matter of the invention is an impression material with at least one compound with at least two alkenyl groups as component (a), at least one compound with at least one chelating group as component (b), at least one organohydropolysiloxane as component (c), at least one hydrosilylation catalyst as component (d) and at least one compound with a chelatable metal atom as component (e), the chelating group of the component (b) exhibiting no reactive groups which can react with the component (c) and/or the component (d). The invention achieves a long storage stability.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: October 2, 2012
    Assignee: Ernst Muehlbauer GmbH & Co. KG
    Inventors: Henrik Boettcher, Stephan Neffgen
  • Patent number: D667798
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: September 25, 2012
    Assignee: Raffel Systems, LLC
    Inventors: Michael Burwell, Paul Stangl