Patents Represented by Attorney Casimir Jones, S.C.
  • Patent number: 8214154
    Abstract: “The present invention provides systems for: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: July 3, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • Patent number: 8211995
    Abstract: The subject matter of the invention is a method for the removal of alkaline or acidic compounds from a solvent-containing metal oxide dispersion, having the following steps: a. conversion of the solvent into gas phase; b. condensation of the solvent; c. bringing the condensed solvent into contact with a neutralizing agent; d. Return of the condensed solvent into the metal oxide dispersion.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: July 3, 2012
    Assignee: Nanoresins AG
    Inventors: Uwe Dietrich Kühner, Onno Graalmann
  • Patent number: 8211645
    Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: July 3, 2012
    Assignees: The Regents of the University of Michigan, The Brigham and Women's Hospital
    Inventors: Scott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
  • Patent number: 8211867
    Abstract: Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: July 3, 2012
    Assignees: Regulus Therapeutics Inc., Rosetta Genomics Ltd.
    Inventors: C. Frank Bennett, Ayelet Chajut, Christine Esau, Eric G. Marcusson, Noga Yerushalmi
  • Patent number: 8206715
    Abstract: Antibodies that bind CSF1R are provided. Antibody heavy chains and light chains that are capable of forming antibodies that bind CSF1R are also provided. Polynucleotides encoding antibodies to CSF1R are provided. Polynucleotides encoding antibody heavy chains and lights chains are also provided. Methods of treatment using antibodies to CSF1R are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis, bone loss, and multiple sclerosis.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: June 26, 2012
    Assignee: Five Prime Therapeutics, Inc.
    Inventors: Justin Wong, Maximiliano Vasquez
  • Patent number: 8206904
    Abstract: The present invention relates to compositions and methods for the detection and characterization of small nucleic acid molecules (e.g., RNA (e.g., small RNAs such as micro RNAs (miRNAs) and small interfering RNAs (siRNAs)) and other short nucleic acid molecules). More particularly, the present invention relates to methods for the detection and quantification of RNA expression. The present invention further provides for the detection of miRNA and siRNA variants.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: June 26, 2012
    Assignee: Third Wave Technologies, Inc.
    Inventors: Hatim T. Allawi, Victor Lyamichev
  • Patent number: 8206946
    Abstract: Bacteria in fluid systems are identified by using a fluorescently labeled virus as a molecular recognition element for bacteria. The virus, or bacteriophage, are optically encoded with fluorescent reporter molecules to allow detection and quantitation of the phage and the host/phage complex. Biosensors are provided in which the molecular recognition element is immobilized on a substrate.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: June 26, 2012
    Inventors: Mary Beth Tabacco, Xiaohua Qian, Jaimie Russo
  • Patent number: 8202700
    Abstract: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: June 19, 2012
    Assignee: Promega Corporation
    Inventors: Aldis Darzins, Lance Encell, Tonny Johnson, Dieter Klaubert, Georgyi V. Los, Mark McDougall, Keith V. Wood, Monika G. Wood, Chad Zimprich
  • Patent number: 8198406
    Abstract: The present invention relates to methods and compositions for modulating angiogenesis. In particular, the present invention relates to Pigment Epithelial-derived Factor (PEDF) fragments for use in modulating angiogenesis and treating angiogenesis mediated disease.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: June 12, 2012
    Assignee: Northwestern University
    Inventors: Olga Volpert, Yelena Mirochnik
  • Patent number: 8198231
    Abstract: Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even staphylococci that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include ?-lactams and glycopeptides.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: June 12, 2012
    Assignee: Nutrition 21, Inc.
    Inventors: Michael Climo, Ellen Murphy, Gordon Archer
  • Patent number: 8197613
    Abstract: The present invention relates to methods and compositions for reducing damaging oxidation of metals. In particular, the present invention relates to nanoparticle surface treatments and use of nanoparticle surface treatments to reduce the damaging oxidation and corrosion of stainless steel and other alloy components in oxidating and corrosive conditions.
    Type: Grant
    Filed: June 14, 2006
    Date of Patent: June 12, 2012
    Assignee: Material Interface, Inc.
    Inventor: Susan J. Kerber
  • Patent number: 8193151
    Abstract: The present invention provides compositions and methods for treating heart conditions. In particular, the present invention provides compositions and methods that block G protein coupled receptor mediated signaling for treating atrial fibrillation.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: June 5, 2012
    Assignee: Northwestern University
    Inventors: Rishi Arora, Alan Kadish, Annette Gilchrist
  • Patent number: 8193310
    Abstract: Disclosed are short chain peptides that are constrained to adopt an alpha helical conformation and their use as alpha helical scaffolds for directing amino acid side chains into positions analogous to those found in longer chain alpha helical peptides. Also disclosed is the use of these peptides for attaching peptidic or non-peptidic appendages in order to mimic side chains of longer alpha helical peptides. The peptides find use in mimicking naturally occurring peptides or proteins or in preparing new materials.
    Type: Grant
    Filed: March 21, 2005
    Date of Patent: June 5, 2012
    Assignee: The University of Queensland
    Inventors: David P. Fairlie, Nicholas E. Shepherd
  • Patent number: 8187814
    Abstract: The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis, mass and abundance data are obtained. The identity of the bioagent is then determined from the molecular mass of the bioagent identifying amplicon and the quantity of the identified bioagent in the sample is determined from the abundance data of the bioagent identifying amplicon and the abundance data of the calibration amplicon.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: May 29, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Rangarajan Sampath, Lawrence B. Blyn, Steven A. Hofstadler, Thomas A. Hall
  • Patent number: 8190371
    Abstract: The present invention provides methods and software applications for quantifying a target in an experimental sample by collecting and processing initial signal data from the experimental sample and at least two standard control samples containing known target copy numbers. In this regards, the present invention allows the quantification of target copy number in the experimental sample.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: May 29, 2012
    Assignee: Third Wave Technologies, Inc.
    Inventors: Hatim T. Allawi, Victor Lyamichev, Rex Piper
  • Patent number: 8182992
    Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of adventitious contaminant viruses by molecular mass and base composition analysis.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: May 22, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventor: Rangarajan Sampath
  • Patent number: 8182991
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to improved cleavage means for the detection and characterization of nucleic acid sequences. Structure-specific nucleases derived from a variety of thermostable organisms are provided. These structure-specific nucleases are used to cleave target-dependent cleavage structures, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: May 22, 2012
    Assignee: Third Wave Technologies, Inc.
    Inventors: Michael W. Kaiser, Victor I. Lyamichev, Natasha Lyamicheva
  • Patent number: 8183305
    Abstract: The invention provides an infiltrant for dental application that comprises crosslinking monomers, having a penetration coefficient PC>50 cm/s. In accordance with the invention the infiltrant comprises at least one nanoscale radiopaque filler and/or radiopaque organic compound, while ensuring sufficient contrast to surrounding tooth and bone tissue in X-ray diagnostics.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: May 22, 2012
    Assignee: Ernst Muhlbauer GmbH & Co. KG
    Inventors: Stephan Neffgen, Swen Neander, Dierk Lübbers
  • Patent number: 8178355
    Abstract: The present invention relates to the field of detection of components in gas phase, and in particular to detection of nitric oxide exhaled as a component of breath, using a liquid crystal assay format and a device utilizing liquid crystals as part of a reporting system.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: May 15, 2012
    Assignee: Platypus Technologies, LLC.
    Inventors: Bharat Acharya, Avijit Sen, Nicholas Abbott, Kurt Kupcho
  • Patent number: D660182
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: May 22, 2012
    Assignee: Atico International USA, Inc.
    Inventor: Jeffrey Rodriguez