Patents Represented by Attorney, Agent or Law Firm Celera
  • Methods and compositions for treating and diagnosing diseases
    Patent number: 8334106
    Abstract: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: December 18, 2012
    Assignee: Celera Corporation
    Inventors: Steve Ruben, Candy N. Lee, Bruno Domon
  • Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
    Patent number: 8227189
    Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease and in particular VT and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: July 24, 2012
    Assignee: Celera Corporation
    Inventors: Lance Bare, James J. Devlin, Frits R. Rosendaal, Pieter H. Reitsma, Irene D. Bezemer
  • Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
    Patent number: 8216786
    Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: July 10, 2012
    Assignee: Celera Corporation
    Inventors: Dov Shiffman, James J. Devlin, Judy Z. Louie, Eric Boerwinkle
  • Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
    Patent number: 8211638
    Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: July 3, 2012
    Assignee: Celera Corporation
    Inventors: Hongjin Huang, Ramasubbu Venkatesh, Michele Cargill
  • Cancer targets and uses thereof
    Patent number: 8168586
    Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: May 1, 2012
    Assignee: Celera Corporation
    Inventors: Dong Fang, Paul Moore, Steve Ruben, Sudeepta Aggarwal
  • Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof
    Patent number: 8148070
    Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: April 3, 2012
    Assignee: Celera Corporation
    Inventors: Olga Iakoubova, James J. Devlin, Carmen Tong, Charles Rowland
  • Methods and compositions for treating and diagnosing diseases
    Patent number: 8110373
    Abstract: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: February 7, 2012
    Assignee: Celera Corporation
    Inventors: Steve Ruben, Candy N. Lee, Bruno Domon
  • Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof
    Patent number: 7695916
    Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: April 13, 2010
    Assignee: Celera Corporation
    Inventors: Olga Iakoubova, James Devlin, Charles Rowland, Carmen Tong
  • Isolated human squalene synthase and composition thereof
    Patent number: 7452974
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: November 18, 2008
    Assignee: Celera Corporation
    Inventors: Ming-Hui Wei, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
    Patent number: 7186812
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR peptides and methods of identifying modulators of the GPCR peptides.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: March 6, 2007
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Fangcheng Gong, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Patent number: 7138499
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: November 21, 2006
    Assignee: Applera Corporation
    Inventors: Trevor Woodage, Ming-Hui Wei, Chinnappa Kodira, Valentina Di Francesco, Ellen M Beasley
  • Isolated proteins essential for survival nucleic acid molecules encoding essential proteins, and uses thereof as insecticidal targets
    Patent number: 7135558
    Abstract: The present invention provides amino acid sequences and transcript sequences that are encoded by 511 genes within the Drosophila melanogaster genome that are essential for survival, the Drosophila proteins of the present invention. The present invention specifically provides isolated protein and nucleic acid molecules, methods of identifying orthologs and paralogs of the Drosophila proteins and methods of identifying modulators of the Drosophila proteins (e.g. insecticides).
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: November 14, 2006
    Assignee: Applera Corporation
    Inventor: Mark D. Yandell
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 7112326
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: September 26, 2006
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
    Patent number: 7094881
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: August 14, 2003
    Date of Patent: August 22, 2006
    Assignee: Applera Corporation
    Inventors: Ellen M Beasley, Zhenya Li
  • Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
    Patent number: 7060481
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: June 13, 2006
    Assignee: Applera Corporation
    Inventors: Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human nuclear hormone receptors, nucleic acid molecules encoding human nuclear hormone receptors, and uses thereof
    Patent number: 7053045
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the nuclear hormone receptor peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the nuclear hormone receptor peptides, and methods of identifying modulators of the nuclear hormone receptor peptides.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: May 30, 2006
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Jane Ye, Chunhua Yan, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human sulfatase-like polypeptides
    Patent number: 7052893
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: May 30, 2006
    Assignee: Applera Corporation
    Inventors: Jane Ye, Ming-Hui Wei, Valentina Di Francesco, Ellen M Beasley
  • Isolated human phosphatase proteins, nucleic acid molecules encoding human phosphatase proteins, and uses thereof
    Patent number: 7052894
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phosphatase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phosphatase peptides, and methods of identifying modulators of the phosphatase peptides.
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: May 30, 2006
    Assignee: Applera Corporation
    Inventors: Ellen M. Beasley, Marion Webster, Valentina Di Francesco, Ming-Hui Wei
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 7049119
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: May 23, 2006
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Histone deacetylase-8 proteins, nucleic acids, and methods for use
    Patent number: 7045126
    Abstract: The present invention is directed to novel nucleic acids that encode novel HDAC proteins, which have an affect on chromatin structure and transcription. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods of producing the polypeptides of the present invention. Further provided by the present invention are methods of identifying novel compositions which mediate HDAC8 and the use of such compositions in diagnosis and treatment of disease.
    Type: Grant
    Filed: September 16, 2004
    Date of Patent: May 16, 2006
    Assignee: Applera Corporation
    Inventor: Joseph Buggy