Patents Represented by Attorney, Agent or Law Firm Celera
  • Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
    Patent number: 7037705
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: May 2, 2006
    Assignee: Applera Corporation
    Inventors: Weiniu Gan, Jane Ye, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 7037701
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: May 2, 2006
    Assignee: Applera Corporation
    Inventors: Marion Webster, Zhenya Li, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 7033809
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: April 25, 2006
    Assignee: Applera Corporation
    Inventors: Weiniu Gan, Jane Ye, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
    Patent number: 7033792
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Grant
    Filed: May 13, 2002
    Date of Patent: April 25, 2006
    Assignee: Applera Corporation
    Inventors: Jennifer Min Zhong, Chunhua Yan, Ellen M. Beasley
  • Isolated human protese proteins, nucleic acid molecules encoding human protease proteins and uses thereof
    Patent number: 7029901
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: April 18, 2006
    Assignee: Applera Corporation
    Inventors: Weiniu Gan, Jane Ye, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 7029894
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: April 18, 2006
    Assignee: Applera Corporation
    Inventors: Karl Guegler, Ellen M. Beasley, Valentina Di Francesco
  • Human secreted hemopexin-related proteins
    Patent number: 7030088
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: April 18, 2006
    Assignee: Applera Corporation
    Inventors: Toni Ceccardi, Emanuel Langit, Min Zhong, Istvan Ladunga
  • Isolated monkey cathepsin S proteins, nucleic acid molecules encoding monkey cathepsin S proteins, and uses thereof
    Patent number: 7029902
    Abstract: The present invention provides isolated monkey Cathepsin S proteins and isolated nucleic acid molecules such as cDNA molecules that encode these monkey Cathepsin S proteins. The present invention specifically provides, for example, isolated monkey Cathepsin S proteins and encoding nucleic acid molecules, methods of producing the monkey Cathepsin S proteins, methods of identifying and screening modulators of the monkey Cathepsin S proteins, and methods of using these modulators to treat a human disease or disorders associated with an orthologous human Cathepsin S protein.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: April 18, 2006
    Assignee: Applera Corporation
    Inventors: Shyr-Jiann Li, James Clark, Hong Zhang
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 7005286
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: February 28, 2006
    Assignee: Applera Corporation
    Inventors: Jane Abu-Threideh, Fangcheng Gong, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human transporter proteins, nucleic acid molecules, encoding human transporter proteins, and uses thereof
    Patent number: 6991920
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: January 31, 2006
    Assignee: Applera Corporation
    Inventors: Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Modified Cdc14 phosphatase proteins and constructs for improved expression and purification
    Patent number: 6991915
    Abstract: The present invention provides modified Cdc14 phosphatase proteins, and novel constructs for expression thereof, in which the sequence C-terminal to the catalytic domain has been deleted. This modification results in the expression of a single form of the enzyme, enabling purification of a homogeneous preparation of active enzyme at a high yield.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: January 31, 2006
    Assignee: Applera Corporation
    Inventors: Craig Hill, Joseph Buggy
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6991928
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: January 31, 2006
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Shiaoping Zhu, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
  • Isolated nucleic acid molecules encoding human drug metabolizing proteins
    Patent number: 6987014
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: January 17, 2006
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6984511
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: January 10, 2006
    Assignee: Applera Corporation
    Inventors: Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen Beasley
  • Isolated human hepsin/46 proteins, nucleic acid molecules encoding human hepsin/46 proteins, and uses thereof
    Patent number: 6977170
    Abstract: The present invention provides hepsin/46 protein, a soluble form of hepsin lacking the transmembrane region. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying molecules that interacting with the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: December 20, 2005
    Assignee: Applera Corporation
    Inventors: Hedy Chan, Kirsta Bowman, Erik Gjerstad
  • Isolated human ras-like proteins, nucleic acid molecules encoding these human ras-like proteins, and uses thereof
    Patent number: 6969588
    Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: November 29, 2005
    Assignee: Applera Corporation
    Inventors: Beena Neelam, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Patent number: 6967094
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: November 22, 2005
    Assignee: Applera Corporation
    Inventors: Trevor Woodage, Ming-Hui Wei, Chinnappa Kodira, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6955625
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: October 18, 2005
    Assignee: Applera Corporation
    Inventors: Ellen M. Beasley, Wei Shao, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Patent number: 6953681
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: October 11, 2005
    Assignee: Applera Corporation
    Inventors: Trevor Woodage, Ming-Hui Wei, Chinnappa Kodira, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Patent number: 6949371
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: September 27, 2005
    Assignee: Applera Corporation
    Inventors: Gennady V. Merkulov, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley