Patents Represented by Attorney, Agent or Law Firm Celera
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6900042
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: May 31, 2005
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Karen A Ketchum, Valentina Di Francesco, Ellen M Beasley
  • Polymorphisms in known genes associated with inflammatory autoimmune disease, methods of detection and uses thereof
    Patent number: 6900016
    Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to inflammatory and autoimmune disorders. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant inflammatory and autoimmune disorders associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: May 31, 2005
    Assignee: Applera Corporation
    Inventors: J. Craig Venter, Jinghui N. Zhang, Xiangjun Liu, William Rowe, Anibal Cravchik, Francis Kalush, Ashwinikumar Naik, Gangadharan Subramanian, Trevor Woodage
  • Isolated human dehydrogenaseproteins, nucleic acid molecules encoding these human dehydrogenase proteins, and uses thereof
    Patent number: 6900040
    Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the dehydrogenase polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the dehydrogenase polypeptides, and methods of identifying modulators of the dehydrogenase polypeptides.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: May 31, 2005
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Zhenya Li, Gennady V Merkulov, Valentina Di Francesco, Ellen Beasley
  • Isolated human G-protein coupled receptors that are members of the aminergic subfamily, nucleic acid molecules encoding human GPCR proteins, and uses thereof
    Patent number: 6890731
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR peptides and methods of identifying modulators of the GPCR peptides.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: May 10, 2005
    Assignee: Applera Corporation
    Inventors: Chinnappa Kodira, Anibal Cravchik, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human enzyme proteins, nucleic acid molecules encoding human enzyme proteins, and uses thereof
    Patent number: 6884609
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: April 26, 2005
    Assignee: Applera Corporation
    Inventors: Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins and uses thereof
    Patent number: 6878808
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: April 12, 2005
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Jiayin Li, Fangcheng Gong, Andrei Gabrielian, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Histone deacetylase-8 proteins, nuclei acids, and methods for use
    Patent number: 6875598
    Abstract: The present invention is directed to novel nucleic acids that encode novel HDAC proteins, which have an affect on chromating structure and transcription. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods of producing the polypeptides of the present invention. Further provided by the present invention are methods of identifying novel compositions which mediate HDAC8 and the use of such compositions in diagnosis and treatment of disease.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: April 5, 2005
    Assignee: Applera Corporation
    Inventor: Joseph Buggy
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Patent number: 6875597
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: April 5, 2005
    Assignee: Applera Corporation
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins and uses thereof
    Patent number: 6869928
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter cofactor peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter cofactor peptides, and methods of identifying modulators of the transporter cofactor peptides.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: March 22, 2005
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human ras-like proteins, nucleic acid molecules encoding these human ras-like proteins, and uses thereof
    Patent number: 6867019
    Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: March 15, 2005
    Assignee: Applera Corporation
    Inventors: Wei Shao, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human lipase proteins, nucleic acid molecules encoding human lipase proteins, and uses thereof
    Patent number: 6867030
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the lipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the lipase peptides, and methods of identifying modulators of the lipase peptides.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: March 15, 2005
    Assignee: Applera Corporation
    Inventors: Gennady V. Merkulov, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human phosphodiesterase proteins, nucleic acid molecules encoding human phosphodiesterase proteins, and uses thereof
    Patent number: 6867029
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phosphodiesterase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phosphodiesterase peptides, and methods of identifying modulators of the phosphodiesterase peptides.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: March 15, 2005
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Xin Wang, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6858420
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: February 22, 2005
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Jane Abu-Threideh, Wei Shao, Gennady Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6852519
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: February 8, 2005
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Karl Guegler, Karen A. Ketchum, Gennady V. Merkulov, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human UDP-glycosyltransferase, nucleic acid molecules encoding human UDP-glycosyltransferase, and uses thereof
    Patent number: 6846661
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: January 25, 2005
    Assignee: Applera Corporation
    Inventors: Marion Webster, Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6835562
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: December 28, 2004
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins and uses thereof
    Patent number: 6830912
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: December 14, 2004
    Assignee: Applera Corporation
    Inventors: Douglas Rusch, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human glutamate receptor DNA
    Patent number: 6830900
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: December 14, 2004
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6830911
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: December 14, 2004
    Assignee: Applera Corporation
    Inventor: Zhaoxi Ke
  • Isolated human metalloprotease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
    Patent number: 6825022
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: November 30, 2004
    Assignee: Applera Corporation
    Inventors: Gennady V. Merkulov, Jane Ye, Valentina Di Francesco, Ellen M. Beasley