Patents Represented by Attorney, Agent or Law Firm Celera
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6946545
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: September 20, 2005
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6946276
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: September 20, 2005
    Assignee: Applera Corporation
    Inventors: Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Methods and kits for obtaining DNA end sequence information for large cloned inserts and uses thereof
    Patent number: 6942975
    Abstract: The present invention provides a method of producing a cloned insert that is representative of the ends of a large segment of DNA from the genome of an organism. Specifically, the present invention provides a clone insert strategy that comprising the steps of: a) isolating a nucleic acid molecule, or portion thereof, wherein said nucleic acid molecule is at least 20 kb; b) ligating said nucleic acid molecule into a vector molecule; c) cutting said nucleic acid molecule with a restriction endonuclease, wherein said restriction endonuclease cuts said isolated nucleic acid molecule of step (a) in at least two sites but does not cut said vector DNA, d) ligating said cut nucleic acid molecule; e) transforming a host cell with said ligated nucleic acid molecule to propagate said molecule; f) determining the sequence of the ends of the nucleic acid insert and the sequence from the restriction endonculease site.
    Type: Grant
    Filed: September 16, 2002
    Date of Patent: September 13, 2005
    Assignee: Applera Corporation
    Inventors: Robert Holt, Hamilton O. Smith, Cynthia Pfannkoch
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6942983
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: September 13, 2005
    Assignee: Applera Corporation
    Inventors: Jiayin Li, Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human enzyme proteins, nucleic acid molecules encoding human enzyme proteins, and uses thereof
    Patent number: 6942999
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: September 13, 2005
    Assignee: Applera Corporation
    Inventors: Wei Shao, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
    Patent number: 6943003
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: September 13, 2005
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Karen A Ketchum, Valentina Di Francesco, Ellen M Beasley
  • Isolated human aminoacylase, nucleic acid molecules encoding human aminoacylase, and uses thereof
    Patent number: 6939700
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: September 6, 2005
    Assignee: Applera Corporation
    Inventors: Wei Shao, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6936451
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: August 30, 2005
    Assignee: Applera Corporation
    Inventors: Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
    Patent number: 6936453
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: August 30, 2005
    Assignee: Applera Corporation
    Inventors: Ellen M Beasley, Chunhua Yan, Valentina Di Francesco
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6930173
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: August 16, 2005
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Zhenya Li, Beena Neelam, Valentina DiFrancesco, Ellen M. Beasley
  • Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
    Patent number: 6927054
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: August 9, 2005
    Assignee: Applera Corporation
    Inventors: Marion Webster, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6921654
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: July 26, 2005
    Assignee: Applera Corporation
    Inventors: Jane Abu-Threideh, Beena Neelam, Chunhua Yan
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6919191
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: July 19, 2005
    Assignee: Applera Corporation
    Inventors: Beena Neelam, Natalia Milshina, Chunhua Yan, Valentina DiFrancesco, Ellen M. Beasley, Karen A. Ketchum
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6916644
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: July 12, 2005
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Karen A. Ketchum, Ellen M. Beasley, Valentina DiFrancesco
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6916643
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: July 12, 2005
    Assignee: Applera Corporation
    Inventors: Beena Neelam, Xianghe Yan, Chunhua Yan
  • Isolated human lipase proteins, nucleic acid molecules encoding human lipase proteins, and uses thereof
    Patent number: 6916473
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the lipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the lipase peptides, and methods of identifying modulators of the lipase peptides.
    Type: Grant
    Filed: September 2, 2003
    Date of Patent: July 12, 2005
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof
    Patent number: 6913904
    Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: July 5, 2005
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof
    Patent number: 6908747
    Abstract: The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: June 21, 2005
    Assignee: Applera Corporation
    Inventors: Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Patent number: 6905855
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the proteins of the present invention, and methods of identifying modulators of the proteins of the present invention.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: June 14, 2005
    Assignee: Applera Corporation
    Inventors: Trevor Woodage, Ming-Hui Wei, Chinnappa Kodira, Valentina Di Francesco, Ellen M. Beasley
  • Sulfonamide compounds as protease inhibitors
    Patent number: 6900237
    Abstract: The present invention relates to novel cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: May 31, 2005
    Assignee: Axys Pharmaceuticals, Inc.
    Inventor: James Palmer