Abstract: A method of selectively suppressing the immune system and conferring immunotolerance against a specific antigen by interferring with the L3T4 differentiation antigens on helper T cells is described. Simultaneous administration of a binding moiety specific for the L3T4-equivalent in the subject species and a specific antigen results in a diminished ability of the subject to respond immunologically to the antigen, whether or not the subject has been exposed previously to the antigen.

Abstract: ECG signals are digitized and a template representative of an arrhythmia free interval for a particular patient is formed. Subsequent ECG signals which match the template are averaged to form averaged ECG signals to reduce noise. A fast Fourier transform (FET) is performed on the terminal 40 millisecond portion of the QRS complex and the ST segment. The 60 db area and 40 Hz intercept of the resultant spectral output are used as a figure of merit in predicting the liklihood of a particular patient experiencing ventricular tachycardia. Alternatively, the FET magnitude is squared to form energy spectra of the ECG signals and a measure of the energy in a first preselected portion such as the 20-50 Hz region is compared with a second preselected portion such as the entire spectra to form a figure of merit for predicting ventricular tachycardia.

Abstract: A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.

Abstract: An electrokinetic process and apparatus employing coherent radiation-excited fluorescence for detection is disclosed. In a preferred embodiment, the support liquid is a chiral liquid and the process is employed to separate and detect the separation of optical isomers.

Abstract: A DNA sequence encoding bovine prolactin and optionally including condons for the preceding 10 amino acids is used to construct expression systems to obtain recombinant production of these proteins.

Abstract: A prosthetic device for use in joint replacement in a bone. The device includes an implant adapted to seat on a receiving surface of the bone, defining a bone/implant interface, and an attachment element adapted to be secured to a portion of the bone which is spaced from the interface by an axially extending bone region. The implant is connected to the attachment element by a connecting member adapted to allow substantially unhindered movement of the implant relative to the attachment member to freely accommodate elastic deformation in the bone region between the implant and attachment element. A low-modulus spring, operatively interposed between the connecting member and the implant or attachment element, functions to hold the implant against the bone surface with a selected compression force.

Abstract: An injector is disclosed for administering fluids such as medications and tissue-augmenting suspensions of collagen to laryngeal tissues. The injector includes a needle, a hollow connector tube, and a syringe receiver into which syringes of collagen or a like low-viscosity fluid are inserted. The injector is adapted for one-hand operation and the serial use of several syringes of collagen or like fluid.

Abstract: A culture contained in a whole grain barm for effecting natural leavening of breads, baked goods and the like is disclosed. The culture contains a newly identified Lactobacillus sp. bacteria named Lactobacillus brevis, atypical and a nonmaltose-digesting Saccharomyces sp. yeast preferably Saccharomyces dairensis. The isolation of Lactobacillus sp. and Saccharomyces sp. organisms and their use in leavening processes are also disclosed.

Abstract: Human cancer is diagnosed/monitored by measuring the levels of certain modified nucleosides, such as N-[(.beta.-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine, in the urine of a subject by a quantitative immunoassay that preferably employs a monoclonal anti-modified nucleoside antibody and comparing that level to the level of the modified nucleoside that occurs in the urine of normal subjects to determine whether the former is substantially elevated over the latter or by comparing that level to the level of the modified nucleoside present in urine specimens taken from the subject at different times.

Abstract: Monoclonal anti-idiotype antibodies against cell surface Ig of human B-cell tumors, labeled conjugates of such antibodies, immunotherapeutic compositions containing such antibodies, and a process for making such antibodies. The nodular lymphoma of a patient treated with a monoclonal anti-idiotpye antibody against the cell surface IgM of the patient's tumor went into complete remission.

Abstract: The complete coding sequences and amino acid sequences for both canine and human alveolar surfactant protein (ASP) are disclosed. Methods and vectors for obtaining these proteins in recombinant form are described. The availability of large amounts of these proteins through recombinant techniques permits the use of ASP in suitable pharmaceutical compositions in the treatment of respiratory deficiency syndromes.

Abstract: An HLA-DR typing test based on lymphocytotoxicity in which a vital dye-labeled total human lymphocyte sample, such as a sample of peripheral blood lymphocytes, is incubated with HLA-DR antisera, a monoclonal antibody against T cells, and complement and the DR type is determined based upon the resultant cytotoxicity as measured by the fluorescence of B cells surviving the incubation.

Abstract: A monochrome or color imager having interlaced, non-interlaced or pseudo-interlaced readout utilizing pixels arranged in groups forming equilateral triangles which are interleaved. Separate vertical shift registers driven by different clock signals to implement different forms of interlaced, non-interlaced and pseudo interlaced signal readout are located on each side of the rectangular array and are coupled to alternating row address lines and different groups of column lines in the array. The clock signals driving each shift register can be controlled to select monochrome or color operation in one of the above noted modes of readout. A horizontal shift register is connected to the gates of MOS coupling transistors which couple the column or bit lines of the array to a pair of monochrome outputs, while a second shift register is connected to the gates of MOS coupling transistors which couple the column or bit lines of the array to a trio of color outputs for color output signals.

Abstract: A catheter device for transferring fluid material to or from one or more selected-length segment of a vessel. The device includes first and second catheters, each having a tube with distal and proximal ends, an inflatable balloon carried on the tube, adjacent the distal tube end, and a fluid conduit for supplying the balloon, with such operatively positioned in the vessel. A central region of the second-catheter tube is axially shiftable within the first-catheter tube, allowing the balloons to be placed at desired relative positions in the vessel. Fluid is injected into the region between the two balloons through a fluid passageway formed in a channel in the first-catheter tube.

Abstract: A process for preparing collagen membranes useful in tissue repair, and wound healing and related membranous implant materials useful in both hard and soft tissue applications is disclosed. The resulting membranes and materials have properties which can be varied as desired to suit intended use. Variation results from altering the precise conditions of formation of the membrane or of related fibers and solids. The process comprises first forming a gel from solubilized collagen, followed by converting the gel into a one-, two- or three-dimensional membranous solid form. This conversion is performed either by applying pressure to the gel, or by disrupting the gel and separating the resulting precipitate for casting.

Abstract: Monoclonal antibodies specific for a protein associated with a lung surfactant complex, decreased levels of which are related to respiratory distress syndrome, are disclosed. The antibodies are useful for prediction and diagnosis of respiratory problems in newborns.

Abstract: A trocar assembly consisting of a trocar tube subassembly and a separable, interfitting trocar subassembly is described. The trocar tube assembly includes a hollow body having a first front opening in which a trocar tube is mounted, a second rear opening for receiving the trocar subassembly, and a manually pivotable flap valve mechanism mounted within the body. The trocar subassembly includes a head having a central bore in which are mounted the (1) rear ends of an elongated obturator having a pyramidal-shaped piercing head with a triangular-shaped base, and a concentric tubular shield having a triangular shaped front opening for the piercing head that is formed by bevels in its leading edge that have approximately the same slope as the surfaces that define the three sides of the piercing head, and (2) a coil spring backing the shield for biasing the shield between retracted and extended positions.