Abstract: Stereoisomerically pure forms of normorphine analogs which have superior analgesic and nonaddicting qualities are described. In addition, a method of separating diastereomeric forms of N-sec-alkyl-substituted analogs utilizes the hydrocarbyl(1-8C) diesters of the normorphine derivatives. A new method for preparing the N-methylalkylmethyl derivatives of normorphine and norcodeine and their conventional analogs is also disclosed. This method employs the corresponding methyl alkyl ketones and a reducing agent.

Abstract: A pattern learning and recognition device. The device includes a parallel processing network for receiving and processing an N-dimensional vector input, and a control system for calculating, and storing output signal correlation information during the learning mode of the device, and for distributing the learned information to the network, in the form of feedback gain, during the pattern-recognition mode of the device. The network is preferably composed of an array of N oscillatory units designed to bifurcate from a rest to an active state when stimulated with a threshold input voltage surge.

Abstract: An interactive drug dispenser which actively controls the pattern in which doses of one or more pharmaceutical preparations are administered to a patient. The dispenser is programmed with information concerning an initial dosing regimen, and monitors deviations from that regimen. The dispenser is adapted to calculate from the dosage deviation a dosing error correction factor which corrects a patient's measured plasma drug concentration for deviations from a prescribed dosing regimen, so as to distinguish the effects of patients' dosing errors from suboptimal prescribed dosage regimens.

Abstract: An underplate for use in the printing of a tubular fabric, which is made in the shape of a polygonal tube that can be transformed in shape along the lines of the angles; and a method for printing a tubular fabric conprising: (1) inserting the underplate into the tubular fabric; (2) making the fabric flat along appropriate lines of angles in said polygonal tube; (3) doing printing on or near the center of the front surface of the fabric, corresponding to the front surface of said flat shape; (4) turning over the fabric with said flat shape; doing printing in the same way on or near the center of the back surface of the fabric, corresponding to the back surface of said flat shape; (5) bringing back said flat shape to its original shape; (6) making the fabric flat again along different lines of angles in said polygonal tube, in such a manner that a different flat shape is formed from the polygonal tube, with the above-mentioned two regions of the fabric that have been printed at the sides of this second flat sha

Abstract: The laser device has a plurality of parallel index-waveguides. The intermediate regions of the waveguides are at an angle of inclination from a line perpendicular to each of both facets of the laser device. The ends of the waveguides are oriented orthogonally to the facets of the laser device.

Abstract: A blood fluid composition for use in a complement-mediated cell lysis system. The composition includes a blood fluid, which may be either a serum source of complement, analyte-containing serum, or both, and lipid vesicles capable of reducing the extent of non-specific cell lysis produced when the blood fluid is added to lysable target cells in the system. The vesicles are present in an amount which increases the ratio of ligand-specific to non-specific cell lysis in the system at least 2-fold and preferably 4-fold or more over that achievable in the system in the absence of the vesicles.

Abstract: The present invention comprises a new class of 2,3,4-tri-O-acylhexoses and mixtures thereof. Members of the new class of compounds are comprised of a hexose sugar having fatty acids attached at the 2, 3 and 4 positions of the hexose moiety. The fatty acids can be saturated or unsaturated, and can have a relative molecular size of up to C.sub.30. When at least one of the acylating fatty acid groups on the hexose molecule contains more than 7 carbons, the resulting 2,3,4-tri-O-acylhexoses (or mixtures thereof) have a non-bitter taste. On the other hand, when none of the acylating fatty acids have more than 7 carbons, the resulting 2,3,4-tri-O-acylhexoses (and mixtures that contain them) are bitter when tasted.The new 2,3,4-tri-O-acylhexoses can be synthesized using known chemical methods. Alternatively, the new compounds, and especially mixtures thereof, are obtained as the result of selective extraction and purification of the epicuticular exudate from Lycopersicon pennellii plant parts.

Abstract: A method of nitrating resorcinol which is selective for the production of the 4,6-dinitro resorcinal isomer. A resorcinol-based starting material is admixed with a nitrating solution from which substantially all nitrogen dioxide and nitrous has been removed. The nitrating solution contains white fuming nitric acid, a nitrosonium ion control agent such as urea, and, optionally, concentrated sulfuric acid. The 4,6-dinitroresorcinal isomer is provided in yields of about 65-85% with minimal production of undesirable side products.

Abstract: A fused protein for use in an enzyme immunoassay system. The protein comprises an enzymatically active .beta.-galactosidase fused, at its C terminus, to an immunologically active peptide. The protein is produced using a plasmid containing a complete .beta.-galactosidase gene fused, at its 3' end, with an oligonucleotide coding for the peptide. The fused protein is designed for use in a solid-phase enzyme immunoassay system, based on immunospecific binding of the fused protein to a solid support, or in a homogeneous enzyme immunoassay system, based on enzyme inhibition resulting from immunospecific binding of an antibody to the protein.

Abstract: The laser device has an Al.sub.x Ga.sub.1-x As (x.gtoreq.0.3) quantum well active region having a thickness of 200 angstroms or less. Al.sub.y Ga.sub.1-y As (y>x) carrier supplying layers sandwich the quantum well active region therebetween. An Al.sub.z Ga.sub.1-z As (z>y) cladding layer is disposed on each of the carrier supplying layers. Finally an Al.sub.w Ga.sub.1-w As (w>z) barrier layer is disposed between each of the carrier supplying layers and each of the cladding layers.

Abstract: New compounds having the generic formula: ##STR1## wherein: X=halogen, Y= ##STR2## X=Y= ##STR3## X=Y= ##STR4## R=hydrogen, halogen such as chlorine, lower alkoxy such as methoxy, or lower alkyl such as methyl.These new compounds are useful as reversible photochromatic solids.

Abstract: A purified human CMV virion protein that has a molecular weight of approximately 86,000 daltons by SDS-PAGE and exhibits in vivo immunizing activity and a murine monoclonal antibody that binds specifically to the protein and exhibits complement-independent human CMV neutralizing activity are described. The antibody is useful for isolating the protein by affinity chromatography and the protein is, in turn, useful for detecting CMV neutralizing antibody in sera and as a vaccine.

Abstract: Fluid, stable glasses that are useful for low temperature sealing applications are made by adding jointly bismuth oxide, zinc oxide, and phosphorus pentoxide to the lead oxide-vanadium oxide binary. The phosphorous pentoxide may be replaced partially or entirely with niobium pentoxide and/or tantalum pentoxide. Additives and fillers may be incorporated into the glass composition to enhance the fluidity or adhesive characteristics of the glass, alter its coefficient of linear thermal expansion or make it suitable for die attach application. Group V metal oxides, particularly niobium pentoxide, are preferred fillers for altering the coefficient of linear thermal expansion. Similarly these Group V metal oxides may also be added as particulate fillers to lead borate, lead borosilicate and zinc borate glasses. Silver metal is a preferred filler for making die attach compositions.

Abstract: A mixing device for preparing inductive and conductive bone repair compositions is disclosed, along with a method for using the device for preparing such compositions. The device provides a simple and rapid method of making a substantially uniform collagen/mineral bone implant preparation.

Abstract: A machine and method for conveniently dynamically balancing heavy rotational members such as large vehicle wheels is disclosed. The machine employs a horizontal rotatable shaft that is movable vertically so as to align and engage the center of the member as it stands vertically in the ground. Thereafter the shaft is raised vertically until the member clears the ground and is rotatable for balancing. In preferred embodiments the balancing mechanism is manually powered and detachable from the machine's base for transport and the base is constructed with its vertical member angled so as to preload and stress the base by the weight of the member and eliminate play in the base. The machine offers portability and transport advantages.

Abstract: A catheter for use with a guide wire which can be guided from an external body access site to an internal tissue, and into the tissue along a tortuous path of at least about 5 cm through vessels of less than about 3 mm lumen inner diameter. The catheter includes a relatively stiff proximal segment dimensioned to track the wire from the access site to a region adjacent the internal tissue, and a relatively flexible distal segment dimensioned to track the wire along the tortuous path within the soft tissue.

Abstract: A vaccine effective in protecting mammals against urinary tract infections is prepared from synthetic peptides substantially equivalent to short sequences contained in HU849 pilin conjugated to substantially antigenically neutral carriers or from a CNBrII fragment of HU849 pilin.

Abstract: A calibration vial is described for storing and calibrating under sterile conditions a blood gas sensor that comprises an optical fiber whose sensing end carries a sensing element, such as a chromophore or fluorophore. The vial contains a calibrating liquid and, in its preferred embodiment, is structured to keep the end of the filter wet and permit fast calibration of the sensor without spillage of the calibrating liquid. The vial has a tubular inner calibration chamber in which the end of the fiber resides and which has a sterile filter-plugged gas inlet in its bottom and an outer concentric calibrating liquid reservoir chamber. The bottoms of the two chambers are interconnected by one or more liquid reflux ports that are positioned such that the gas coming into the bottom of the calibration chamber aspirates liquid from the reservoir chamber into the calibration chamber. This permits rapid mixing and circulation of the liquid upwardly through the calibration chamber.

Abstract: A multi-player, multi-character video game where the game rules force the players to cooperate in negotiating the maze at least until the characters reach a portion of the maze where a specific objective is located. Certain limited resources to change the attributes of the characters or to increase their longevity are displayed in a maze. The players may compete to obtain possession of these limited resources when the characters have cooperated in their movements sufficiently to move to the location of the limited resources. Cooperation among the characters is forced by forcing all characters active in the game to remain visible in the displayed window. Players may enter the game at any time, and they may leave the game at any time without affecting the status of the game or the status of the other characters in the game. All active players may simultaneously, independently control their characters so long as they do not attempt to move their characters outside the currently displayed window.

Abstract: A reaginic agglutination test for syphilis-associated antibodies is disclosed. The test uses an antigen reagent that comprises a buffered aqueous suspension of cardiolipin antigen ionically coupled to latex particles via a polypeptide bridge. Positive sera react with the antigen reagent and yield an agglutination pattern characterized by medium to large aggregates. Negative sera yield no agglutinated particles.