Abstract: A human monoclonal antibody that directly agglutinates type A human red blood cells is described. The exemplified antibody is an IgM and is produced by hybrid cells lines S-H22 and HHA1. The antibody is useful as an ABO typing reagent.

Abstract: A semiconductor laser array device comprising an oscillation operating area provided with a plurality of first index-waveguides in a parallel manner and a non-oscillation operating area provided with a plurality of second index-waveguides in a parallel manner through which laser light produced in said oscillation operating area are guided through the waveguide from said oscillation operating area to the end facets of the second index-waveguides of said non-oscillation operating area, wherein the second index-waveguides are different in length between the adjacent waveguides and the end facet of each of the second index-waveguides does not function as a cavity facet of the laser but it functions as the light-emitting facet of the device.

Abstract: A lipid coupling reagent for use in coupling amine-containing molecules, such as proteins, to liposomes. The reagent includes phosphatidylethanolamine coupled to a 3-20 atom carbon-containing spacer arm terminating at a carboxyl or thiocarboxyl group. Also disclosed are liposomes prepared to include between about 1 and 20 mole percent of the coupling reagent, and liposomes containing surface arrays of proteins attached to the liposomes through the coupling reagent.

Abstract: A robotic manipulator provides three degrees of freedom of movement of an end effector or gripper using only motors which are mounted on a frame. Included is a first actuator assembly providing rotation of a first input link about first and second axes. A compound motor provides this rotation about two axes through a differential gear mechanism. A second actuator provides rotation of a second input link about a third axis. The two input links are each connected to an output link, which in turn are connected, with an end effector being disposed on the end of one of the output links.

Abstract: An optical system for producing stereoscopic imaging of a subject. The system includes an objective lens for producing an image of the subject, and right and left ocular lenses for viewing the image through right and left eyes, respectively. A polarizing filter device positioned near the objective lens divides the image produced by the objective lens into left and right perspective components characterized by different polarization directions. Right and left polarizing filters positioned near the right and left ocular lenses allow these right and left perspective components to be viewed exclusively through the right and left ocular lenses, respectively. One embodiment of the invention is a high-power stereoscopic microscope. Another embodiment is a single-objective binocular telescope.

Abstract: A soft tissue wound healing composition comprising an aqueous mixture of fibrillar collagen, heparin, and undegranulated platelets or platelet releasate. The composition is applied topically to the wound site in conjunction with means to keep it at the site and hydrated or in the form of an occlusive dressing.

Abstract: A bleomycin conjugate for use in targeting a compound to a body tumor. The conjugate includes an oxidized bleomycin/cobalt(III) complex and the compound to be targeted joined to the complex through a monodentate cobalt/sulfur coordinate bond. Also disclosed are methods for preparing the conjugate, and for targeting the compound to a body tumor, for purposes of tumor radioimaging or therapy.

Abstract: Animal traps are usually difficult to sterilize in order to remove human odor therefrom and difficult to hide when setting and often contain moving parts, tubes, pins and the like. The present device consists of a pair of spring arms made of heavy wire with a hairpin spring at the junction thereof. Eye loops are formed one on each distal end of the arms and one of these has a slotted semi-circular plate welded otherwise secured into the base of the eye. A freely running snare loop is provided on one end of a standing part, in which part extends through the slot in the disk or plate and through a cotter pin assembly spanning the other eye and terminates with a ferrule outboard of the other eye. A trigger block is secured to the standing part inboard of the slotted disk when the trap is set with the two arms close together and being urged apart by the spring.

Abstract: Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or vasodilators, or as intermediates for or modulators of such useful compounds or of native Atrial Natriuretic Peptides.

Abstract: Apparatus for use in correlating actual tape play times, tape length, or predetermined tape program locations with tape-spool revolution values provided by a tape-revolution index counter in a tape machine. The calculator has a lower circular base plate and a smaller, upper circular plate which rotates concentrically with respect to the lower plate. The base plate carries a scale corresponding to tape-spool revolution values indicated by the machine, and one or more time scales relating tape spool revolution values to actual tape-play times, and/or to remaining play times or program locations. A ratio marker and time scale indicator are positioned on the upper member such that alignment of the ratio marker with a selected tape-revolution value on the base plate brings the time scale indicator into alignment with the corresponding playing-time value on the base plate.

Abstract: Method and apparatus for producing enhanced EEG or MEG information related to a selected brain activity in a subject. The apparatus includes a two-dimensional array of at least about 16 sensors for recording EEG or MEG traces from the subject. Control and test traces recorded before and during an interval in which the brain activity is occurring, respectively, are each decomposed into a series of basis functions which may be analytic components such as temporal frequency components, generated by spectral decomposition of an ensemble average of the recorded traces, or principal components determined by principal component analysis. The control and test traces are then represented as a sum of the products of the individual basis functions times a spatial domain matrix which represents the spatial pattern of amplitudes of that basis function, as measured by the individual sensors in the array.

Abstract: Topical compositions for the treatment of an epithelial disease, such as psoriasis and cervical displasia, containing phototoxic derivatives of hematoporphyrin and methods for treating epithelial diseases with phototoxic derivatives of hematoporphyrin.

Abstract: Methods and compositions are provided for high level production of foreign proteins in yeast. The system is exemplified by production of .alpha..sub.1 -antitrypsin in yeast strain AB110, derived from yeast strains 2150-2-3 and AB103.1.S. carlsbergensis/S. cerevisiae hybrid strain AB110 containing plasmid pCl/1GAPATi9 was deposited at the A.T.C.C. on May 9, 1984, and given Accession No. 20709.

Abstract: Contact lens compositions containing monomers or cross-linking materials which result in satisfactory moisture content but lowered protein absorption capability are described. Lenses are comfortable for extended wear, but because of lowered protein absorption do not become opaque, and present less infection risk. Included are compositions with over 10% conventional cross-linkers, with 0.1-100% cross-linkers which are unsaturated diesters of the alcohol of the formula HO(CH.sub.2 CH.sub.2 O).sub.n H wherein n is 5-300; or 10-50% copolymerizing monomer which is an ester of an alcohol of similar formula; or 0.1-90% cross-linkers which are diesters of the diol of the formula HOCH.sub.2 (CF.sub.2).sub.m CH.sub.2 OH, and compositions containing more than 10% cross-linker; or with inclusions of 1-40% polyethylene glycol or polyethylene oxide; or copolymers containing 1-60% polyethylene oxide segments.

Abstract: A method of preparing a suspension of liposomes containing a water-soluble compound predominantly in liposome-encapsulated form. A solution of vesicle-forming lipids in a chlorofluorocarbon solvent is infused under selected conditions into an aqueous medium, with continual solvent removal. The lipid infusion and solvent removal steps are continued until a lipid concentration of at least about 150 .mu.m/ml is reached, at which point more than about half of the compound contained in the resultant liposome suspension is in encapsulated form.

Abstract: A semiconductor laser array device comprising a plurality of waveguides in a parallel manner to achieve an optical phase coupling therebetween within an active layer, wherein said device includes a region composed of a plurality of waveguide portions in the direction vertical to the waveguide direction, the effective refractive indexes of which are alternately different, whereby optical waves passing through said region attain a 180.degree. phase shift between the waveguide portions having different effective refractive indexes.

Abstract: The present invention comprises novel adamantyl purine derivatives, in which the purine ring is substituted at the 6-position with a moiety incorporating an adamantane ring system. The purine may also be substituted at the 9-position with a carbohydrate, to give a nucleoside analog, or may be unsubstituted at that position.The substituent at the 6-position contains an adamantane ring system, either substituted or unsubstituted, in which a linker connects a carbon atom in the adamantane ring system with the 6-carbon of the purine ring. This linker consists of a combination of a heteroatom such as N, O or S, which is directly connected to the purine, and a short (five or less) atom chain, consisting either of carbon or other atoms such as N, O or S, with or without additional pendant moieties, which is connected either to the secondary or tertiary carbon of the adamantane ring system. The adamantane ring system itself may be unsubstituted, or substituted with a wide variety of non-ionic groups.

Abstract: Novel methods and compositions are provided for enhanced yield of heterologous proteins in fungi. The method and compositions involve employing fusion sequences involving a sequence encoding a heterologous product produced in relatively large amount as a stable polypeptide in the host fused to a second sequence in open reading frame with the prior sequence coding for a different heterologous polypeptide, where the two polypeptides are joined by a selectively cleavable linkage. In particular, a sequence coding for superoxide dismutase is joined to another polypeptide of interest at either terminus of the superoxide dismutase in a yeast expression vector under transcriptional control of an active promoter and the vector introduced into a yeast host and the host grown. High yields of the fusion product are obtained in this manner, where the fusion product can be selectively cleaved so as to produce both the superoxide dismutase and the other polypeptide in high yield.The S.

Abstract: An active layer for laser oscillation and optical guiding layers for guiding laser light sandwiching the active layer therebetween are included in the device. At least one of the optical guiding layers is formed by a superlattice, the optical refractive index of which is lower than that of the active layer. Further, the optical refractive index is gradually decreased in the direction from the portion of the optical guiding layer adjacent to the active layer, to the outside of the optical guiding layer.