Patents Represented by Attorney Donald Brown

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  • Pesticidal compositions
    Patent number: 5047423
    Abstract: Compositions for treating timber, especially timber to be exposed to the ground, comprising creosote and a compound of formula I: ##STR1## wherein Z and Z.sup.1 are the same or different and are each halo, halophenyl or haloalkyl, X is hydrogen or cyano, and Y is hydrogen or a fluorine atom.The preferred pyrethroid is Permethrin.The compositions are unusually stable and have a prolonged protective action against termites, beetles, molluscs, woodworm and the like.
    Type: Grant
    Filed: September 12, 1989
    Date of Patent: September 10, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: Barry A. Richardson, Timothy R. G. Cox, Stuart W. Carter
  • Physiologically active compositions of growth hormone and serum albumin or Ig G
    Patent number: 5045312
    Abstract: Growth hormone is conjugated to any ligand, preferably a protein such as bovine serum albumin, optionally by use of a cross-linking agent such as a carbodiimide. The conjugates have enhanced activity when compared with unmodified growth hormone, and also better aqueous solubility at acid pH's.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: September 3, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: Roger Aston, Robert Bomford, Andrew T. Holder
  • Liquid formulations
    Patent number: 5045536
    Abstract: A pour-on formulation comprising one or more ectoparasiticides in a solvent system comprising 80 to 98% w/v of a fixed oil and 2 to 20% w/v of a volatile silicone, a method for its preparations and its use in the control of ectoparasiticides on animals.
    Type: Grant
    Filed: November 9, 1989
    Date of Patent: September 3, 1991
    Inventor: Ivor P. Baker
  • Body electrode holder
    Patent number: 5042481
    Abstract: A body electrode holder includes a holding member to be disposed on an outer surface of a living body, and a plurality of perforations formed in predetermined positions of the holding member, through which perforations a plurality of body electrodes pass respectively, the holding member being formed of a sheet material. The predetermined positions correspond to portions of the living body in which portions bioelectricity is to be measured. The body electrode holder makes it possible to a plurality of body electrodes at once and easily to predetermined positions without requiring special technic or knowledge regarding positions to attach the body electrodes.
    Type: Grant
    Filed: January 29, 1990
    Date of Patent: August 27, 1991
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Takashi Suzuki, Yosinobu Iguchi, Yoshihiro Wada
  • Antiviral compounds
    Patent number: 5043339
    Abstract: The present invention relates to amino acid esters of pyrimidine and purine nucleosides containing an acyclic side chain, and their use in medical therapy, particularly the treatment of herpes virus infections. Also provided are pharmaceutical formulations and processes for the preparation of compounds according to the invention.
    Type: Grant
    Filed: December 18, 1989
    Date of Patent: August 27, 1991
    Assignee: Burroughs Wellcome Co.
    Inventor: Lilia M. Beauchamp
  • Positioning device
    Patent number: 5042982
    Abstract: A positioning means for stabilizing segments of the spinal column or dummies between two such segments has a simple design and allows a certain alignment of the connecting rods to be connected thereto. To this end a positioning screw (1) is provided which comprises a threaded shaft part (2) and a receiver part (3) for a rod (5) provided at the head side. The rod and the receiver part are rigidly connectable with each other by means of two nuts (6, 7; 18, 19; 20, 21). The respective part of the receiver part (3) forming the abutment for the nuts (6, 7) or for the intermediate members (6',7'; 16, 17) is formed as a spherical or cylindrical segment. The part which has to be brought in engagement with this segment comprises an inner surface which is formed as a hollow sphere or a hollow cylinder and which is concentric to the central axis of the nut or the intermediate piece, resp.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: August 27, 1991
    Inventors: Jurgen Harms, Lutz Biedermann
  • Nucleoside and use thereof
    Patent number: 5041543
    Abstract: A compound 1-(3-azido-2,3-dideoxy-.beta.-D-erythro-pentofuranoxyl)-5-methyl-2(1H)-pyr imidinone and its use in a method of generating (forming, providing) 3'-azido-3'-deoxythymidine (zidovudine sometimes referred to as AZT) in the body of an animal (a mammal such as human) by systemically administering 1-(3-azido-2,3-dideoxy-.beta.-D-erythro-pentofuranosyl)-5-methyl-2(1H)-pyr iminone to said animal (mammal such as a human) is disclosed. AZT is approved and used for treating HIV infections, e.g., AIDS and ARC in humans and also has activity against gram-negative bacteria in animals.
    Type: Grant
    Filed: September 16, 1988
    Date of Patent: August 20, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: Sammy R. Shaver, George A. Freeman, Janet L. Rideout
  • Stabilization member for stabilizing bones
    Patent number: 5041113
    Abstract: The invention refers to a stabilization member serving for fixing broken or partly cracked bones in a predetermined position during the healing process or an even longer period. The stabilization member comprises a bar having elongated holes and the bar is fastened to the bone part to be stabilized by means of screws extending through the elongated holes. It is a drawback of such conventional stabilizing members that generally the screws can not be screwed in a direction perpendicular to the bar, because the screwing direction depends on the direction and form of the bone part. It is therefore intended to modify this conventional design such that a strong connection is obtained even in case that the screw does not extend in a direction perpendicular to the bar.
    Type: Grant
    Filed: July 16, 1990
    Date of Patent: August 20, 1991
    Inventors: Lutz Biedermann, Jurgen Harms
  • Cantilever support system for taking up objects running on roller wheels
    Patent number: 5040765
    Abstract: A support system comprises a cantilever for taking up objects running on roller wheels. The cantilever is formed to roll the objects onto the cantilever in a first direction up to a lock position and to remove them from the cantilever by rolling in a substantially opposite direction. The roller wheels shall be locked in a rest position and removal of the objects by rolling the roller wheels from the cantilever shall be eased. In order to achieve this object the cantilever comprises a depression formed at the lock position of the roller wheels and extending transversely to the roll-on direction. A substantially plane portion is provided at the roll-on side of the depression and a roller wheel arriving in the depression contacts said plane portion.
    Type: Grant
    Filed: May 17, 1990
    Date of Patent: August 20, 1991
    Assignee: F.M.K. Kreuzer GmbH & Co. KG
    Inventor: Jurgen Schonfelder
  • Antiparasitic 3(4-amino benzotriazo-1-yl-)1,2-cyclopentanediols
    Patent number: 5039689
    Abstract: The present invention relates to the use of a compound of formula (I) ##STR1## wherein R representsa hydrogen atom; a C.sub.1-4 alkyl group;a group COR.sup.1 wherein R.sup.1 represents amino or C.sub.1-4 alkoxy; ora group --CH.sub.2 R.sup.2 wherein R.sup.2 represents a halogen atom (e.g. chlorine or bromine), C.sub.1-4 alkylthio, or azido,X and Y each independently represent --CH-- or --N; andZ represents --CR.sup.3, wherein R.sup.3 is hydrogen or C.sub.1-4 alkyl, or Z represents --N--;or a physiologically acceptable salt, ester or other physiologically functional derivative thereof,for the manufacture of a medicament for the treatment and/or prophylaxis of a parasitic infection in a mammal, and to certain novel compounds of formula (I), pharmaceutical compositions containing them and processes for their preparation.
    Type: Grant
    Filed: November 8, 1989
    Date of Patent: August 13, 1991
    Assignee: Burroughs Wellcome Co.
    Inventor: Susan M. Daluge
  • Aryl derivatives
    Patent number: 5036157
    Abstract: Novel compounds of formula (I)Ar--(L--Ar').sub.q --(X).sub.k --(Y).sub.p --Q (I)wherein:k, p and q are independently 0 or 1;Ar represents either:(i) naphthyl, tetrahydronaphthyl, pyridyl or(ii) phenyl, optionally substituted,L is selected from --(CH.sub.2).sub.r -- (where r is 1-4), --O--, --CH.sub.2 O--, --CH.sub.2 S--, --OCH.sub.2 --, --CONH--, --NHCO--, --CO-- and --CH.sub.2 NH--, and,Ar' represents phenylene, thienylene or pyridylene optionally substituted,X represents oxygen, sulphur or carbonyl,Y is C.sub.1-10 alkylene or C.sub.1-10 alkenylene;Q represents a non-cyclic moiety selected from groups of formula ##STR1## in which one of m and n is 0 and the other is 1, R.sup.1 and R.sup.2 is selected from hydrogen, C.sub.1-4 alkyl, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, C.sub.5-7 cycloalkylamino, C.sub.5-7 cycloalkyl (C.sub.1-4 alkyl) amino, anilino, N-C.sub.
    Type: Grant
    Filed: March 10, 1987
    Date of Patent: July 30, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: Geoffrey Kneen, William P. Jackson, Peter J. Islip, Peter J. Wates
  • Therapeutic nucleosides
    Patent number: 5034394
    Abstract: The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. Also provided are pharmaceutical formulations and processes for the preparation of compounds according to the invention.
    Type: Grant
    Filed: December 22, 1989
    Date of Patent: July 23, 1991
    Assignee: Burroughs Wellcome Co.
    Inventor: Susan M. Daluge
  • Method and apparatus for electrophoretic separations
    Patent number: 5032247
    Abstract: A method and apparatus for conducting electrophoretic separations is described in which heat exchange fluid is passed through hollow fibers in the electrophoretic chamber during the separation process and the separations are conducted in the interstices of the hollow fiber. Hollow fibers made of organic polymers, inorganic materials such as glass and silica, and natural fibers may be used.
    Type: Grant
    Filed: September 14, 1989
    Date of Patent: July 16, 1991
    Assignee: Separations Technology, Inc.
    Inventor: Yuri Tarnopolsky
  • Methods of treating pulmonary hypertension
    Patent number: 5028628
    Abstract: The present invention is concerned with methods for the treatment and diagnosis of pulmonary hypertension which comprise the administration of an effective amount of a compound of formula (I) ##STR1## wherein X is hydrogen or methyl;Y is --O-- or --CH.sub.2 --;R is --C(R.sup.1)(R.sup.2)CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 wherein R.sup.1 and R.sup.2, which may be the same or different, are selected from hydrogen and halogen; andthe dotted line represents an optional double bond; andpharmaceutically acceptable salts and acid derivatives thereof.Medicaments and diagnostic aids for use in the methods of the invention are also within the scope of the invention.
    Type: Grant
    Filed: October 13, 1989
    Date of Patent: July 2, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: Anjaneyulu S. Tadepalli, Brendan J. R. Whittle
  • 1-(.beta.-D-arabinofuranosyl)-5-propynyluracil for treatment of VZV infections
    Patent number: 5028596
    Abstract: The invention is a method for using 1-(.beta.-D-arabinofuranosyl)-5-propynyluracil or its salts as the active ingredient in pharmaceutical compositions in the treatment of varicella zoster viral infections whether expressed as chicken pox or shingles.
    Type: Grant
    Filed: December 14, 1987
    Date of Patent: July 2, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: Dorothy J. M. Purifoy, Saad G. Rahim
  • Appliance carrier
    Patent number: 5026017
    Abstract: An appliance carrier for use in particular with supports for appliances in a hospital is adapted for mounting appliance receiving supports in an adjustable height. To this end an extension arm of the carrier comprises a profiled portion having grooves extending in longitudinal direction of the carrier on two opposite sides thereof. The grooves receive a respective support member for connection with a carrier member. The support members are slidable in the respective grooves.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: June 25, 1991
    Assignee: F.M.K. Kruezer GmbH & Co.
    Inventor: Friedhelm Kreuzer
  • 2-acetylpyridine 5-[(2-chloroanilino)thiocarbonyl]thiocarbonohydrazone compound and salts thereof
    Patent number: 5021437
    Abstract: The present invention relates to a novel ribonucleotide reductase inhibitor and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus infections, especially viruses of the herpes group.
    Type: Grant
    Filed: June 26, 1989
    Date of Patent: June 4, 1991
    Assignee: Burroughs Wellcome Co.
    Inventor: Todd A. Blumenkopf
  • Tunnel finisher
    Patent number: 5018371
    Abstract: A tunnel finisher is provided with an entrance and an outlet and respective pairs of air drums associated to the entrance and the outlet. The tunnel finisher comprises a conveyer with grippers for passing a garment to be treated through the tunnel finisher, a steam supply at the inner side of the inlet pair of air drums and close thereto, a recirculation apparatus for the atmosphere and a supply of air into the interior of the air drums. The conventional separation between the steam chamber and the finishing chamber is omitted by providing a detector actuated by a garment to be finished and controlling the cross-section of the air outlet of the recirculation apparatus.
    Type: Grant
    Filed: January 29, 1990
    Date of Patent: May 28, 1991
    Inventor: Gunther Riba
  • Novel compounds and use
    Patent number: 5019577
    Abstract: The present invention provides a compound selected from:N-[4-(3 -(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propylamino)-2-flurobenzoyl] -(L)-glutamic acid,N-[4-( 3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propylamino)-3-flurobenzoyl ]-(L)-glutamic acid,N-[4 -(3 -(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propylamino)-3-methylbenzoyl ]-(L)-glutamic acid,N-[4-( 2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propylamino)-3-(methoxy)benzoy l](L)-glutamic acid andN-[4-(3 -(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propylamino)-2-chlorobenzoyl ](L)-glutamic acid,or a salt thereof, methods for the preparation of the compounds, intermediates in their preparations, pharmaceutical formulations containing them, and their use in the treatment of tumors.
    Type: Grant
    Filed: April 15, 1988
    Date of Patent: May 28, 1991
    Assignee: Burroughs Welcome Co.
    Inventor: Eric C. Bigham
  • Tricyclic derivatives
    Patent number: 5017600
    Abstract: The present invention relates to compounds of formula (I)ArCH.sub.2 R.sup.
    Type: Grant
    Filed: August 24, 1989
    Date of Patent: May 21, 1991
    Assignee: Burroughs Wellcome Co.
    Inventor: Kenneth W. Bair