Patents Represented by Attorney Donald Brown

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  • Therapeutic nucleosides
    Patent number: 5175274
    Abstract: This invention relates to certain 2'-fluoro nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of HIV infections. Also provided are pharmaceutical formulations and processes for the production of the compounds according to the invention.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: December 29, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Joel Van Tuttle, Thomas A. Krenitsky
  • Naphthoquinone derivatives
    Patent number: 5175319
    Abstract: Novel antiprotozoal naphthoquinones having the general formula ##STR1## (wherein either R.sup.1 is hydrogen and R.sup.2 is selected from C.sub.1-6 alkoxy, aralkoxy, C.sub.1-6 alkyl-C.sub.1-6 alkoxy, phenyl substituted by one or two groups selected from halogen and C.sub.1-6 alkyl, halogen and perhalo-C.sub.1-6 alkyl; or R.sup.1 and R.sup.2 are both C.sub.1-6 alkyl or phenyl; and n is 0 or 1) and salt thereof. The compounds of formula (I) are useful for the treatment or prophylaxis of protozoal diseases including malaria, theileriosis and coccidiosis. Various processes for preparing compounds of formula (I) are described.
    Type: Grant
    Filed: September 12, 1991
    Date of Patent: December 29, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Alan T. Hudson, Anthony W. Randall
  • Antiviral combinations and compounds therefor
    Patent number: 5175165
    Abstract: The present invention relates to novel ribonucleotide reductase inhibitors and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus infections, espectially viruses of the herpes group.
    Type: Grant
    Filed: June 26, 1989
    Date of Patent: December 29, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Todd A. Blumenkopf, Thomas Spector, Devron R. Averett, Robert W. Morrison, Jr., Eric C. Bigham, Virgil L. Styles
  • Quinoline compound
    Patent number: 5166160
    Abstract: The present invention is concerned with the compound of formula (I) ##STR1## and its acid addition salts. The invention is also directed to the use of the compound of formula (I) and its pharmaceutically acceptable acid addition salts as positive conotropic agents in mammals.
    Type: Grant
    Filed: August 11, 1988
    Date of Patent: November 24, 1992
    Assignee: Burroughs Wellcome Co.
    Inventor: Arthur P. Phillips
  • Pharmacologically active compounds
    Patent number: 5166209
    Abstract: This invention describes the preparation and use of anticonvulsant agents. In particular, triazolopyridine compounds are described which have utility in the treatment of epilepsy in mammals.
    Type: Grant
    Filed: October 16, 1990
    Date of Patent: November 24, 1992
    Assignee: Burroughs Wellcome Co.
    Inventor: James L. Kelley
  • Antiviral acetyl pyridine derivative or said acetyl pyridine derivative in combination with acyclovir
    Patent number: 5164395
    Abstract: The present invention relates to a novel ribonucleotide reductase inhibitor and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus infections, especiallly viruses of the herpes group.
    Type: Grant
    Filed: March 1, 1991
    Date of Patent: November 17, 1992
    Assignee: Burroughs Wellcome Co.
    Inventor: Todd A. Blumenkopf
  • Expandable baton with spring biased latch means
    Patent number: 5160140
    Abstract: An expandable police baton embodying a cylindrical sleeve within which is slidably disposed a cylindrical shaft and further embodying structure for limiting the position of the shaft on the one hand within the sleeve and on the other hand expanded therefrom. Preferably, the sleeve is comprised of aluminum and the shaft is comprised of polycarbonate or aluminum. A spring-biased nylon steel pin assembly is employed to limit contraction and extension of the shaft relative to the sleeve and a shock absorbent plug is employed to constrain extension.
    Type: Grant
    Filed: May 15, 1991
    Date of Patent: November 3, 1992
    Assignee: Monadnock Lifetime Products, Inc.
    Inventor: Paul D. Starrett
  • 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
    Patent number: 5157114
    Abstract: The present invention relates to a 3'-substituted pyrimidine nucleoside and its use in medical therapy, particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations.
    Type: Grant
    Filed: August 17, 1989
    Date of Patent: October 20, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Saad G. Rahim, Thomas A. Krenitsky
  • Method and device for the examination of cellular changes in an organism
    Patent number: 5157703
    Abstract: To investigate cellular changes in a living organism, in particular pathological cellular changes in a human being, the cellular substance is irradiated with two x-ray pulses in rapid succession. The difference in attenuation of the intensity between the two x-ray pulses is then evaluated.
    Type: Grant
    Filed: May 7, 1991
    Date of Patent: October 20, 1992
    Inventor: Hans-Detlef Wolf
  • 3'-Azido nucleoside compound
    Patent number: 5153318
    Abstract: The present invention relates to 3'-azido purine nucleosides and their use in medical therapy, particularly for the treatment of human immunodeficiency virus and hepatitis B virus infections, to methods for their preparation and to compositions containing them.
    Type: Grant
    Filed: October 2, 1990
    Date of Patent: October 6, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Janet L. Rideout, George A. Freeman, Steven A. Short, Merrick R. Almond, Jon L. Collins
  • Method of treating pulmonary hypertension with benzidine prostaglandins
    Patent number: 5153222
    Abstract: The present invention is concerned with methods for the prophylaxis, treatment and diagnosis of pulmonary hypertension which comprise the administrative of an effective amount of a compound of formula (I) ##STR1## wherein a is an integer of from 1 to 3; X and Y, which may be the same or different, are selected from --O-- and --CH.sub.2 --;R is --(CH.sub.2).sub.5 R.sup.1 wherein R.sup.1 is hydrogen or methyl, or R is cyclohexyl, orR is --CH(CH.sub.3)CH.sub.2 C.tbd.CCH.sub.3 ; andthe dotted line represents an optional double bond;or of a physiologically acceptable salt or acid derivative thereof.Medicaments and diagnostic aids for use in the methods of the invention are also within the scope of the invention.
    Type: Grant
    Filed: June 14, 1991
    Date of Patent: October 6, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Anjaneyulu S. Tadepalli, Walker A. Long, James W. Crow, Kenneth B. Klein
  • Baculovirus vectors and methods of use
    Patent number: 5147788
    Abstract: A baculovirus transfer vector incorporates a restriction site into which a foreign gene may be cloned a short distance downstream of the N-terminus of the polyhedrin gene body and the natural ATG translation start codon for the polyhedrin gene is not provided such that the N-terminal polyhedrin coding sequence prior to the restriction site is retained but not capable of being translated.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: September 15, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Martin J. Page, Brian C. Rodgers
  • Treatment of idiopathic thrombocytopaenic purpura
    Patent number: 5145840
    Abstract: A method of treating idiopathic thrombocytopaenia purpura with 2',3'-dideoxy-3'-azidonucleosides, in particular 3'-azido-3'-deoxythymidine, is disclosed.
    Type: Grant
    Filed: April 2, 1991
    Date of Patent: September 8, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Leone E. Kirk, III, Dannie H. King, Richard H. Clemons, Sandra N. Lehrman, David W. Barry
  • Nitrile compounds
    Patent number: 5136080
    Abstract: A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy.
    Type: Grant
    Filed: June 5, 1990
    Date of Patent: August 4, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Alistair A. Miller, Malcolm S. Nobbs, Richard M. Hyde, Michael John
  • Container
    Patent number: 5133497
    Abstract: In a container such as a cardboard container for packaging milk which comprises sidewalls, a bottom flap and a top flap as well as an ear to be folded down around a folding edge for forming a pouring spout the problem is encountered that, for opening the container, an outer portion of the ear has to be cut away and, after opening the container, no reclosure is possible, but the pouring spout remains open and may be a source of pollution.In order to obviate this problem the ear of the inventive container comprises a socket member projecting from the ear at the surface thereof adjacent to the folding edge and facing a sidewall of the container, and there is an aperture provided in the facing sidewall for receiving the socket member. In this manner, the socket member forms a reclosable pouring spout of the container.
    Type: Grant
    Filed: May 14, 1991
    Date of Patent: July 28, 1992
    Assignee: Dipl. - Physiker Lutz H. Prufer
    Inventor: Gerd Kuppersbusch
  • Synergistic compounds
    Patent number: 5134132
    Abstract: Acaricidal compositions comprising a pyrethroid of formula ##STR1## wherein Z and Z.sup.1 are the same or different and each is halo and wherein X is hydrogen or cyano, provided that when Z and Z.sup.1 are both chloro, X must be cyano together with at least one organophosphorus compound, formulations containing them and their use for the control of veterinary ectoparasites of the sub-Orders Ixodoidea and Sarcoptiformes.
    Type: Grant
    Filed: March 11, 1991
    Date of Patent: July 28, 1992
    Inventor: Michael D. Matthewson
  • Coaxial planar magic tee
    Patent number: 5132646
    Abstract: A Coaxial Planar Magic Tee in which the tee portion is positioned inside a ridged waveguide. When used in one application the device also includes a load to dissipate power in an arm thereof.
    Type: Grant
    Filed: April 6, 1988
    Date of Patent: July 21, 1992
    Inventor: Terry A. Faxon
  • Electronic talking board game
    Patent number: 5120065
    Abstract: A talking board game having a board and an electronic computer system providing speech information to the players, and cards which can be read by the electronic computer system.
    Type: Grant
    Filed: February 8, 1991
    Date of Patent: June 9, 1992
    Assignee: Hasbro, Incorporated
    Inventors: Robert W. Driscoll, Daniel J. Marceau
  • Pharmaceutical delivery system
    Patent number: RE33994
    Abstract: A composition for use in an aqueous environment which .[.comprise.]. .Iadd.comprises .Iaddend.a formulation containing a water-soluble pharmaceutically beneficial agent, a water-insoluble, water-permeable film coating surrounding the formulation, and particulate, water-soluble, pore-forming material dispersed within the film coating.The questions raised in reexamination request No. 90/001,344, filed Oct. 5, 1987, have been considered and the results thereof are reflected in this reissue patent which constitutes the reexamination certificate required by 35 U.S.C. 307 as provided in 37 CFR 1.570(e).
    Type: Grant
    Filed: August 4, 1989
    Date of Patent: July 14, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Richard W. Baker, James W. Brooke
  • Battery pack for a mobile telephone or the like
    Patent number: D328888
    Type: Grant
    Filed: February 21, 1990
    Date of Patent: August 25, 1992
    Assignee: Lloyd Wise & Company
    Inventor: Jing Y. Zhu