Patents Represented by Attorney Donald J. Perrella

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  • Assay for hepatitis B core antibody
    Patent number: 4241175
    Abstract: HB.sub.c Ab is detected in biological fluid by contacting HB.sub.c Ag derived from Dane particles and adhered to a surface with the biological fluid and an antibody-enzyme conjugate. The HB.sub.c Ag is adhered to the surface in the presence of a nonionic surfactant.
    Type: Grant
    Filed: December 18, 1978
    Date of Patent: December 23, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. Miller, William J. McAleer, Lynn T. Callahan
  • Pretreatment of microcarriers for cell culture
    Patent number: 4237033
    Abstract: A method is provided for pretreatment of microcarrier beads to make them suitable for use in mass culture of vertebrate anchorage dependent cells such as primary and diploid cells. The beads are soaked and heated in fetal calf serum (FCS) at from about 65.degree. to about 95.degree. C. for about 3 minutes to about 1 hour.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: December 2, 1980
    Assignee: Merck & Co., Inc.
    Inventor: Edgar M. Scattergood
  • Liposome particle containing viral or bacterial antigenic subunit
    Patent number: 4235877
    Abstract: Subunit viral or bacterial antigens are incorporated into liposomes containing a positively charged amino-containing surfactant. The resulting complex is antigenically more active than the free antigen.
    Type: Grant
    Filed: June 27, 1979
    Date of Patent: November 25, 1980
    Assignee: Merck & Co., Inc.
    Inventor: William W. Fullerton
  • High molecular weight meningococcal group C vaccine and method for preparation thereof
    Patent number: 4235994
    Abstract: A vaccine against Group C meningococcal meningitis consisting of a polysaccharide of which at least 80% by weight has a molecular weight in excess of 1,000,000 daltons is prepared. The polysaccharide was isolated from Group C hexadecyl trimethylammonium bromide cell paste with 1.0M CaCl.sub.2 extraction and purified by phenol extraction, ultracentrifugation at 100,000 g. and ethanol fractionation (30%-45% v/v in ethanol).
    Type: Grant
    Filed: June 26, 1978
    Date of Patent: November 25, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Thomas H. Stoudt, Dennis J. Carlo, Arpi Hagopian
  • Liner for deck chute
    Patent number: 4234182
    Abstract: A deck chute for an automatic pinsetter is provided with a lining of low coefficient of friction material.
    Type: Grant
    Filed: January 30, 1978
    Date of Patent: November 18, 1980
    Inventor: Thomas M. Camilleri
  • Hepatitis B core antigen composition
    Patent number: 4234564
    Abstract: Compositions comprising HB.sub.s Ag and a physiologically acceptable medium are useful as diagnostic and immunologic agents.
    Type: Grant
    Filed: December 19, 1977
    Date of Patent: November 18, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, William J. Miller, Edward H. Wasmuth
  • Positive turret indexing apparatus
    Patent number: 4230315
    Abstract: Pin contacting means deflect a bowling pin as it exits the cross conveyor belt so that it contacts the turret indexing paddle rather than the wires of the turret baskets.
    Type: Grant
    Filed: December 26, 1978
    Date of Patent: October 28, 1980
    Inventor: Thomas M. Camilleri
  • Immunologic adjuvant
    Patent number: 4229441
    Abstract: Glycolipid compounds of the formulae ##STR1## wherein R is ##STR2## are useful immunologic adjuvants in vaccines.
    Type: Grant
    Filed: December 1, 1978
    Date of Patent: October 21, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Bugianesi, Mitree M. Ponpipom, Tsung-Ying Shen
  • Carpet belt
    Patent number: 4226417
    Abstract: A carpet belt for an automatic pinspotter machine formed of a soft, flexible, material capable of embedding therein a hard object without being torn.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: October 7, 1980
    Inventor: Thomas M. Camilleri
  • Antigenic complex from N. Gonorrhoeae
    Patent number: 4220638
    Abstract: An antigenic, immunogenic, non-toxic complex is obtained from the cell surface of N. gonorrhoeae.
    Type: Grant
    Filed: October 12, 1978
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Yashwant D. Karkhanis, Dennis J. Carlo
  • Valve operator
    Patent number: 4220313
    Abstract: The present invention provides a valve operator whereby movement of linkage arms connected to a spring loaded movable pressure plate and to a valve stem support opens and closes the valve diaphragm. A manual override clutch assembly disengages the drive means and permits manual operation of the valve.
    Type: Grant
    Filed: May 12, 1978
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth M. Petersen, John E. Soulier
  • Recovery of small particles by flow centrifugation
    Patent number: 4217418
    Abstract: It has now been found that small size particles may be extracted from a proteinaceous liquid at a low flow rate in flow-centrifuge operation by precooling the liquid before it enters the centrifuge and by employing a multi-step gradient.
    Type: Grant
    Filed: March 9, 1979
    Date of Patent: August 12, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, William M. Hurni
  • Parainfluenza virus vaccine and its preparation
    Patent number: 4215107
    Abstract: By serially passaging virulent parainfluenza virus in tissue culture prepared from embryonated hens' eggs or human diploid lung fibroblasts, a live, non-pathogenic but antigenic live parainfluenza virus is produced. This virus is useful in preparing a live virus vaccine.
    Type: Grant
    Filed: December 29, 1978
    Date of Patent: July 29, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Eugene B. Buynak, Maurice R. Hilleman
  • Antihypertensive N-heterocyclicalanines
    Patent number: 4206216
    Abstract: A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: June 3, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, Clarence S. Rooney, Yves Girard, Edward L. Engelhardt
  • Isolation of hepatitis B e antigen
    Patent number: 4204989
    Abstract: Hepatitis B e antigen or hepatitis B e antibody are separated from human biological fluid by centrifugation in a density gradient and isolated in the 1.04-1.15 g/cc density region.
    Type: Grant
    Filed: December 13, 1978
    Date of Patent: May 27, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Swine atropic rhinitis vaccine
    Patent number: 4203970
    Abstract: A sub-cellular antigenic fraction of Bordetella bronchiseptica protects against the incidence and severity of swine atropic rhinitis.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: May 20, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Dennis J. Carlo, Arpi Hagopian, Peter J. Kniskern
  • Viral liposome particle
    Patent number: 4201767
    Abstract: The outer membrane of influenza virus is attached to a liposome by two different techniques. In addition, one of the techniques allows the entrapment of intact virus, usually one virus per liposome. The techniques can be performed with either influenza virus A or B.
    Type: Grant
    Filed: November 8, 1978
    Date of Patent: May 6, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Wardle Fullerton, Bohdan Wolanski
  • Liposome particle containing viral or bacterial antigenic subunit
    Patent number: 4199565
    Abstract: Subunit viral or bacterial antigens are incorporated into liposomes containing a positively charged amino-containing surfactant. The resulting complex is antigenically more active than the free antigen.
    Type: Grant
    Filed: March 26, 1979
    Date of Patent: April 22, 1980
    Assignee: Merck & Co., Inc.
    Inventor: William W. Fullerton
  • Immunologic glycolipid adjuvants
    Patent number: 4189471
    Abstract: Glycolipid compounds of the formulae ##STR1## are useful immunologic adjuvants in vaccines.
    Type: Grant
    Filed: July 11, 1978
    Date of Patent: February 19, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Mitree M. Ponpipom, John Chabala, Tsung-Ying Shen
  • Method for recovering embryos from embryonated eggs
    Patent number: 4187989
    Abstract: A method and apparatus for recovering embryos from embryonated eggs wherein the egg is cracked open the shell discarded and the contents dropped onto a continuously vibrating screen which separates the embryo from the yolk sac and accompanying fluid. This associated material, which is less cohesive than the embryo, passes through the screen. The screen itself is tilted at a compound angle from the horizontal and its vibrating action causes the embryos to move along the upper surface of the screen toward a discharge chute located at the lower corner of the screen.
    Type: Grant
    Filed: June 22, 1978
    Date of Patent: February 12, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, William M. Hurni