Patents Represented by Attorney Donald J. Perrella

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  • Hepatitis B antigen
    Patent number: 4186193
    Abstract: Hepatitis B surface antigen free of gradient-derived added cesium and potassium ions, for example the antigen in an aqueous solution of sodium bromide.
    Type: Grant
    Filed: October 25, 1977
    Date of Patent: January 29, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Isolation of HB.sub.s Ag
    Patent number: 4181713
    Abstract: High purity HB.sub.s Ag is injected into guinea pigs to stimulate formulation of HB.sub.s Ab-positive serum. Gamma globulins containing HB.sub.s Ab are separated from the serum and the globulin fraction containing HB.sub.s Ab is isolated and coupled to a Sepharose gel. HB.sub.s Ag from HB.sub.s Ag-positive plasma is adsorbed on the gel by formation of an HB.sub.s Ab-HB.sub.s Ag complex. HB.sub.s Ag is eluted from the column and dialysed.
    Type: Grant
    Filed: October 30, 1978
    Date of Patent: January 1, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Pin orientator
    Patent number: 4177988
    Abstract: An automatic bowling machine is provided with means adapted to maintain the distributor belt closer than otherwise to the orientating pan.
    Type: Grant
    Filed: December 14, 1977
    Date of Patent: December 11, 1979
    Inventor: Thomas M. Camilleri
  • Method for preparing hepatitis B immune globulin
    Patent number: 4174388
    Abstract: Hepatitis B immune globulin is prepared from individuals who exhibit an increase in hepatitis B surface antibody of at least 2,000 PHA units/ml following immunization with hepatitis B surface antigen.
    Type: Grant
    Filed: July 19, 1978
    Date of Patent: November 13, 1979
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Rear filler pad assembly
    Patent number: 4171810
    Abstract: A rear filler pad assembly for an automatic pinspotter bowling machine is formed of two ribbed attaching segments and a grommet receiving segment having elongated serrated slots. Each slot has a wide opening at one end thereof into which a grommet is inserted. The grommet is then moved along the slot until it is in registration with the associated ball kicker shaft. The narrow portion of each slot holds the grommet firmly in place.
    Type: Grant
    Filed: December 14, 1977
    Date of Patent: October 23, 1979
    Inventor: Thomas M. Camilleri
  • Respot cell protective bearing member
    Patent number: 4171809
    Abstract: The end of the gripping finger member of a respot cell is provided with a tightly fitted elastomeric wheel-like protective bearing member.
    Type: Grant
    Filed: August 9, 1977
    Date of Patent: October 23, 1979
    Inventor: Thomas M. Camilleri
  • Direct acidified yogurt
    Patent number: 4169854
    Abstract: A direct acidified yogurt is prepared from milk, a thickener blend containing starch, sodium carboxymethyl cellulose, xanthan gum and locust bean gum, and optionally a carbohydrate sweetener. To prepare yogurt, the thickener blend is mixed with milk, the mixture is pasteurized, an acidulent is added and the acidified mixture is subjected to a shearing treatment to produce a yogurt-like texture.
    Type: Grant
    Filed: May 12, 1977
    Date of Patent: October 2, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Robert S. Igoe
  • Riboflavin purification
    Patent number: 4165250
    Abstract: Riboflavin is recovered from fermentation broth by diluting the broth with a predetermined quantity of water, centrifuging the diluted broth to form a sludge, resuspending the sludge with a predetermined quantity of water, and centrifuging the resuspended sludge to yield a product usuable directly as an animal feed supplement or suitable for further purification for pharmaceutical use. Optionally the broth or resuspended sludge is treated with an enzyme before centrifugation.
    Type: Grant
    Filed: November 14, 1977
    Date of Patent: August 21, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Albert Epstein, Glen Graham, William A. Sklarz
  • Hepatitis a virus cell culture in vitro
    Patent number: 4164566
    Abstract: Hepatitis A virus is passaged at least once in a susceptible sub-human primate; the infected liver from such passage is used to inoculate an in vitro cell culture, the inoculated cell culture is incubated until hepatitis A antigen is detected in the cell sheet or culture fluid, and at least two serial in vitro passages in cell culture are carried out. The hepatitis A virus so modified can be used to prepare live, attenuated hepatitis A vaccine or an inactivated hepatitis A vaccine.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: August 14, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Philip J. Provost, Maurice R. Hilleman
  • Citrus fruit juice and drink
    Patent number: 4163807
    Abstract: Appearance, taste and stability of citrus fruit juices and drinks are improved by incorporating xanthan gum and CMC.
    Type: Grant
    Filed: March 15, 1978
    Date of Patent: August 7, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Kristina R. Jackman
  • Indolyl amino acids useful as antihypertensive agents
    Patent number: 4153715
    Abstract: A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.
    Type: Grant
    Filed: August 16, 1977
    Date of Patent: May 8, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, Clarence S. Rooney, Yves Girard, Edward L. Engelhardt
  • Deck pad for automatic bowling machine
    Patent number: 4151992
    Abstract: An improved deck pad for a pinsetter automatic bowling machine is formed of medium density flexible, resilient, compression resistent cellular material.
    Type: Grant
    Filed: November 21, 1977
    Date of Patent: May 1, 1979
    Inventor: Thomas M. Camilleri
  • Vaccine stabilizer
    Patent number: 4147772
    Abstract: A stabilized lyophlized or liquid live viral vaccine contains a live virus, partially hydrolyzed gelatin, a 6-carbon polyhydric alcohol, Medium 199 and acidic buffer.
    Type: Grant
    Filed: February 23, 1978
    Date of Patent: April 3, 1979
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Henry Z. Markus
  • Respiratory syncytial vaccine
    Patent number: 4145252
    Abstract: By serially passaging virulent respiratory syncytial virus in human diploid lung fibroblasts, a non-pathogenic but antigenic live respiratory syncytial virus is produced. This virus is useful in preparing a live virus vaccine.
    Type: Grant
    Filed: June 26, 1978
    Date of Patent: March 20, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Eugene B. Buynak, Maurice R. Hilleman
  • Treatment of xanthan gum to improve clarity
    Patent number: 4135979
    Abstract: A xanthan gum fermentation beer containing at least about 1% gum is filtered at a temperature of at least about 112.degree. C. The gum subsequently recovered from the filtrate has improved clarity.
    Type: Grant
    Filed: August 24, 1976
    Date of Patent: January 23, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Foss E. Corley, Joe B. Richmon
  • Freeze-drying process for the preparation of meningococcus vaccine without degradation of potency
    Patent number: 4134214
    Abstract: The purified Group A polysaccharide antigen isolated from N. meningitidis for vaccination against this type of bacterial meningitidis is prepared from an isotonic ratio of aqueous sodium chloride solution freeze-dried at temperatures of from -20.degree. C. to -30.degree. C. This low temperature lyophilization dries the sodium chloride polysaccharide menstrum without loss of molecular weight, i.e., potency.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: January 16, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Glen D. Graham, William A. Sklarz
  • Stabilized icings
    Patent number: 4135005
    Abstract: Freeze-thaw and heat stable icings are obtained by using an icing composition containing a high melting point fat and a gelling system consisting essentially of xanthan gum and locust bean gum.
    Type: Grant
    Filed: May 9, 1977
    Date of Patent: January 16, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Hsiung Cheng
  • Isolating hepatitis B Dane particles
    Patent number: 4129646
    Abstract: Biological fluid containing hepatitis B surface antigen is subjected to isopycnic banding with collection of fractions rich in Dane particles. The Dane particles are useful as diagnostic and immunologic agents.
    Type: Grant
    Filed: April 4, 1977
    Date of Patent: December 12, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Method for preparing high molecular weight meningococcal Group C vaccine
    Patent number: 4123520
    Abstract: A vaccine against Group C meningococcal meningitis consisting of a polysaccharide of which at least 80% by weight has a molecular weight in excess of 1,000,000 daltons is prepared. The polysaccharide was isolated from Group C hexadecyl trimethylammonium bromide cell paste with 1.0M CaCl.sub.2 extraction and purified by phenol extraction, ultracentrifugation at 100,000 g. and ethanol fractionation (30%-45% v/v in ethanol).
    Type: Grant
    Filed: August 1, 1977
    Date of Patent: October 31, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Arpi Hagopian, Dennis J. Carlo, Thomas H. Stoudt
  • Respiratory synctial vaccine
    Patent number: 4122167
    Abstract: By serially passaging virulent respiratory syncytial virus in human diploid lung fibroblasts, a non-pathogenic but antigenic live respiratory syncytial virus is produced. This virus is useful in preparing a live virus vaccine.
    Type: Grant
    Filed: August 17, 1977
    Date of Patent: October 24, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Eugene B. Buynak, Maurice R. Hilleman