Patents Represented by Attorney Donald J. Perrella

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  • Hepatitis B antigen
    Patent number: 4118477
    Abstract: An improved process for the preparation of hepatitis B antigen by subjecting biological fluid containing heptatitis B surface antigen to isopycanic banding wherein the step gradient is NaBr. Faster and more economical processing is obtained by multiple loading of the step gradient, either NaBr or conventional gradients.
    Type: Grant
    Filed: September 2, 1977
    Date of Patent: October 3, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Automated plate reader
    Patent number: 4115010
    Abstract: Apparatus and method for automatically reading a microtiter plate comprises a light source, a photo sensor, means enabling the photo sensor to measure light transmittance and means for recording and processing the measurements.
    Type: Grant
    Filed: February 3, 1976
    Date of Patent: September 19, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, William M. Hurni
  • Apparatus for recovering embryos from embryonated eggs
    Patent number: 4110223
    Abstract: A method and apparatus for recovering embryos from embryonated eggs wherein the egg is cracked open the shell discarded and the contents dropped onto a continuously vibrating screen which separates the embryo from the yolk sac and accompanying fluid. This associated material, which is less cohesive than the embryo, passes through the screen. The screen itself is tilted at a compound angle from the horizontal and its vibrating action causes the embryos to move along the upper surface of the screen toward a discharge chute located at the lower corner of the screen.
    Type: Grant
    Filed: November 23, 1976
    Date of Patent: August 29, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, William M. Hurni
  • Sulfomethylated graft copolymers of xanthan gum and polyacrylamide
    Patent number: 4105605
    Abstract: A water-soluble anionic graft copolymer of xanthan gum and polyacrylamide wherein at least part of the amide function is sulfomethylated.
    Type: Grant
    Filed: December 21, 1976
    Date of Patent: August 8, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Ian W. Cottrell, Richard A. Empey, Joseph S. Racciato
  • Thickening compositions containing xanthan gum, guar gum and starch
    Patent number: 4105461
    Abstract: A blend of xanthan gum, guar gum, or guar gum derivatives, a starch ether has unique thickening properties. The blend is particularly useful in printing pastes, salad dressings and oil well drilling muds.
    Type: Grant
    Filed: August 26, 1976
    Date of Patent: August 8, 1978
    Assignee: Merck & Co., Inc.
    Inventor: Joseph S. Racciato
  • Method of preparing hepatitis B core antigen
    Patent number: 4102996
    Abstract: HB.sub.c Ag is prepared by isolating Dane particles by isopycnic banding of fluid from HB.sub.s Ag positive donors, optionally but preferably pelleting the Dane particles, and then removing the surface antigen by contacting the Dane particles with a nonionic surfactant having from about 15 to about 35 oxyethylene units in the presence of a reducing agent such as mercaptoethanol. The isolated core antigen is used as a diagnostic and immunologic agent.
    Type: Grant
    Filed: April 20, 1977
    Date of Patent: July 25, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, William J. Miller, Edward H. Wasmuth
  • Separation of trachoma agent from growth medium impurities
    Patent number: 4096035
    Abstract: Trachoma agent is separated from growth medium impurities by density gradient centrifugation in a sodium bromide solution.
    Type: Grant
    Filed: June 15, 1977
    Date of Patent: June 20, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Roy A. Machlowitz, Edward H. Wasmuth
  • Hepatitis B surface antigen
    Patent number: 4088748
    Abstract: Biological fluid containing hepatitis B surface antigen is concentrated using ammonium sulfate, and subjected to an isopycnic banding followed by rate zonal banding.
    Type: Grant
    Filed: May 4, 1977
    Date of Patent: May 9, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Cushion blocks
    Patent number: 4084817
    Abstract: A cushion block assembly for a cylinder which supports a bowling ball backstop consists of two substantially U-shaped blocks, one block provided with means to lock the cylinder, the other block provided with a hub over which the cylinder is fitted.
    Type: Grant
    Filed: April 26, 1976
    Date of Patent: April 18, 1978
    Inventor: Thomas M. Camilleri
  • Cell and vaccine production
    Patent number: 4080258
    Abstract: Production of cells and vaccines utilizing a multiplate propagator in which the fluid dynamics of the system can be controlled during the growth cycle and/or the harvesting conditions can be controlled by rapidly cooling the harvested vaccine or by using multiple harvests, with or without automated collection of the vaccine thereby producing cells and vaccines in significantly increased yields and at substantially reduced costs in comparison with presently utilized procedures.
    Type: Grant
    Filed: January 30, 1974
    Date of Patent: March 21, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Raymond E. Spier
  • 3-(2-Substitutedbenzimidazolyl) alanines
    Patent number: 4073929
    Abstract: Benzimidazol-5(6)-yl alanine derivatives useful as antihypertensive agents are disclosed as well as methods for their preparation.
    Type: Grant
    Filed: February 13, 1976
    Date of Patent: February 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Patrick S. Callery, Jeremy Wright, Nicolas Zenker
  • Printing paste compositions containing sodium cellulose sulfate, and processes therefor
    Patent number: 4073653
    Abstract: Sodium cellulose sulfate can be used alone, or in combination with other natural or synthetic gums, as thickening agents for fabric printing paste compositions containing acid dyes. The printing paste is applied in the usual manner, and then the printed goods are heated. The sodium cellulose sulfate content of the paste, upon heating, fixes the acid dye on the printed goods, thereby eliminating the necessity of using acid or acid salts in printing pastes.
    Type: Grant
    Filed: February 10, 1976
    Date of Patent: February 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Thomas A. Lindroth, Joseph S. Racciato
  • Process for preparing an emulsion
    Patent number: 4073743
    Abstract: A process for preparing a highly stable water-in-oil type emulsion consisting of (a) a disperse aqueous phase; (b) a continuous oil phase containing isomannide monooleate emulsifier and a non-hydrated physiologically acceptable fatty acid metal salt. A particular use of the invention is the preparation of an emulsion adjuvant vaccine, wherein the vaccine is incorporated in the aqueous phase.The emulsion is prepared by mixing the aqueous and oil phases at a relatively low agitator speed, optionally cooling, increasing the speed of agitation to form an emulsion and optionally homogenizing the emulsion.
    Type: Grant
    Filed: August 13, 1976
    Date of Patent: February 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Michael Midler, Jr., Edward Paul
  • Cellulase-free xanthan gum and process for producing same
    Patent number: 4070535
    Abstract: Intimate intermingling, as in a tumble reactor, of wet particulate xanthan gum, with either propylene oxide, .beta.-propiolactone, glutaraldehyde or pivalolactone, as essentially the only gas present, at about 40.degree.-70.degree. C., for from 1-5 hours, produces xanthan gum in which the cellulase enzyme is inactivated, but in which the viscosity of solutions is increased; the propylene oxide is removed to afford a residual propylene oxide content of not more than 300 ppm in the product xanthan gum.
    Type: Grant
    Filed: August 22, 1975
    Date of Patent: January 24, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Empey, David J. Pettitt
  • Water-in-oil adjuvant composition
    Patent number: 4069313
    Abstract: Pure isomannide monooleate and pure aluminum monostearate are used singularly or in combination in the preparation of emulsion type adjuvant vaccines to yield an adjuvant superior to prior art adjuvants which employ commercial mannide monooleate and aluminum monostearate. Highly desirable formulations are obtained by the inclusion of pure aluminum monostearate as a stabilizer in combination with the pure isomannide monooleate.
    Type: Grant
    Filed: April 7, 1976
    Date of Patent: January 17, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Allen F. Woodhour, Maurice R. Hilleman
  • Fastening method for flexible material
    Patent number: 4067570
    Abstract: A strong flexible material is fastened to itself by a plurality of slits and cut-out sections which form flaps which are pushed through openings formed by a second plurality of slits and smaller cut-out sections.
    Type: Grant
    Filed: April 2, 1976
    Date of Patent: January 10, 1978
    Inventor: Thomas M. Camilleri
  • Cell removing device
    Patent number: 4065359
    Abstract: Apparatus for physically removing cells in a sterile manner from a disc stack on which the cells have been cultured comprises a substantially shaft-like member having at least one butressed rod-like member mounted at substantially a right angle to the axis of the rod.
    Type: Grant
    Filed: July 6, 1976
    Date of Patent: December 27, 1977
    Assignee: Merck & Co., Inc.
    Inventor: William M. Hurni
  • Amino acids and esters thereof useful as antihypertensive agents
    Patent number: 4065572
    Abstract: A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.
    Type: Grant
    Filed: February 13, 1976
    Date of Patent: December 27, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Joseph George Atkinson, Clarence Stanley Rooney, Yves Girard, Edward L. Engelhardt
  • Instant acidified milk gel
    Patent number: 4058636
    Abstract: A composition and method are provided for preparing an instant acidified milk gel product, characterized by smooth body with no graininess and good flavor. The dry composition comprises color, flavor, food acidulent, carbohydrate sweetener, and a thickener system which is a blend of carboxymethyl cellulose, xanthan gum and locust bean gum, and optionally starch.
    Type: Grant
    Filed: October 26, 1976
    Date of Patent: November 15, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Robert S. Igoe
  • Flexible plank support unit
    Patent number: 4050695
    Abstract: The supporting arms of the plank support unit for an automatic pinsetting machine are attached to the horizontal shaft by upper and lower portions which are detachably secured to one another around the shaft. Cushioning material is disposed between the portions and the shaft. The arms support a plank which constitutes a backstop. A cushion is disposed between the arms and the plank.
    Type: Grant
    Filed: February 24, 1976
    Date of Patent: September 27, 1977
    Inventor: Thomas M. Camilleri