Patents Represented by Attorney Edward A. Conroy, Jr.

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  • Platinum chelates of 2-hydrazino-azoles
    Patent number: 4550169
    Abstract: This disclosure describes platinum chelates of 2-hydrazino-1-aza (or 1,3-diaza,1-oxa-3-aza or 1-thia-3-aza)-1-cyclo-alkenes which possess activity as antitumor agents.
    Type: Grant
    Filed: November 21, 1983
    Date of Patent: October 29, 1985
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Panayota Bitha, Yang-I Lin
  • (Pyridinyl)-1,2,4-triazolo[4,3-a]pyridines
    Patent number: 4550166
    Abstract: This disclosure describes novel substituted 1,2,4-triazolo[4,3-a]pyridines which possess anxioltic activity.
    Type: Grant
    Filed: May 21, 1984
    Date of Patent: October 29, 1985
    Assignee: American Cyanamid Company
    Inventors: Daniel B. Moran, Dennis W. Powell, Jay D. Albright
  • Platinum chelates of 3-amino-substituted-[1,2,4]triazolo[1,5-a]-pyrimidin-7(3H)-ones
    Patent number: 4546181
    Abstract: Platinum chelates of 3-amino-substituted-[1,2,4]-triazolo[1,5-a]pyrimidin-7(3H)-ones which are antitumor agents.
    Type: Grant
    Filed: August 22, 1983
    Date of Patent: October 8, 1985
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Panayota Bitha, Yang-i Lin
  • Platinum complexes of antitumor agents
    Patent number: 4544759
    Abstract: The compounds are the class of substituted hydrazine carboximidamides which are useful for inducing the regression and/or palliation of leukemia and related cancers in mammals when administered in amounts of from about one mg. to about 1.2 gm. per square meter of body surface area per day.
    Type: Grant
    Filed: July 29, 1983
    Date of Patent: October 1, 1985
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Panayota Bitha, Yang-i Lin
  • Schiff bases of [(aminoalkyl or substituted aminoalkyl)amino]-9,10-anthracenediones
    Patent number: 4540788
    Abstract: This disclosure describes novel Schiff bases of 1,4-bis[(.omega.-aminoalkyl)amino]-9,10-anthracenediones and leuco bases thereof which are useful as chelating agents and for inducing regression of leukemia and/or inhibiting tumor growth in mammals.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: September 10, 1985
    Assignee: American Cyanamid Company
    Inventor: Keith C. Murdock
  • Method of treating tumors in warm-blooded animals
    Patent number: 4540583
    Abstract: This disclosure describes novel compositions of matter useful as growth inhibitors of transplanted tumors in mammals and the method of inducing the regression and/or palliation of leukemia and solid tumors in mammals therewith, the active ingredients of said compositions of matter being certain symmetrical 1,4-bis(substituted-amino)anthraquinones and the non-toxic acid-addition salts thereof.
    Type: Grant
    Filed: December 8, 1980
    Date of Patent: September 10, 1985
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
    Patent number: 4540519
    Abstract: This disclosure describes symmetrical 1,4-bis-(substituted-amino)-5,8-hydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: April 9, 1984
    Date of Patent: September 10, 1985
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • Method of treating diabetes mellitus using arylglyoxals
    Patent number: 4536517
    Abstract: A method of treating diabetes mellitus using arylglyoxals which are known compounds.
    Type: Grant
    Filed: April 25, 1983
    Date of Patent: August 20, 1985
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Jo A. Goidl
  • Aralkanamidophenyl compounds
    Patent number: 4536346
    Abstract: This disclosure describes novel substituted aralkanamidobenzoic acids and analogs thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: August 20, 1985
    Assignee: American Cyanamid Company
    Inventors: Robert G. Shepherd, Janis Upeslacis
  • 2-Amino-4'(phenylsulfonyl) acetanilides
    Patent number: 4532349
    Abstract: A method of modulating the immune response system in a warm-blooded animal by the administration of N-substituted-phenylthioanilines, N-substituted-phenylsulfinylanilines, and N-substituted-phenylsulfonylanilines, certain of which are new compounds.
    Type: Grant
    Filed: June 3, 1983
    Date of Patent: July 30, 1985
    Assignee: American Cyanamid Company
    Inventors: Stanley A. Lang, Jr., Thomas L. Fields, Raymond G. Wilkinson, Soon M. Kang, Yang-I Lin
  • 3a-(substituted phenyl)-2,3,3a,4,7,7a-hexahydro[or 3a-(substituted-phenyl)octahydro]-4,7-alkano-1H-isoindoles for treating depression in warm-blooded animals
    Patent number: 4529736
    Abstract: This disclosure describes 3a-(substituted-phenyl)-2,3,3a,4,7,7a-hexahydro[or 3a-(substituted-phenyl) octahydro]-4,7-alkano-1H-isoindoles which possess activity as antidepressants and as antistress agents in mammals.
    Type: Grant
    Filed: April 6, 1983
    Date of Patent: July 16, 1985
    Assignee: American Cyanamid Company
    Inventors: Thomas C. McKenzie, William J. Fanshawe, Joseph W. Epstein
  • 1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
    Patent number: 4526989
    Abstract: This disclosure describes symmetrical 1,4-bis (substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
    Type: Grant
    Filed: October 23, 1979
    Date of Patent: July 2, 1985
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • Polymeric[[(oxazolidinyl)alkyl]amino]anthraquinones
    Patent number: 4526788
    Abstract: This disclosure describes novel polymeric 1,4-bis-[(1,3-oxazolidin-3-yl)alkylamino]anthraquinones prepared by condensation of 1,4-bis-[(2-hydroxyalkylamino)alkylamino]anthraquinones with dialdehydes which are useful as anti-cancer agents.
    Type: Grant
    Filed: March 18, 1983
    Date of Patent: July 2, 1985
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Richard L. Webb
  • Substituted phenyl-1,2,4-triazolo[2,3-b]pyridazin-3(2H)ones as anti-asthma agents
    Patent number: 4515791
    Abstract: Substituted phenyl-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-ones, useful as anti-asthma agents.
    Type: Grant
    Filed: June 15, 1981
    Date of Patent: May 7, 1985
    Assignee: American Cyanamid Company
    Inventors: George R. Allen, Jr., John W. Hanifin, Jr., Daniel B. Moran, Jay D. Albright
  • Process for preparing 1-substituted-6-n-propyl-8-methylimidazo[1,5-d]-as-triazin-4-(3H)-ones
    Patent number: 4499283
    Abstract: This disclosure describes a novel process for the preparation of 2-(n-propyl)-4-methyl-5-(lower alkanoyl)imidazoles which are useful as intermediates for the preparation of anti-asthmatic agents.
    Type: Grant
    Filed: June 28, 1982
    Date of Patent: February 12, 1985
    Assignee: American Cyanamid Company
    Inventors: Sivaraman Raghu, Steven L. Peake
  • 2-(Pyridyl)imidazolyl ketones
    Patent number: 4499097
    Abstract: This disclosure describes novel substituted 2-(pyridyl)imidazol-4-yl ketones and derivatives thereof which possess activity as hypotensive agents.
    Type: Grant
    Filed: March 10, 1983
    Date of Patent: February 12, 1985
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, Walter E. Meyer, Nancy H. Eudy
  • Substituted N-[.omega.-(1H-imidazol-1-yl)alkyl]-amides
    Patent number: 4489089
    Abstract: This disclosure describes novel N-[.omega.-(1H-imidazol-1-yl)alkyl]amides which possess the property of inhibiting the enzyme thromboxane synthetase.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: December 18, 1984
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Jeffrey B. Press
  • Dibenzocycloalkanamido and dibenzothioxanthenyl benzoic acids
    Patent number: 4489090
    Abstract: This disclosure describes novel dibenzocycloalkanamido-benzoic acids and esters. Also described are dibenzothioxanthenyl-benzoic acids and esters. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial walls of mammals.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: December 18, 1984
    Assignee: American Cyanamid Company
    Inventors: Vern G. DeVries, Robert G. Shepherd
  • Arylalkylaminobenzoic acids
    Patent number: 4489094
    Abstract: This disclosure describes novel [Bis(phenyl or substituted phenyl)alkyl]amino benzoic acids, esters, and derivatives thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial walls of mammals.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: December 18, 1984
    Assignee: American Cyanamid Company
    Inventors: Robert G. Shepherd, Janis Upeslacis
  • Method of treating arthritic disease
    Patent number: 4486430
    Abstract: This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being certain 2,4,6-tris(substituted-amino)-s-triazines.
    Type: Grant
    Filed: March 27, 1980
    Date of Patent: December 4, 1984
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, Adolph E. Sloboda