Abstract: This disclosure describes 8-substituted-4-phenyl-1-oxa-8-azaspiro[4,5]dec-3-en-2-ones and 8-substituted-4-phenyl-1-oxa-8-azaspiro[4,5]decan-2-ones useful as analgesic or neuroleptic agents.
Abstract: This disclosure describes compounds of the class of 6-[D-.alpha.-(substituted-coumarin-3-carboxamido)phenylacetamido]penicilla nic acids which possess antimicrobial activity.
Abstract: Novel substituted 3-[2-(4-phenyl or pyridyl-1-piperazinyl or piperidino)ethyl]indolines useful as antipsychotic agents in mammals as well as substituted 3-[2-(4-phenylpiperidino)ethyl]indole intermediates for their preparation.
Type:
Grant
Filed:
May 8, 1980
Date of Patent:
November 24, 1981
Assignee:
American Cyanamid Company
Inventors:
William J. Fanshawe, Thomas C. McKenzie, Lantz S. Crawley
Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
Type:
Grant
Filed:
April 28, 1980
Date of Patent:
November 10, 1981
Assignee:
American Cyanamid Company
Inventors:
Francis J. McEvoy, William B. Wright, Jr., Gary H. Birnberg, Jay D. Albright
Abstract: This disclosure describes metal chelates of symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones useful for inhibiting the growth of tumors and as colorants or dyes.
Abstract: This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
Abstract: This disclosure describes novel heteroalkylenebisanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
Abstract: This disclosure describes 1,4-bis(guanidinylamino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
Abstract: This disclosure describes 1-(aminoalkylamino)-5,8-dihydroxy-4-substituted-anthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
Abstract: This disclosure describes novel 5-, 7-, and 8-(substituted-phenyl)-1,2,4-triazolo[4,3-c]pyrimidines and 5-, 7-, and 8-(substituted-phenyl)-1,2,4-triazolo[1,5-c]pyrimidines and their use as anxiolytic agents.
Type:
Grant
Filed:
December 17, 1979
Date of Patent:
May 26, 1981
Assignee:
American Cyanamid Company
Inventors:
Robert A. Hardy, Jr., Jannie S. Baker, Nicanor Q. Quinones
Abstract: This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being certain 2-(substituted-amino)-4,6-bis(alkylamino)-s-triazines.
Abstract: This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being certain 2,4,6-tris(substituted-amino)-s-triazines.
Abstract: This disclosure describes novel substituted 2-benzoyl-3-alkoxy-2-alkenonitriles and substituted 2-benzoyl-3-amino-2-alkenonitriles which are useful as intermediates for the preparation of certain substituted cis-2-benzoyl-3-hydroxy-2-alkenonitriles which possess anti-inflammatory activity.
Abstract: This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the novel active ingredients of said compositions of matter being certain substituted 1-phenyl-1H-1,2,4-triazoles and/or the pharmacologically acceptable acid-addition salts thereof.
Type:
Grant
Filed:
August 27, 1979
Date of Patent:
March 31, 1981
Assignee:
American Cyanamid Company
Inventors:
Stanley A. Lang, Jr., Yang-I Lin, David N. Ridge