Patents Represented by Attorney Edward A. Conroy, Jr.

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  • Combinations of agents which give enhanced anti-inflammatory activity
    Patent number: 4390545
    Abstract: This disclosure describes compatible additive anti-inflammatory compositions comprising certain novel anti-arthritic agents and the known non-steroidal anti-inflammatory agents.
    Type: Grant
    Filed: July 6, 1982
    Date of Patent: June 28, 1983
    Assignee: American Cyanamid Company
    Inventor: Adolph E. Sloboda
  • Substituted 2-alkylimino-3-alkyl-4-benzhydryl-4-thiazolidinols
    Patent number: 4377589
    Abstract: This disclosure describes substituted 2-alkylimino-3-alkyl-4-benzhydryl-4-thiazolidinols which are useful as diuretic agents.
    Type: Grant
    Filed: April 9, 1981
    Date of Patent: March 22, 1983
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • Oxaza heterocycle-anthraquinones, pharmaceutical compositions thereof and method of use thereof
    Patent number: 4375469
    Abstract: Novel 1,4-di(substituted amino)-5,8-dihydroxyanthraquinones wherein the substituents are alkylamino alcohol and/or alkyl cyclicamide and their pharmacologically acceptable acid-addition salts useful as antitumor and chelating agents are described.
    Type: Grant
    Filed: February 4, 1982
    Date of Patent: March 1, 1983
    Assignee: American Cyanamid Company
    Inventor: Keith C. Murdock
  • 4-Heteroarylimidazo-[1,5-A]pyrimidines
    Patent number: 4374988
    Abstract: Novel pyrimidine compounds are disclosed of the class represented by the formula: ##STR1## wherein R.sub.1 is selected from the class consisting essentially of hydrogen, chloro, bromo, cyano (--CN), carbamoyl (--CO--NH.sub.2), carboxyl (--COOH), and lower alkoxycarbonyl (--CO--O--R.sub.3, where R.sub.3 is a lower alkyl radical having 1-4 carbon atoms), and wherein R.sub.2 is a monovalent radical selected from the class consisting essentially of furyl, thienyl, 3-pyridyl and 3-pyridyl-N-oxide, either of said pyridyl radicals optionally being substituted with an alkyl radical having from 1 to 4 carbon atoms. Processes of preparing such compounds are disclosed.The novel compounds are useful as anxiolytic agents in ameliorating anxiety in a mammal.
    Type: Grant
    Filed: November 5, 1981
    Date of Patent: February 22, 1983
    Assignee: American Cyanamid Company
    Inventors: John P. Dusza, Jay D. Albright
  • [4R]-3-(.omega.-Aroylpropionyl)-4-thiazolidinecarboxylic acids and esters
    Patent number: 4374249
    Abstract: This disclosure describes novel [4R]-3-(.omega.-aroylpropionyl)-4-thiazolidinecarboxylic acids and esters and the cationic salts thereof which are useful as hypotensive agents in mammals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: February 15, 1983
    Assignee: American Cyanamid Company
    Inventors: Daniel B. Moran, Jay D. Albright
  • N'-(2, 6-Dichloro-4-(substituted-benzylamino)phenyl)-N,N-dimethyl-formamidines
    Patent number: 4368335
    Abstract: This disclosure describes novel N'-[2,6-dichloro-4-(substituted-benzylamino)phenyl]-N,N-dimethyl-formamidi nes which possess activity as hypotensive agents and as diuretics.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: January 11, 1983
    Assignee: American Cyanamid Company
    Inventors: Walter E. Meyer, Andrew S. Tomcufcik, Joseph W. Marsico, Jr.
  • N'-[2,6-Dichloro-4-(substituted-benzylideneamino)phenyl]-N,N-d imethylformamidines
    Patent number: 4360466
    Abstract: This disclosure describes novel N'-[2,6-dichloro-4-(substituted-benzylideneamino)phenyl]-N,N-dimethylforma midines which possess activity as hypotensive agents and as diuretics.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: November 23, 1982
    Assignee: American Cyanamid Company
    Inventors: Walter E. Meyer, Andrew S. Tomcufcik, Joseph W. Marsico, Jr.
  • Combinations of agents which give enhanced anti-inflammatory activity
    Patent number: 4350689
    Abstract: This disclosure describes compatible additive anti-inflammatory compositions comprising certain novel anti-arthritic agents and the known non-steroidal anti-inflammatory agents.
    Type: Grant
    Filed: November 19, 1981
    Date of Patent: September 21, 1982
    Assignee: American Cyanamid Company
    Inventor: Adolph E. Sloboda
  • 2,3-Disubstituted-thiazolo[3,2-a]pyrimidines
    Patent number: 4347248
    Abstract: This disclosure describes 2,3-disubstituted-thiazolo[3,2-a]pyrimidines which are useful as diuretic agents.
    Type: Grant
    Filed: March 23, 1981
    Date of Patent: August 31, 1982
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik, Joseph W. Marsico, Jr.
  • 2,3-Disubstituted-2,3,5,6,7,8-hex ahydro-thiazolo[3,2-a]-[1,3]diazepin-3-ols
    Patent number: 4344954
    Abstract: This disclosure describes certain novel 2,3-disubstituted-2,3,5,6,7,8-hexahydro-thiazolo[3,2-][1,3]diazepin-3-ols which are useful as diuretic agents.
    Type: Grant
    Filed: July 9, 1980
    Date of Patent: August 17, 1982
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • 7-[D.alpha.-(Coumarin-3-carboxamido)arylacetamido]-cephalosporanic acids or salts
    Patent number: 4343938
    Abstract: This disclosure describes compounds of the class of 6-[D-.alpha.-(substituted-coumarin-3-carboxamido)phenylacetamido ]penicillanic acids which possess antimicrobial activity.
    Type: Grant
    Filed: September 23, 1981
    Date of Patent: August 10, 1982
    Assignee: American Cyanamid Company
    Inventors: Martin L. Sassiver, James H. Boothe
  • .omega.-Heteroaroyl(propionyl or butyryl)-L-prolines
    Patent number: 4342691
    Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
    Type: Grant
    Filed: March 11, 1981
    Date of Patent: August 3, 1982
    Assignee: American Cyanamid Company
    Inventors: Francis J. McEvoy, William B. Wright, Jr., Gary H. Birnberg, Jay D. Albright
  • .omega.-Heteroaroyl(propionyl or butyryl)-L-prolines
    Patent number: 4342690
    Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
    Type: Grant
    Filed: March 11, 1981
    Date of Patent: August 3, 1982
    Assignee: American Cyanamid Company
    Inventors: Francis J. McEvoy, William B. Wright, Jr., Gary H. Birnberg, Jay D. Albright
  • .omega.-Heteroaroyl(propionyl or butyryl)-L-prolines
    Patent number: 4342689
    Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
    Type: Grant
    Filed: March 11, 1981
    Date of Patent: August 3, 1982
    Assignee: American Cyanamid Company
    Inventors: Francis J. McEvoy, William B. Wright, Jr., Gary H. Birnberg, Jay D. Albright
  • 6-[D-.alpha.-(Coumarin-3-carboxamido)arylacetamido]-penicillanic acids or salts
    Patent number: 4341703
    Abstract: This disclosure describes compounds of the class of 6-[D-.alpha.-(benzocoumarin-3-carboxamido)phenylacetamido] penicillanic acids which possess antimicrobial activity.
    Type: Grant
    Filed: September 23, 1981
    Date of Patent: July 27, 1982
    Assignee: American Cyanamid Company
    Inventors: Martin L. Sassiver, James H. Boothe
  • 3-(.alpha.-Substituted-benzyl)-2,3-dihydrothiazolo [3,2-a][1,3]diazacyclan-3-ol derivatives
    Patent number: 4340734
    Abstract: This disclosure describes certain novel 3-(.alpha.-substituted-benzyl)-2,3-dihydrothiazolo[3,2-a][1,3]diazacyclan- 3-ols which are useful as diuretic agents.
    Type: Grant
    Filed: November 14, 1980
    Date of Patent: July 20, 1982
    Assignee: American Cyanamid Company
    Inventors: Andrews S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • 5,8-Dihydroxy-1,4-bis(guanidinylamino)anthraquinones
    Patent number: 4333875
    Abstract: This disclosure describes 1,4-bis(guanidinylamino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
    Type: Grant
    Filed: February 4, 1981
    Date of Patent: June 8, 1982
    Assignee: American Cyanamid Company
    Inventor: Keith C. Murdock
  • Substituted 1H-1,2,4-triazoles
    Patent number: 4329463
    Abstract: This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the novel active ingredients of said compositions of matter being certain substituted 1-phenyl-1H-1,2,4-triazoles and/or the pharmacologically acceptable acid-addition salts thereof.
    Type: Grant
    Filed: December 2, 1980
    Date of Patent: May 11, 1982
    Assignee: American Cyanamid Company
    Inventors: Stanley A. Lang, Jr., Yang-i Lin, David N. Ridge
  • Combinations of agents which give enhanced anti-inflammatory activity
    Patent number: 4325949
    Abstract: This disclosure describes compatible additive anti-inflammatory compositions comprising certain novel anti-arthritic agents and the known non-steroidal anti-inflammatory agents.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: April 20, 1982
    Assignee: American Cyanamid Company
    Inventor: Adolph E. Sloboda
  • Substituted 3-benzhydrylthiazolo(3,2-a)pyrimidines
    Patent number: 4325955
    Abstract: This disclosure describes substituted 3-benzhydrylthiazolo(3,2-a)pyridines which are useful as diuretic agents.
    Type: Grant
    Filed: March 23, 1981
    Date of Patent: April 20, 1982
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik, Joseph W. Marisco, Jr.