Abstract: This disclosure describes anthracene-9,10-bis-carbonyl-hydrazones and derivatives thereof useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or palliation of leukemia and related cancers.
Abstract: Substituted phenyl-2-cyano-2-alkenoic acid esters which are useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease.
Abstract: Substituted-phenyl alkylidene acetoacetonitriles which are useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease.
Abstract: Substituted phenyl-2-cyano-2-thioalkenoic acid esters which are useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease.
Abstract: This disclosure describes novel substituted 6-phenyl-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridines and their use as agents for treating anxiety.
Abstract: This disclosure describes the monoalkylaminobenzene multi-carboxylic acids, derivatives and salts thereof useful as hypolipidemic and anti-atherosclerotic agents.
Abstract: This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being .beta.-oxo-3-thiophenepropionitrile, .beta.-amino-2-thiopheneacrylonitrile, and/or .beta.-amino-3-thiopheneacrylonitrile.
Abstract: This disclosure describes 9,10-dihydroanthracene-9,10-dicarboxaldehyde-bis-hydrazones and derivatives thereof useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or palliation of leukemia and related cancers in mammals.
Type:
Grant
Filed:
September 19, 1978
Date of Patent:
November 25, 1980
Assignee:
American Cyanamid Company
Inventors:
Ralph G. Child, Stanley A. Lang, Jr., Ving J. Lee, Yang-I Lin
Abstract: This disclosure describes novel substituted .omega.-aroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
Abstract: This application discloses novel substituted 4-(alkoxy or alkanoyloxy)-3-thiophenecarboxylic acids, esters, and amides which possess analgesic and antipyretic activity in warm-blooded animals.
Abstract: This disclosure describes substituted 9-(4-methyl-1-piperazinyl)-4H-thieno[3,4-b][1,4]benzodiazepines which possess analgesic and anti-depressant activity and are also useful as anti-psychotic or neuroleptic agents.
Type:
Grant
Filed:
January 30, 1979
Date of Patent:
August 5, 1980
Assignee:
American Cyanamid Company
Inventors:
Corris M. Hofmann, Jeffery B. Press, Sidney R. Safir
Abstract: There is provided a process for the manufacture of substituted 9,10-anthracenedicarboxaldehydes and substituted 9,10-dihydro-9,10-anthracenedicarboxaldehydes useful as intermediates in the preparation of antibacterial agents.
Abstract: This disclosure describes substituted 1,2,4-triazolo[1,5-a]pyrimidines and substituted 1,2,4-triazolo[4,3-a]pyrimidines which possess anxiolytic activity.
Type:
Grant
Filed:
April 27, 1979
Date of Patent:
June 24, 1980
Assignee:
American Cyanamid Company
Inventors:
John P. Dusza, Robert A. Hardy, Jr., Jay D. Albright
Abstract: There is provided substituted imidazo[1,5-d]-as-triazine-4(3H)-ones and substituted imidazo[1,5-d]-as-triazin-4(3H)-thiones useful as inhibitors of the enzyme cyclic-AMP phosphodiesterase and as broad spectrum herbicides.