Patents Represented by Attorney Edward McC. Roberts
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Patent number: 6211240Abstract: Compounds of the formula I in which Y is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, Z is a group a) R1 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4-alkynyl, C3-C6cycloalkyl, phenyl which is unsubstituted or at most trisubstituted by halogen, C1-C4alkyl, C1-C4alkoxy, C1-C4alkylthio, or benzyl which is unsubstituted or at most trisubstituted in the aromatic ring in the same manner; or is cyclopropylmethyl, C1-C4haloalkyl, C2-C5alkoxyalkyl, cyanomethyl, CO—R6, OH, NH2, C1-C4alkylamine or C1-C4alkoxycarbonyl-C1-C2alkyl; X is oxygen, sulfur or NR5; R2 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C3-C6cycloalkyl, C(O)R6, OH or C1-C4alkoxy, NH2 or C1-C4alkylamine; R5 is hydrogen, C1-C4alkyl, C2-C4alkenyl or C2-C4alkynyl; R6 is hydrogen, C114 C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C3-C6cycloalkyl, C1-C4alkoxycarbonyl or phenyl which is unsubstituted or at most trisubstituted; and in which R3 and R4 independently of one another are hType: GrantFiled: October 29, 1996Date of Patent: April 3, 2001Assignee: Novartis CorporationInventor: René Zurflüh
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Patent number: 5770758Abstract: Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compounds of the formulae I and III: X is halogen,n is 0,1,2 or 3;Z is CN, CO-A or CS-A,A is hydrogen, halogen, OR.sub.1, SR.sub.2 and N(R.sub.3)R.sub.4 ;R.sub.1 to R .sub.4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R.sub.3 and R.sub.Type: GrantFiled: December 20, 1996Date of Patent: June 23, 1998Assignee: Novartis CorporationInventors: Walter Kunz, Beat Jau
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Patent number: 5756426Abstract: Described herein are compounds of the formula I ##STR1## and the isomers thereof, in which either a) X is an N atom andY is OR.sub.11 or N(R.sub.12)R.sub.13, orb) X is CH andY is OR.sub.11,and in which furthermore:R.sub.11 is C.sub.1 -C.sub.4 alkyl;R.sub.12 and R.sub.13, independently, are hydrogen or C.sub.1 -C.sub.4 alkyl;A is an O atom or the group NR.sub.4 ; and whereinR.sub.1, R.sub.2 and R.sub.3 are as defined herein, are pesticidal active ingredients. They can be used for pest control, in particular as microbicides, insecticides and acaricides in agriculture, horticulture and in the hygiene sector.Type: GrantFiled: September 11, 1995Date of Patent: May 26, 1998Assignee: Novartis CorporationInventors: Hugo Ziegler, Stephan Trah, Saleem Farooq, Rene Zurfluh
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Patent number: 5728875Abstract: .alpha.-Amino acid amides of the formula I ##STR1## in which n is the number zero or one;R.sub.1 is C.sub.1 -C.sub.12 alkyl, which is unsubstituted or can be substituted by C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.3 -C.sub.8 cycloalkyl, cyano, C.sub.1 -C.sub.6 alkoxycarbonyl, C.sub.3 -C.sub.6 alkenyloxycarbonyl or C.sub.3 -C.sub.6 alkynyloxycarbonyl; C.sub.3 -C.sub.8 cycloalkyl; C.sub.2 -C.sub.12 alkenyl;C.sub.2 -C.sub.12 alkynyl; C.sub.1 -C.sub.12 halogenoalkyl or a group NR.sub.13 R.sub.14 ; in which R.sub.13 and R.sub.14 independently of one another are hydrogen or C.sub.1 -C.sub.6 alkyl or together are tetra- or pentamethylene;R.sub.2 and R.sub.3 independently of one another are hydrogen; C.sub.1 -C.sub.8 alkyl; C.sub.1 -C.sub.8 alkyl which is substituted by hydroxyl, C.sub.1 -C.sub.4 alkoxy, mercapto or C.sub.1 -C.sub.4 alkylthio; C.sub.3 -C.sub.8 alkenyl;C.sub.3 -C.sub.8 alkynyl; C.sub.3 -C.sub.8 cycloalkyl or C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.Type: GrantFiled: August 26, 1996Date of Patent: March 17, 1998Assignee: Novartis CorporationInventor: Martin Zeller
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Patent number: 5726343Abstract: Process for the preparation of 2-methoxyimino-2-arylacetic esters of formula (I) in which R is C.sub.1 -C.sub.12 alkyl, which comprises reacting an appropriately substituted boronic acid of general formula (II) or the trimeric form (lII) herein, which is in equilibrium with it, in the presence of a Pd catalyst, with a methoxyiminoacetic ester of formula (IV) in which R is C.sub.1 -C.sub.12 alkyl and X is a leaving group. According to a further process variant, in principle the groups which split off the two reactants may change places. The process can be applied not only to phenyl derivatives but also to larger ring systems (naphthyl, pyridyl, heterocycles).Type: GrantFiled: July 22, 1996Date of Patent: March 10, 1998Assignee: Novartis CorporationInventors: Hugo Ziegler, Denis Neff, Wolfgang Stutz
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Patent number: 5723491Abstract: If the R-enantiomer of metalaxyl, furalaxyl or benalaxyl is used, this results in a markedly increased biodegradability of these plant fungicides in the soil and a higher activity on the plants, as compared with the data of the racemic active ingredients. Fungicidal compositions exhibiting said improved properties comprise either of these fungicides with a content of R-enantiomer of more than 70 percent by weight based on the total amount of active ingredient.Type: GrantFiled: June 2, 1995Date of Patent: March 3, 1998Assignee: Novartis CorporationInventors: Cosima Nuninger, John Edward Nicholas Goggin, Dino Sozzi, Holm Ellgehausen
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Patent number: 5710314Abstract: Compounds of formula I ##STR1## and possible isomers and isomeric mixtures thereof, wherein a)X is CH.sub.2 F or CHF.sub.2 ;Y is CH andZ is OMe, orb)X is CH.sub.2 F or CHF.sub.2 ;Y is a nitrogen atom andZ is OMe or NHCH.sub.3,and wherein alsom is 0, 1, 2, 3, 4 or 5 andU represents identical or different substituents selected from halogen, cyano, nitro, C.sub.1 -C.sub.12 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkenyloxyiminomethyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkoxyiminomethyl, C.sub.1 -C.sub.2 haloalkyl, C.sub.1 -C.sub.2 haloalkoxy, unsubstituted or substituted phenyl, unsubstituted or substituted phenoxy and unsubstituted or substituted benzyl or represents substituents at two adjacent positions of the phenyl ring of formula I that define a fused hydrocarbon bridge so as to form a larger hydrocarbon ring having up to 14 carbon atoms, are suitable for controlling and preventing microorganisms, insects and Acarina on plants.Type: GrantFiled: June 2, 1995Date of Patent: January 20, 1998Assignee: Novartis CorporationInventors: Albert Pfiffner, Stephan Trah
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Patent number: 5710124Abstract: A method for treating or preventing mastitis in cows is disclosed. The method contemplates the intramammary injection or dipping the teat with Gallidermin and/or Epidermin or one of their pharmaceutically acceptable acid salts. Gallidermin and/or Epidermin or one of their pharmaceutically acceptable acid salts can be administered prior to infection to effectively suppress the rate, severity, and duration of subsequent bacterial infection, or can be administered subsequent to infection to effectively treat mastitis.Type: GrantFiled: February 16, 1996Date of Patent: January 20, 1998Assignee: Novartis CorporationInventors: John Edmondson Peel, Bruno Suri
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Patent number: 5679115Abstract: Process for dyeing or printing organic material, in particular fibre material which comprises applying dyes containing no polymerizable double bond together with at least one colorless cationic compound containing at least one polymerizable double bond and, if desired, one or more colorless nonionic compounds containing at least one polymerizable double bond and, if desired, further auxiliaries to the fibre material and then fixing them by means of ionizing radiation, or applying dyes containing no polymerizable double bond together with at least one colorless cationic compound containing one polymerizable double bond, and if desired, one or more colorless nonionic compounds containing at least one polymerizable double bond and at least one photoinitiator and also, if desired, further auxiliaries to the fibre material and then fixing them by means of UV light.Type: GrantFiled: August 28, 1995Date of Patent: October 21, 1997Assignee: Ciba-Geigy CorporationInventors: Katharina Fritzsche, Peter Aeschlimann, Peter Scheibli
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Patent number: 5665840Abstract: The present invention describes a water-soluble crosslinkable prepolymer that comprises, in the copolymer chain, units derived from the following monomeric structural units: a vinyl lactam (a), vinyl alcohol (b), optionally a lower alkanecarboxylic acid vinyl ester (c), a vinylic crosslinking agent (d) and optionally a vinylic photoinitiator (e); a process for the preparation of the novel prepolymers; crosslinked water-insoluble polymeric networks therefrom; hydrogels and moulded articles made from the crosslinked water-insoluble polymeric networks, especially contact lenses; and a process for the manufacture of hydrogels and finished contact lenses using the mentioned crosslinkable water-soluble prepolymers.Type: GrantFiled: November 3, 1995Date of Patent: September 9, 1997Assignee: Novartis CorporationInventors: Thomas Pohlmann, Achim Muller, Bernhard Seiferling
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Patent number: 5663453Abstract: Compounds of the formula ##STR1## in which: n is 0, 1 or 2, and, if n is 2, the two radicals R.sub.3 are identical or different;R.sub.2 is methyl, fluorine, chlorine or bromine;R.sub.3 is C.sub.1 -C.sub.3 -alkyl, halo-C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, halo-C.sub.1 -C.sub.3 alkoxy, fluorine, chlorine or bromine:R.sub.5 is hydrogen or C.sub.1 -C.sub.9 alkyl andX is methylene, O, S or C(.dbd.O):can be used as intermediates for agrochemical active ingredients.Type: GrantFiled: January 17, 1995Date of Patent: September 2, 1997Assignee: Ciba-Geiby CorporationInventor: Friedrich Karrer
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Patent number: 5663176Abstract: Mixtures of certain triazole fungicides (component I) and 4,6-dimethyl-N-phenyl-2-pyrimidinamine (component II) achieve synergistically enhanced activity against fungus infestation. Components I and II can also be applied to plant crops individually, one immediately after the other.Type: GrantFiled: May 2, 1996Date of Patent: September 2, 1997Assignee: Ciba-Geigy CorporationInventors: Adolf Hubele, Ronald Zeun
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Patent number: 5650517Abstract: 2,3-Difluoro-5-halopyridines of the formula I ##STR1## wherein X is Cl or Br are prepared by a process which comprises reacting a starting 2,3,5-trihalopyridine of the formula II ##STR2## wherein each X is individually Br or Cl and Y is F, Cl or Br with an effective amount of potassium fluoride in the presence of a mixture of sulfolane and a tetralkylurea and/or a dialkyl-alkyleneurea as diluent, at an effective temperature up to the boiling point of the diluent, optionally in the presence of a phase-transfer catalyst such as a crown ether or polyglycol ether. The compounds are useful as intermediates to prepare herbicides.Type: GrantFiled: November 1, 1994Date of Patent: July 22, 1997Assignee: Ciba-Geigy CorporationInventor: Balakrishnan Venugopal
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Patent number: 5648383Abstract: When used in admixture with mancozeb, chlorothalonil, a copper salt, folpet, fluazinam or cymoxanil (it being possible for the latter to be used also together with one of the other five components), metalaxyl having a high R-enantiomer content of more than 70% by weight, or pure R-metalaxyl, exhibits a markedly increased fungicidal action against plant diseases as compared with a similar mixture in which metalaxyl is used in the form of the racemate.Type: GrantFiled: June 2, 1995Date of Patent: July 15, 1997Assignee: Ciba-Geigy CorporationInventors: Cosima Nuninger, John Edward Nicholas Goggin, Dino Sozzi
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Patent number: 5645169Abstract: A package containing water-soluble bags filled with agricultural chemicals in gel or liquid form facilitates the transport of the bags in a manner which prevents the breakage thereof. The package includes compartments for holding the bags. The walls and base of these compartments contain raised and unraised portions in a pattern such that a baffling effect is created to damper transport shock waves in the gel or liquid bag. These and other features result in the transmission of dynamic shock loads in the package in a manner which prevents such shock loads from breaking the fragile water-soluble bags during transport.Type: GrantFiled: January 10, 1995Date of Patent: July 8, 1997Assignee: Ciba-Geigy CorporationInventors: Lawrence Clifford Dull, Larry Arnold Simmons
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Patent number: 5643360Abstract: An apparatus for a process for wet-treating seeds with an acaricidal, fungicidal, insecticidal or nutritive agent which consists of a foam-forming apparatus comprising a first foam-formation chamber equipped with openings which allow a gas and the aqueous composition containing at least one nonphytotoxic foaming agent to be admitted and containing, downstream of these openings, at least one sieve, this first chamber continuing into a second chamber for compressing and structuring the foam, which ends in an outlet nozzle for the foam.Type: GrantFiled: May 31, 1995Date of Patent: July 1, 1997Assignee: Ciba-Geigy CorporationInventors: Cornelis Willem Rensing, Hubert Sainsard
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Patent number: 5627188Abstract: Mixtures of certain triazole fungicides (component I) and 4-cyclopropyl-6-methyl-N-phenyl-2-pyrimidinamine (component II) have a synergistically increased activity against fungus infestation. Components I and II can also be applied to crops individually in immediate succession.Type: GrantFiled: July 18, 1995Date of Patent: May 6, 1997Assignee: Ciba-Geigy CorporationInventors: Ludwig Mittermeier, Wilhelm Ruess
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Patent number: 5621018Abstract: Compounds of formula I: ##STR1## are disclosed. The compounds are photoinitiators which can be functionalized by means of ethylenic groups or can be bonded to H-active substances, in order, for example, to modify surfaces by means of photopolymerizable substances. The compounds are especially useful in the manufacture of contact lenses.Type: GrantFiled: June 6, 1995Date of Patent: April 15, 1997Assignee: CIBA GEIGY CorporationInventors: Peter Chabrecek, Dieter Lohmann
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Patent number: D379714Type: GrantFiled: July 21, 1995Date of Patent: June 10, 1997Assignee: Ciba Geigy CorporationInventors: David E. Cerny, Paul J. Mulhauser, Christopher J. Brooks
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Patent number: D380898Type: GrantFiled: January 26, 1995Date of Patent: July 15, 1997Inventor: Francis John Lovell