Abstract: The present invention discloses new cytotoxic tris(oxazole)-containing macrolides having the formula: wherein X represents a lower alkyl; R1 and R2 represent hydrogen or lower alkyl; R3a represents hydrogen, and R3b represents or R3a and R3b together represent oxygen; R4 represents hydrogen, lower alkoxy or lower alkyl; R5 represents hydrogen, carbamoyl, or lower alkanoyl; R6a represents hydrogen, and R6b represents hydroxy, or R6a and R6b together represent oxygen; R7 represents hydrogen, lower alkyl, or hydroxymethyl; R8 represents lower alkoxy or lower alkyl; Y1 represents hydrogen or methyl, and y2 represents hydrogen, or Y1 and Y2 together represent a double bond. Also disclose are methods for treating mammals using the macrolides and pharmaceutical preparations including the macrolides.

Abstract: Disclosed is a synthetic method for the preparation of analogs of Didemnin A (1), particularly the Amino-Hip analog of Didemnin A, also known as “AipDidemnin A” (8).

Abstract: This invention relates to an epoxy composition especially designed for use as a primer for sealing and filling small pores in concrete. Advantageously, the composition is a low temperature curing, sag-resistant epoxy primer, which provides good adhesion to concrete and to a polyurea coating applied to the primed concrete. Advantageously the epoxy primer is curable at a temperature below 40° F. and comprises an admixture of two parts, Component A and Component B; wherein Component A comprises a crystallization resistant reactive epoxy resin and Component B comprises an amine curing agent. The resulting primer bonds to concrete at 200 psi or greater, when measured by ASTM D 4541.

Abstract: Shermilamine D, a novel cytotoxic pyridoacridine alkaloid of Formula 1, has been isolated from the tunicate Cystodytes violatinctus. The structure of the compound has been established on the basis of 1-D and 2-D NMR data.

Abstract: The present invention is directed to a stable, non-hazardous solution for calibrating oxidation-reduction potential (ORP) measurement cells. The redox standard calibration solution of the present invention consists essentially of an aqueous solution containing the triiodide/iodide redox couple. In a preferred embodiment, the solution of the present invention consists essentially of an aqueous solution containing up to about 0.01 moles per liter of iodine (I2) and at least about 1 mole per liter of potassium iodide. In a most preferred embodiment, the solution of the present invention consists of an aqueous solution of 4 molar potassium iodide (KI) and 0.0067 molar iodine (I2).

Abstract: The present invention is directed to two forms of safety tips for friction lock, expandable batons; namely the Safety Tip™ and the Power Safety Tip™. Both safety tips of invention have a threaded end that is used to connect the tip to the small end of the baton. A step section with the same diameter as the small end diameter is advantageously used in the basic tip design to allow the shaft to be seated far enough into the handle to have full retention spring contact. The steel flange in the basic tip design also protects the softer peripheral tip cover material from being sheared off by the middle baton section when the baton is closed with a hard material in place on the steel section. In the power safety tip, the step section is the same diameter as the middle shaft of the baton, and this allows full contact with the retention spring. In both of the tip designs, the very end of the tip is rounded steel, the sides of which blend into the peripheral soft rubber-like material.

Abstract: The present invention is directed to the synthesis and characterization of compounds having the formula: wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from the group consisting of H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, NHC(O)R′, CN, halogen, ═O, C(═O)H, C(═O)R′, CO2H, CO2R′, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, and substituted or unsubstituted heteroaromatic; wherein each of the R′ groups is independently selected from the group consisting of H, OH, NH2, NO2, SH, CN, halogen, ═O, C(═O)H, C(═O)CH3, CO2H, CO2CH3, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, aryl, aralkyl, and heteroaromatic; wherein each dotted circle represents one, two or three optional double bonds; wherein R7 and R8 may be joined into a carbocyclic or heterocyclic ring system; and wherein X1 and X2

Abstract: The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value, which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204.

Abstract: Disclosed is a document storage and/or transport system with a permanently attached media storage member specifically designed to hold two different sizes of computer media. The storage member is dual-purpose; one part of the storage member is sized to hold 3½ disks and the other part of the storage member is sized to hold compact discs or similar sized computer media. Advantageously, the dual-purpose media storage member of the present invention is formed from a single sheet of rigid material that is shaped during manufacture to form necessary perforations and bending lines therein. The media storage member is adapted to be mounted either on the inside or on the outside of one or more covers of various paper storage devices, including binders, portfolios, envelopes, file folders, and the like.

Abstract: The present invention relates generally to headwear wearable about the head and ears of a user, and more particularly to an improved headwear construction that can, if desired, easily support a pair of sun glasses or eyeglasses, using open slots, buttonholes, or the like, aligned strategically on each side of the headwear, thereby providing an entrance for the arm(s) of a pair of sun/eyeglasses that will be positioned behind the headwear.

Abstract: Kalahide F, of formula I below, may be isolated from a sacoglossan. The compound may be used in the manufacture of pharmaceutical compositions or in the treatment of tumors or viral conditions.

Abstract: A clothing combination for keeping a person warm including sleepwear and a blanket-member that can be secured to the pajama. The sleepwear covers the legs, torso and arms of a person, and has fastening means placed across the front and back of the upper torso for fastening the blanket-member to the sleepwear. The blanket-member has a bag-like configuration that is formed from two equal sized portions that are sealed together at all but one edge to create an opening that enables the sleepwear to be placed inside the blanket-member. The blanket-member has fastening-members that are located inside the blanket-member and positioned to align with the fastening-members of the sleepwear when the blanket-member is placed around the sleepwear, such that the blanket may be fastened and thereby secured to the pajama.

Abstract: The use of alkali metal, alkaline earth metal, ammonium and substituted ammonium salts of alkyl and alkanol sulfonic acids as additives in pure metal and metal alloy sulfate electroplating baths has a number of unexpected benefits including wider useful current density range, improved appearance and in the case of tin improved oxidative stability. The metals and alloys include but are not limited to tin, nickel, copper, chromium, cadmium, iron, rhodium, ruthenium, iron/zinc and tin/zinc.

Abstract: An expandable police baton having tubular members, and positive ball bearing locking with an axially positioned cam release mechanism, which will maintain the members in an expanded telescoped position and then can release the locking mechanism by pushing a single button at the rear thereof so that the members can slide over one another to a collapsed position convenient for carrying the baton.

Abstract: An expandable police baton having tubular members, and a positive lock with an axially positioned cam release mechanism, which will maintain the members in an expanded telescoped position and then can release the locking mechanism by pushing a single button at the rear thereof so that the members can slide over one another to a collapsed position convenient for carrying the baton.

Abstract: The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.