Patents Represented by Attorney, Agent or Law Firm Ernest V. Linek
  • Packaging components
    Patent number: 5570788
    Abstract: A packaging component having an inflatable peripheral portion and an interior portion having one or more non-inflatable regions which are shaped to conform to one or more portions of an end or a side of a product so that, when the component is inflated, the component fits firmly and snugly against an end or side of the product. A plurality of such components can be integrally formed in a selected pattern adjacent one another to fit firmly and snugly against the ends or sides of a plurality of products which are corresponding positioned adjacent one another. A pair of such components can also be hingedly connected in an integral fashion so that, when inflated, they can be folded together to enclose a product therebetween.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: November 5, 1996
    Assignee: Air-Ride Packaging of America, Inc.
    Inventor: Charles A. Batsford
  • 9-deazaadenosine and its 5'-.alpha.-D-glycopyranoside isolated from the cyanobacterium anabaena affinis strain VS-1
    Patent number: 5569757
    Abstract: The present invention is based upon the discovery that a MeOH extract of Anabaena affinis strain VS-1 showed strong cytotoxicity to L1210 murine leukemia cells, and from that extract was isolated the compounds having the following structures, Compounds 1 and 2. These two compounds are believed to be responsible for the cytotoxicity of the marine organism. This is the first report of the isolation and characterization of pyrrolo[3,2-d] pyrimidine derivatives as biosynthetic products.
    Type: Grant
    Filed: March 30, 1993
    Date of Patent: October 29, 1996
    Inventors: Kenneth L. Rinehart, Wayne W. Carmichael, Michio Namikoshi
  • Immunosuppressive pharmaceutical compositions new biological activity from a marine agrobacterium sp.
    Patent number: 5556777
    Abstract: The active component of the pharmaceutical composition of the present invention is a compound which has been isolated from the controlled aerobic fermentation of a marine microorganism, Agrobacterium sp. PH-103. The pharmaceutical compositions of the present invention, useful for post surgical graft tolerance, are thus directed to compositions comprising a pharmaceutically acceptable carrier, diluent or excipient, and an effective amount of the compound having the formula: ##STR1## This compound, known as Sesbanimide, is an alkaloid that has been previously been isolated from seeds and reported to be useful as an antitumor drug. Prior to the present invention however, this compound had not been isolated from any fermentation broth nor had it been determined to have immunomodulatory activity.
    Type: Grant
    Filed: September 9, 1993
    Date of Patent: September 17, 1996
    Assignee: PharmaMar, s.a.
    Inventors: Glynn T. Faircloth, Jr., Francisco R. Millan, Librada M. C. Fernandez, Cristina A. Sarabia
  • Ultramulsions
    Patent number: 5538667
    Abstract: The present invention relates to water-free, co-solvent free, stable, dispersions of certain polydimethylsiloxanes in certain nonionic, poloxamer surfactants; wherein:a. the dispersed polydimethylsiloxanes, which are insoluble in said surfactant, are oriented by the surfactant such that when dispersed in water they are particularly adept at forming oriented, monolayer coatings on various substrates, andb. the particle size of the dispersed polydimethylsiloxane is from between about 0.5 and about 10 microns, with a particle size distribution such that from between about 80 and 95% of the dispersed polydimethylsiloxane is within this particle size range. These stable dispersions are described as ultramulsions, which, together with their physical properties, distinguishes them from emulsions, microemulsions and solutions.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: July 23, 1996
    Assignee: WhiteHill Oral Technologies, Inc.
    Inventors: Ira D. Hill, Dale G. Brown
  • Epidioxymanadic acids A and B
    Patent number: 5514705
    Abstract: The present invention is directed to two novel compounds isolated from a Pacific sponge, Plakortis (Homosclerophorida, Plakinidae) which are designated herein as epidioxymanadic acids A and B. These two compounds have been obtained by a bioassay-guided (i.e., antibiotic activity) isolation procedure, involving solvent partition and chromatography on Sephadex LH-20, cyano, and C-18 columns, from extracts of sponge.
    Type: Grant
    Filed: September 7, 1994
    Date of Patent: May 7, 1996
    Assignee: PharmaMar, S.A.
    Inventors: Toshio Ichiba, Paul J. Scheuer, Dolores G. Gravalos
  • Cytotoxic metabolites from Myriapora truncata
    Patent number: 5514708
    Abstract: The present invention is based upon the discovery that the methanol extract of the bryozoan Myriapora truncata showed potent cytotoxicity against L1210 murine leukemia cells (99% inhibition at 50 .mu.g/mL). Fractionation and purification of active components from this extract, guided by a cytotoxicity assay, resulted in the isolation of a novel, highly cytotoxic polyketide-derived metabolite MT-332 (Compound 3) and its equilibrium isomer (Compound 4), along with two less active compounds, MT-381 (Compound 1) and MT-381-B (Compound 2). The equilibrium mixture of Compounds 3 and 4 showed 88% inhibition at 0.2 .mu.g/mL against L1210 cells.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: May 7, 1996
    Assignee: PharmaMar, S.A.
    Inventors: Kenneth L. Rinehart, Jie-Fei Cheng, Jong-Soo Lee
  • Connectorized capillaries for use with separation instrumentation components
    Patent number: 5494641
    Abstract: A connectorized capillary and in-line flow cell system which greatly expedites the construction of capillary zone electrophoresis (CZE) and other separation instrumentation. A capillary is mounted within a cavity formed in a body, and a mechanical fastener is positioned about the body. The inner diameter of the fastener is less than the outer diameter of the body, so that the connector may be firmly coupled to any system component having a corresponding portion adapted to accept the fastener. The connectorized capillaries thus permit permanent or semi-permanent attachment to various in-line flow cell devices such as detectors, valves, buffer reservoirs and the like. For example, an in-line conductivity detector is assembled by connecting a conductivity meter to the opposing ends of the flow cell body. Annular sensing surfaces can also be provided within the cell.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: February 27, 1996
    Assignee: Orion Research, Inc.
    Inventor: Srdjan Krstanovic
  • Apparatus for projecting devices through tubes and conduits
    Patent number: 5494235
    Abstract: An apparatus for storing a flexible lance whereby the lance may be projected from the apparatus and into and through a tube to be cleaned or surveyed, the apparatus comprising a storage drum with a peripheral helical groove into which a lance is placed in a plurality of wound coils for storage purposes, the lance being projected from the drum by rotating same and at the same time passing the lance through a guide member that is permitted to move axially in response to rotational movement of the drum, the lance being retained in the groove in the storage position by a plurality of axially extending rollers spaced circumferentially around the drum.
    Type: Grant
    Filed: June 8, 1993
    Date of Patent: February 27, 1996
    Assignee: Barry Bros. Specialised Services Pty. Ltd.
    Inventor: Robert W. Vowles
  • Air inflatable/deflatable packaging component shaped to fit a corner of an article
    Patent number: 5480029
    Abstract: A packaging component which, in one preferred embodiment is made of a first generally rectangular plastic element and a second generally oval plastic element, each of such elements being inflatable and deflatable. A plastic coupling element couples the first and second elements and a valve is used to permit air under pressure to be supplied to, or to be released from, the first and second elements so that they can be inflated and deflated. The elements are preferably made of laminates of a polyurethane plastic material. A plurality of said components when inflated can be manipulated into suitable cushion configurations which can be placed, for example, at each corner of a product which product can then be placed in a container so that the components provide a snug fit of the product therein and protect the product during shipment or other handling thereof.
    Type: Grant
    Filed: April 14, 1994
    Date of Patent: January 2, 1996
    Assignee: Air-Ride Packaging of America, Inc.
    Inventor: Charles A. Batsford
  • Ecteinascidins
    Patent number: 5478932
    Abstract: Ecteinascidins (Et's), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma zenografts.
    Type: Grant
    Filed: December 2, 1993
    Date of Patent: December 26, 1995
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kenneth L. Rinehart, Ryuichi Sakai
  • Tee marker and method of providing tee to green center distance
    Patent number: 5464219
    Abstract: The present invention provides an adjustable distance golf course tee marker which can be used, either singularly (with a non-adjustable marker) or in pairs to define a teeing ground, especially as described in Rule 11 of the Rules of Golf. One unique feature of the adjustable distance tee marker (ADTM for short) of this invention is that unlike prior art devices, it requires a minimum of operating parts, namely:a. an openable hollow housing having a top portion and a bottom portion;b. three parallel positioned movable numbered drums, each bearing the numbers 0, 1, 2, 3, 4, 5, 6, 7, 8, and 9 in a spaced apart relationship, wherein said drums are situated in the interior of said housing, and wherein said drums interact with either the top or the bottom (or both) interior shapes of said housing to fix the positions of said drums in said housing;c.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: November 7, 1995
    Inventors: H. William Bradford, Peter E. Carr
  • Cytotoxic compounds
    Patent number: 5449684
    Abstract: Compounds isolated from a marine sponge, and derivatives thereof, have the formulae: ##STR1## in which R.sup.1 is H or lower alkyl; R.sup.2 is OH or CH.sub.3 ; R.sup.3 is OH or CH.sup.3, and R.sup.4 H or MPTA. The compounds have antitumor and antiviral activity. The invention also provides pharmaceutical compositions containing the compounds and methods of treatment employing them.
    Type: Grant
    Filed: February 3, 1994
    Date of Patent: September 12, 1995
    Assignee: PharmaMar, S.A.
    Inventors: Jun-Ichi Tanaka, Tatsuo Higa, Khanit Suwanoborirux, C. W. Jefford, G. Bernardinelli, Dolores G. Gravalos
  • Carrying case or pouch for portable electronic equipment
    Patent number: D368581
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: April 9, 1996
    Inventor: John C. Cincotta
  • Bracket for optical and carrier cables
    Patent number: D368648
    Type: Grant
    Filed: August 16, 1994
    Date of Patent: April 9, 1996
    Inventor: Richard J. Losier
  • Tote cover
    Patent number: D371305
    Type: Grant
    Filed: August 6, 1993
    Date of Patent: July 2, 1996
    Assignee: Sterilite Corporation
    Inventor: Cory J. Kruger
  • Modular storage drawer
    Patent number: D372378
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: August 6, 1996
    Assignee: Sterilite Corporation
    Inventor: Cory J. Kruger
  • Hanging towel holder
    Patent number: D372388
    Type: Grant
    Filed: June 15, 1995
    Date of Patent: August 6, 1996
    Inventor: David A. Kincman, Sr.
  • Hanging towel holder
    Patent number: D372389
    Type: Grant
    Filed: June 15, 1995
    Date of Patent: August 6, 1996
    Inventor: David A. Kincman, Sr.
  • File segment
    Patent number: D372413
    Type: Grant
    Filed: January 12, 1993
    Date of Patent: August 6, 1996
    Assignee: Simonds Industries, Inc.
    Inventor: Elias P. Alam
  • Laundry basket
    Patent number: D372568
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: August 6, 1996
    Assignee: Steriite Corporation
    Inventor: Hangwind F. Lippisch