Patents Represented by Attorney, Agent or Law Firm Felfe & Lynch
  • Master batch compositions containing organic peroxides
    Patent number: 5589526
    Abstract: The present invention provides a master batch composition based on elastomeric carriers, comprising an organic peroxide, a plasticizer and a filling material and optionally further additives compatible with the organic peroxide, wherein, in addition to the elastomeric carrier, it contains a polyoctenamer.The present invention also provides a process for the production of a master batch composition, wherein (a) the elastomeric carrier, the polyoctenamer, the plasticizer and optionally a part of the filling material or filling material mixture are homogeneously mixed and thereafter (b) the filling material or the filling material mixture or possibly the remaining amounts thereof, together with the organic peroxide, are incorporated at a temperature below the decomposition temperature of the peroxide.
    Type: Grant
    Filed: October 13, 1995
    Date of Patent: December 31, 1996
    Assignee: Peroxid-Chemie GmbH
    Inventors: Gunter Sienel, Maximilian Dorn, Heinz Zimmermann
  • Electrode for electrolysis cells
    Patent number: 5589044
    Abstract: An electrode for mercury chlor-alkali electrolytic cells includes a plurality of activated electrode elements consisting of flat sections standing on edge and having recesses on their lateral surfaces which extend from the lower edge to the upper edge of the lateral surfaces. The recesses in the lateral surfaces promote the transport of the gas bubbles produced electrolytically away from the area of the electrode gap and achieve a boundary surface as free of gas bubbles as possible between the anode and the electrolyte in the area of the electrode gap for the purpose of improving the energy efficiency.
    Type: Grant
    Filed: May 1, 1995
    Date of Patent: December 31, 1996
    Assignee: Heraeus Electrochemie GmbH
    Inventors: Robert Scannell, Bernd Busse, Helmut Vormwald
  • Isolated nucleic acid molecule which codes for a tumor rejection antigen precursor which is processed to an antigen presented by HLA-B44, and uses thereof
    Patent number: 5589334
    Abstract: A nucleic acid molecule which codes for a tumor rejection antigen precursor which is in turn processed to an antigen presented by HLA-B44 molecule is described. The antigen is also described. These materials are useful in diagnostic and therapeutic methodologies. The tumor rejection antigen precursor is not tyrosinase, which has previously been identified as a tumor rejection antigen precursor processed to an antigen presented by HLA-B44.
    Type: Grant
    Filed: June 3, 1994
    Date of Patent: December 31, 1996
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Pierre Coulie, Thierry Boon-Falleur
  • Device for the variable control of the valves of internal combustion engines, more particularly for the throttle-free load control of 4-stroke engines
    Patent number: 5586527
    Abstract: The invention relates to a possibility for the relative rotation of two camshafts for the control of internal combustion engines, more particularly to reduce the gas exchange losses of reciprocating 4-stroke engines. The invention more particularly enables very large adjustment angles of up to 220.degree. crank angle to be obtained.
    Type: Grant
    Filed: June 9, 1995
    Date of Patent: December 24, 1996
    Assignee: Meta Motoren-und Energie-Technik GmbH
    Inventor: Peter Kreuter
  • Controlled feeding Czochralski apparatus
    Patent number: 5587016
    Abstract: A source (1) is equipped with a conveying device (4) for discharging the particles (2, 2a) at adjustable rates per unit time. A crystal (16), formed from doped particles, is withdrawn from the melting crucible (13) at a predetermined rate per unit time. So that the control process can be conducted smoothly over prolonged periods of time with precise doping, the particles (2, 2a) are fed single file to the melting crucible (13) and counted by at least one sensor (21, 22). The sequence of count pulses is sent to a counter (25) and compared there with a corresponding sequence of reference input pulses. The comparison signal formed from the count pulses and the reference input pulses is used, in accordance with its sign, as a control signal for adjusting the amount of particles being discharged per unit time from source (1) to correspond to the reference value.
    Type: Grant
    Filed: November 13, 1995
    Date of Patent: December 24, 1996
    Assignee: Leybold Aktiengesellschaft
    Inventors: Burkhard Altekruger, Joachim Aufreiter, Dieter Bruss, Klaus Kalkowski
  • Isolated nucleic acid molecules which are members of the MAGE-Xp family and uses thereof
    Patent number: 5587289
    Abstract: The invention relates to members of the MAGE-Xp family of nucleic acid molecules. These molecules differ from the previously described MAGE nucleic acid molecules in that members of the MAGE-Xp family do not hybridize to the previously identified MAGE sequences. Further, the members of the MAGE-Xp family are found on the Xp arm of the X chromosome rather than on the Xq chromosome, as was the case with the previously identified MAGE genes.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: December 24, 1996
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Christophe Lurquin, Thierry Boon-Falleur
  • T cell growth factor
    Patent number: 5587302
    Abstract: The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports interleukin 2- and interleukin 4-independent growth of helper T cells especially from murine and human sources and further which is capable of augmenting proliferation of IL3- or IL4-responsive cells. Even more particularly, the present invention relates to the helper T cell growth factor P40, pharmaceutical compositions thereof, antibodies thereto and recombinant DNA clones thereof. The present invention also contemplates a method for inducing the proliferation of helper T cells as well as IL3- and Il4-responsive cells. The helper T cells growth factor contemplated herein is useful in the stimulation of specific cells in the immune system, either alone or in combination with IL3 or IL4.
    Type: Grant
    Filed: January 8, 1990
    Date of Patent: December 24, 1996
    Assignee: Ludwig Institute For Cancer Research
    Inventors: Jacques Van Snick, Catherine Uyttenhove, Richard J. Simpson
  • Isolated nucleic acid molecule coding for fibroblast activation protein alpha and uses thereof
    Patent number: 5587299
    Abstract: The invention describes the identification and isolation of nucleic acid molecules which code for fibroblast activation protein alpha, or "FAP.alpha.". Various applications of the isolated molecules are also described.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: December 24, 1996
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Wolfgang J. Rettig, Matthew J. Scanlan, Pilar Garin-Chesa, Lloyd J. Old
  • Compositions useful in prophylaxis and therapy of endotoxin related conditions
    Patent number: 5587366
    Abstract: Treatment and prophylaxis of endotoxin caused toxicity is disclosed. This is accomplished by administering phospholipid containing compositions to the subject. The compositions are protein and peptide free, and may contain triglycerides, or other polar or neutral lipids.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 24, 1996
    Assignee: The Rogosin Institute
    Inventors: Thomas S. Parker, Daniel M. Levine, Albert L. Rubin, Bruce R. Gordon, Stuart D. Saal
  • Ring and traveller system for spinning and twisting frames
    Patent number: 5584168
    Abstract: Disclosed is an improved ring and traveller system for spinning and twisting frames. At least the surface of the ring coming into contact with the traveller consists of a polycrystalline ceramic material and the ceramic surface of the ring has a surface structure with rounded grain boundaries which form a storage volume for a self-generating lubricating film of fibers. The traveller consists of a resilient carrier material, especially metal, and has a metal and/or ceramic surface, the hardness of which is greater than the hardness of the ceramic surface of the ring.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: December 17, 1996
    Assignee: Cerasiv GmbH, Innovatives Keramik-Engineering
    Inventors: Peter Artzt, Eckhard Sonntag, Helmut Sommer, Hans-Dieter Weber
  • Lubricant carrier salt for metal forming
    Patent number: 5584945
    Abstract: Disclosed is a lubricant carrier salt for facilitating the cold forming of a workpiece of iron or steel, based on boric acid and/or alkali borate. The salt has an additional content of aliphatic di- or tricarboxylic acid, which either is unsubstituted or substituted by at least one hydroxyl group, and/or of alkali salts thereof, the weight ratio of boric acid/alkali borate to the acid is (5 to 15):1. Especially appropriate carboxylic acids are malonic acid, maleic acid, succinic acid, tartaric acid and/or citric acid.Inorganic or organic thickening agents, such as bentonite and/or polysaccharide, aluminate and/or silicate, dispersants, lubricants and/or antioxidants as well as titanium salt can be contained as additional components in the lubricant carrier salt of the invention.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: December 17, 1996
    Assignee: Metallgesellschaft Aktiengesellschaft
    Inventors: Klaus-Dieter Nittel, Norbert Schwinke-Kruse
  • Metal sheet laminated with triple layered thermoplastic resin and a method for production thereof
    Patent number: 5585177
    Abstract: A triple layered thermoplastic resin laminated metal sheet for a can stock having excellent flavor retention of packed foods and drinks, excellent formability, excellent adhesion of the thus laminated resin layer to a metal sheet and excellent denting resistance, particularly excellent denting resistance at a low temperature, which comprises formation of a triple layered thermoplastic resin layer wherein a polycarbonate resin layer is sandwiched between polyester resin outer and inner layers on one or both sides of a metal sheet covered with a single layer of hydrated chromium oxide or a double layer consisting of an upper layer of hydrated chromium oxide and a lower layer of metallic chromium by using conventional film laminating, extrusion coating or the combination of these techniques.
    Type: Grant
    Filed: October 19, 1993
    Date of Patent: December 17, 1996
    Assignee: Toyo Kohan Co., Ltd.
    Inventors: Takaaki Okamura, Kenzo Matsui, Tsuneo Inui
  • Isolated toxin associated with Kawasaki syndrome
    Patent number: 5585465
    Abstract: The invention relates to the isolated toxin associated with Kawasaki syndrome and the bacteria from which these are isolated.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: December 17, 1996
    Assignees: National Jewish Center for Immunology and Respiratory Medicine, New England Medical Center Hospital, Inc., Regents of the University of Minnesota
    Inventors: Donald Leung, Patrick Schlievert, Cody Meissner
  • Isolated, MAGE-3 derived peptides which complex with HLA-A2 molecules and uses thereof
    Patent number: 5585461
    Abstract: Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.
    Type: Grant
    Filed: March 24, 1994
    Date of Patent: December 17, 1996
    Assignees: Ludwig Institute for Cancer Research, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Alan Townsend, Judy Bastin, Thierry Boon-Falleur, Pierre van der Bruggen, Pierre Coulie
  • Method for filtering a wheel speed signal
    Patent number: 5583773
    Abstract: Wheel speed sensor signals are monitored to determine whether physically impossible values of change in wheel speed occur during wheel acceleration. Changes are compared to two different comparison thresholds which are brought into effect alternately depending on whether the wheel is found to be accelerating continuously or not.
    Type: Grant
    Filed: January 18, 1995
    Date of Patent: December 10, 1996
    Assignee: Robert Bosch GmbH
    Inventor: Martin Pfau
  • Fragments of neurofibromin (NF1) and method to reverse activated ras induced malignant transformation in mammalian cells
    Patent number: 5580955
    Abstract: This invention provides for a mechanism to reverse the activated Ras induced malignant transformation of mammalian cells by use of certain peptides. Specifically, the anti-oncogenic protein fragments of the Neurofibromatosis type 1 protein (NF1) were found to reverse, inhibit, or otherwise interfere with the malignant transformation of V-HaRas induced transformed cells. The invention further identifies several specific fragments of the NF1 protein which are capable of reversing activated Ras induced transformation, including the NF338, NF91, NF78 and NF56 protein fragments. The invention also provides for nucleic acid molecules, cell lines, and expression vectors associated with the NF1 fragments, in addition to protein complexes of the NF1 and Ras proteins. A method for screening molecules which are capable of reversing activated Ras induced transformation is also disclosed herein.
    Type: Grant
    Filed: August 2, 1995
    Date of Patent: December 3, 1996
    Assignee: Ludwig Institute for Cancer Research
    Inventors: M. S. A. Nur-E-Kamal, Hiroshi Maruta
  • Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step
    Patent number: 5580743
    Abstract: The invention relates to a method useful in separating non-high density lipoproteins, referred to as "non-HDLs", from biological fluids containing them. A porous carrier is provided which contains a non-HDL precipitating agent. One need only contact the sample of interest to the carrier for one minute or less, after which the precipitated non-HDLs are no longer present in the sample being tested. The applications of the method include the ability to determine high density lipoproteins in the sample without interference from non-HDLs.
    Type: Grant
    Filed: February 6, 1995
    Date of Patent: December 3, 1996
    Assignee: Boehringer Mannheim GmbH
    Inventors: Walter Rittersdorf, Ulfert Deneke, Gerhard Hiller, Hartmut Merdes, Klaus Buecker, Uwe Goebbert
  • Brake system for a motor vehicle
    Patent number: 5580136
    Abstract: Valves for maintaining pressure at the vehicle brakes are activated when the vehicle reference speed falls below a predetermined value, whether the pressure is supplied by the brake pedal or an ASR. The energy supply for the valves is prevented from being switched off while the pressure is maintained.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: December 3, 1996
    Assignee: Robert Bosch GmbH
    Inventor: Franz Hanschek
  • DNA encoding the human cytokine, interleukin-9
    Patent number: 5580753
    Abstract: The invention involves DNA molecules which encode a human protein of 144 amino acids, referred to as interleukin-9, or IL-9. The protein is an erythropoietic growth factor. Also disclosed are processes for producing the IL-9 protein via genetic engineering techniques.
    Type: Grant
    Filed: April 27, 1990
    Date of Patent: December 3, 1996
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Yu-Chung Yang, Agnes B. Ciarletta, Susan T. Ricciardi, Steven C. Clark, Robert E. Donahue
  • Substantially pure receptor like TFG-.beta.1 binding molecules
    Patent number: 5578703
    Abstract: The invention relates to a family of substantially pure, receptor like TGF-.beta.1 binding glycoproteins. These molecules are characterized by molecular masses of 160 kd, 70-80 kd, and 30-40 kd as determined by SDS-PAGE, and the ability to bind the TGF-.beta.1 molecule. This family of molecules is useful in identifying and/or quantifying TGF-.beta.1 in a sample, as well as inhibiting its effect on cells. Also described are nucleic acid sequences which code for the protein monomer making up the molecules.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: November 26, 1996
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Hidenori Ichijo, Kohei Miyazono, Lars Ronnstrand, Ulf Hellman, Christer Wernstedt, Carl-Hendrik Heldin