Patents Represented by Attorney Henry C. Nields
  • Patent number: 4997923
    Abstract: The present invention provides novel dihydrate crystals of etoposide-2-dimethylamino compound hydrochloride [4'-demethylepipodophillotoxin 9-(4,6-O-ethylidene-2-dimethylamino-2-deoxy-.beta.-D-glucopyranoside hydrochloride] used as a carcinostatic agent and a process for production thereof.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: March 5, 1991
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Takao Izawa, Tadashi Fujii, Yukio Chikui, Kazuo Ohtsuki
  • Patent number: 4997972
    Abstract: A 2-acylamino-5-halogenated-cinnamic acid derivative represented by the formula (III) which is useful as an intermediate for producing medicines and agricultural chemicals: ##STR1## wherein Ac represents a lower acyl group, R represents a hydrogen atom or a lower alkyl group, and X.sub.1 represents a halogen atom. This derivative is obtained by reacting a compound represented by the formula (I), ##STR2## wherein Ac and X.sub.1 are as defined above, and X.sub.2 represents a bromine or iodine atom, with acrylic acid or its ester represented by the formula (II),CH.sub.2 .dbd.CHCOOR (II)where R is as defined above, in the presence of a palladium catalyst, a tri(unsubstituted- or substituted-phenyl)phosphine and an acid-binding agent.
    Type: Grant
    Filed: December 14, 1989
    Date of Patent: March 5, 1991
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Hiroaki Ohno, Daisaku Matsunaga
  • Patent number: 4996505
    Abstract: Frequency triplicator for microwaves having frequencies above about 30 GHz, for example 70 GHz, comprising a non-linear element of a weakly doped semiconductor material, in particular n-Si with a carrier concentration of 10.sup.13 cm.sup.-3 and less.
    Type: Grant
    Filed: March 29, 1989
    Date of Patent: February 26, 1991
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventor: Fritz Keilmann
  • Patent number: 4993721
    Abstract: The space between a rotary shaft movable in the axial direction within and extending from a casing is sealed by a rotary shaft seal component mounted around the rotary shaft and on a cylindrical pipe between the casing and the rotary shaft. The cylindrical pipe is movable in the axial direction in synchronism with the rotary shaft, but does not rotate therewith. Two seals movable in the axial direction are provided for sealing off the space between the casing and the cylindrical pipe.
    Type: Grant
    Filed: March 9, 1989
    Date of Patent: February 19, 1991
    Assignee: Tanken Seiko Kabushiki Kaisha
    Inventor: Teiji Uezono
  • Patent number: 4994377
    Abstract: This invention relates to a novel method for assaying 1,5-anhydroglucitol, which is expected to serve as a marker for diabetes, and a kit therefor. More particularly, it relates to:(1) a method for assaying 1,5-anhydroglucitol, which comprises selectively removing sugars from a specimen containing 1,5-anhydroglucitol; allowing pyranose oxidase or L-sorbose oxidase to act on 1,5-anhydroglucitol contained in the sample thus obtained in the presence of oxygen; and determining 1,5-anhydroglucitol from the amount of the hydrogen peroxide thus formed; and(2) a reagent kit for assaying 1,5-anhydroglucitol which comprises an agent for removing sugars, a reagent for detecting hydrogen peroxide and an enzyme for oxidizing 1,5-anhydroglucitol.
    Type: Grant
    Filed: September 18, 1987
    Date of Patent: February 19, 1991
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Tsuneo Nakamura, Hiroshi Akanuma, Masahiko Yabuuchi, Kazuo Kato, Minoru Masuda
  • Patent number: 4994582
    Abstract: This invention relates to an antibiotic NK130119 of the formula: ##STR1## which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities.
    Type: Grant
    Filed: January 17, 1990
    Date of Patent: February 19, 1991
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Takaaki Nishikiori, Masanori Yamazaki, Seiichi Saito, Nobuyoshi Shimada, Takashi Kurokawa, Kiyonobu Hirose, Takumi Yamashita, Takashi Harada
  • Patent number: 4992368
    Abstract: The present invention provides a novel process for producing oxetanocin G by hydrolysis of alkoxylated 2-amino-oxetanocin A thereby to convert ##STR1## at the 6-position thereof into >C.dbd.O. Oxetanocin G is expectedly useful as an antiviral agent.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: February 12, 1991
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Seiichi Saito, Shigeru Hasegawa, Masayuki Kitagawa, Nobuyoshi Shimada, Noriyuki Yamashita
  • Patent number: 4990536
    Abstract: The present invention provides a use for the preparation of an immunopotentiator of a spergualin-related compound represented by the following general formula [I] or a pharmacologically acceptable salt thereof: ##STR1## wherein X represents ##STR2## or --(CH.sub.2).sub.n --, Y represents a hydrogen atom or a hydroxyl or hydroxymethyl group,n is an integer of 3 or 5, andR represents --(CH.sub.2).sub.4 --R.sub.1 (wherein R.sub.1 is --NH.sub.2 or --OH), --(CH.sub.2).sub.3 --R.sub.2 (wherein R.sub.2 is --COOH or --CHO), --(CH.sub.2).sub.4 --NH--(CH.sub.2).sub.3 --OH or --(CH.sub.2).sub.4 --NH--(CH.sub.2).sub.2 --R.sub.2 (wherein R.sub.2 is as defined above).
    Type: Grant
    Filed: March 16, 1990
    Date of Patent: February 5, 1991
    Assignees: Nippon Kayaku Kabushiki Kaisha, Takara Shuzo Co., Ltd.
    Inventors: Takeji Sakasai, Tsugio Tomiyoshi, Keiko Watanabe, Kyuichi Nemoto, Tetushi Saino, Yoshihisa Umeda
  • Patent number: 4988566
    Abstract: High strength, flexible compositions with improved mechanical properties at elevated temperatures for wire insulation coatings and other shaped articles used in hostile environments are disclosed, consisting of a high temperature fluorocarbon polymer, such as an ethylene-tetrafluoroethylene copolymer or the like, and from abot 1% wt. to about 50% wt. of a polyvinylidene fluoride compound.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: January 29, 1991
    Inventor: Frank J. Glaister
  • Patent number: 4986618
    Abstract: A memory card storage device is adapted to be used in various electronic apparatus, in which a memory card is used. The device has a lid so hinged to a case of a main body of the apparatus as to open receiving the memory card, a card connector slidably mounted in the lid, and a revolving link pivotted at a part of the case near the front end of the lid. The revolving link and the card connector are so connected as to interlock. The case and the lid form a closed space storing the memory card when the lid is closed. The memory card is stored in the closed space. When the lid is open, the link revolves and the connector is drawn toward the outside of the case, ejecting the memory card.
    Type: Grant
    Filed: June 8, 1989
    Date of Patent: January 22, 1991
    Assignee: Kabushiki Kaisha TOPCON
    Inventor: Hiroshi Wakatsuki
  • Patent number: 4986341
    Abstract: The present invention relates to a process for making non-oriented high Si steel sheet without problems during the sequence from the step of making molten steel to the step of rolling to final sheet thickness. An ingot (or a continuously cast piece) of high Si steel (containing 4.0 to 7.0% Si and specified with Al, Mn, C and P) is subjected to slabbing-hot rolling (or else directly slab rolling-hot rolling) and subsequently the hot rolled steel is reduced to thin thickness. The steel material is maintained at temperature of more than a determined temperature from the step of making molten steel to the step of hot rolling. In the step of hot rolling, information regarding finish rolling conditions and coiling conditions is used to provide structure suitable for the subsequent thin rolling. The hot rolled steel is then warm-rolled to the required thickness.
    Type: Grant
    Filed: December 15, 1988
    Date of Patent: January 22, 1991
    Assignee: Nippon Kokan Kabushiki Kaisha
    Inventors: Sadakazu Masuda, Fumio Fujita, Masamoto Kamata, Masahiko Yoshini, Takashi Ariizumi, Yuji Okami, Yoshikazu Takada, Junichi Inagaki
  • Patent number: 4982373
    Abstract: The present invention relates to a fluid agitator which may stir fluid in a closed space without leakage of the fluid. The fluid agitator has a motive means and a bearing means installed in the closed space.In the fluid agitator employing a electric motor as the motive means, only the stator coil of the motor which is weak in its resistance against high temperatures and humid atmosphere is sealed in a sealing chamber. The sealing chamber may be provided with a cooling device to cool the inside thereof. The driving shaft of the motor is supported by a bearing having resistance to high temperatures and high humidity and is provided with an agitating blade.In the fluid agitator employing a turbine system as the motive means, a turbine chamber and a turbine blade are set in the closed space. A fluid supply is furnished to introduce fluid into the turbine chamber from outside of the closed space for driving and rotating the turbine blade.
    Type: Grant
    Filed: October 17, 1989
    Date of Patent: January 1, 1991
    Assignee: Tanken Seiko Kabushiki Kaisha
    Inventors: Yataro Nagai, Sanjiro Nagai, Mitsuyoshi Matsushita, Hiroshi Ohbori, Yuji Yamauchi
  • Patent number: 4980556
    Abstract: Disclosed is an apparatus for the generation of large currents of negative ions for use in tandem accelerators, suitable for employment in ion implantation on an industrial production scale. The apparatus includes a high current positive ion source which is coupled to a charge exchange canal where a fraction of the positive ions are transformed into negative ions.
    Type: Grant
    Filed: March 6, 1990
    Date of Patent: December 25, 1990
    Assignee: Ionex/HEI Corporation
    Inventors: John P. O'Connor, Nicholas R. White
  • Patent number: 4977882
    Abstract: A fuel injection pump of the type wherein the fuel injection timing is controlled by a timer and a solenoid-operated timing control valve. The timer has a high-pressure chamber and a low-pressure chamber which are defined at both sides, respectively, of a timer piston. The high-pressure chamber communicates with a high-pressure groove formed in the timing control valve through a passage. The low-pressure chamber communicates with the suction side of a feed pump through a low-pressure passage and also communicates with a low-pressure hole formed in the timing control valve through a passage. The timer piston is not provided with a passage mechanism which provides communication between a pump chamber and the high-pressure chamber. The pump chamber communicates directly with the high-pressure groove in the timing control valve through a fixed orifice disposed in the wall of the pump housing and a passage leading to the orifice.
    Type: Grant
    Filed: August 22, 1989
    Date of Patent: December 18, 1990
    Assignee: Diesel Kiki Co., Ltd.
    Inventors: Hisashi Nakamura, Ken-ichi Kubo, Toshiro Hirakawa
  • Patent number: 4973500
    Abstract: An inventive method may perform a plating the surface of the metals sheet without using a molten plating metal. This method successively melts a supplied solidus plating metal in close proximity of the passing metal sheet and adheres the molten plating metal as a plating film to the surface of the metal sheet, where the metal sheet passes upwardly and the plating metal is supplied through an upwardly-directed nozzle disposed near the passing sheet, and when or immediately before the plating metal is supplied from the nozzle, it is molten by a heat melting means. The molten plating metal forms a pool at a corner defined between the surface of the passing sheet and the tip of the nozzle, and the molten metal of the pool forms a plating adheres to the sheet surface and forms the plating film.
    Type: Grant
    Filed: October 13, 1989
    Date of Patent: November 27, 1990
    Assignee: NKK Corporation
    Inventors: Toshio Ishii, Shunichi Sugiyama, Yasuhisa Tajiri, Michitaka Sakurai
  • Patent number: 4973841
    Abstract: A method of detecting the amount of C-14 in a sample, comprising the following steps:ionizing the sample to form a negative-ion beam; deflecting said beam in a magnetic field and directing the deflected beam through a first acceptance aperture to remove all negative ions except mass-14 particles; accelerating said mass-14 negative ions to an energy E of the order of 10 MeV by a high voltage electrostatic field; stripping three electrons from a majority of said negative ions to form doubly-charged positive ions; deflecting said doubly-charged positive ions in an electrostatic deflecting field through 180.degree. and directing the deflected beam through a second acceptance aperture to remove particles in other than the 2.sup.
    Type: Grant
    Filed: February 2, 1990
    Date of Patent: November 27, 1990
    Assignee: Genus, Inc.
    Inventor: Kenneth H. Purser
  • Patent number: 4971636
    Abstract: A method of producing highly corrosion-resistant surface-treated steel plates where Cr elusion is small in spite of drying at low temperatures and corrosion resistance is excellent. In a process for producing surface treated steels where Zn type plated steels are treated through (i) chromate treatment, (ii) coating a resin composition and (iii) baking treatment, zirconium fluoride ion and Zn ion of appropriate amounts are added into the chromate bath, and Cr.sup.6+ /Cr.sup.3+ ratio in the bath is controlled to be low. Further the resin composition to be coated after the chromate treatment is rendered a solvent type resin composition obtained by adding silica and/or sparingly water soluble Cr compound to basic epoxy resin.
    Type: Grant
    Filed: June 21, 1989
    Date of Patent: November 20, 1990
    Assignee: NKK Corporation
    Inventors: Tsutomu Watanabe, Masaaki Yamashita, Takahiro Kuboto
  • Patent number: 4970126
    Abstract: This invention relates to a highly corrosion-resistant, multi-layer coated steel sheet, and includes an undercoat film obtained by galvanization or zinc-alloy plating and a chromate coated film thereon, on which a resin-composition film is further applied, comprising an organic high-molecular weight resin having a glass transision temperature of 343.degree. to 423.degree. K. and soluble in organic solvent and hydrophobic silica.For the purpose of improvement of corrosion preventiveness, a sparingly water soluble Cr compound may be contained in this resin composition film. Together with this sparingly water soluble Cr compound, a di- or tri-alkoxysilane compound may be also contained in the resin composition film.
    Type: Grant
    Filed: March 1, 1988
    Date of Patent: November 13, 1990
    Assignees: Nippon Kokan Kabushiki Kaisha, Kansai Paint Co., Ltd.
    Inventors: Takeshi Adaniya, Masaaki Yamashita, Takahiro Kubota, Norio Nikaido, Yoshiaki Miyosawa, Tadashi Nishimoto, Kazuhiko Ozawa
  • Patent number: 4968784
    Abstract: Disazo compounds represented by the following formula (I): ##STR1## in which R.sub.1 and R.sub.2 are hydrogen, C.sub.1-3 alkyl, C.sub.1-4 alkoxy C.sub.1-3 alkyl, phenyl C.sub.1-3 alkyl, phenoxy C.sub.1-3 alkyl, hydroxy C.sub.1-3 alkyl, cyano C.sub.1-3 alkyl, C.sub.1-4 alkoxyhydroxy C.sub.1-3 alkyl or hydroxyphenoxy C.sub.1-3 alkyl,R.sub.3 is C.sub.1-4 alkyl,R.sub.4 is methyl or ethyl,R.sub.5 is hydrogen, chlorine, methyl or methoxy,n is 2 or 3 respectivelyin the form of the free acid is disclosed and these present compounds are used for dyeing of various fibre materials, leather, wood, pulp and paper etc. in black shade and preparing of black ink for ink-jet, felt-pen and signpen etc. The present compounds have high color value, high affinity and high dyeing velocity on paper and excellent fastnesses.
    Type: Grant
    Filed: May 31, 1989
    Date of Patent: November 6, 1990
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Hidenori Imai, Masahiro Hiraki, Yoshiaki Shimizu
  • Patent number: 4967078
    Abstract: A Rutherford backscattering analyzer comprising in combination:a hollow electrode,a voltage source for impressing upon said hollow electrode a positive voltage of the order of 10.sup.
    Type: Grant
    Filed: February 2, 1990
    Date of Patent: October 30, 1990
    Assignee: Genus, Inc.
    Inventor: Kenneth H. Purser