Patents Represented by Attorney Henry C. Nields
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Patent number: 4966774Abstract: A stable SOD composition comprising superoxide dismutase (SOD), a phosphate, an alkali metal chloride and sucrose is disclosed.Type: GrantFiled: June 21, 1989Date of Patent: October 30, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Michinobu Nakano, Kazuo Katoh
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Patent number: 4963588Abstract: This invention relates to a use of ubenimex or a pharmacologically acceptable salt thereof for treating myelodysplastic syndrome (MDS).Type: GrantFiled: January 10, 1990Date of Patent: October 16, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Yoshiro Uzuka, Yoshiko Saito
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Patent number: 4961775Abstract: Disclosed herein is a novel brassinosteroid derivative represented by the formula: ##STR1## wherein R.sub.3 represents C.sub.1-2 -alkyl,R.sub.1 and R.sub.2 which may be the same or different, represent hydrogen or acyl, respectively, otherwise R.sub.1 and R.sub.2, combining together, may form ##STR2## wherein R.sub.4 and R.sub.5 represent C.sub.1-2 -alkyl, and R.sub.3 represents methyl only in this case.The brassinosteroid derivative represented by the above formula (I) exhibits a favorable plant growth regulating effect on various plants in agriculture and horticulture.Type: GrantFiled: October 27, 1988Date of Patent: October 9, 1990Assignees: Nippon Kayaku Kabushiki Kaisha, Tama Biochemical Co., Ltd.Inventors: Suguru Takatsuto, Hitoshi Sato, Fumio Futatsuya
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Patent number: 4961028Abstract: Equipment for lighting a work area has a plurality of light sources, at least one of which is usually lighted; the others are spare light sources and are usually turned off. The equipment has means such as an optical fiber to conduct light from the light source to the work area. Converting means is provided with the equipment to distribute electric power selectively to the light sources. Detecting means is also installed in the equipment to detect cutting off of the light source which is in the lighted condition. The converting means changes the distribution of the output from the power supply to a light source other than the light source which was cut off.Type: GrantFiled: November 10, 1988Date of Patent: October 2, 1990Assignee: Hayashi Tokei Kogyo Kabushiki KaishaInventor: Hiroaki Tanaka
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Patent number: 4960435Abstract: A crystalline form of the dye represented by the following formula (1): ##STR1## characterized by an X-ray diffraction pattern having a strong peak at the angle of diffraction (2.theta.) of 23.2.degree. and relatively strong peaks respectively at the angles of diffraction (2.theta.) of 8.3.degree., 12.3.degree., 20.8.degree., 21.9.degree., 25.0.degree., 27.1.degree., 29.2.degree. and 30.8.degree. according to X-ray powder diffractometry through the use of a Cu-K.alpha. line and a process for preparing the same by heat-treating a heat-instable crystalline form of the dye represented by the formula (1) in water, water containing a water-soluble organic solvent, or water containing an anionic or nonionic surfactant at a temperature of 40.degree. C. or above.It withstands dyeing at high temperature, e.g. 130.degree. C. or higher, to provide dyed fibers having excellent fastness properties.Type: GrantFiled: December 5, 1989Date of Patent: October 2, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Mituaki Tunoda, Nobuharu Suzuki
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Patent number: 4960910Abstract: The present invention relates to an oxetane derivative represented by the general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are each an acyl group and R.sub.3 is a hydrogen atom or a lower alkyl group, which is useful as an intermediate for the preparation of a compound having a (bishydroxymethyl)oxetane structure in its saccharide moiety, for example, oxetanosine, and a process for the preparation of the same.Type: GrantFiled: June 13, 1989Date of Patent: October 2, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Kuniki Kato, Tomohisa Takita, Shigeru Nishiyama, Shosuke Yamamura
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Patent number: 4958553Abstract: A spool type directional control valve switches flow of oil discharged from an oil hydraulic pump to a hydraulic actuator, and decreases internal leak of a cylinder. Two sets of separated cylinder passages are formed on a valve body provided with a main spool, and a nonleak valve is provided across them. The nonleak valve is equipped with a main passage switching puppet having a throttle on the nose, a spring for energizing it to a close side, a pilot poppet for controlling pressure of a spring chamber in which the spring is enclosed, and a piston for operating the poppet.Type: GrantFiled: April 20, 1989Date of Patent: September 25, 1990Assignee: Diesel KIKI Co., Ltd.Inventor: Katsumi Ueno
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Patent number: 4959097Abstract: Disclosed herein is a novel steroids represented by the formula (1): ##STR1## wherein Z represents ##STR2## n is integer of 1 to 3, R represents hydrogen, halogen, CF.sub.3, lower alkyl, lower alkoxy or --CO.sub.2 R', wherein R' represents hydrogen, alkali metal or lower alkyl, andR.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent hydrogen or acyl, respectively.The compound of the formula (1) of the present invention exhibits high durability as well as excellent plant growth regulation.Type: GrantFiled: October 4, 1989Date of Patent: September 25, 1990Assignees: Nippon Kayaku Kabushiki Kaisha, Tama Biochemical Co., Ltd.Inventors: Sei-ichi Hayashi, Tadashi Hohjoh, Atsuhiko Shida, Nobuo Ikekawa
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Patent number: 4956333Abstract: A heat-sensitive recording material characterized in that a heat-sensitive color-developing layer containing a compound represented by the formula (I), ##STR1## wherein R represents a hydrogen atom or a methyl group, a leuco dye and an acidic substance is formed on a support.Type: GrantFiled: September 18, 1989Date of Patent: September 11, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Kenichi Kawahara, Masaharu Nomura, Hiroaki Tsugawa, Hirofumi Iwamoto
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Patent number: 4954522Abstract: The present invention relates to a lyophilized preparation comprising cis-1,1-cyclobutanedicarboxylate-(2R)-2-methyl-1,4-butanediamine platinum (II), which is useful as an antitumor drug, and dextran. This preparation has a greatly improved resolubility.Type: GrantFiled: November 22, 1988Date of Patent: September 4, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Shintaro Suzuki, Noriaki Yanagisawa, Taka'aki Ohkuma
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Patent number: 4951916Abstract: Herein disclosed a disc type electromagnetic valve which is disposed in the passage of a fluid represented by pressurized gases or air for controlling the flow of the fluid. In a casing at the back of a stator, there is formed a chamber in which a diaphragm is arranged. This diaphragm has its radially inner side connected to either a movable receiver of a spring for biasing an armature apart from the attracting surface of the stator or the armature. The chamber at the back of the diaphragm is caused to communicate with a communication passage of the pressurized fluid through a passage hole which extends through the armature and a valve member. When the pressure of the fluid exerted upon the valve member fluctuates, the diaphragm is moved to automatically adjust the seating force of the valve member against a valve seat.Type: GrantFiled: November 20, 1989Date of Patent: August 28, 1990Assignee: Diesel Kiki Co., Ltd.Inventors: Yasumasa Kanameda, Takeo Kushida
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Patent number: 4952409Abstract: Disclosed is an agent for prevention and remedy of injuries caused by ischemia, which comprises, as an active ingredient, an SOD-containing liposome comprising a superoxidase dismutase (SOD) retained in a liposome having an electrically neutral or negative membrane.Type: GrantFiled: May 16, 1989Date of Patent: August 28, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Ko Bando, Yoshimasa Senoo, Minoru Noji, Kazuo Ootsuki, Hisao Ekimoto, Yukio Irie
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Patent number: 4950679Abstract: Disclosed herein is a compound of the formula: ##STR1## wherein Ar is pyridine ring, pyridazine ring, pyrimidine ring, pyrazine ring, isoquinoline ring or thiazole ring, and those rings may be substituted by 1.about.3 of substituents selected from the group consisting of halogen, C.sub. 1 .about.C.sub.4 -alkyl, C.sub.1 .about.C.sub.4 -alkoxy, CF.sub.3 and nitro,R.sup.1 is C.sub.1 .about.C.sub.8 -alkyl; C.sub.1 .about.C.sub.7 -alkyl which is substituted by 1.about.3 of F, Cl or Br, C.sub.1 .about.C.sub.4 -alkoxy or C.sub.1 .about.C.sub.4 -alkylthio; C.sub.3 .about.C.sub.7 -cycloalkyl which may be substituted by 1.about.4 of F, Cl or methyl; C.sub.3 .about.C.sub.6 -cycloalkylmethyl which may be substituted by 1.about.4 of F, Cl, Br or methyl; allyl, propargyl, phenyl or benzyl; R.sup.2 is C.sub.1 .about.C.sub.4 -alkyl which may be substituted by 1.about.3 of F or Cl,x is integer of 0, 1 or 2, excepting wherein Ar is pyridine ring which is substituted by R.sup.1 --S(O)x and --O--SO.sub.2 R.sup.Type: GrantFiled: August 15, 1988Date of Patent: August 21, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Shoichi Kato, Tatsumi Hayaoka, Akio Masui
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Patent number: 4942817Abstract: An explosive cartridge produced by packaging an explosive with a paper polyethylene-laminated on both the sides, the outer surface of the cartridge having an angle of slide of not more than 12 degrees and a paper polyethylene-laminated on both the sides, at least one of the outer surfaces of the paper polyethylene-laminated on both the sides having an angle of slide of not more than 12 degrees used in the explosive cartridge are disclosed.The explosive cartridge of the present invention can be easily loaded into a dry or watery borehole and give good blasting performance.Type: GrantFiled: December 7, 1989Date of Patent: July 24, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Yoshiyuki Ikeda, Toshinori Ariki
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Patent number: 4942048Abstract: A process for preserving food which comprises packing the food in a hermetically sealed container together with:(a) a deoxygenating material; and(b) at least one compound having amino group(s) selected from among a basic anion exchange resin optionally substituted by a halide ion, an amino acid having one to five carbon atoms in the alkylene chain and a polyamino acid obtained by polycondensing it or a salt thereof, a powdery or granular protein, a polypeptide of a molecular weight of 500 to 20,000 obtained by hydrolyzing a protein and a polymer comprising amino sugar(s);in such a manner that they are not in direct contact with the food. A deoxygenating composition including the components (a) and (b) as defined above is also disclosed.Type: GrantFiled: October 22, 1986Date of Patent: July 17, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Yasunobu Nasu, Taichi Ogishima, Akira Dei, Haruhiko Uchida, Mitsuru Inami, Tatsuo Furuhashi, Yasuhiko Hino, Hideo Sugimura
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Patent number: 4941923Abstract: A water-insoluble black pigment produced by reacting C. I. Solubilized Sulphur Black 1 with a salt-forming agent selected from the group consisting of inorganic acid salts of alkylamine, alkoxyalkylamine, alkanolamine, carboxyalkylamine, alkylcarboxamide, allylamine, amide of unsaturated carboxylic acid, cyclic amine, cycloalkylamine, oxacycloalkylamine, morpholine derivative, arylamine, aralkylamine, pyridine derivative, quinoline, phthalimide, DL-.alpha.-amino-.epsilon.-caprolactam and .epsilon.-aminocaprolactam, and ammonium salt of the formula (1): ##STR1## wherein A.sub.1, A.sub.2, A.sub.3 and A.sub.4 each represent an alkyl or phenyl group and X- represents an anionic group.The water-insoluble black pigment is usable as a colorant for printing ink, ink for jet printers, dot printer ribbon, and melt-transfer type printer, a charge-regulator for toner used on electrostatic recording system, a laser marking agent, a colorant for resin, an infrared absorber and the like.Type: GrantFiled: January 6, 1989Date of Patent: July 17, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Teruhito Sotogoshi, Yukio Ishizaka, Katsunori Nakamura
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Patent number: 4938049Abstract: The present invention relates to a warm rolling method for high Si steel strips, in which the steel strip is connected at both ends with leader strips which are excellent in cold or warm workability, and the ends of the leader strips are connected to tension reels for undertaking warm rolling on the steel strip. Whereby the leader strips are passed through rolls, the rolls can be preheated, and further whereby the both tension reels are disposed within warming furnaces and at least one of the leader strips is made longer than a distance between the tension reels, recovery treatment between passes can be carried out on the steel strip in the full length.Type: GrantFiled: December 20, 1988Date of Patent: July 3, 1990Assignee: Nippon Kokan Kabushiki KaishaInventors: Sadakazu Masuda, Fumio Fujita, Tadayoshi Murakami, Masahiko Yoshino, Ryuichi Yagi, Masamoto Kamata
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Patent number: 4926080Abstract: A linear actuator comprising a stepping motor having a hollow motor shaft prevented from moving in a thrust direction and a flange on either shaft end, a screw extending through the hollow shaft, a nut connected to the motor shaft with a coupling and rotated to linearly move the screw. A plate member is mounted upon screw and a bar so as to connect them to each other, said screw and said bar passing through and being supported by a motor flange, said bar moving through a bearing of a holder mounted to the plate member such that the holder is in parallel to the screw.Type: GrantFiled: November 28, 1988Date of Patent: May 15, 1990Inventor: Satoru Koyama
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Patent number: 4919919Abstract: The present invention relates to a nitroglycerin spray prepared by filling a solution comprising nitroglycerin, ethanol and water and having a pH of about 2.4 to about 6.7 into a liquid-pressurized container.Type: GrantFiled: September 14, 1988Date of Patent: April 24, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Yukio Aouda, Hiroshi Ninomiya, Genichi Izu, Yuichi Yazawa, Megumi Tachibana
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Patent number: 4918208Abstract: A process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline (minocycline) which comprises treating the reaction liquid containing minocycline and formaldehyde with hydroxylamine or urea, the reaction liquid being obtained after reductive methylation of 7-amino-6-demethyl-6-deoxytetracycline by using aldehyde, then subjecting the reaction liquid to an adsorption treatment with a nonionic adsorption resin (adsorbent), and subsequently eluting the intended product adsorbed to the adsorbent.Type: GrantFiled: July 22, 1988Date of Patent: April 17, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Ryoichi Hasegawa, Hiroaki Ohno, Kazuaki Sano, Yoshinori Saito