Patents Represented by Law Firm Jacobs & Jacobs
  • Patent number: 4943582
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: X, Y and R.sub.1 -R.sub.6 are as defined have blood pressure lowering activity and K+ channel activator activity and are useful in the treatment of hypertension.
    Type: Grant
    Filed: May 1, 1987
    Date of Patent: July 24, 1990
    Assignee: Beecham Group p.l.c.
    Inventors: John M. Evans, Geoffrey Stemp, Frederick Cassidy
  • Patent number: 4941882
    Abstract: A dressing for retaining a cannula on the skin is described. The dressing comprises a backing film coated on one face with an adhesive layer and with first and second release sheets covering the adhesive layer. A hole and a dividing line are cut through the dressing and second release sheet so that the dividing line extends from the hole to one edge of the dressing and the edge of the second release sheet. In use when the second release sheet is removed the hole in the dressing fits around the indwelling cannula. In a preferred form a portion of the dressing comprises an adhesive coated handle which is stiffer than the remainder of the dressing and which carries the hole and dividing line.
    Type: Grant
    Filed: March 8, 1988
    Date of Patent: July 17, 1990
    Assignee: Smith and Nephew Associated Companies, p.l.c.
    Inventors: William J. Ward, Joanne Shorthouse
  • Patent number: 4942029
    Abstract: A medicated skin composition comprises a mixture of a copolymer of methylvinylether and methacrylic acid, isopropyl alcohol, citric acid ester plasticizer and 2,4,4'-trichloro-2'-hydroxydiphenyl ether. This composition is applied to the skin to form an antimicrobial barrier.
    Type: Grant
    Filed: March 14, 1989
    Date of Patent: July 17, 1990
    Assignee: Smith & Nephew United, Inc.
    Inventor: Milton H. Scheps
  • Patent number: 4940701
    Abstract: A pharmaceutical composition for topical administration consisting of two liquid phases designed to be admixed in situ or prior to use. The first phase contains a dissolved drug, and is preferably saturated in the drug, while the second phase is a chemically or physically different liquid from that in the first phase and contains no drug, but is miscible with the first phase. The two liquids are selected so that, on admixture of suitable volumes of the phases, the resultant drug concentration exceeds the saturated drug solubility in the resultant mixture. This produces a liquid mixture supersaturated in drug, which has been found to increase the rate of drug penetration into the skin. The two liquid phases may be gels, and the drug may be hydrocortisone.At least one phase contains an antinucleant to improve stability of the resulting supersaturated solution.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: July 10, 1990
    Assignee: Beecham Group p.l.c.
    Inventor: Adrian F. Davis
  • Patent number: 4940702
    Abstract: .beta.-Lactam antibiotics are disclosed which have the formulae (Ia) or pharmaceutically acceptable salts or pharmaceutically acceptable in vivo hydrolysable esters thereof: ##STR1## wherein R.sup.1 is phenyl, substituted phenyl, cyclohexenyl, cyclohexadienyl, or an optionally substituted 5- or 6-membered heterocyclic ring containing up to three hetero-atoms selected from oxygen, sulphur or nitrogen; R.sup.2 is hydrogen or optionally substituted C.sub.1-6 alkyl; R.sup.3 is an optionally substituted 5- or 6- membered heterocyclic group containing one or two nitrogen heteroatoms; or R.sup.2 and R.sup.3 together with the nitrogen atom to which they are attached form an optionally substituted 5- or 6- membered heterocyclic group contaning one or two nitrogen heteroatoms; R.sup.4 is a substituted pyridinium group; and CO.sub.2 R is carboxy or a carboxylate anion; and also the use thereof.Processes for the preparation of the compounds are disclosed together with intermediates for use therein.
    Type: Grant
    Filed: August 8, 1986
    Date of Patent: July 10, 1990
    Assignee: Beecham Group p.l.c.
    Inventors: Stephen C. Finch, Michael J. Pearson
  • Patent number: 4939305
    Abstract: Cured resins of high fracture toughness are prepared from N,N'-bisimides of formula I ##STR1## and alkenyl compounds of formula IID(G).sub.m IIin which D is an m-valent group and G represents a phenyl ring having at least one alkenyl (e.g. allyl or 1-propenyl) substituent.
    Type: Grant
    Filed: November 30, 1988
    Date of Patent: July 3, 1990
    Assignee: Technochemie GmbH
    Inventors: Horst Stenzenberger, Peter Koenig
  • Patent number: 4938955
    Abstract: An antibiotic resin composition comprises at least one antibiotic zeolite of which ion-exchangeable ions are partially or completely replaced with ammonium ionsand antibiotic metal ions, at least one discoloration inhibitor and at least one resin. The antibiotic resin composition exhibits excellent antibiotic property and does not discolor with time. Thus, the resin composition can be employed to form a variety of products which require antibacterial and/or antifungus properties.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: July 3, 1990
    Assignees: Shingawa Fuel Co., Ltd, Shinanen New Ceramic Corporation
    Inventors: Reiji Niira, deceased, Tatuo Yamamoto, Masashi Uchida, Yoshihiro Fukuoka
  • Patent number: 4938358
    Abstract: For storing frame-like objects during shipment, which comprises a box having a normally vertical wall portion and a normally horizontal base together defining an inner space, the box having an opening into the inner space; upper and lower pairs of elongated brackets projecting from the vertical wall portion into the inner space for supporting a plurality of frame-like objects suspended therefrom, the pairs of brackets each having proximal ends at the vetical wall portion and distal free ends, the pair of lower brackets being lower with respect to the base than and spaced inwardly of the pair of upper brackets, the upper and lower pairs of brackets being accessible through the opening, whereby the frame-like objects can be loaded onto and unloaded from the upper and lower brackets via the opening; and a movable cover for closing the opening of the box.
    Type: Grant
    Filed: August 18, 1989
    Date of Patent: July 3, 1990
    Assignee: Pantasote, Inc.
    Inventor: Hans A. Johansen
  • Patent number: 4938958
    Abstract: An antibiotic zeolite and an antibiotic resin composition containing thereof are provided. The antibiotic zeolite is prepared by replacing all or a part of ion-exchangeable ions in zeolite with ammonium ions and antibiotic metal ions such as silver, copper, zinc, mercury, tin, lead, bismuth, cadmium, chromium and thallium. The antibiotic resin composition comprises the antibiotic zeolite and a resin such as polyethylene, polypropylene, polyvinyl chloride and polystyrene.
    Type: Grant
    Filed: December 2, 1987
    Date of Patent: July 3, 1990
    Assignees: Shinagawa Fuel Co., Ltd., Shinanen New Ceramic Corporation
    Inventors: Reiji Niira, deceased, Tatuo Yamamoto, Masashi Uchida
  • Patent number: 4935248
    Abstract: In the technology of applying, spraying, or sponging antimicrobially effective amounts of aqueous iodophor peroxide solutions to the udder surfaces of cows, or other animals to be milked prior to milking, the present invention comprises the improvement which avoids iodides and staining which consists essentially of the step of shampooing said udders with a non-staining shampoo containing (a) from about 0.5% to 2% of iodine in a povidone-iodine complex and (b) about 0.5% to 5% of hydrogen peroxide as a nascent oxygen source, said individual components (a) and (b) being combined, with water, at the time of use and having been maintained dry and out of contact with one another in a container or receptacle.
    Type: Grant
    Filed: July 28, 1988
    Date of Patent: June 19, 1990
    Assignee: Albert L. Jacobs
    Inventor: Roy T. Witkin
  • Patent number: 4935465
    Abstract: A conjugate comprising a pharmaceutically useful protein linked to at least one water-soluble polymer by means of a reversible linking group.
    Type: Grant
    Filed: November 27, 1985
    Date of Patent: June 19, 1990
    Assignee: Beecham Group p.l.c.
    Inventor: Andrew J. Garman
  • Patent number: 4933336
    Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, ##STR1## in which, R.sub.1 is hydrogen, lower alkyl or CH.sub.2 OR.sub.6 ;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is hydrogen or lower alkyl;each of W and Z, which are different, represents --CR.sub.4 R.sub.5 -- or --(CR.sub.x R.sub.y).sub.n --, in which,R.sub.4 is hydrogen, C.sub.1-3 alkyl, C.sub.1-3 alkylthio or C.sub.1-3 alkoxy;R.sub.5 is C.sub.1-3 alkyl, C.sub.1-3 alkylthio or C.sub.1-3 alkoxy; or together R.sub.4 and R.sub.5 form a 3 to 6 membered carbocyclic ring, or a heterocyclic ring containing one or two ring oxygen, nitrogen or sulphur atoms;or R.sub.4 and R.sub.5 together form an oxo or methylene group;each of R.sub.x and R.sub.y is hydrogen or C.sub.1-3 alkyl; n is zero or 1;R.sub.6 is hydrogen, lower alkyl, lower alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heteroarylcarbonyl, optionally substituted aminocarbonyl, lower alkoxycarbonyl and aryloxycarbonyl;R.sub.
    Type: Grant
    Filed: August 9, 1988
    Date of Patent: June 12, 1990
    Assignee: Laboratoires Sobio S.A.
    Inventors: Michel Martin, Guy Nadler, Richard Zimmermann
  • Patent number: 4928680
    Abstract: An adhesive coated thin film dressing (1) in combination with an applicator (4) to facilitate its application is described. The applicator (4) comprises a pair of superimposed laminar members (5,6) hinged at one end. The lower member (6) is adapted to be grasped at the end (13) remote from the hinge (7). The upper member (5) supports the thin film dressing and is in releasable contact with a major portion of the adhesive surface (3) of the thin film (2). A protector (11) is in releaseable contact with the remaining portion of the adhesive surface (3) and extends beyond the hinged end of the upper member (5). In one preferred form the dressing has a medicated pad or a medicated area located on the adhesive side of the coated film.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: May 29, 1990
    Assignee: Smith & Nephew plc
    Inventor: Barry M. Sandbank
  • Patent number: 4927835
    Abstract: Compounds of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R.sup.1 is cycloalkyl of 5 to 7 carbon atoms; aryl of 6 to 10 carbon atoms unsubstituted or substituted by straight or branched chain alkyl of 1 to 4 carbon atoms, halo or trifluoromethyl; or ##STR2## wherein A is oxygen, sulfur or NR.sup.5, wherein R.sup.5 is hydrogen, straight or branched chain alkyl of 1 to 4 carbon atoms or halo, and R.sup.6 is hydrogen, straight or branched chain alkyl of 1 to 4 carbon atoms or halo;R.sup.2 is straight or branched chain alkyl of 1 to 4 carbon atoms or cycloalkyl of 5 to 7 carbon atoms; andR.sup.3 and R.sup.4 are the same or different and each is hydrogen; straight or branched chain alkyl of 1 to 8 carbon atoms unsubstituted or substituted by hydroxy, acyloxy of 2 to 5 carbon atoms, carboxyl or carbamoyl;are useful for treating pain, inflammation and fever in humans and animals.
    Type: Grant
    Filed: March 1, 1989
    Date of Patent: May 22, 1990
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Masahiro Kise, Yoshihiko Yoshimoto, Hiroshi Fujisawa, Yasuo Sasaki, Shoji Yasufuku
  • Patent number: 4926466
    Abstract: A permanent connection public telephone appliance is provided for connection to the switched network by a connection unit. It is permanently fed with power romotely by a source of the connection unit connected in parallel across the line of the appliance. The switched network is isolated from the source by capacitors. Line connection to the appliance is provided by a relay of the connection unit.
    Type: Grant
    Filed: May 12, 1989
    Date of Patent: May 15, 1990
    Assignee: Crouzet
    Inventors: Jean-Claude Ayello, Thierry Serradura
  • Patent number: 4923684
    Abstract: A storage stable anticalculus toothpaste comprising at least about 4%, by weight, based on the total weight of the toothpaste, of a water-soluble alkali metal tripolyphosphate, a phosphatase enzyme inhibitor consisting of a fluoride ion source in an amount sufficient to supply from about 25 ppm to about 3500 ppm of fluoride ion, a silica dental abrasive and an orally acceptable vehicle, the toothpaste having a pH of from about 8 to about 10.
    Type: Grant
    Filed: May 8, 1989
    Date of Patent: May 8, 1990
    Assignee: Beecham, Inc.
    Inventors: Nader Ibrahim, Jeanette L. Sodano
  • Patent number: 4923677
    Abstract: Dental and medical instruments and appliances are chemically sterilized by immersion in or subjection to a formulation or composition comprising as active antimicrobial agents a combination or admixture of an iodophor such as the povidone-iodine complex or a quaternary ammonium compound such as cetyl pyridinium chloride and a peroxide such as H.sub.2 O.sub.2, the antimicrobial action of the iodine derived from the iodophor being enhanced or potentiated by oxygen released from the peroxide. The invention is applicable also to the chemical sterilization of surgical sites. Procedure for making and using the sterilizing formulation or composition is described.
    Type: Grant
    Filed: August 7, 1985
    Date of Patent: May 8, 1990
    Assignees: Roy T. Witkin, Gilbert I. Simon
    Inventors: Gilbert I. Simon, Roy T. Witkin
  • Patent number: 4921839
    Abstract: Antibacterially active 11,12-carbonate derivatives of erythromycin 9-(optionally substituted)oxime and 9-imino compounds and their pharmaceutically acceptable ester or acid addition salt thereof: ##STR1## wherein R.sup.1 denotes an oxime group, a substituted oxime group, or an imino group;R.sup.3 denotes a hydrogen atom or an unsubstituted or substituted alkyl group;R.sup.7 denotes hydrogen or methyl;one of R.sup.8 and R.sup.9 denotes hydrogen, hydroxy, alkoxy, alkanoyloxy, amino, substituted amino, or a group of the formula R.sup.A --SO.sub.2 --O--, in which R.sup.A denotes an organic group, and the other of R.sup.8 and R.sup.9 denotes hydrogen, orR.sup.8 and R.sup.9 together denote an oxo group, an oxime group, or a substituted oxime group.
    Type: Grant
    Filed: February 22, 1988
    Date of Patent: May 1, 1990
    Assignee: Beecham Group p.l.c.
    Inventors: Edward G. Brain, Eric Hunt, Andrew K. Forrest
  • Patent number: D307373
    Type: Grant
    Filed: July 13, 1987
    Date of Patent: April 24, 1990
    Inventor: Harold Bearak
  • Patent number: D309755
    Type: Grant
    Filed: February 9, 1988
    Date of Patent: August 7, 1990
    Assignee: Lingner & Fischer GmbH
    Inventor: Hans Halm