Patents Represented by Attorney Janice E. Williams

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  • Feline viral rhinotracheitis vaccine and combination feline viral rhinotracheitis-calicivirus vaccine prepared therefrom
    Patent number: 4031204
    Abstract: A modified live feline viral rhinotracheitis vaccine is prepared by treating with ultraviolet light a feline viral rhinotracheitis virus which has been subjected to chemical treatment with mutagens. A combination feline viral rhinotracheitis-calicivirus vaccine is prepared by combining a modified live feline viral rhinotracheitis virus and naturally-occurring calicivirus.
    Type: Grant
    Filed: March 30, 1976
    Date of Patent: June 21, 1977
    Assignee: Norden Laboratories, Inc.
    Inventor: Eldon Davis
  • 7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)-cephalosporins
    Patent number: 4025626
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 9, 1975
    Date of Patent: May 24, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity
    Patent number: 4024273
    Abstract: The compounds of this invention are substituted benzofurans and benzothiophenes having pharmacological activity. In particular, these compounds have coronary vasodilator activity and are useful in the treatment of angina pectoris.
    Type: Grant
    Filed: November 17, 1975
    Date of Patent: May 17, 1977
    Assignee: SmithKline Corporation
    Inventors: L. Martin Brenner, John M. Petta, Stephen T. Ross
  • Substituted phenylglycylcephalosporins
    Patent number: 4022895
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: May 10, 1977
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • 7.beta.-Acyloxy cephalosporins
    Patent number: 4020057
    Abstract: The compounds of this invention are cephalosporins having a 7.beta.-acyloxy group and 7.beta.-hydroxy intermediates for the preparation thereof. The compounds have antibacterial activity.
    Type: Grant
    Filed: June 18, 1975
    Date of Patent: April 26, 1977
    Assignee: SmithKline Corporation
    Inventor: John G. Gleason
  • Substituted phenylglycylcephalosporins
    Patent number: 4018921
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: April 19, 1977
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • Pharmaceutical compositions comprising substituted phenylglycylcephalosporins and methods of treating bacterial infections
    Patent number: 4013764
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporinic acid. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: March 22, 1977
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • Substituted benzofurans and benzothiophenes
    Patent number: 4001426
    Abstract: The compounds are benzoyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris and intermediates for the preparation thereof.
    Type: Grant
    Filed: May 9, 1975
    Date of Patent: January 4, 1977
    Assignee: SmithKline Corporation
    Inventors: L. Martin Brenner, Charles K. Brush
  • 3-Substituted-6.beta.-(amino- and acylamino)-7-oxo-1,3-diazabicyclo[3.2.0]- h
    Patent number: 4000154
    Abstract: Novel bicyclic .beta.-lactam penicillin analogs which have antibacterial activity and intermediates for the synthesis thereof are disclosed. In particular, 3-acetyl-7-oxo-6.beta.-phenoxyacetylamino-1,3-diazabicyclo[3.2.0]heptane-2 -carboxylic acid and derivatives thereof are prepared.
    Type: Grant
    Filed: September 3, 1975
    Date of Patent: December 28, 1976
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, William F. Huffman
  • Substituted glycines and intermediates thereof
    Patent number: 3997584
    Abstract: A new process is disclosed for the preparation of N-acyl-.alpha.-aromatic and N-acyl-.alpha.-heteroaromatic glycines by reaction of an .alpha.-ester or ether of an N-acylglycine ester or acid with an aromatic or heteroaromatic compound. Also disclosed are new intermediates for preparing N-acyl-.alpha.-aromatic and N-acyl-.alpha.-heteroaromatic glycines.
    Type: Grant
    Filed: October 3, 1975
    Date of Patent: December 14, 1976
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, Nelson C. F. Yim
  • Process for preparing substituted glycines
    Patent number: 3994954
    Abstract: A new process is disclosed for the preparation of N-acyl-.alpha.-aromatic and N-acyl-.alpha.-heteroaromatic glycines by reaction of an .alpha.-ester or ether of an N-acylglycine ester or acid with an aromatic or heteroaromatic compound. Also disclosed are new intermediates for preparing N-acyl-.alpha.-aromatic and N-acyl-.alpha.-heteroaromatic glycines.
    Type: Grant
    Filed: June 24, 1975
    Date of Patent: November 30, 1976
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, Nelson C. F. Yim
  • 7-Acyl-3-(substituted triazolyl thiomethyl)cephalosporins
    Patent number: 3989694
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted triazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 27, 1974
    Date of Patent: November 2, 1976
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Benzophenalenofurans
    Patent number: 3985896
    Abstract: The compounds are benzophenalenofurans having pharmacological activity, in particular, coronary vasodilator activity.
    Type: Grant
    Filed: July 15, 1975
    Date of Patent: October 12, 1976
    Assignee: SmithKline Corporation
    Inventors: L. Martin Brenner, Charles K. Brush
  • Compositions comprising tetramic acid analogs of pulvinic acid and methods of combating arthritis
    Patent number: 3984559
    Abstract: Pharmaceutical compositions comprising tetramic acid analogs of pulvinic acid and methods of combating arthritis by administration of these compositions are disclosed.
    Type: Grant
    Filed: October 17, 1975
    Date of Patent: October 5, 1976
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
    Patent number: 3983245
    Abstract: The compounds of this invention are substituted benzofurans and benzothiophenes having pharmacological activity. In particular, these compounds have coronary vasodilator activity and are useful in the treatment of angina pectoris.
    Type: Grant
    Filed: February 6, 1975
    Date of Patent: September 28, 1976
    Assignee: SmithKline Corporation
    Inventors: David L. Ladd, Stephen T. Ross
  • Substituted cyano,trifluoromethylphenyl linear triazenes
    Patent number: 3976633
    Abstract: The compounds of this invention are substituted cyano,trifluoromethylphenyl linear triazenes having pharmacological activity. In particular, these compounds have anorectic and anti-obesity activity. A preferred compound is 1,3-bis(2-cyano-5-trifluoromethylphenyl)triazene.
    Type: Grant
    Filed: June 3, 1974
    Date of Patent: August 24, 1976
    Assignee: SmithKline Corporation
    Inventors: Charles E. Berkoff, David T. Hill, Bernard Loev
  • Pharmaceutical compositions and methods of producing coronary vasodilation
    Patent number: 3975537
    Abstract: Pharmaceutical compositions and methods of producing coronary vasodilation by administering substituted benzofurans, for example 2-n-butyl-3-[4' -(2-hydroxy-3-isopropylamino)propoxybenzoyl] benzofuran.
    Type: Grant
    Filed: February 20, 1975
    Date of Patent: August 17, 1976
    Assignee: Smith Kline
    Inventors: David T. Hill, Bernard Loev
  • Anti-arthritic 1H-pyrimido-(5,4,3-kl)phenothiazine-1,3(2H)-diones and 1-thiones
    Patent number: 3962438
    Abstract: 1H-Pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-diones are prepared from the corresponding 1-thione-3-one compounds by methylation followed by acid hydrolysis. The 1,3-dione products and 1-thione-3-one intermediates are useful as anti-arthritic agents.
    Type: Grant
    Filed: January 7, 1975
    Date of Patent: June 8, 1976
    Assignee: SmithKline Corporation
    Inventors: Charles E. Berkoff, Blaine M. Sutton, Joseph Weinstock
  • 1,3,5-Tricarbo-1,4-dihydropyridines
    Patent number: 3956341
    Abstract: N-Substituted 1,4-dihydropyridines are prepared by reaction of the corresponding N-unsubstituted 1,4-dihydropyridines with an alkyl haloformate, an acid halide or a carbamyl halide in the presence of base. These compounds have hypotensive activity.
    Type: Grant
    Filed: February 21, 1974
    Date of Patent: May 11, 1976
    Assignee: SmithKline Corporation
    Inventor: Bernard Loev
  • 5-Heterocyclic-1,2,3,6-tetrahydro-4(5H) pyrimidinone
    Patent number: 3956325
    Abstract: The compounds of this invention are 5-heterocyclic-1,2,3,6-tetrahydro-4(5H)-pyrimidinethiones which have pharmacological activity, in particular gastric acid secretion inhibitory activity, and 5-heterocyclic-1,2,3,6-tetrahydro-4(5H)-pyrimidinones which are intermediates in the preparation therefor.
    Type: Grant
    Filed: June 6, 1975
    Date of Patent: May 11, 1976
    Assignee: SmithKline Corporation
    Inventor: Bernard Loev