Patents Represented by Attorney Janice E. Williams

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  • Influenza virus and process of producing a vaccine therefrom
    Patent number: 4338296
    Abstract: The invention relates to a novel influenza virus strain and to the influenza virus vaccine containing said strain.The new strain, which is the CNCM N.degree. I-099 strain, is prepared by recombination of the influenza A/PR/8/34 virus strain with the influenza A/California/10/78 (CNCM N.degree. I-098) virus strain.The vaccine is prepared by allowing the CNCM N.degree. I-099 strain to grow in the allantoic cavity of fertile hen's eggs, harvesting and freeze-drying the yielded virus material.The strain and the vaccine deriving therefrom are valuable for the immunization against influenza caused by influenza type A (H.sub.1 N.sub.1) virus strains.
    Type: Grant
    Filed: February 4, 1981
    Date of Patent: July 6, 1982
    Assignee: SmithKline-RIT
    Inventors: Michele Lobmann, Gerard Florent
  • Processes for the growth of a modified Pasteurella multocida bacteria and preparation of a vaccine therefrom
    Patent number: 4335106
    Abstract: The chemical modification of virulent Pasteurella multocida and Pasteurella haemolytica strains and preparation of live bacteria vaccines from the modified organisms for immunization of bovine, porcine and ovine animal species are disclosed.
    Type: Grant
    Filed: April 17, 1981
    Date of Patent: June 15, 1982
    Assignee: Norden Laboratories Inc.
    Inventor: Carrell J. Kucera
  • Modified Pasteurella bacteria and vaccines prepared therefrom
    Patent number: 4328210
    Abstract: The chemical modification of virulent Pasteurella multocida and Pasteurella haemolytica strains and preparation of live bacteria vaccines from the modified organisms for immunization of bovine, porcine and ovine animal species are disclosed.
    Type: Grant
    Filed: April 17, 1981
    Date of Patent: May 4, 1982
    Assignee: Norden Laboratories, Inc.
    Inventor: Carrell J. Kucera
  • Live influenza virus vaccine and the preparation thereof
    Patent number: 4318903
    Abstract: The invention relates to a novel influenza virus strain and to the influenza virus vaccine containing said strain.The new strain, which is the CNCM I-062 strain, is prepared by recombination of the influenza A/PR/8/34 virus strain with the influenza A/Alaska/5/77 virus strain.The vaccine is prepared by allowing the CNCM I-062 strain to grow in the allantoic cavity of fertile hen's eggs, harvesting and freeze-drying the yielded virus material.The strain and the vaccine deriving therefrom are valuable for the immunization against influenza caused by influenza type A (H.sub.3 N.sub.2) virus strains.
    Type: Grant
    Filed: July 12, 1978
    Date of Patent: March 9, 1982
    Assignee: Smithkline-Rit
    Inventors: Michele Lobmann, Gerard Florent
  • Immunogenic E. coli ST enterotoxin derivatives and compositions containing them
    Patent number: 4314993
    Abstract: E. coli heat stable (ST) enterotoxin derivatives are prepared by reaction of E. coli ST enterotoxin with crosslinking agents for proteins. The so-obtained crosslinked ST enterotoxins show immunogenic activity; they are valuable prophylactic agent for protecting man and animals against diarrheal disease provoked by E. coli enterotoxin and they may be formulated into compositions for intramuscular, subcutaneous or oral administration.
    Type: Grant
    Filed: April 4, 1980
    Date of Patent: February 9, 1982
    Assignee: Smithkline-RIT
    Inventor: Frans V. Wijnendaele
  • Feline infectious peritonitis virus vaccines
    Patent number: 4303644
    Abstract: The isolation, identification and in vitro propagation of feline infectious peritonitis virus and preparation of vaccines for immunization of animals of the genus Felis, family felidae therefrom are disclosed.
    Type: Grant
    Filed: October 16, 1979
    Date of Patent: December 1, 1981
    Assignee: Norden Laboratories, Inc.
    Inventor: Eldon Davis
  • Modified Pasteurella multocida bacteria vaccines
    Patent number: 4293545
    Abstract: The chemical modification of virulent Pasteurella multocida and Pasteurella haemolytica strains and preparation of live bacteria vaccines from the modified organisms for immunization of bovine, porcine and ovine animal species are disclosed.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: October 6, 1981
    Assignee: Norden Laboratories, Inc.
    Inventor: Carrell J. Kucera
  • 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
    Patent number: 4286089
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 27, 1974
    Date of Patent: August 25, 1981
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Attenuated influenza type A virus vaccine
    Patent number: 4278662
    Abstract: The invention relates to a novel influenza virus strain and to the influenza virus vaccine containing said strain.The new strain, which is the DNCM No. I-099 strain, is prepared by recombination of the influenza A/PR/8/34 virus strain with the influenza A/California/10/78 (CNCM No. I-098) virus strain.The vaccine is prepared by allowing the CNCM No. I-099 strain to grow in the allantoic cavity of fertile hen's eggs, harvesting and freeze-drying the yielded virus material.The strain and the vaccine deriving therefrom are valuable for the immunization against influenza caused by influenza type A (H.sub.1 N.sub.1) virus strains.
    Type: Grant
    Filed: October 16, 1979
    Date of Patent: July 14, 1981
    Assignee: Smith Kline - RIT
    Inventors: Michele Lobmann, Gerard Florent
  • Live Newcastle disease virus vaccine
    Patent number: 4235876
    Abstract: The invention relates to an avian vaccine and to the preparation thereof.The vaccine according to the invention is a Newcastle disease virus vaccine. Its active ingredient is the P/77/8 NDV strain.The vaccine of the invention is useful in the prevention of Newcastle disease by administration to chickens in the form of an aerosol.
    Type: Grant
    Filed: April 24, 1978
    Date of Patent: November 25, 1980
    Assignee: SmithKline-Rit
    Inventors: Jacqueline Gits, Nathan Zygraich
  • 7.beta.-Acyloxy-3-heterocyclicthiomethyl cephalosporins
    Patent number: 4236001
    Abstract: The compounds of this invention are cephalosporine having a 7.beta.-acyloxy group and 7.beta.-hydroxy intermediates for the preparation thereof. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 1, 1976
    Date of Patent: November 25, 1980
    Assignee: Smithkline Corporation
    Inventor: John G. Gleason
  • 7-Acylamino-3-(substituted tetrazolyl thiomethyl) cephalosporins
    Patent number: 4220644
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: September 2, 1980
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7.beta.-Hydroxy-3-heterocyclicthio-methyl cephalosporin intermediates
    Patent number: 4218564
    Abstract: The compounds of this invention are 7.beta.-hydroxy-3-heterocyclicthiomethyl cephalosporins useful as intermediates for the preparation of 7.beta.-acyloxy cephalosporins.
    Type: Grant
    Filed: December 1, 1976
    Date of Patent: August 19, 1980
    Assignee: SmithKline Corporation
    Inventor: John G. Gleason
  • Phosphonoalkyl and esterified phosphonoalkyl substituted tetrazole thiols
    Patent number: 4211703
    Abstract: The compounds of this invention are phosphonoalkyl and esterified phosphonoalkyl substituted tetrazole thiols useful for preparing antibacterially active 7-acylamino-3-(phosphonoalkyl and esterified phosphonoalkyl substituted tetrazolylthiomethyl)cephalosporins.
    Type: Grant
    Filed: August 14, 1978
    Date of Patent: July 8, 1980
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Substituted azetidinones
    Patent number: 4200572
    Abstract: Substituted azetidine intermediates for preparing novel bicyclic .beta.-lactam penicillin analogs which have antibacterial activity are disclosed.
    Type: Grant
    Filed: May 1, 1978
    Date of Patent: April 29, 1980
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, William F. Huffman
  • 7-Amino-3-(phosphonoalkyl and esterified phosphonoalkyl substituted tetrazolylthiomethyl)cephalosporins
    Patent number: 4189573
    Abstract: The compounds of this invention are 7-amino-3-(phosphonoalkyl and esterified phosphonoalkyl substituted tetrazolylthiomethyl)cephalosporins useful as intermediates for preparing antibacterially active 7-acylamino cephalosporins.
    Type: Grant
    Filed: August 14, 1978
    Date of Patent: February 19, 1980
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 2,2-Alkyldiylbis(thio)bis(imidazoles)
    Patent number: 4188397
    Abstract: New 2,2'-alkyldiylbis(thio)bis(imidazoles) having substituted phenyl groups in the 4- and 5- positions of the imidazole rings are disclosed. These compounds regulate cell-mediated immunity and/or have anti-arthritic activity and are useful to relieve inflammation, for example in the treatment of rheumatoid arthritis.
    Type: Grant
    Filed: September 22, 1978
    Date of Patent: February 12, 1980
    Assignee: SmithKline Corporation
    Inventor: David T. Hill
  • 2,3-Di(4-substituted phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles
    Patent number: 4186205
    Abstract: New 6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles having substituted phenyl groups in the 2- and 3- positions are disclosed. These compounds regulate cell-mediated immunity and/or have anti-arthritic activity and are useful to relieve inflammation, for example in the treatment of rheumatoid arthritis.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: January 29, 1980
    Assignee: SmithKline Corporation
    Inventor: Paul E. Bender
  • Sulfaminoalkyl substituted tetrazole thiol intermediates for preparing cephalosporins
    Patent number: 4178288
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: December 11, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acylamino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them
    Patent number: 4171368
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges