Patents Represented by Attorney Janice E. Williams

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  • 7-Amino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporin intermediates for preparing 7-acylamino cephalosporins
    Patent number: 4171433
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acylamino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins antibacterial compositions containing them and methods of treating bacterial infections with them
    Patent number: 4171362
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 14, 1978
    Date of Patent: October 16, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Methods and intermediates for preparing cis-4-oxoazetidine intermediates
    Patent number: 4166816
    Abstract: The stereospecific cycloaddition of nitrogen containing acetic acid halides or anhydrides with Schiff bases having a carbalkoxy group substituted on the methine carbon atom offers new intermediates and methods for preparing synthetic cephalosporin congeners having antibacterial activity.
    Type: Grant
    Filed: August 3, 1977
    Date of Patent: September 4, 1979
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, William F. Huffman
  • 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins
    Patent number: 4159373
    Abstract: The compounds of this invention are cephalosporins having a 3- or 4-aminomethylphenylacetamido substituent at the 7-position and a sulfonic acid substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus. The compounds have antibacterial activity.
    Type: Grant
    Filed: April 4, 1978
    Date of Patent: June 26, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7.beta.-Acyloxy-3-acetoxymethyl cephalosporins
    Patent number: 4158733
    Abstract: The compounds of this invention are cephalosporins having a 7.beta.-acyloxy group and 7.beta.-hydroxy intermediates for the preparation thereof. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 1, 1976
    Date of Patent: June 19, 1979
    Assignee: SmithKline Corporation
    Inventor: John G. Gleason
  • Intermediates for the preparation of 7-acyl-3-(substituted triazolylthiomethyl)cephalosporins
    Patent number: 4142046
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted triazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: February 27, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Intermediates for preparing 7-acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolylthiomethyl)cephalosporins
    Patent number: 4140694
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 11, 1977
    Date of Patent: February 20, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Amino-3-(sulfonic acid and sulfamoyl substituted tetrazolythiomethyl)cephalosporin intermediates
    Patent number: 4139701
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 10, 1977
    Date of Patent: February 13, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Amino-3-(sulfoalkyl substituted oxadiazolylthiomethyl) cephalosporins
    Patent number: 4138556
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: February 6, 1979
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Vaccines against oedema disease of piglets
    Patent number: 4136181
    Abstract: Vaccines against oedema disease of piglets comprising an effective amount of E. coli neurotoxin isolated from a culture of an E. coli serotype which is capable of causing piglet oedema disease and adsorbed on an adjuvant. The vaccines are administered by intramuscular or subcutaneous route.
    Type: Grant
    Filed: December 29, 1977
    Date of Patent: January 23, 1979
    Assignee: Recherche et Industrie, Therapeutiques, RIT
    Inventors: Lucia Dobrescu, Constant Huygelen, Frans Van Wijnendaele
  • 7.beta.-Acyloxy-3-heterocyclicthiomethyl cephalosporins
    Patent number: 4131734
    Abstract: The compounds of this invention are cephalosporins having a 7.beta.-acyloxy group. The compounds have antibacterial activity.
    Type: Grant
    Filed: December 1, 1976
    Date of Patent: December 26, 1978
    Assignee: SmithKline Corporation
    Inventor: John G. Gleason
  • 7-Acylamine-3-(sulfoalkyl substituted oxadiazolylthiomethyl) cephalosporins and pharmaceutical compositions containing them
    Patent number: 4130644
    Abstract: The compounds of this invention are cephalosporins having various acylamino substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: December 19, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(carboxyalkyl and carbamoylalkyl substituted oxadiazolylthiomethyl) cephalosporins and antibacterial compositions and methods employing them
    Patent number: 4126682
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a carboxyalkyl or carbamoylalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: March 18, 1977
    Date of Patent: November 21, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them
    Patent number: 4118491
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfaminoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated cephalosporin compounds have antibacterial activity.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: October 3, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins and pharmaceutical compositions containing them
    Patent number: 4118490
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds having antibacterial activity.
    Type: Grant
    Filed: May 11, 1977
    Date of Patent: October 3, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Sulfonyl benzofurans and benzothiophenes having coronary vasodilator activity
    Patent number: 4117128
    Abstract: The compounds are sulfonyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris.
    Type: Grant
    Filed: August 3, 1976
    Date of Patent: September 26, 1978
    Assignee: SmithKline Corporation
    Inventor: L. Martin Brenner
  • Intermediates for preparing substituted phenylglycylcephalosporins
    Patent number: 4111981
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have antibacterial activity.
    Type: Grant
    Filed: April 28, 1977
    Date of Patent: September 5, 1978
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • 7-Acyl-3-(sulfoalkyl substituted oxadiazolylthiomethyl) cephalosporins
    Patent number: 4112088
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: September 5, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7.beta.-Acylamino-3-(phosphonoalkyl and esterified phosphonoalkyl substituted tetrazolylthiomethyl)cephalosporins
    Patent number: 4112086
    Abstract: The compounds of this invention are cephalosporins having various acylamino substituents at the 7-position and a phosphonoalkyl or esterified phosphonoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: September 5, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Process for preparing substituted glycines
    Patent number: 4108854
    Abstract: A new process is disclosed for the preparation of N-acyl-.alpha.-aromatic and N-acyl-.alpha.-heteroaromatic glycines by reaction of an .alpha.-ester or ether of an N-acylglycine ester or acid with an aromatic or heteroaromatic compound. Also disclosed are new intermediates for preparing N-acyl-.alpha.-aromatic and N-acyl-.alpha.-heteroaromatic glycines.
    Type: Grant
    Filed: August 16, 1976
    Date of Patent: August 22, 1978
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, Kenneth G. Holden, Nelson C. F. Yim