Patents Represented by Attorney Janice E. Williams

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  • Fused thiadiazines
    Patent number: 4616013
    Abstract: This invention relates to thiadiazinone derivatives which have inotropic and vasodilator activity. A specific compound of this invention is 7-acetamido-9,9a-dihydroindeno[1,2-e][1,3,4]thiadiazine-2(3H)-one.
    Type: Grant
    Filed: November 6, 1984
    Date of Patent: October 7, 1986
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Anthelmintic benzamides
    Patent number: 4587361
    Abstract: Flukicidal N-[4-(1-phenylethenyl)phenyl]-2-hydroxy-3,5-dihalobenzamides are prepared by reacting a halosalicylic acid with a 1-(4-aminophenyl)-1-phenylethylene in the presence of a halo condensing agent. A species of the invention is N-[4-(1-phenylethenyl)phenyl]-2-hydroxy-3,5-diiodobenzamide.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: May 6, 1986
    Assignee: SmithKline Beckman Corporation
    Inventors: Alfred W. Chow, Vassilios J. Theodorides
  • Intermediates for preparing octapeptide vasopressin antagonists
    Patent number: 4587045
    Abstract: Certain octapeptides, which have structures characterized by being a six unit cyclic peptide ring with a dipeptide tail which lacks a glycine unit at position 9, have potent vasopressin antagonist activity. The compounds here claimed are in general characterized by having an amino acid unit at position 4 which is other than valine. An important species of the group is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl-D-tyrosine)-4-.alpha.-aminobutyric acid-8-arginine-9-desglycine]vasopressin.
    Type: Grant
    Filed: May 16, 1985
    Date of Patent: May 6, 1986
    Assignee: SmithKline Beckman Corporation
    Inventors: William F. Huffman, Michael L. Moore
  • Inactivated rabies vaccine for veterinary use
    Patent number: 4584194
    Abstract: The preparation of a vaccine for immunization of canine and feline animals from inactivated HCP-SAD strain of rabies virus is disclosed.
    Type: Grant
    Filed: April 8, 1985
    Date of Patent: April 22, 1986
    Assignee: Norden Laboratories, Inc.
    Inventors: Edmund P. Bass, Richard L. Sharpee
  • 7 -D-Mandelamido-3(1-sulfomethyltetrazol-5-yl)thiomethyl-3-cephem-4-carboxy lic acid monosodium salt
    Patent number: 4576937
    Abstract: A new cephalosporin compound, 7-D-mandelamido-3-(1-sulfomethyltetrazol-5-yl) thiomethyl-3-cephem-4-carbo xylic acid monosodium salt, having unique antibacterial activity and advantageously high stability, is disclosed. Pharmaceutical compositions comprising the new cephalosporin monosodium salt are also disclosed.
    Type: Grant
    Filed: February 29, 1984
    Date of Patent: March 18, 1986
    Assignee: SmithKline Beckman Corporation
    Inventor: Theodore J. Polansky
  • Modified Pasteurella multocida bacteria
    Patent number: 4559306
    Abstract: The chemical modification of virulent Pasteurella multocida and Pasteurella haemolytica strains and preparation of live bacteria vaccines from the modified organisms for immunization of bovine, porcine and ovine animal species are disclosed.
    Type: Grant
    Filed: February 5, 1982
    Date of Patent: December 17, 1985
    Assignee: Norden Laboratories, Inc.
    Inventor: Carrell J. Kucera
  • 5-(4-Amino or acylaminophenyl)-2(1H)-pyrazinones having inotropic activity
    Patent number: 4556711
    Abstract: This invention relates to 5-(phenyl)-2(1H)-pyrazinones substituted in the 4-position of the phenyl ring by an amino or acylamino group. These compounds have inotropic activity. One specific compound is 5-(4-acetamidophenyl)-2(1H)-pyrazinone.
    Type: Grant
    Filed: June 2, 1983
    Date of Patent: December 3, 1985
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: John C. Emmett, Robert A. Slater, Brian H. Warrington
  • Antibiotics produced by Kibdelosporangium aridum shearer
    Patent number: 4548974
    Abstract: A novel antibiotic complex of "Vancomycin-like" antibiotics, AAD 216 complex, is produced by the cultivation of a fermentation broth containing Kibdelosporangium aridum Shearer gen. nov., sp. nov. ATCC 39323 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The AAD 216 complex and its major bioactive components; AAD 216A, AAD 216B, and AAD 216C exhibit antibiotic activity and growth promotant activity.
    Type: Grant
    Filed: July 13, 1983
    Date of Patent: October 22, 1985
    Assignee: SmithKline Beckman Corporation
    Inventors: Betty A. Bowie, David J. Newman, Marcia C. Shearer, Robert D. Sitrin, Joseph R. Valenta
  • 1-Benzyl-2-aminomethyl imidazole derivatives
    Patent number: 4532331
    Abstract: Potent DBH inhibitors having the formula: ##STR1## wherein R is --CO.sub.2 H or --CH.sub.2 NHR.sup.1 can be used to inhibit DBH activity in mammals.
    Type: Grant
    Filed: April 12, 1983
    Date of Patent: July 30, 1985
    Assignee: Smithkline Beckman Corporation
    Inventors: James S. Frazee, Carl Kaiser, Lawrence I. Kruse
  • Aglycone and pseudo-aglycones of the AAD 216 antibiotics
    Patent number: 4521335
    Abstract: Novel aglycone and pseudo-aglycones of the AAD 216 antibiotics are prepared by partial acid hydrolysis of the AAD 216 antibiotic complex or its individual factor antibiotics. AAD 216 aglycone, AAD 216 pseudo-aglycone and AAD 216A pseudo-aglycone, AAD 216B pseudo-aglycone and AAD 216C pseudo-aglycone exhibit antibacterial activity and are useful in animal health applications.
    Type: Grant
    Filed: May 17, 1984
    Date of Patent: June 4, 1985
    Assignee: SmithKline Beckman Corporation
    Inventors: George W. Chan, Robert D. Sitrin
  • 5-(4-Nitrophenyl)-2(1H)-pyrazinones
    Patent number: 4514568
    Abstract: This invention relates to 5-(phenyl)-2(1H)-pyrazinones substituted in the 4-position of the phenyl ring by a nitro group, and to a process for their preparation. These compounds are useful intermediates in the synthesis of inotropic compounds. One specific compound is 5-(4-nitrophenyl)-2(1H)-pyrazinone.
    Type: Grant
    Filed: June 2, 1983
    Date of Patent: April 30, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Modified Pasteurella haemolytica bacteria
    Patent number: 4506017
    Abstract: The chemical modification of virulent Pasteurella multocida and Pasteurella haemolytica strains and preparation of live bacteria vaccines from the modified organisms for immunization of bovine, porcine and ovine animal species are disclosed.
    Type: Grant
    Filed: January 19, 1983
    Date of Patent: March 19, 1985
    Assignee: Norden Laboratories, Inc.
    Inventor: Carrell J. Kucera
  • Preservation of relationship of particles and supporting liquid of a monolayer during drying
    Patent number: 4483882
    Abstract: Disclosed is a process of preparing blood spreads for microscopical examination wherein a smooth and homogeneous plasma layer is obtained. A combination of steps including timely fixation for the purpose of cell preservation, producing a cross-linked matrix in the plasma and performing of chemical reactions by diffusing reagents across an interface, are performed for the purpose of stabilizing both the cell shape and the smoothness and homogeneity of the plasma layer, while the fresh and still wet blood spread is immersed in a non-polar, water immisicible, solvent.
    Type: Grant
    Filed: August 1, 1983
    Date of Patent: November 20, 1984
    Assignee: SmithKline Beckman Corporation
    Inventor: Alex M. Saunders
  • Cosmid cloning vectors
    Patent number: 4476227
    Abstract: Small cosmid cloning vectors having two antibiotic resistance markers, selected from chloramphemicol resistance, streptomycin and spectinomycin resistance and tetracycline resistance markers, at least one having a unique restriction site.
    Type: Grant
    Filed: October 6, 1982
    Date of Patent: October 9, 1984
    Assignee: Smithkline Beckman Corporation
    Inventor: Dean P. Taylor
  • Detoxified E. coli neurotoxin, preparation thereof and immunological preparations containing it
    Patent number: 4465665
    Abstract: Detoxified but still immunogenic E. coli neurotoxin is prepared by bringing E. coli neurotoxin into contact with glutaraldehyde in mild operative conditions, the reaction being stopped where no more than 90% of the neurotoxin are inactivated.The obtained detoxified neurotoxin is valuable for immunizing piglets against oedema disease.
    Type: Grant
    Filed: March 4, 1982
    Date of Patent: August 14, 1984
    Assignee: Smithkline-Rit
    Inventor: Lucia Dobrescu
  • Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them
    Patent number: 4451446
    Abstract: Process for the non-degrading preparation of polysaccharide-protein complexes from bacterial capsules; the so-obtained products which are useful as vaccines against infection by the same bacteria and method for protecting human beings against the same infection by administration of pharmaceutical composition containing the polysaccharide-protein complexes.
    Type: Grant
    Filed: March 4, 1982
    Date of Patent: May 29, 1984
    Assignee: Smithkline-Rit
    Inventors: Jean Vandevelde, Robert De Neys
  • Rabies virus adapted for growth in swine testicle cell culture
    Patent number: 4429045
    Abstract: The preparation of a vaccine for immunization of canine and feline animals from inactivated HCP-SAD strain of rabis virus is disclosed.
    Type: Grant
    Filed: May 10, 1982
    Date of Patent: January 31, 1984
    Assignee: Norden Laboratories, Inc.
    Inventors: Edmund P. Bass, Richard L. Sharpee
  • Modified pasteurella bacteria and vaccines prepared therefrom
    Patent number: 4388299
    Abstract: The chemical modification of virulent Pasteurella multocida and Pasteurella haemolytica strains and preparation of live bacteria vaccines from the modified organisms for immunization of bovine, porcine and ovine animal species are disclosed.
    Type: Grant
    Filed: April 17, 1981
    Date of Patent: June 14, 1983
    Assignee: Norden Laboratories, Inc.
    Inventor: Carrell J. Kucera
  • Inactivated rabies vaccine for veterinary use
    Patent number: 4347239
    Abstract: The preparation of a vaccine for immunization of canine and feline animals from inactivated HCP-SAD strain of rabies virus is disclosed.
    Type: Grant
    Filed: July 30, 1980
    Date of Patent: August 31, 1982
    Assignee: Norden Laboratories, Inc.
    Inventors: Edmund P. Bass, Richard L. Sharpee
  • Methods of vaccinating humans against rotavirus infection
    Patent number: 4341763
    Abstract: The invention relates to rotavirus vaccines for man and to methods of using them.The vaccines comprise an effective dose of bovine rotavirus which is either attenuated or inactivated.The invention comprises a method of immunizing human beings against human rotavirus infections by administering said vaccines by intramuscular, oral or nasal route; it further comprises a method of immunizing infants by boosting their mother with said vaccines prior to the birth of said infants.
    Type: Grant
    Filed: March 10, 1981
    Date of Patent: July 27, 1982
    Assignee: SmithKline-Rit
    Inventor: Nathan Zygraich