Patents Represented by Attorney Janice E. Williams

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  • Intermediates for preparing substituted phenylglycylcephalosporins
    Patent number: 4107440
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have antibacterial activity.
    Type: Grant
    Filed: April 28, 1977
    Date of Patent: August 15, 1978
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • 7.beta.-Acylamino-3-(alkanesulfonamidoalkyl substituted tetrazolylthiomethyl) cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them
    Patent number: 4101656
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an alkanesulfonamidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: July 18, 1978
    Assignee: Smithkline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl) cephalosporins, antibacterial compositions containing them, and methods of treating bacterial infections using them
    Patent number: 4096256
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: June 20, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Process for preparing triazolethiols
    Patent number: 4094881
    Abstract: 1,2,3-Triazole-4(5)-thiol is prepared by treating 1-benzyl-1,2,3-triazole with a strong base, treating the resulting anion with sulfur, removing the benzyl group by reductive means, and acidifying the resulting thiolate with strong acid.
    Type: Grant
    Filed: December 16, 1976
    Date of Patent: June 13, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins
    Patent number: 4093723
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus. The compounds have antibacterial activity.
    Type: Grant
    Filed: January 13, 1977
    Date of Patent: June 6, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Intermediates for preparing substituted phenylglycylcephalosporins
    Patent number: 4092480
    Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have anti-bacterial activity.
    Type: Grant
    Filed: April 28, 1977
    Date of Patent: May 30, 1978
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • Intermediates for preparing 7-acyl-3-(sulfoalkyl substituted oxadiazolylthiomethyl)cephalosporins
    Patent number: 4067880
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: January 10, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Amino intermediates for preparing 7-acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)-cephalosporins
    Patent number: 4068073
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: January 10, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)cephalosporins
    Patent number: 4066761
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have anti-bacterial activity.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: January 3, 1978
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Intermediates for preparing .alpha.-carboxy-.alpha.-(3-thienyl)penicillin and cephalosporin derivatives
    Patent number: 4066664
    Abstract: A new process is disclosed for the preparation of alpha-carboxy-alpha-phenyl(or 3-thienyl)penicillin and cephalosporin derivatives.The process comprises reacting a 1.3-dioxane-4.6-dione derivative with the desired penicillanic or cephalosporanic acid derivative.
    Type: Grant
    Filed: September 27, 1976
    Date of Patent: January 3, 1978
    Assignee: Recherche et Industrie Therapeutiques
    Inventors: Pierre Crooij, Guy Simonet
  • Pharmaceutical compositions comprising 7-acyl-3-(substituted triazolyl thiomethyl)-cephalosporins and methods of treating bacterial infections
    Patent number: 4060610
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted triazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: November 29, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Ureidoalkyl substituted tetrazole thiol intermediates for preparing cephalosporins
    Patent number: 4059591
    Abstract: The uriedoalkyl substituted tetrazolethiol compounds of this invention are used for preparing 7-acyl-3-(uriedoalkyl substituted tetrazolythiomethyl)-cephalosporins.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: November 22, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Pre-farrowing pregnant sow piglet colibacillosis vaccines and process for their administration to pregnant sows before farrowing
    Patent number: 4053584
    Abstract: Piglet colibacillosis vaccine for intramuscular or subcutaneous administration to pregnant sows comprising cell-free heat labile (LT) E. coli enterotoxin with an adjuvant and the method for preventing piglet colibacillosis consisting in administering said vaccine to pregnant sows from 3 to 6 weeks before farrowing.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: October 11, 1977
    Assignee: Recherche et Industrie Therapeutiques
    Inventors: Lucia Dobrescu, Constant Huygelen
  • Live Newcastle disease virus vaccines
    Patent number: 4053583
    Abstract: The improved live Newcastle disease virus vaccines of the invention contain a cold or cold and temperature-sensitive strain of Newcastle disease virus obtained by U.V. or nitrous acid mutation. The vaccines are administered to chickens in the form of an aerosol.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: October 11, 1977
    Assignee: SmithKline Corporation
    Inventors: Jacqueline Gits, Nathan Zygraich
  • Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
    Patent number: 4053468
    Abstract: A process for preparing 7-oxo cephalosporins and 6-oxo penicillins by reaction of a 7-amino cephalosporin or 6-amino penicillin with a carbonyl-containing oxidizing agent is disclosed.
    Type: Grant
    Filed: February 25, 1976
    Date of Patent: October 11, 1977
    Assignee: SmithKline Corporation
    Inventor: Kenneth G. Holden
  • Process for preparing 5-(alkoxy- and aminoethyl thio)methylthiazole compounds
    Patent number: 4049669
    Abstract: A process for preparing 5-(alkoxy- and aminoethylthio)methylthiazole compounds via displacement of the trisubstituted phosphonium group from 5-(trisubstituted phosphonium)methylthiazole compounds is disclosed.
    Type: Grant
    Filed: October 29, 1975
    Date of Patent: September 20, 1977
    Assignee: SmithKline Corporation
    Inventors: Bing Lun Lam, Joseph James Lewis, Robert Lee Webb, George Robert Wellman
  • 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins
    Patent number: 4048311
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfonic acid or sulfamoyl substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 19, 1976
    Date of Patent: September 13, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Intermediates for preparing substituted phenylglycylcephalosporins
    Patent number: 4044047
    Abstract: Cephalosporia compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have anti-bacterial activity.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: August 23, 1977
    Assignee: SmithKline Corporation
    Inventor: John Gerald Gleason
  • 7-Acyl-3-(sulfoalkyl substituted oxadiazolylthiomethyl) cephalosporins
    Patent number: 4041162
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: March 11, 1976
    Date of Patent: August 9, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7-Acyl-3-(carboxyalkyl and carbamoylalkyl substituted oxadiazolylthiomethyl) cephalosporins
    Patent number: 4034092
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a carboxyalkyl or carbamoylalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: July 5, 1977
    Assignee: SmithKline Corporation
    Inventor: David A. Berges