Patents Represented by Attorney Janice E. Williams

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  • Des-proline-N-methylarginine vasopressins
    Patent number: 4687758
    Abstract: Peptides having vasopressin antagonist activity are prepared by a peptide synthesizer to insert a N-methylarginine at the 7-position of the structure. An example of this series of compounds is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl-D-tyrosine)-4-valine-7-desproline-8-N-methylarginine-9-de sglycine]-vasopressin.
    Type: Grant
    Filed: November 19, 1985
    Date of Patent: August 18, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Fadia E. Ali, William F. Huffman, Garland R. Marshall, Michael L. Moore
  • Polypeptide intermediates
    Patent number: 4684716
    Abstract: 2- or 3-.beta.-Indolylalanyl and .beta.-indolylglycyl vasopressins are prepared by standard peptide synthetic methods. These 2- or 3-TRP vasopressins have vasopressin antagonist activity.
    Type: Grant
    Filed: April 16, 1986
    Date of Patent: August 4, 1987
    Assignee: SmithKline Beckman Corporation
    Inventor: Nelson C. Yim
  • Compositions and methods for producing vasodilation and antioxytocic activity
    Patent number: 4684622
    Abstract: Vasopressin derivatives having V.sub.1 and oxytocin antagonist activity whose structures are characterized by a Mpa unit at position 1 and a des-Pro unit at position 7 are prepared by standard peptide synthetic methods also using an oxidative cyclization of a dimercaptan. Representative species are [1-deaminopenicillamine-2-(O-methyl)-tyrosine-7-desproline-8-arginine-9-de sglycine]vasopressin or [1-.beta.-mercaptopropionic acid-2-D-(O-ethyl)tyrosine-3-isoleucine-4-threonine-7-desproline-8-arginin e-9-desglycine]-vasopressin.
    Type: Grant
    Filed: April 18, 1986
    Date of Patent: August 4, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Fadia E. Ali, William F. Huffman
  • Methods of producing vasodilation or antioxytocic activity
    Patent number: 4684621
    Abstract: Certain vasopressin-like peptides, which have an acyclic unit at position 1 and which have an .omega.-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have V.sub.1 -vasopressin and oxytocin antagonist activity. A species of this series of new compounds is [1-desaminopenicillamine-2-(O-ethyl-D-tyrosine)-8-(1,4-diaminobutane)-9-de sglycinamide]-vasopressin.
    Type: Grant
    Filed: April 16, 1986
    Date of Patent: August 4, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Michael L. Moore, Nelson C. Yim
  • Process for the extraction and purification of proteins from culture media producing them
    Patent number: 4683294
    Abstract: The process is applicable to the supernatant of engineered yeast cells disrupted in the presence of a non-ionic detergent: it comprises the precipitation of contaminants by polyethylene glycol and the treatment cation or, after eventual ultrafiltration, with ammonium sulfate.
    Type: Grant
    Filed: April 3, 1985
    Date of Patent: July 28, 1987
    Assignee: Smith Kline RIT, S.A.
    Inventors: Frans Van Wijnendaele, Daniel Gilles, Guy Simonet
  • Feed compositions containing 2-(.alpha.-pyridyl)-.DELTA..sup.2 -heterocyclic compounds
    Patent number: 4680304
    Abstract: Selected 2-(.alpha.-pyridyl)-.DELTA..sup.2 -heterocyclic compounds are used as active ingredients in animal feed compositions and in methods for increasing the growth or feed efficiency of monogastric animals. An active ingredient for use in this invention is 3,4-dihydro-4-hydroxy-5-(3-hydroxy)-2-pyridinyl)-4-methyl-2H-pyrrole-5-car boxamide.
    Type: Grant
    Filed: March 12, 1985
    Date of Patent: July 14, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Govind K. Menon, Winfred J. Sanders
  • Chemical process
    Patent number: 4677228
    Abstract: This invention relates to a Friedel-Crafts acylation process using trichlorobenzene as solvent.
    Type: Grant
    Filed: February 7, 1986
    Date of Patent: June 30, 1987
    Assignee: Smith Kline & French Laboratories, Ltd.
    Inventor: Brian M. Adger
  • Moraxella bovis protease vaccine
    Patent number: 4675176
    Abstract: Protease produced by Moraxella bovis can be used as an immunoprophylactic agent for protection against infection by M. bovis.
    Type: Grant
    Filed: December 12, 1983
    Date of Patent: June 23, 1987
    Assignee: Norden Laboratories
    Inventor: Jay D. Gerber
  • Tetraphosphine-coordinated gold(I) complexes
    Patent number: 4675427
    Abstract: Tetraphosphine-coordinated gold(I) compounds, pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound, and a method for treating tumor cells sensitive to such a compound which comprises administering a tumor cell growth-inhibiting amount of such a compound to an animal afflicted by said tumor cells.
    Type: Grant
    Filed: December 23, 1985
    Date of Patent: June 23, 1987
    Assignee: Smith Kline Beckman Corporation
    Inventors: David T. Hill, Randall K. Johnson
  • Pure cultures of Kibdelsporangium aridum Shearer gen. nov., sp. nov. ATCC 39323 and mutants thereof
    Patent number: 4672036
    Abstract: A novel antibiotic complex of "vancomycin-like" antibiotics, AAD 216 complex, is produced by the cultivation of a fermentation broth containing Kibdelosporangium aridum Shearer gen. nov., sp. nov. ATCC 39323 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The AAD 216 complex and its major bioactive components; AAD 216A, AAD 216B, and AAD 216C exhibit antibiotic activity and growth promotant activity.
    Type: Grant
    Filed: June 26, 1985
    Date of Patent: June 9, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Betty A. Bowie, David J. Newman, Marcia C. Shearer
  • DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits
    Patent number: 4666837
    Abstract: DNA sequences and recombinant DNA molecules comprising at least a portion coding for all or part of subunits A and/or B of cholera toxin are prepared by enzymatic digestion of DNA of V. cholerae strains, isolating specific fragments and inserting them in appropriate vectors and subunits A and/or B of cholera toxin are prepared by culture of microorganisms containing said modified vectors.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: May 19, 1987
    Assignee: SmithKline-RIT
    Inventors: Nigel Harford, Michel De Wilde
  • Process for the preparation of purified vancomycin class antibiotics
    Patent number: 4667024
    Abstract: A novel process for the isolation and purification of vancomycin class antibiotics which utilized affinity chromatography by the formation of a sorption complex between the antibiotic and an immobilizing ligand selected from -D-alanyl-D-alanine or -X-D-alanyl-D-alanine, wherein X is an amino acid radical and the novel affinity chromatography sorbent employed therein are disclosed.
    Type: Grant
    Filed: July 13, 1983
    Date of Patent: May 19, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Robert D. Sitrin, Kenneth M. Snader, Gail F. Wasserman
  • Heterocyclic compounds having inotropic activity
    Patent number: 4657906
    Abstract: This invention relates to 5-(phenyl)-2(1H)-pyrazinones substituted in the 4-position of the phenyl ring by an amino or acylamino group. These compounds has inotropic activity. One specific compound is 5-(4-acetamidophenyl)-2(1H)-pyrazinone.
    Type: Grant
    Filed: September 19, 1985
    Date of Patent: April 14, 1987
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: John C. Emmett, Robert A. Slater, Brian H. Warrington
  • 6-(cyanoguanidinophenyl)pyridazinones as cardiac stimulants
    Patent number: 4654342
    Abstract: This invention relates to cyanoguanidine derivatives that have utility in the treatment of congestive heart failure. A specific compound of this invention is 6-[4-(N.sup.3 -methyl-N.sup.2 -cyanoguanidino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
    Type: Grant
    Filed: January 14, 1985
    Date of Patent: March 31, 1987
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventor: Robert A. Slater
  • Method for the isolation and purification of hepatitis B surface antigen using polysorbate
    Patent number: 4649192
    Abstract: The supernatant of engineered yeast cells having produced hepatitis B surface antigaen and disrupted in the presence of a polysorbate non-ionic detergent is clarified by addition of urea and adsorbed on colloidal silica from which the purified antigen is desorbed with a low ionic strength buffer supplemented with urea and a polysorbate non-ionic detergent.
    Type: Grant
    Filed: May 30, 1985
    Date of Patent: March 10, 1987
    Assignee: Smith Kline-RIT
    Inventors: Frans Van Wijnendaele, Guy Simonet
  • [.alpha.,.omega.-bis(diphenylphosphino)hydrocarbon]bis[(thiosugar)gold] and bis[(selenosugar)gold] derivatives, pharmaceutical compositions and method of use
    Patent number: 4645756
    Abstract: This invention relates to [.alpha.,.omega.-bis(diphenylphosphino)hydrocarbon]bis[(thiosugar)gold] and bis[(selenosugar)gold] derivatives, pharmaceutical compositions comprising an effective tumor cell growth-inhibiting amount of such a derivative, and a method of treating tumor cells sensitive to such a derivative which comprises administering a tumor cell growth-inhibiting amount of such a derivative to an animal afflicted by said tumor cells.
    Type: Grant
    Filed: September 27, 1985
    Date of Patent: February 24, 1987
    Assignee: Smith Kline Beckman Corporation
    Inventors: David T. Hill, Randall K. Johnson
  • Externalization of products of bacteria
    Patent number: 4637980
    Abstract: A bacterial product is made by transforming a temperature sensitive lysogen with a DNA molecule which codes, directly or indirectly, for the product, culturing the transformant under permissive conditions and externalizing the product by raising the temperature to induce phage encoded functions.
    Type: Grant
    Filed: August 9, 1983
    Date of Patent: January 20, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Jeffrey I. Auerbach, Martin Rosenberg
  • 5-(4-substituted)phenyl-2-pyrazinones
    Patent number: 4632924
    Abstract: This invention relates to 5-(4-substituted)phenylpyrazinone compounds which have positive inotropic and vasodilator activity. One such compound is 5-(4-carboxamidophenyl)pyrazin-2(1H)-one.
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: December 30, 1986
    Assignee: SmithKline Beckman Corporation
    Inventors: John C. Emmett, Robert A. Slater
  • Alpha-1-antiprotease purification
    Patent number: 4629567
    Abstract: Alpha-1-antiprotease is highly purified from an impure solution thereof by a series of chromtographic procedures.
    Type: Grant
    Filed: March 7, 1986
    Date of Patent: December 16, 1986
    Assignee: SmithKline-RIT
    Inventors: Alex J. Bollen, Paul Chuchana, Marc Hoylaerts
  • Temperature sensitive strains of bovine viral diarrhoea virus, preparation thereof and vaccines containing them
    Patent number: 4618493
    Abstract: A live bovine viral diarrhoea (BVD) virus vaccine capable of producing immunity in bovines without causing significant side effects comprising a temperature sensitive (ts) mutant of BVD virus which is obtained by mutating a strain of BVD virus with nitrous acid. The temperature sensitive mutants show a replication ability considerably limited at the animal body temperature of 39.5.degree. C. The vaccine may be combined with other live bovine vaccines such as respiratory virus vaccines and then administered to bovines.
    Type: Grant
    Filed: October 13, 1982
    Date of Patent: October 21, 1986
    Assignee: SmithKline-RIT
    Inventors: Jean-Claude Delgoffe, Michele Lobmann, Nathan Zygraich
  • Tetraphosphine-coordinated gold(I) complexes
    Patent number: 4758589
    Abstract: Tetraphosphine-coordinated gold (I) compounds, pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound, and a method of treating tumor cells sensitive to such a compound which comprises administering a tumor cell growth-inhibiting amount of such a compound to an animal afflicted by said tumor cells.
    Type: Grant
    Filed: February 2, 1987
    Date of Patent: July 19, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: David T. Hill, Randall K. Johnson