Patents Represented by Attorney Julian S. Levitt

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  • 7.beta.-(D-5-amino-5-carboxyvaleramido )-7-methoxy-3-substituted-3-cephem-4-carboxylic acid antibiotics
    Patent number: 4017487
    Abstract: Disclosed are 7.beta.-(D-5-amino-5-carboxyvaleramido)-7-methoxy-3-cephem-4-carboxylic acids which are substituted in the three position of the "cephem" nucleus by a variety of alkyl, haloalkyl or oxygen, sulfur and nitrogen containing substitutents; and the salts, esters and amide derivatives thereof. Certain of the products are obtained by fermentation and others are obtained by synthetic means. The products exhibit activity against gram-negative and gram-positive bacteria.
    Type: Grant
    Filed: October 4, 1974
    Date of Patent: April 12, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward O. Stapley, Justo M. Mata
  • Process for the production of 7-acylamidocephalosporins
    Patent number: 4014873
    Abstract: New 7-diacylimido cephalosporins are produced by reacting 7-acylamido cephalosporins with an acylating agent in the presence of a silyl reagent. The 7-diacylimido cephalosporins are cleaved to produce cephalosporins containing a different acylamido moiety. Thus, the aminoadipoyl group of cephalosporins produced by fermentation is replaced by a different acyl group by the process of the present invention. The cephalosporins produced are antibiotics having enhanced activity against gram-negative and gram-positive pathogens.
    Type: Grant
    Filed: November 29, 1974
    Date of Patent: March 29, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Lovji D. Cama, Meyer Sletzinger, Sandor Karady
  • N-(Benzimidazol-2-yl)arylcarboxamides as ultraviolet (UV) light absorbers
    Patent number: 4011236
    Abstract: This invention relates to compositions containing N-(benzimidazol-2-yl)arylcarboxamides as ultraviolet (UV) light absorbers. The compounds are useful to protect UV sensitive materials, particularly plastic compositions, or ingredients thereof such as dyes, anti-microbial agents, or plasticizers from attack by ultraviolet light. The compositions are suitable for those uses where UV protection is required only for short periods of time, for example in sun tan lotions, as well as for uses which require protection for extended periods of time.
    Type: Grant
    Filed: May 27, 1975
    Date of Patent: March 8, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Nathaniel Grier
  • Thienamycin production
    Patent number: 4006060
    Abstract: The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: November 18, 1975
    Date of Patent: February 1, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Edward O. Stapley, Robert T. Goegelman, Sebastian Hernandez
  • Fluorination of organic compounds
    Patent number: 4004996
    Abstract: Organic amines, amino acids, polyamides and vinylpolymers are fluorinated by the action of fluorine in liquid hydrogen fluoride optionally containing boron trifluoride or antimony pentafluoride at about -80.degree. to 15.degree. C. and optionally under irradiation with light.
    Type: Grant
    Filed: December 23, 1974
    Date of Patent: January 25, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Janos Kollonitsch
  • Di-bicyclo[3.1.1] and [2.2.1]heptyl and di-bicyclo[3.1.1] and [2.2.1]heptenyl ketones
    Patent number: 4003934
    Abstract: Novel di-bicyclo[3.1.1] and [2.2.1]heptyl and dibicyclo[3.1.1] and [2.2.1]heptenyl ketones are useful as intermediates for preparing novel polyamines useful as antimicrobial agents, as well as algae inhibitors.
    Type: Grant
    Filed: September 2, 1975
    Date of Patent: January 18, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas
  • Process for purifying thienamycin
    Patent number: 4000161
    Abstract: Fermentation broths or impure solutions containing thienamycin, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are purified using ion exchange resins, poly-acrylamide gels or adsorbents such as polyester polymers or polystyrene, hydrophobic crosslinked divinyl benzene polymers.
    Type: Grant
    Filed: September 18, 1975
    Date of Patent: December 28, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Robert T. Goegelman, Frederick M. Kahan
  • Varicella vaccine and process for its preparation
    Patent number: 4000256
    Abstract: Preparation of safe, live, attenuated varicella virus vaccine by serial propagation of varicella virus in tissue cell culture systems.
    Type: Grant
    Filed: July 2, 1975
    Date of Patent: December 28, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Maurice R. Hilleman, Eugene B. Buynak, Beverly J. Neff
  • 3-Substituted methyl-7-acylamino-7-methoxy-2-cephem-4-carboxylic acid and its esters
    Patent number: 3987040
    Abstract: Process for preparing an ester of 3-substituted methyl-7-acylamido-7-methoxy(or hydrogen)-2-cephem-4-carboxylic acid and its corresponding sulfoxide by treating an ester of 3-carbamoyloxymethyl(or 3-lower alkanoyloxymethyl)-7-acylamido-7-methoxy(or hydrogen)-2-cephem-4-carboxyli c acid with a hydrohalic acid or another compound containing an active hydrogen and then with an oxidizing agent. The products obtained are useful as intermediates in the preparation of antibiotics.
    Type: Grant
    Filed: December 5, 1974
    Date of Patent: October 19, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Theresa Y. Cheng, Sandor Karady, Seemon H. Pines, Meyer Sletzinger
  • Process for preparing 3-hydroxymethyl cephalosporins
    Patent number: 3985742
    Abstract: Disclosed are 7.beta.-(D-5-amino-5-carboxyvaleramido)-7-methoxy-3-cephem-4-carboxylic acids which are substituted in the three position of the "cephem" nucleus by a variety of alkyl, haloalkyl or oxygen, sulfur and nitrogen containing substituents; and the salts, esters and amide derivatives thereof. Certain of the products are obtained by fermentation and others are obtained by synthetic means. The products exhibit activity against gram-negative and gram-positive bacteria.
    Type: Grant
    Filed: February 18, 1975
    Date of Patent: October 12, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Edward O. Stapley, Justo M. Mata
  • Water-in-oil adjuvant composition
    Patent number: 3983228
    Abstract: Pure isomannide monooleate and pure aluminum monostearate are used singularly or in combination in the preparation of emulsion type adjuvant vaccines to yield an adjuvant superior to prior art adjuvants which employ commercial mannide monooleate and aluminum monostearate. Highly desirable formulations are obtained by the inclusion of pure aluminum monostearate as a stabilizer in combination with the pure isomannide monooleate.
    Type: Grant
    Filed: November 19, 1974
    Date of Patent: September 28, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Allen F. Woodhour, Maurice R. Hilleman
  • C-3 Substituted cephalosporins
    Patent number: 3979384
    Abstract: This invention relates to novel organic compounds and to methods for preparing them. More particularly, this invention provides new and useful cephalosporin compounds which are active antibiotics against both gram-positive and gram-negative microorganisms and compounds which are useful intermediates in the preparation of other new cephalosporin compounds.
    Type: Grant
    Filed: March 20, 1975
    Date of Patent: September 7, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Raymond A. Firestone, John L. Fahey, Burton G. Christensen
  • Fermentation of cephamycin C
    Patent number: 3977942
    Abstract: Increased yields of the known and useful antibiotic cephamycin C [7-(D-5-amino-5-carboxyvaleramido)-3-(carbamoyloxymethyl)-7-methoxy-3-ceph em-4-carboxylic acid] are obtained by the addition of D- or DL-arginine, D- or DL-ornithine and/or one of several polyamines; or D- or DL-lysine in combination with one of several polyamines to fermentation media composed of complex organic nutrients.
    Type: Grant
    Filed: November 21, 1975
    Date of Patent: August 31, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Edward Inamine, Jerome Birnbaum
  • Cell and vaccine production
    Patent number: 3976547
    Abstract: Cell growth surfaces having controlled surface topography which permits the optimization of the fit between the cells and the growth surface. These surfaces may be constructed from sintered or sputtered titanium, glass, ceramic, plastic, or stainless steel, or may consist of a substrate having microspheres adhered to the surface thereof.
    Type: Grant
    Filed: November 19, 1974
    Date of Patent: August 24, 1976
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Raymond E. Spier, Abner J. Schlabach
  • Process for preparing 3-fluoro-D-alanine and its deutero analogs
    Patent number: 3976689
    Abstract: 3-Fluoro-D-alanine and its deutero analogs, which are potent antibacterial agents, are prepared from fluoropyruvic acid by asymmetric synthesis using an optically active amine such as D-.alpha.-methyl-benzylamine.
    Type: Grant
    Filed: November 20, 1974
    Date of Patent: August 24, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Donald F. Reinhold
  • Cephalosporin compounds
    Patent number: 3974151
    Abstract: Novel 7-methoxy 3-phosphoranylidene cephem compounds which find utility as intermediates in the preparation of antibiotically active 7-methoxy-3-vinyl cephalosporins.
    Type: Grant
    Filed: June 5, 1973
    Date of Patent: August 10, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Thomas R. Beattie, Burton G. Christensen
  • Process for the preparation of chloromethyl methyl ether
    Patent number: 3972947
    Abstract: Single vessel, closed system, anhydrous, process for preparing high purity chloromethyl methyl ether comprising reacting methylal with hydrogen chloride; wherein said hydrogen chloride is generated, in situ, by contacting methanol, a reaction intermediate, with an acid chloride.
    Type: Grant
    Filed: July 15, 1975
    Date of Patent: August 3, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Leonard M. Weinstock, Sandor Karady, Meyer Sletzinger
  • Synthesis of racemic 2-deutero-3-fluoro-alanine and its salts
    Patent number: 3972921
    Abstract: The racemates of 2-deutero-3-fluoro-alanine and its salts are prepared by reductive amination of 3-fluoro-pyruvic acid, its hydrate or salts thereof, via the intermediate 2-imino-3-fluoro propionic acid salt, using alkali metal borodeuterides as reducing agents. The racemates thus obtained are valuable in the production of the corresponding 2-deutero-3-fluoro-D-alanine, and its pharmacologically acceptable salts, and derivatives thereof, which are potent antibacterial agents.
    Type: Grant
    Filed: November 8, 1974
    Date of Patent: August 3, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Ulf-H. Dolling, Edward J. J. Grabowski, Erwin F. Schoenewaldt, Meyer Sletzinger
  • Cephalosporin compounds
    Patent number: 3962224
    Abstract: Novel 7-azido-3-cephem compounds are prepared via .alpha.-amino-phosphonoacetate esters. The cephem compounds are intermediates for the preparation of novel and known useful antibiotic cephalosporins.
    Type: Grant
    Filed: March 5, 1973
    Date of Patent: June 8, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ronald W. Ratcliffe
  • Vaccine production
    Patent number: 3959074
    Abstract: A process for the controlled manufacture of cells and vaccines in which reproducable real time quantitative assays are utilized to ascertain the physical and chemical state of the system, in order to more efficiently manage the system, so that cell sheet formation may be determined and the vaccine may be harvested at its maximum titre, thereby resulting in significantly increased yields and decreased production costs.
    Type: Grant
    Filed: December 6, 1974
    Date of Patent: May 25, 1976
    Assignee: Merck & Co., Inc.
    Inventors: William J. Miller, Raymond E. Spier, William J. McAleer