Patents Represented by Attorney Julian S. Levitt

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  • Antibiotics 890A.sub.1 and 890A.sub.3
    Patent number: 4162324
    Abstract: The antibiotics MSD 890A.sub.1 and MSD 890A.sub.3 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.1 and 890A.sub.3) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: August 25, 1977
    Date of Patent: July 24, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Patrick J. Cassidy, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
  • Enzymatic cleavage of N-acyl-thienamycins
    Patent number: 4162193
    Abstract: A method is disclosed for cleaving N-acyl-thienamycin compounds to yield thienamycin. The new method disclosed herein utilizes enzymes which are penicillin amidohydrolases to treat the starting compounds resulting in the antibiotic thienamycin.
    Type: Grant
    Filed: August 19, 1977
    Date of Patent: July 24, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan
  • 1,3,5-S-Hexahydrotrisubstituted triazines and hydrocarbon metal-working fluids containing same
    Patent number: 4159253
    Abstract: 1,3,5-s-Hexahydrotrisubstituted triazines exemplified by 1,3,5-tris(furfuryl)-1,3,5-hexahydro-s-triazines are useful as antimicrobial agents particularly when employed as a component of metal-working compositions subject to fungal and bacterial attack.
    Type: Grant
    Filed: May 22, 1978
    Date of Patent: June 26, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Bruce E. Witzei
  • 1,3,5-S-Hexahydrotrisubstituted triazines and hydrocarbon metal working fluids containing same
    Patent number: 4159254
    Abstract: 1,3,5-s-Hexahydrotrisubstituted triazines exemplified by 1,3,5-tris(tetrahydrofurfuryl)-1,3,5-hexahydro-s-triazines are useful as antimicrobial agents particularly when employed as a component of metal-working compositions subject to fungal and bacterial attack.
    Type: Grant
    Filed: May 22, 1978
    Date of Patent: June 26, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Bruce E. Witzel
  • Water diverting gel compositions
    Patent number: 4157322
    Abstract: This invention relates to the recovery of oil from underground deposits. The invention relates to novel gel compositions consisting of water, a polysaccharide polymer, an acid generating salt and a melamine resin. The invention also relates to the method of utilizing said composition to recovery underground oil.
    Type: Grant
    Filed: January 19, 1978
    Date of Patent: June 5, 1979
    Assignee: Merck & Co., Inc.,
    Inventor: George T. Colegrove
  • Amphoteric graft copolymers of xanthomonas hydrophilic colloid and partially N-aminomethylated acrylamide
    Patent number: 4155885
    Abstract: A series of novel amphoteric graft copolymers of xanthomonas hydrophilic colloid and partially N-aminoalkylated acrylamide has been prepared by reacting the corresponding acrylamide copolymer with an alkyl amine and an active aldehyde. The new copolymer is cationized via acidification or quaternization, and is reverted to its anionic form via basification.
    Type: Grant
    Filed: April 28, 1978
    Date of Patent: May 22, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Joseph S. Racciato, Ian W. Cottrell, Jaewon L. Shim
  • 7-(Substituted methyl)-3-(substituted thio)-cephalosporins, derivatives and pharmaceutical compositions containing them
    Patent number: 4150156
    Abstract: Disclosed are antibiotic 3-(substituted thio)-7-(substituted methyl) cephalosporins, derivatives and analogues thereof; wherein the methyl substituent is, inter alia, hydroxyl, ketonic oxygen, imino nitrogen, amino or mercapto. Also disclosed are processes for the preparation of such compounds and their pharmaceutically acceptable salt, ester and amide derivatives; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: May 8, 1978
    Date of Patent: April 17, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Thomas R. Beattie, Lovji D. Cama, Burton G. Christensen, Frank P. Dininno
  • Cephalosporin phosphonic acid, sulfonic acid and sulfonamide compounds
    Patent number: 4150223
    Abstract: Novel antibiotics of the formula: ##STR1## and its salts, esters and amides wherein R is acyl; B is H, OCH.sub.3, CH.sub.3 or SR" wherein R" is lower alkyl; A is hydrogen, hydroxy, or an organic group; and, Y is a radical of the formula PO(OH).sub.2 ; PO(OH)(OR") wherein R" is loweralkyl; SO.sub.2 (OH); or SO.sub.2 NH.sub.2.The products are prepared by a multi-step process starting with an .alpha.-aminophosphonoacetate and terminating in the acylation of the 7-amino compound, and, if desired, removing the ester blocking group. The products are useful antibiotics.
    Type: Grant
    Filed: April 28, 1978
    Date of Patent: April 17, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ronald W. Ratcliffe
  • N-alkylated derivatives of thienamycin sulfoxide and sulfone
    Patent number: 4150145
    Abstract: Disclosed are N-alkylated derivatives of thienamycin sulfoxide (I, n=1) and sulfone (I, n=2): ##STR1## wherein n=1 or 2; and R.sup.5, R.sup.6, and R.sup.7 are, inter alia, hydrogen or alkyl. Such compounds the their pharmaceutically acceptable O- and carboxyl- derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: September 15, 1977
    Date of Patent: April 17, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Raymond A. Firestone, William J. Leanza
  • Synthesis of racemic 3-fluoro-alanine and its salts
    Patent number: 4149012
    Abstract: The racemate of 3-fluoro-alanine, and salts thereof, are prepared by reductive amination of 3-fluoro-pyruvic acid, its hydrate, or salts thereof, via the intermediate 2-imino-3-fluoro propionic acid salt, using alkali metal borohydrides as reducing agents. The racemates thus obtained are valuable in the production of 3-fluoro-D-alanine and its pharmacologically acceptable salts, and derivatives thereof, which are potent antibacterial agents.
    Type: Grant
    Filed: October 7, 1977
    Date of Patent: April 10, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Ulf-H. Dolling, Edward J. J. Grabowski, Erwin F. Schoenewaldt, Meyer Sletzinger
  • Vaccine stabilizer
    Patent number: 4147772
    Abstract: A stabilized lyophlized or liquid live viral vaccine contains a live virus, partially hydrolyzed gelatin, a 6-carbon polyhydric alcohol, Medium 199 and acidic buffer.
    Type: Grant
    Filed: February 23, 1978
    Date of Patent: April 3, 1979
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Henry Z. Markus
  • .DELTA..sup.3 -Thienamycin
    Patent number: 4146633
    Abstract: The antibiotic .DELTA..sup.3 -thienamycin is disclosed: ##STR1## It is prepared by double bond isomerization of thienamycin. Also disclosed are pharmaceutical compositions comprising .DELTA..sup.3 -thienamycin, and methods of treatment comprising administering .DELTA..sup.3 -thienamycin when an antibiotic effect is indicated.
    Type: Grant
    Filed: October 31, 1977
    Date of Patent: March 27, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ronald W. Ratcliffe, David H. Shih
  • Respiratory syncytial vaccine
    Patent number: 4145252
    Abstract: By serially passaging virulent respiratory syncytial virus in human diploid lung fibroblasts, a non-pathogenic but antigenic live respiratory syncytial virus is produced. This virus is useful in preparing a live virus vaccine.
    Type: Grant
    Filed: June 26, 1978
    Date of Patent: March 20, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Eugene B. Buynak, Maurice R. Hilleman
  • Anti-microbial piperidino butan-2-ones
    Patent number: 4145426
    Abstract: Compounds of the structure: ##STR1## where A is either ##STR2## where R.sub.1 to R.sub.4 are various substituents are active as antibacterials and antifungals.
    Type: Grant
    Filed: July 18, 1977
    Date of Patent: March 20, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Bruce E. Witzel
  • Gelled explosive compositions
    Patent number: 4144107
    Abstract: This invention relates to a gelled explosive and a method for its preparation. More specifically, the invention relates to a gelled explosive composition containing water, at least one member selected from the group of a polysaccharide colloid and synthetic polymer; water-soluble melamine resin and a water-soluble explosive salt.
    Type: Grant
    Filed: January 10, 1978
    Date of Patent: March 13, 1979
    Assignee: Merck & Co., Inc.
    Inventor: George T. Colegrove
  • Antibiotics 890A.sub.2 and 890A.sub.5
    Patent number: 4141986
    Abstract: The antibiotics MSD 890A.sub.2 and MSD 890A.sub.5 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.2 and 890A.sub.5) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: February 27, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Patrick J. Cassidy, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
  • Process for preparation of 1-[1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentyl]-1,5,9-triazanonane and novel intermediates
    Patent number: 4139559
    Abstract: A process for preparing 1-[1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentyl]-1,5,9-triazanonane from 1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentanone by reaction with ammonia to form, after reduction, 3-amino-[1,5-di-(3,3-dimethylnorborn-2-yl)pentane]. This latter compound is reacted with acrylonitrile, reduced, and the diamine product again reacted with acrylonitrile and again reduced. Alternative routes wherein the ketone is reduced to the novel alcohol and optionally the novel halide and either then reacted with 3,3'-iminobispropylamine to form the desired polyamine are also shown.
    Type: Grant
    Filed: January 16, 1978
    Date of Patent: February 13, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Isolation of antibiotic Cephamycin C
    Patent number: 4137405
    Abstract: Fermentation broths or impure solutions containing Cephamycin C, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are isolated using liquid anion exchange systems.
    Type: Grant
    Filed: July 28, 1977
    Date of Patent: January 30, 1979
    Assignee: Merck & Co., Inc.
    Inventors: George T. Wildman, Rathin Datta
  • Production of N-acyl-thienamycins
    Patent number: 4135978
    Abstract: The disclosed invention is directed to a process for preparing N-acyl-thienamycins from thienamycin and the appropriate acyl group by reacting the same in the presence of certain penicillin amidohydrolases capable of producing N-acyl thienamycins.
    Type: Grant
    Filed: August 19, 1977
    Date of Patent: January 23, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan
  • Treatment of xanthan gum to improve clarity
    Patent number: 4135979
    Abstract: A xanthan gum fermentation beer containing at least about 1% gum is filtered at a temperature of at least about 112.degree. C. The gum subsequently recovered from the filtrate has improved clarity.
    Type: Grant
    Filed: August 24, 1976
    Date of Patent: January 23, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Foss E. Corley, Joe B. Richmon