Patents Represented by Attorney Julian S. Levitt

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  • Freeze-drying process for the preparation of meningococcus vaccine without degradation of potency
    Patent number: 4134214
    Abstract: The purified Group A polysaccharide antigen isolated from N. meningitidis for vaccination against this type of bacterial meningitidis is prepared from an isotonic ratio of aqueous sodium chloride solution freeze-dried at temperatures of from -20.degree. C. to -30.degree. C. This low temperature lyophilization dries the sodium chloride polysaccharide menstrum without loss of molecular weight, i.e., potency.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: January 16, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Glen D. Graham, William A. Sklarz
  • Caustic washed molecular sieves
    Patent number: 4134965
    Abstract: A novel improved molecular sieve is prepared by a caustic wash process. The sieves so prepared show improved properties in reactions involving e.g., superior acid scavenging ability.
    Type: Grant
    Filed: August 31, 1977
    Date of Patent: January 16, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Alan J. Rein, David D. Saperstein, Seemon H. Pines
  • Stabilized icings
    Patent number: 4135005
    Abstract: Freeze-thaw and heat stable icings are obtained by using an icing composition containing a high melting point fat and a gelling system consisting essentially of xanthan gum and locust bean gum.
    Type: Grant
    Filed: May 9, 1977
    Date of Patent: January 16, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Hsiung Cheng
  • Isolating hepatitis B Dane particles
    Patent number: 4129646
    Abstract: Biological fluid containing hepatitis B surface antigen is subjected to isopycnic banding with collection of fractions rich in Dane particles. The Dane particles are useful as diagnostic and immunologic agents.
    Type: Grant
    Filed: April 4, 1977
    Date of Patent: December 12, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Substituted 3-oxo-6-thia-2-azabicyclo [2.2.0] hexanes
    Patent number: 4126692
    Abstract: Disclosed is the antibiotic 5-methyl-2-(1-carboxyl-2-methyl-propen-1-yl)-3-oxo-6-thia-2-azabicyclo [2.2.0] hexane (I): ##STR1## Also disclosed are processes for preparing I and its pharmaceutically acceptable salts and esters; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: November 28, 1977
    Date of Patent: November 21, 1978
    Assignee: Merck & Co., Inc.
    Inventor: Frank P. Di Ninno
  • 1,3,5-S-Hexahydrotrisubstituted triazines
    Patent number: 4125719
    Abstract: 1,3,5-s-Hexahydrotrisubstituted triazines exemplified by 1,3,5-tris(furfuryl)-1,3,5-hexahydro-s-triazines are useful as antimicrobial agents particularly when employed as a component of metal-working compositions subject to fungal and bacterial attack.
    Type: Grant
    Filed: August 1, 1977
    Date of Patent: November 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Bruce E. Witzel
  • Thienamycin sulfoxide and sulphone
    Patent number: 4123547
    Abstract: Thienamycin sulfoxide (I, n=1), Thienamycin sulfone (I, n=2), and their pharmaceutically acceptable salts are disclosed to be useful as antibiotics: ##STR1## Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: September 15, 1977
    Date of Patent: October 31, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Edward Walton
  • 6-Ethylpenicillanic acid
    Patent number: 4123539
    Abstract: Disclosed are the antibiotics 6-ethylpenicillanic acid and 6-ethylpenicillanic acid sulfoxide (I): ##STR1## Also disclosed are processes for preparing I and its pharmaceutically acceptable salts and esters; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: December 29, 1977
    Date of Patent: October 31, 1978
    Assignee: Merck & Co., Inc.
    Inventor: Frank P. DiNinno
  • Method for preparing high molecular weight meningococcal Group C vaccine
    Patent number: 4123520
    Abstract: A vaccine against Group C meningococcal meningitis consisting of a polysaccharide of which at least 80% by weight has a molecular weight in excess of 1,000,000 daltons is prepared. The polysaccharide was isolated from Group C hexadecyl trimethylammonium bromide cell paste with 1.0M CaCl.sub.2 extraction and purified by phenol extraction, ultracentrifugation at 100,000 g. and ethanol fractionation (30%-45% v/v in ethanol).
    Type: Grant
    Filed: August 1, 1977
    Date of Patent: October 31, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Arpi Hagopian, Dennis J. Carlo, Thomas H. Stoudt
  • 3-(Substituted thio) cephalosporins, derivatives and nuclear analogues thereof
    Patent number: 4123528
    Abstract: Disclosed is a class of cephalosporins including the carba, aza and oxa nuclear analogues thereof which bear at the 3-position a substituted thio substituent; such compounds are useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: July 27, 1977
    Date of Patent: October 31, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Lovji D. Cama, Burton G. Christensen
  • Respiratory synctial vaccine
    Patent number: 4122167
    Abstract: By serially passaging virulent respiratory syncytial virus in human diploid lung fibroblasts, a non-pathogenic but antigenic live respiratory syncytial virus is produced. This virus is useful in preparing a live virus vaccine.
    Type: Grant
    Filed: August 17, 1977
    Date of Patent: October 24, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Eugene B. Buynak, Maurice R. Hilleman
  • 7-(Amidinothio)acetamido-7-methoxy cephalosporins
    Patent number: 4121041
    Abstract: New 7-(Amidinothio)acetamido-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxy lic acid compounds are prepared which are useful as antibacterial agents, especially Pseudomonas.
    Type: Grant
    Filed: February 4, 1977
    Date of Patent: October 17, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Robert F. Czaja, Edward J. J. Grabowski
  • 1,3,5-S-Hexahydrotrisubstituted triazines
    Patent number: 4119779
    Abstract: 1,3,5-s-Hexahydrotrisubstituted triazines exemplified by 1,3,5-tris(tetrahydrofurfuryl)-1,3,5-hexahydro-s-triazines are useful as antimicrobial agents particularly when employed as a component of metal-working compositions subject to fungal and bacterial attack.
    Type: Grant
    Filed: May 11, 1977
    Date of Patent: October 10, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Bruce E. Witzel
  • 7-Diacylimido cephalosporins
    Patent number: 4107432
    Abstract: New 7-diacylimido cephalosporins are produced by reacting 7-acylamido cephalosporins with an acylating agent in the presence of a silyl reagent. The 7-diacylimido cephalosporins are cleaved to produce cephalosporins containing a different acylamido moiety. Thus, the aminoadipoyl group of cephalosporins produced by fermentation is replaced by a different acyl group by the process of the present invention. The cephalosporins produced are antibiotics having enhanced activity against gram-negative and gram-positive pathogens.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: August 15, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Lovji D. Cama, Sandor Karady, Meyer Sletzinger
  • Process to prepare novel antibiotic compounds
    Patent number: 4102882
    Abstract: A process is provided which yields derivatives of cephalosporins and penicillins. The process starts with 7-acylaminocephalosporin, or 6-acylaminopenicillin, then the latter compounds are treated with an organolithium compound, followed with t-butyl-hypochlorite. Finally, a defined reagent is added yielding a side chain on the carbon adjacent to the amino-nitrogen. Novel intermediate compounds are also described. The end compounds prepared are active against both gram-positive and gram-negative bacteria.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: July 25, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Raymond A. Firestone, Lovji D. Cama, Burton G. Christensen
  • Novel dibicyclo [2.2.2] octyl and dibicyclo [2.2.2] octenyl polyamines and methods for their preparation
    Patent number: 4100193
    Abstract: Novel dibicyclo [2.2.2] octyl dibicyclo [2.2.2] octenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.
    Type: Grant
    Filed: June 10, 1976
    Date of Patent: July 11, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Process for preparing di-7-azido cephalosporin compounds
    Patent number: 4099000
    Abstract: A novel total synthesis process is provided, yielding cephalosporin or penicillin compounds. The process uses as starting material a glycine ester, which first is reacted to yield a dihydrothiazine, and subsequently condensed with azidoacetyl chloride to form the cepham nucleus, then dehydrated to yield the desired 3-unsaturation. Subsequent reduction and acylation steps are analogous to known chemistry. The end products are antibacterial agents.
    Type: Grant
    Filed: March 30, 1976
    Date of Patent: July 4, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ronald W. Ratcliffe
  • Fluorodehydroxylation of serine
    Patent number: 4096180
    Abstract: Organic compounds containing one or more alcoholic hydroxyl groups are transformed into fluorine compounds by reacting them with sulfur tetrafluoride in liquid hydrogen fluoride solution, at temperatures between around -80.degree. C. and +20.degree. C. The method can be descriptively termed "fluorodehydroxylation", because it represents the reaction:ROH.fwdarw.RF.
    Type: Grant
    Filed: January 3, 1977
    Date of Patent: June 20, 1978
    Assignee: Merck & Co., Inc.
    Inventor: Janos Kollonitsch
  • Chemical synthesis of flavipucine
    Patent number: 4094878
    Abstract: A method for the total chemical synthesis of flavipucine employs the condensation of 4-hydroxy-6-methyl-2-pyridone with isobutylglyoxal in alkali alkoxide. The resulting alkali salt is acylated in both the 1' and 4 positions. Treatment of the 1',4-diacyloxy derivative with excess alkaline peroxide yields flavipucine.
    Type: Grant
    Filed: May 19, 1977
    Date of Patent: June 13, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Norman L. Wendler, Narindar N. Girotra, Zbigniew S. Zelawski, deceased
  • 2-R-Substituted-1,2,5-thiadiazole-3-one antimicrobials
    Patent number: 4094986
    Abstract: 2-R-substituted-1,2,5-thiadiazole-3-ones have broad spectrum antibacterial and antifungal activity. They are especially useful in agriculture to protect plants against diseases such as leaf, stem, and fruit spotting, internal discoloration and decay of fruits and vegetables. These compounds are particularly active against diseases caused by the genera Pseudomonas, Xanthomonas, Erwinia, and Corynebacterium.
    Type: Grant
    Filed: July 5, 1977
    Date of Patent: June 13, 1978
    Assignee: M. S. & D. (I.A.) Corp.
    Inventors: Joshua Rokach, Grant W. Reader