Patents Represented by Attorney Julian S. Levitt

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  • Method for the preparation of di-bicyclo[3.1.1] and [2.2.1]heptyl and di-bicyclo-[3.1.1] and [2.2.1]heptenyl ketones
    Patent number: 4091020
    Abstract: Novel di-bicyclo[3.1.1] and [2.2.1]heptyl and dibicyclo[3.1.1] and [2.2.1]heptenyl ketones are useful as intermediates for preparing novel polyamines useful as antimicrobial agents, as well as algae inhibitors.
    Type: Grant
    Filed: August 23, 1976
    Date of Patent: May 23, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas
  • Hepatitis B surface antigen
    Patent number: 4088748
    Abstract: Biological fluid containing hepatitis B surface antigen is concentrated using ammonium sulfate, and subjected to an isopycnic banding followed by rate zonal banding.
    Type: Grant
    Filed: May 4, 1977
    Date of Patent: May 9, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Process for cephem synthesis
    Patent number: 4086423
    Abstract: Cephalosporin antibiotics of the formula: ##STR1## are produced by cycloaddition of a glycine derivative of the formula ##STR2## with a thiazine derivative of the formula ##STR3##
    Type: Grant
    Filed: October 21, 1975
    Date of Patent: April 25, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Raymond A. Firestone, Ronald W. Ratcliffe, Burton G. Christensen
  • Antibiotics
    Patent number: 4081548
    Abstract: The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: September 3, 1976
    Date of Patent: March 28, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Edward O. Stapley, Robert T. Goegelman, Sebastian Hernandez
  • Cell and vaccine production
    Patent number: 4080258
    Abstract: Production of cells and vaccines utilizing a multiplate propagator in which the fluid dynamics of the system can be controlled during the growth cycle and/or the harvesting conditions can be controlled by rapidly cooling the harvested vaccine or by using multiple harvests, with or without automated collection of the vaccine thereby producing cells and vaccines in significantly increased yields and at substantially reduced costs in comparison with presently utilized procedures.
    Type: Grant
    Filed: January 30, 1974
    Date of Patent: March 21, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Raymond E. Spier
  • 6-Loweralkoxy or loweralkylthio-3-cephem-4-carboxylic acids
    Patent number: 4079179
    Abstract: Cephalosporin compounds having a loweralkoxy or loweralkylthio substituent in the 6-position are prepared by a multi-step total synthesis route using as starting material a glycine ester, which first is reacted to yield a dihydrothiazine, and subsequently condensed with azidoacetyl chloride to form the cepham nucleus, then dehydrated to yield the desired 3-unsaturation. Subsequent reduction and acylation steps are analogous to known chemistry, and yield the novel 6-loweralkoxy- or loweralkylthio-7-amino intermediates and the antibacterially active 6-loweralkoxy or loweralkylthio-7-acylamido end products.
    Type: Grant
    Filed: March 30, 1976
    Date of Patent: March 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ronald W. Ratcliffe
  • Diphenyl derivatives of polyamine compounds having a piperidine moiety
    Patent number: 4079059
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: February 12, 1976
    Date of Patent: March 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • 3-(.beta.-Aminoethylidene)-6-(.alpha.-hyd roxyethyl)-7-oxo-4-oxaazabicyclo[3.]heptane-2-carboxylic acid and derivatives thereof
    Patent number: 4078068
    Abstract: 3-(.beta.-aminoethylidene)-6-(.alpha.-hydroxyethyl)-7-oxo-4-oxaazabicyclo[3 .2.0]heptane-2-carboxylic acid having the structural formula: ##STR1## and the pharmaceutically acceptable salt, ester and amide derivatives thereof are disclosed to be useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: April 12, 1976
    Date of Patent: March 7, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Robert B. Morin, Edward Walton
  • 3-(.beta .-Aminoethylidene)-7-oxo-4-oxaazabicyclo[3.2.0]heptane-2-carboxylic acid and derivatives thereof
    Patent number: 4078067
    Abstract: 3-(.beta.-aminoethylidene)-7-oxo-4-oxaazabicyclo [3.2.0]heptane-2-carboxylic acid and derivatives thereof having the structural formula: ##STR1## and the pharmaceutically acceptable salt, ester and amide derivatives thereof are disclosed to be useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: April 12, 1976
    Date of Patent: March 7, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Robert B. Morin, Edward Walton
  • 3-(.bet a.-Hydroxyethylidene)-6-(.alpha.-Hydroxyethyl)-7-oxo-4-oxaazabicyclo[3.2. 0]heptene-2-carboxylic acid and derivatives thereof
    Patent number: 4076826
    Abstract: 3-(.beta.-Hydroxyethylidene)-6-(.alpha.-Hydroxyethyl)-7-oxo-4-oxaazabicyclo [3.2.0]heptane-2-carboxylic acid having the structural formula: ##STR1## and the pharmaceutically acceptable salt, ester and amide derivatives thereof are disclosed to be useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: August 6, 1976
    Date of Patent: February 28, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Burton A. Christensen, Robert B. Morin, Edward Walton
  • Printing paste compositions containing sodium cellulose sulfate, and processes therefor
    Patent number: 4073653
    Abstract: Sodium cellulose sulfate can be used alone, or in combination with other natural or synthetic gums, as thickening agents for fabric printing paste compositions containing acid dyes. The printing paste is applied in the usual manner, and then the printed goods are heated. The sodium cellulose sulfate content of the paste, upon heating, fixes the acid dye on the printed goods, thereby eliminating the necessity of using acid or acid salts in printing pastes.
    Type: Grant
    Filed: February 10, 1976
    Date of Patent: February 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Thomas A. Lindroth, Joseph S. Racciato
  • Antibiotic A21A
    Patent number: 4071631
    Abstract: There is disclosed a new antibiotic A21A which is produced by cultivating the microorganism, Streptomyces filipinensis, in aqueous nutrient medium. The antibiotic has growth-improving activity.
    Type: Grant
    Filed: October 29, 1976
    Date of Patent: January 31, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Sheldon B. Zimmerman, John H. Chalmers, Jr.
  • Diphenyl polyamides having a cyclohexylene moiety
    Patent number: 4070400
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: October 16, 1975
    Date of Patent: January 24, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines
    Patent number: 4065497
    Abstract: Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: December 27, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Production of antibiotic FR-02A (efrotomycin) by streptomyces lactamdurans
    Patent number: 4065356
    Abstract: An antibiotic, designated FR-02A or efrotomycin, is obtained by culturing Streptomyces lactamdurans in a fermentation broth and extracting the whole broth with a water immiscible polar organic solvent to obtain the antibiotic FR-02A.
    Type: Grant
    Filed: March 1, 1977
    Date of Patent: December 27, 1977
    Assignee: Merck & Co., Inc.
    Inventors: William M. Maiese, Richard G. Wax
  • 7-Methoxy-3-phosphoranylidenemethyl-cephalosporins
    Patent number: 4064344
    Abstract: Novel 7-methoxy 3-phosphoranylidene cephem compounds which find utility as intermediates in the preparation of antibiotically active 7-methoxy-3-vinyl cephalosporins.
    Type: Grant
    Filed: April 14, 1976
    Date of Patent: December 20, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Thomas R. Beattie, Burton G. Christensen
  • Polyamine compounds as antibacterial agents
    Patent number: 4061775
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: September 2, 1975
    Date of Patent: December 6, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Cephalosporins having a 3-.alpha. substituted alkyl grouping
    Patent number: 4060687
    Abstract: Novel cephalosporin compounds having a 3'-.alpha.-methyl, a 3-aryl or 3-heterocycle substituent are prepared by total synthesis. The novel cephalosporin compounds are active against gram-negative and gram-positive microorganisms.
    Type: Grant
    Filed: October 23, 1975
    Date of Patent: November 29, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ronald W. Ratcliffe
  • Broad spectrum antibacterial compositions containing tris-(hydroxymethyl)-aminoethane and dicycloaliphatic-alkyl polyamines
    Patent number: 4060639
    Abstract: A composition comprising tris-(hydroxymethyl)aminomethane and dicyclohexyl-, dicyclohexenyl- and cyclohexylcyclohexenyl-alkyl polyamines, their acid addition salts, and mixtures thereof are useful as antibacterial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: November 29, 1977
    Assignee: Merck & Co., Inc.
    Inventors: David P. Jacobus, Eugene L. Dulaney, Nathaniel Grier
  • 7-Diacyl cephalosporins
    Patent number: 4058661
    Abstract: New 7-diacylimido cephalosporins are produced by reacting 7-acylamido cephalosporins with an acylating agent in the presence of a silyl reagent. The 7-diacylimido cephalosporins are cleaved to produce cephalosporins containing a different acylamido moiety. Thus, the aminoadipoyl group of cephalosporins produced by fermentation is replaced by a different acyl group by the process of the present invention. The cephalosporins produced are antibiotics having enhanced activity against gram-negative and gram-positive pathogens.
    Type: Grant
    Filed: April 7, 1975
    Date of Patent: November 15, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Lovji D. Cama, Burton G. Christensen, Sandor Karady, Meyer Sletzinger