Patents Represented by Attorney Julian S. Levitt

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  • Sag resistant Portland cement compositions
    Patent number: 4219362
    Abstract: Cold-water soluble tamarind gum is used to prepare portland cement compositions having improved anti-sag control.
    Type: Grant
    Filed: February 28, 1979
    Date of Patent: August 26, 1980
    Assignee: Merck & Co., Inc.
    Inventor: George T. Colegrove
  • Xanthan gum and locust bean gum in confectionery use
    Patent number: 4219582
    Abstract: From 0.08 to 0.50% (weight) of a 1:3 to 3:1 blend of xanthan gum and locust bean gum can be employed in high solids starch jelly confectionery products to decrease the setting time of such products.
    Type: Grant
    Filed: March 29, 1979
    Date of Patent: August 26, 1980
    Assignee: Merck & Co., Inc.
    Inventor: Hsiung Cheng
  • Suspension stabilization of MgO in liquid feed supplements using xanthan gum
    Patent number: 4219572
    Abstract: A high (4% to 6%) magnesium-containing liquid feed supplement is provided which has stable suspension properties over 1-8 weeks and which is flowable at 20.degree.-30.degree. F. and higher.
    Type: Grant
    Filed: January 22, 1979
    Date of Patent: August 26, 1980
    Assignee: Merck & Co., Inc.
    Inventor: Kristina R. Jackman
  • Process for the preparation of cephamycin antibiotics
    Patent number: 4218563
    Abstract: An improved process for preparing the antibiotic compound 7.beta.-(2-thienylacetamido)-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-car boxylic acid, from the N-blocked esters of the compound 7.beta.-(D-5-amino-5-carboxyvaleramido)-3-carbamoyloxymethyl-7-methoxy-3-c ephem-4-carboxylic acid (Cephamycin C), by conducting the transacylation of the latter in a homogenous solution containing N-trimethylsilyl loweralkyl carbamates.
    Type: Grant
    Filed: March 30, 1979
    Date of Patent: August 19, 1980
    Assignee: Merck & Co., Inc.
    Inventors: George M. Love, Paul Sohar, Leonard M. Weinstock
  • Trichostatin as an antiprotozoal agent
    Patent number: 4218478
    Abstract: Trichostatin (I) is disclosed to be useful as an antiprotozoal agent for the treatment of diseases in man and animals. Also disclosed are pharmaceutical compositions comprising trichostatin for treating protozoal infections.
    Type: Grant
    Filed: January 5, 1979
    Date of Patent: August 19, 1980
    Inventors: Satoshi Omura, Ruiko Oiwa
  • 3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
    Patent number: 4218463
    Abstract: Disclosed are 3-substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acids having the structure: ##STR1## wherein: R.sup.1 is hydrogen or acyl and R.sup.8 is, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: December 28, 1977
    Date of Patent: August 19, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ravindra N. Guthikonda, David B. R. Johnston, Susan M. Schmitt
  • 6-Amido-1-carba-2-penem-3-carboxylic acid
    Patent number: 4218459
    Abstract: Disclosed are 6-amido-1-carba-2-penem-3-carboxylic acids of the following structure: ##STR1## wherein R.sup.1 is hydrogen or acyl and R.sup.3 is, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl, and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: December 28, 1977
    Date of Patent: August 19, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Lovji D. Cama, Burton G. Christensen, Ravindra N. Guthikonda
  • 6-(1-Hydroxyethyl)-2-(2-aminoeth ylthio)-1-substituted-1-carbade-thiapen-2-em-3-carboxylic acids
    Patent number: 4218462
    Abstract: Disclosed are 1-substituted-6-(1-hydroxyethyl)-2-(2-aminoethylthio)-1-carbadethiapen-2-e m-3-carboxylic acids (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics; such compounds are prepared by total synthesis. ##STR1## wherein R.sup.1 is, inter alia, substituted and unsubstituted alkyl, aryl and aralkyl.
    Type: Grant
    Filed: October 24, 1978
    Date of Patent: August 19, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, David H. Shih
  • Recovery of small particles by flow centrifugation
    Patent number: 4217418
    Abstract: It has now been found that small size particles may be extracted from a proteinaceous liquid at a low flow rate in flow-centrifuge operation by precooling the liquid before it enters the centrifuge and by employing a multi-step gradient.
    Type: Grant
    Filed: March 9, 1979
    Date of Patent: August 12, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, William M. Hurni
  • 6-Amido-3-substitu ted-amino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid
    Patent number: 4217453
    Abstract: Disclosed are 6-amido-3-substituted-amino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxyli c acids (I): ##STR1## wherein R.sup.1 is hydrogen or acyl; and R' and R" are independently selected from the group consisting of: hydrogen, substituted and unsubstituted: alkyl and aralkyl, or together form a substituted or unsubstituted cyclic group. Such compounds and their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: July 24, 1978
    Date of Patent: August 12, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ravindra N. Guthikonda, Ronald W. Ratcliffe
  • Deacetylated borate-biosynthetic gum compositions
    Patent number: 4214912
    Abstract: This invention relates to a deacetylated borate-biosynthetic gum or a partially deacetylated borate-biosynthetic gum having improved dispersion characteristics. The invention also relates to a method of preparing such compositions.
    Type: Grant
    Filed: June 4, 1979
    Date of Patent: July 29, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Joseph S. Racciato, Ian W. Cottrell
  • Parainfluenza virus vaccine and its preparation
    Patent number: 4215107
    Abstract: By serially passaging virulent parainfluenza virus in tissue culture prepared from embryonated hens' eggs or human diploid lung fibroblasts, a live, non-pathogenic but antigenic live parainfluenza virus is produced. This virus is useful in preparing a live virus vaccine.
    Type: Grant
    Filed: December 29, 1978
    Date of Patent: July 29, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Eugene B. Buynak, Maurice R. Hilleman
  • 6 Substituted amino-2-substituted-pen-2-em-3-carboxylic acid
    Patent number: 4215124
    Abstract: Disclosed are 6-substituted amino-2-substituted-pen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein R.sup.1 is hydrogen or acyl, R.sup.2 is hydrogen or methoxyl, and R.sup.3 is inter alia, hydrogen, --R, --OR, --SR, --NR.sub.2, R is alkyl, aryl, aralkyl, heterocyclyl or heterocyclylalkyl; n is 0 or 1; when n=1, R.sup.3 is not --SR.Such compounds and their pharmaceutically acceptable salt, and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: October 10, 1978
    Date of Patent: July 29, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Frank P. DiNinno
  • Process for deacylating N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carbox ylic acids
    Patent number: 4212807
    Abstract: Disclosed is a process for chemically cleaving the acyl group from N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carboxyl ic acids which proceeds via an imino chloride intermediate. The acylated substrate and the deacylated product are antibiotics.
    Type: Grant
    Filed: August 10, 1978
    Date of Patent: July 15, 1980
    Assignee: Merck & Co., Inc.
    Inventor: Ronald W. Ratcliffe
  • Process for hydrolytically cleaving O-sulfo thienamycins
    Patent number: 4211707
    Abstract: Disclosed is a process for the hydrolytically cleaving O-sulfo thienamycins: ##STR1## wherein R is H or acetyl and M is H, an alkali or alkaline earth metal cation or an organo cationic species such as pyridinium; and wherein the dotted line indicates saturated and unsaturated species.
    Type: Grant
    Filed: August 10, 1978
    Date of Patent: July 8, 1980
    Assignee: Merck & Co., Inc.
    Inventor: Ronald W. Ratcliffe
  • Bacterial polysaccharide S-21 and complex thereof
    Patent number: 4211774
    Abstract: A high-viscosity heteropolysaccharide composed of 33% mannose, 29% glucose, 21% galactose and 17% glucuronic acid, and containing 5.7% acetyl and 4.9% pyruvate.
    Type: Grant
    Filed: March 23, 1978
    Date of Patent: July 8, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth S. Kang, George T. Veeder, III
  • Process for the preparation of 3-carbamoyl cephalosporins using isocyanates
    Patent number: 4210750
    Abstract: Alcohols are reacted with certain isocyanate compounds to produce the N-substituted carbamoyloxy derivatives which are cleaved to obtain the carbamate.
    Type: Grant
    Filed: November 17, 1976
    Date of Patent: July 1, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Stephen Marburg, Janos Kollonitsch
  • 1-Substituted-pen-2-em-3-carboxylic acids
    Patent number: 4208422
    Abstract: Disclosed are 1-substituted-pen-2-em-3-carboxylic acids (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics; such compounds are prepared by total synthesis. ##STR1## wherein R.sup.1 is, inter alia, substituted and unsubstituted alkyl, aryl and aralkyl.
    Type: Grant
    Filed: October 24, 1978
    Date of Patent: June 17, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, David H. Shih
  • O-Derivatives of thienamycin
    Patent number: 4208330
    Abstract: Disclosed are O- derivatives (esters and ethers of the secondary alcohol group) of the antibiotic thienamycin which has the following structure: ##STR1## Such derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives, and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: December 16, 1977
    Date of Patent: June 17, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, William J. Leanza
  • Process for deacylating N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carbox ylic acids
    Patent number: 4207395
    Abstract: Disclosed is a process for enzymatically cleaving the acyl group from N-acyl-6-substituted-2-substituted-1-carbadethiapen-2-em-3-carboxylic acids. The acylated substrate and the deacylated product are antibiotics.
    Type: Grant
    Filed: November 2, 1978
    Date of Patent: June 10, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Patrick J. Cassidy, Jean S. Kahan