Patents Represented by Attorney Julian S. Levitt

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  • Carboxyl derivatives of thienamycin
    Patent number: 4181733
    Abstract: Disclosed are carboxyl derivatives, i.e., esters, anhydrides and amides, of the antibiotic thienamycin, which has the following structure: ##STR1## Such derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives, and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: December 16, 1977
    Date of Patent: January 1, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Raymond A. Firestone
  • 6.beta.-Bromo penicillanic acid
    Patent number: 4180506
    Abstract: 6.beta.-Bromo penicillanic acid is a novel compound which is an antibacterial agent as well as a potent .beta.-lactamase inhibitor.
    Type: Grant
    Filed: January 18, 1978
    Date of Patent: December 25, 1979
    Inventor: Rex Pratt
  • Compositions for stabilizing soft serve and hard frozen yogurt
    Patent number: 4178390
    Abstract: This invention relates to a stabilizer for soft serve and hard frozen yogurt. The stabilizer blend which consists of propylene glycol alginate, sodium alginate, guar, carrageenan and an emulsifier.
    Type: Grant
    Filed: December 14, 1977
    Date of Patent: December 11, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Robert S. Igoe
  • Process for producing antibiotic A21A
    Patent number: 4175007
    Abstract: Antibiotic A21A is produced by cultivating Stneptomyces filipinesis under aerobic conditions.
    Type: Grant
    Filed: November 21, 1977
    Date of Patent: November 20, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Sheldon B. Zimmerman, John H. Chalmers, Jr.
  • Method for preparing hepatitis B immune globulin
    Patent number: 4174388
    Abstract: Hepatitis B immune globulin is prepared from individuals who exhibit an increase in hepatitis B surface antibody of at least 2,000 PHA units/ml following immunization with hepatitis B surface antigen.
    Type: Grant
    Filed: July 19, 1978
    Date of Patent: November 13, 1979
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • 4-Iodomethylazetidin-2-one
    Patent number: 4174316
    Abstract: Disclosed is a process for preparing 7-(1-hydroxethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and its pharmaceutically acceptable salts and esters (I) by total synthesis starting with L-aspartic acid and proceeding via intermediates II and IIa (4-iodomethylazetidin-2-one): ##STR1##
    Type: Grant
    Filed: August 14, 1978
    Date of Patent: November 13, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ronald W. Ratcliffe, Thomas N. Salzmann
  • Preparation of carbamates
    Patent number: 4173703
    Abstract: Alcohols are reacted with silylated isocyanate compounds to produce the N-substituted carbamoyloxy derivatives which are cleaved to obtain the carbamate.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: November 6, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Floyd E. Roberts
  • 6-(1'-Hydroxyethyl)-2-aminoethylthio-oxapen-2-em-3-carboxylic acid
    Patent number: 4172895
    Abstract: Disclosed is 6-(1'-Hydroxyethyl)-2-aminoethylthiooxapen-2-em-3-carboxylic acid: ##STR1## Such compound and its pharmaceutically acceptable salt and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: December 28, 1977
    Date of Patent: October 30, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Frank P. DiNinno
  • Substituted 3-oxo-6-thia-2-azabicyclo (2.2.0) hexanes
    Patent number: 4172837
    Abstract: Disclosed is the antibiotic 5-methyl-2-(1-carboxyl-2-methyl-propen-1-yl)-3-oxo-6-thia-2-azabicyclo [2.2.0] hexane (I): ##STR1## Also disclosed are processes for preparing I and its pharmaceutically acceptable salts and esters; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: September 11, 1978
    Date of Patent: October 30, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Frank P. Di Ninno
  • Schiff's base derivatives of thienamycin
    Patent number: 4172144
    Abstract: Disclosed are Schiff's base derivatives of the antibiotic thienamycin, which has the following structure: ##STR1## Such compounds and their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives, and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: May 19, 1978
    Date of Patent: October 23, 1979
    Assignee: Merck & Co., Inc.
    Inventors: F. Aileen Bouffard, Burton G. Christensen, Nathan G. Steinberg
  • Polyamine compounds
    Patent number: 4172094
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: December 3, 1976
    Date of Patent: October 23, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Direct acidified yogurt
    Patent number: 4169854
    Abstract: A direct acidified yogurt is prepared from milk, a thickener blend containing starch, sodium carboxymethyl cellulose, xanthan gum and locust bean gum, and optionally a carbohydrate sweetener. To prepare yogurt, the thickener blend is mixed with milk, the mixture is pasteurized, an acidulent is added and the acidified mixture is subjected to a shearing treatment to produce a yogurt-like texture.
    Type: Grant
    Filed: May 12, 1977
    Date of Patent: October 2, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Robert S. Igoe
  • Process for isolating thienamycin
    Patent number: 4168268
    Abstract: Fermentation broths or impure solutions containing thienamycin, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are isolated using liquid ion exchange systems.
    Type: Grant
    Filed: August 24, 1978
    Date of Patent: September 18, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Rathin Datta, George T. Wildman
  • 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
    Patent number: 4168314
    Abstract: Disclosed is 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid: ##STR1## Such compound and its pharmaceutically acceptable salt and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: November 17, 1977
    Date of Patent: September 18, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Frank P. DiNinno
  • Process for producing antibiotics
    Patent number: 4168202
    Abstract: The antibiotics MSD 890A.sub.2 and MSD 890A.sub.5 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.2 and 890A.sub.5) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: July 8, 1977
    Date of Patent: September 18, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Patrick J. Cassidy, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
  • N-acetyl thienamycin
    Patent number: 4165379
    Abstract: The antibiotic N-acetyl thienamycin and its non-toxic pharmaceutically acceptable salts are active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a species of Streptomyces on suitable fermentation media or alternatively by acetylation of thienamycin.
    Type: Grant
    Filed: August 25, 1977
    Date of Patent: August 21, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
  • Riboflavin purification
    Patent number: 4165250
    Abstract: Riboflavin is recovered from fermentation broth by diluting the broth with a predetermined quantity of water, centrifuging the diluted broth to form a sludge, resuspending the sludge with a predetermined quantity of water, and centrifuging the resuspended sludge to yield a product usuable directly as an animal feed supplement or suitable for further purification for pharmaceutical use. Optionally the broth or resuspended sludge is treated with an enzyme before centrifugation.
    Type: Grant
    Filed: November 14, 1977
    Date of Patent: August 21, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Albert Epstein, Glen Graham, William A. Sklarz
  • Hepatitis a virus cell culture in vitro
    Patent number: 4164566
    Abstract: Hepatitis A virus is passaged at least once in a susceptible sub-human primate; the infected liver from such passage is used to inoculate an in vitro cell culture, the inoculated cell culture is incubated until hepatitis A antigen is detected in the cell sheet or culture fluid, and at least two serial in vitro passages in cell culture are carried out. The hepatitis A virus so modified can be used to prepare live, attenuated hepatitis A vaccine or an inactivated hepatitis A vaccine.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: August 14, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Philip J. Provost, Maurice R. Hilleman
  • Citrus fruit juice and drink
    Patent number: 4163807
    Abstract: Appearance, taste and stability of citrus fruit juices and drinks are improved by incorporating xanthan gum and CMC.
    Type: Grant
    Filed: March 15, 1978
    Date of Patent: August 7, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Kristina R. Jackman
  • Antibiotic N-acetyl-dehydro-thienamycin
    Patent number: 4162323
    Abstract: Antibiotic N-acetyl-dehydro-thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a species of Streptomyces in suitable fermentation media.
    Type: Grant
    Filed: April 18, 1977
    Date of Patent: July 24, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Jean S. Kahan