Patents Represented by Attorney Morris L. Nielsen

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  • 9-Deoxy-6,9.alpha.-epoxymethano-PG C-1 alcohols
    Patent number: 4206303
    Abstract: Processes for preparing prostacyclin analogs which are 9-deoxy-6,9-epoxymethano derivatives of prostaglandin F.sub.1.alpha. -type compounds, illustrated, for example, by a compound of the formula ##STR1## wherein .about. indicates alpha or beta configuration; including the products and intermediates produced therein, said products having pharmacological utility.
    Type: Grant
    Filed: September 11, 1978
    Date of Patent: June 3, 1980
    Assignee: The Upjohn Company
    Inventor: Robert C. Kelly
  • Esters of 9-deoxy-6,9 .alpha.-epoxymethano-pg analogs
    Patent number: 4206304
    Abstract: Processes for preparing prostacyclin analogs which are 9-deoxy-6,9-epoxymethano derivatives of prostaglandin F.sub.1.alpha. -type compounds, illustrated, for example, by a compound of the formula ##STR1## wherein .about. indicates alpha or beta configuration; including the products and intermediates produced therein, said products having pharmacological utility.
    Type: Grant
    Filed: September 11, 1978
    Date of Patent: June 3, 1980
    Assignee: The Upjohn Company
    Inventor: Robert C. Kelly
  • 6-Keto prostaglandin E-type compounds
    Patent number: 4205178
    Abstract: Prostaglandin E (PGE)-type derivatives and analogs having a 6-keto feature are disclosed, including processes for preparing them and the appropriate intermediates, said derivatives having pharmacological activity.A typical 6-keto compound is 6-keto-PGE.sub.
    Type: Grant
    Filed: September 2, 1977
    Date of Patent: May 27, 1980
    Assignee: The Upjohn Company
    Inventor: Udo F. Axen
  • Enlarged-hetero-ring prostacyclin analogs
    Patent number: 4200739
    Abstract: Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, together with a 9-deoxy-9-hydroxymethyl feature for example ##STR1## or (2) a 9-deoxy-6,9-epoxymethano feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## or a 5,6-didehydro feature, for example in an enol ether of the formula ##STR3## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: August 21, 1978
    Date of Patent: April 29, 1980
    Assignee: The Upjohn Company
    Inventor: Robert C. Kelly
  • 6-Keto prostaglandin derivatives
    Patent number: 4197257
    Abstract: Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, for example ##STR1## and amides thereof or (2) a 9-deoxy-6,9-epoxy feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: November 9, 1978
    Date of Patent: April 8, 1980
    Assignee: The Upjohn Company
    Inventor: Udo F. Axen
  • Prostaglandin derivatives
    Patent number: 4196283
    Abstract: Prostaglandin (PG.sub.1 derivatives having (1) a 5-keto feature, for example ##STR1## or (2) a 9-deoxy-5,9-epoxy feature together with a 4-halo or 5-hydroxy feature, for example ##STR2## or a 4,5-didehydro feature, for example in an enol ether of the formula ##STR3## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: August 11, 1978
    Date of Patent: April 1, 1980
    Assignee: The Upjohn Company
    Inventor: Roy A. Johnson
  • Methylenecyclopentane derivatives
    Patent number: 4195178
    Abstract: Methylenecyclopentane derivatives, for example ##STR1## wherein R.sub.2 is a blocking group such as tetrahydropyranyl, and a process for preparing them; said derivatives having utility as prostaglandin intermediates.
    Type: Grant
    Filed: October 2, 1978
    Date of Patent: March 25, 1980
    Assignee: The Upjohn Company
    Inventor: Douglas R. Morton, Jr.
  • Enlarged-hetero-ring prostacyclin analogs
    Patent number: 4192808
    Abstract: Prostaglandin (PG.sub.1 derivatives having (1) a 5-keto feature, for example ##STR1## or (2) a 9-deoxy-5,9-epoxy feature together with a 4-halo or 5-hydroxy feature, for example ##STR2## or a 4,5-didehydro feature, for example in an enol ether of the formula ##STR3## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: August 11, 1978
    Date of Patent: March 11, 1980
    Assignee: The Upjohn Company
    Inventor: Roy A. Johnson
  • Enlarged-hetero-ring prostacyclin analogs
    Patent number: 4191691
    Abstract: Prostaglandin (PG.sub.1, derivatives having (1) a 5-keto feature, for example ##STR1## or (2) a 9-deoxy-5,9-epoxy feature together with a 4-halo or 5-hydroxy feature, for example ##STR2## or a 4,5-didehydro feature, for example in an enol ether of the formula ##STR3## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: August 11, 1978
    Date of Patent: March 4, 1980
    Assignee: The Upjohn Company
    Inventor: Roy A. Johnson
  • 5-Halo PGI compounds
    Patent number: 4191824
    Abstract: Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, for example ##STR1## or (2) a 9-deoxy-6,9-epoxy feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: November 9, 1978
    Date of Patent: March 4, 1980
    Assignee: The Upjohn Company
    Inventor: Udo F. Axen
  • Phenyl-substituted 5,6-dihydro-prostacyclin analogs
    Patent number: 4188468
    Abstract: 5,6-Dihydro-prostacyclin (PGI.sub.1) analogs substituted with hydroxyphenyl groups, illustrated for example, by a compound of the formula ##STR1## i.e. 9-deoxy-6S,9.alpha.-epoxy-17-(o-hydroxyphenyl)-18,19,20-trinor-PGF.sub.1, said products having pharmacological utility.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: February 12, 1980
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxymethyl-5,6-dihydro-proslacylin analogs
    Patent number: 4187224
    Abstract: 2-Decarboxy-2-hydroxymethyl-5,6-dihydro-prostacyclin analogs (PGI.sub.1 derivatives) illustrated by a compound of the formula ##STR1## wherein .about. indicates alpha or beta configuration, and the processes for producing them, said analogs having pharmacological utility.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: February 5, 1980
    Assignee: The Upjohn Company
    Inventor: Udo F. Axen
  • 5-Keto prostaglandin F.alpha. analogs
    Patent number: 4181808
    Abstract: Prostaglandin (PG.sub.1 derivatives having (1) a 5-keto feature, for example ##STR1## or (2) a 9-deoxy-5,9-epoxy feature together with a 4-halo or 5-hydroxy feature, for example ##STR2## or a 4,5-didehydro feature, for example in an enol ether of the formula ##STR3## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: August 11, 1978
    Date of Patent: January 1, 1980
    Assignee: The Upjohn Company
    Inventor: Roy A. Johnson
  • Methylenecyclopentane derivatives
    Patent number: 4181798
    Abstract: Methylenecyclopentane derivatives, for example ##STR1## wherein R.sub.2 is a blocking group such as tetrahydropyranyl, and a process for preparing them; said derivatives having utility as prostaglandin intermediates.
    Type: Grant
    Filed: October 2, 1978
    Date of Patent: January 1, 1980
    Assignee: The Upjohn Company
    Inventor: Douglas R. Morton, Jr.
  • Acyl-substituted phenyl esters of prostacyclin-type compounds
    Patent number: 4180657
    Abstract: Acyl-substituted phenyl esters of prostacyclin-type compounds, for example the 4-acetylphenyl ester of prostacyclin (PGI.sub.2) illustrated by the formula ##STR1## and including esters of the isomeric 6-hydroxy-PGI.sub.1 and 6-keto-PGF.sub.1 .alpha. compounds, said esters having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: August 14, 1978
    Date of Patent: December 25, 1979
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Enlarged-hetero-ring prostacyclin analogs
    Patent number: 4178440
    Abstract: Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, together with a 9-deoxy-9-hydroxymethyl feature for example ##STR1## or (2) a 9-deoxy-6,9-epoxymethano feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## or a 5,6-didehydro feature, for example in an enol ether of the formula ##STR3## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: August 21, 1978
    Date of Patent: December 11, 1979
    Assignee: The Upjohn Company
    Inventor: Robert C. Kelly
  • Enlarged-hetero-ring prostacylin analogs
    Patent number: 4178441
    Abstract: Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, together with a 9-deoxy-9-hydroxymethyl feature for example ##STR1## or (2) a 9-deoxy-6,9-epoxymethano feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## or a 5,6-didehydro feature, for example in an enol ether of the formula. ##STR3## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: August 21, 1978
    Date of Patent: December 11, 1979
    Assignee: The Upjohn Company
    Inventor: Robert C. Kelly
  • 4,5,6-Trinor-3,7,-inter-m-phenylene prostaglandin A.sub.1 analogs
    Patent number: 4175202
    Abstract: This invention is a group of 4,5,6-trinor-3,7-inter-m-phenylene prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including hypotensive control and inhibition of platelet aggregation.A typical formula for a PGA.sub.
    Type: Grant
    Filed: June 29, 1978
    Date of Patent: November 20, 1979
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Phenacyl ester of PGF.sub.2 .alpha.
    Patent number: 4172206
    Abstract: The phenacyl ester of PGF.sub.2 .alpha. represented by the formula ##STR1## is disclosed. The compound is useful for the same pharmacological and medical purposes as PGF.sub.2 .alpha., is useful in crystalline form as a convenient form for ease of handling, administering, and purifying.
    Type: Grant
    Filed: April 26, 1978
    Date of Patent: October 23, 1979
    Assignee: The Upjohn Company
    Inventor: Frank H. Lincoln
  • Tri-halo prostaglandin intermediates
    Patent number: 4171447
    Abstract: Prostaglandin E (PGE)-type derivatives and analogs having a 6-keto feature are disclosed, including processes for preparing them and the appropriate intermediates, said derivatives having pharmacological activity.A typical 6-keto compound is 6-keto-PGE.sub.
    Type: Grant
    Filed: May 10, 1978
    Date of Patent: October 16, 1979
    Assignee: The Upjohn Company
    Inventor: Herman W. Smith