Patents Represented by Attorney Morris L. Nielsen
  • Patent number: 3983158
    Abstract: This invention is a group of 3-oxa and 4-oxa phenyl-substituted PGE type, PGF type, PGA type and PGB type compounds, and processes for making those. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: October 23, 1975
    Date of Patent: September 28, 1976
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • Patent number: 3983163
    Abstract: 5-Oxa phenyl- and phenoxy-substituted prostaglandin-.beta..sub.1 type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including stimulation of epidermal proliferation and keratinization, and wound healing.
    Type: Grant
    Filed: November 18, 1974
    Date of Patent: September 28, 1976
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 3983157
    Abstract: This invention is a group of 3-oxa and 4-oxa phenyl-substituted PGE type, PGF type, PGA type and PGB type compounds, and processes for making those. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: October 23, 1975
    Date of Patent: September 28, 1976
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • Patent number: 3983165
    Abstract: This invention is a group of 8-beta, 12-alpha-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: September 28, 1976
    Assignee: The Upjohn Company
    Inventor: Ernest W. Yankee
  • Patent number: 3981902
    Abstract: 5-Oxa-prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: December 6, 1974
    Date of Patent: September 21, 1976
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 3980692
    Abstract: 5-Oxa-prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: December 6, 1974
    Date of Patent: September 14, 1976
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 3980694
    Abstract: This invention is a group of 3-oxa and 4-oxa phenyl-substituted PGE type, PGF type, PGA type and PGB type compounds, and processes for making those. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: October 23, 1975
    Date of Patent: September 14, 1976
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • Patent number: 3979439
    Abstract: This invention is a group of 8-beta, 12-alpha-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: September 7, 1976
    Assignee: The Upjohn Company
    Inventor: Ernest W. Yankee
  • Patent number: 3979440
    Abstract: Phenacyl-type esters of PGE.sub.2, PGE.sub.1, and 13,14-dihydro-PGE.sub.1 and their 15-methyl, 16,16-dimethyl, and 17-phenyl analogs, including the respective 15(R)epimers, are disclosed, represented by the formula ##EQU1## wherein M is ##EQU2## wherein R.sub.3 is hydrogen or methyl; wherein Q is ##EQU3## wherein each of R.sub.4 and R.sub.5 is hydrogen or methyl, being the same or different, or ##SPC1##Wherein the moiety -C.sub.t H.sub.2t - represents a valence bond or alkylene of one to 10 carbon atoms, inclusive, with one to 7 carbon atoms, inclusive, between ##EQU4## and the phenyl ring; wherein R.sub.1 is phenyl, p-bromophenyl, p-biphenylyl, p-nitrophenyl, p-benzamidophenyl, or 2-naphthyl; wherein R.sub.2 is hydrogen or benzoyl; and wherein (a) X is --CH.sub.2 CH.sub.2 -- or trans-CH=CH- and Y is -CH.sub.2 CH.sub.2 --, or (b) X is trans-CH=CH- and Y is cis-CH=CH-.
    Type: Grant
    Filed: September 9, 1975
    Date of Patent: September 7, 1976
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • Patent number: 3979438
    Abstract: This invention is a group of 8-beta, 12-alpha-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: September 7, 1976
    Assignee: The Upjohn Company
    Inventor: Ernest W. Yankee
  • Patent number: 3979435
    Abstract: This invention is a group of 8-beta, 12-alpha-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: September 7, 1976
    Assignee: The Upjohn Company
    Inventor: Ernest W. Yankee
  • Patent number: 3978112
    Abstract: This invention is a group of 8-.beta., 12-.alpha.-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: August 31, 1976
    Assignee: The Upjohn Company
    Inventor: Ernest W. Yankee
  • Patent number: 3978110
    Abstract: This invention is a group of 8-.beta., 12-.alpha.-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: August 31, 1976
    Assignee: The Upjohn Company
    Inventor: Ernest W. Yankee
  • Patent number: 3978114
    Abstract: This invention is a group of 8-.beta., 12-.alpha.-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: August 31, 1976
    Assignee: The Upjohn Company
    Inventor: Ernest W. Yankee
  • Patent number: 3978111
    Abstract: This invention is a group of 8-.beta., 12-.alpha.-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: August 31, 1976
    Assignee: The Upjohn Company
    Inventor: Ernest W. Yankee
  • Patent number: 3978113
    Abstract: This invention is a group of 8-.beta., 12-.alpha.-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: August 31, 1976
    Assignee: The Upjohn Company
    Inventor: Ernest W. Yankee
  • Patent number: 3975426
    Abstract: This invention is a group of 8-beta, 12-alpha-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: August 17, 1976
    Assignee: The Upjohn Company
    Inventor: Ernest W. Yankee
  • Patent number: 3975404
    Abstract: Intermediates useful for preparing prostaglandin-type compounds with an alkoxy group replacing the hydroxyl at the C-15 position are disclosed. These products are useful for the same pharmacological properties as the unsubstituted prostaglandins.
    Type: Grant
    Filed: February 20, 1975
    Date of Patent: August 17, 1976
    Assignee: The Upjohn Company
    Inventors: Frank H. Lincoln, Jr., John E. Pike, Gilbert A. Youngdale
  • Patent number: 3974193
    Abstract: Prostaglandin-type compounds with one or two fluoro substituents at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 21, 1975
    Date of Patent: August 10, 1976
    Assignee: The Upjohn Company
    Inventor: Barney J. Magerlein
  • Patent number: 3974190
    Abstract: Prostaglandin-type compounds with one or two fluoro substituents at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 21, 1975
    Date of Patent: August 10, 1976
    Assignee: The Upjohn Company
    Inventor: Barney J. Magerlein