Patents Represented by Attorney Morris L. Nielsen

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  • Phenacyl-type esters of PGA.sub.1 and PGA.sub.2
    Patent number: 4080506
    Abstract: Phenacyl-type esters of PGA.sub.1 and PGA.sub.2 are disclosed, represented by the formula ##STR1## wherein R.sub.1 is phenyl, p-bromophenyl, p-biphenylyl, p-nitrophenyl, p-benzamidophenyl, or 2-naphthyl; wherein R.sub.2 is hydrogen or benzoyl; and wherein Y is --CH.sub.2 CH.sub.2 -- or cis--CH.dbd.CH--. The products are useful for the same pharmacological and medical purposes as the corresponding prostaglandins and analogs, and are also useful as a means of obtaining highly purified products.
    Type: Grant
    Filed: August 14, 1974
    Date of Patent: March 21, 1978
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • 4,5-Cis-didehydro-PGE.sub.1 analogs
    Patent number: 4063026
    Abstract: This invention is a group of 4,5-didehydro PG.sub.1 (prostaglandin-type) analogs having variable chain length, branching and fluoro substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: November 7, 1975
    Date of Patent: December 13, 1977
    Assignee: The Upjohn Company
    Inventor: Barney J. Magerlein
  • Substituted phenyl esters of PGA.sub.2
    Patent number: 4058551
    Abstract: Substituted esters of PGA.sub.2, 15-alkyl-PGA.sub.2, and 15(R)-15-alkyl-PGA.sub.2, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as PGA.sub.2, 15-alkyl-PGA.sub.2, and 15(R)-15-alkyl-PGA.sub.2, and are also useful as a means for obtaining highly purified PGA.sub.2, 15-alkyl-PGA.sub.2, and 15(R)-15-alkyl-PGA.sub.2 products.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: November 15, 1977
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • Cyano intermediates for prostaglandins
    Patent number: 4055563
    Abstract: Intermediates for preparing prostaglandins, represented by the formula ##STR1## wherein L.sub.3 represents ##STR2## and wherein R.sub.25 is hydrogen or tetrahydropyranyl or similar group as defined herein. These cyano intermediates are useful intermediates in preparing prostaglandin analogs having pharmacological utility.
    Type: Grant
    Filed: June 11, 1976
    Date of Patent: October 25, 1977
    Assignee: The Upjohn Company
    Inventor: David R. White
  • Tricyclic prostaglandin intermediates
    Patent number: 4053485
    Abstract: Process for preparing bicyclic diols of the formula ##STR1## wherein C.sub.p H.sub.2p is a valence bond or alkylene of one to 4 carbon atoms, inclusive, with one or 2 carbon atoms in the chain between the phenylene ring and --O--; wherein Y is a hydrocarbyl or substituted hydrocarbly group; and wherein indicates attachment to the cyclopropane ring in exo or endo configuration. These diols and the intermediates prepared herein are useful intermediates in preparing prostaglandin analogs having pharmacological utility.
    Type: Grant
    Filed: July 26, 1976
    Date of Patent: October 11, 1977
    Assignee: The Upjohn Company
    Inventor: Douglas R. Morton, Jr.
  • Process for bicyclic lactone dials
    Patent number: 4048193
    Abstract: Process for preparing bicyclic lactone diols of the formula ##STR1## wherein W is 1-pentyl, cis 1-pent-2-enyl, or 1-pent-2-ynyl by way of a cyclic ortho ester; and the intermediates prepared therein. The diols are useful intermediates in preparing prostaglandins having pharmacological utility.
    Type: Grant
    Filed: June 4, 1975
    Date of Patent: September 13, 1977
    Assignee: The Upjohn Company
    Inventor: Robert C. Kelly
  • Substituted phenyl esters of PGA.sub.2
    Patent number: 4042606
    Abstract: Substituted esters of PGA.sub.2, 15-alkyl-PGA.sub.2, and 15(R)-15-alkyl-PGA.sub.2, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as PGA.sub.2, 15-alkyl-PGA.sub.2, and 15(R)-15-alkyl-PGA.sub.2, and are also useful as a means for obtaining highly purified PGA.sub.2, 15-alkyl-PGA.sub.2, and 15(R)-15-alkyl-PGA.sub.2 products.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: August 16, 1977
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • 4,5-Cis-didehydro-PGE.sub.1 compounds
    Patent number: 4041066
    Abstract: This invention is a group of 4,5-didehydro and 4,5,17,18-tetrahydro PG.sub.1 (prostaglandin-type) compounds, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: September 9, 1975
    Date of Patent: August 9, 1977
    Assignee: The Upjohn Company
    Inventors: Bengt Samuelsson, Barney J. Magerlein
  • Oxa phenylene prostaglandin analogs
    Patent number: 4032560
    Abstract: Process for preparing bicyclic diols of the formula ##STR1## wherein C.sub.p H.sub.2p is a valence bond or alkylene of one to 4 carbon atoms, inclusive, with one or 2 carbon atoms in the chain between the phenylene ring and --0--; wherein Y is a hydrocarbyl or substituted hydrocarbyl group; and wherein .about. indicates attachment to the cyclopropane ring in exo or endo configuration. These diols and the intermediates prepared herein are useful intermediates in preparing prostaglandin analogs having pharmacological utility.
    Type: Grant
    Filed: July 26, 1976
    Date of Patent: June 28, 1977
    Assignee: The Upjohn Company
    Inventor: Douglas R. Morton, Jr.
  • Bicyclic intermediates for preparing 16-alkylated prostaglandin analogs
    Patent number: 4031081
    Abstract: Prostaglandin-type compounds with one or two fluoro substituents at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 21, 1975
    Date of Patent: June 21, 1977
    Assignee: The Upjohn Company
    Inventor: Barney J. Magerlein
  • Phenyl-substituted prostaglandin-e type analogs
    Patent number: 4029814
    Abstract: This invention is a group of phenyl-substituted PGE-type, PGF-type, PGA-type and PGB-type compounds, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: September 22, 1976
    Date of Patent: June 14, 1977
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • Bicyclo [3.1.0]hexane-3-one derivatives of 11-deoxy PGE
    Patent number: 4020097
    Abstract: This invention is a group of 4,5,6-trinor-3,7-inter-m-phenylene prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including hypotensive control and inhibition of platelet aggregation.
    Type: Grant
    Filed: May 7, 1976
    Date of Patent: April 26, 1977
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Substituted tolyl esters of 16-substituted-PGE.sub.2 -type compounds
    Patent number: 4017535
    Abstract: Substituted phenyl and naphthyl esters of PGE.sub.2 analogs, including the 16-alkyl, 16-fluoro, 16-phenoxy, and phenyl-substituted analogs, and their 15-epimers, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as these PGE.sub.2 analogs, and are also useful as a means for obtaining highly purified 16,16-dimethyl-PGE.sub.2, 16-phenoxy-17,18,19,20-tetranor-PGE.sub.2, and 17-phenyl-18,19,20-trinor-PGE.sub.2.
    Type: Grant
    Filed: November 21, 1975
    Date of Patent: April 12, 1977
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • Substituted phenyl esters of PGA.sub.1
    Patent number: 4013693
    Abstract: Substituted phenyl and naphthyl esters of PGA.sub. 1, 15-alkyl-PGA.sub.1, and 15(R)-15-alkyl-PGA.sub.1, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as PGA.sub.1, 15-alkyl-PGA.sub.1, and 15(R)-15-alkyl-PGA.sub.1, and are also useful as a means for obtaining highly purified PGA.sub.1, 15-alkyl-PGA.sub.1, and 15(R)-15-alkyl-PGA.sub.1 products.
    Type: Grant
    Filed: April 21, 1976
    Date of Patent: March 22, 1977
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • Substituted phenyl esters of PGA.sub.1
    Patent number: 4013707
    Abstract: Substituted phenyl and naphthyl esters of PGA.sub.1, 15-alkyl-PGA.sub.1, and 15(R)-15-alkyl-PGA.sub.1, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as PGA.sub.1, 15-alkyl-PGA.sub.1, and 15(R)-15-alkyl-PGA.sub.1, and are also useful as a means for obtaining highly purified PGA.sub.1, 15-alkyl-PGA.sub.1, and 15(R)-15-alkyl-PGA.sub.1 products.
    Type: Grant
    Filed: April 21, 1976
    Date of Patent: March 22, 1977
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • Substituted phenyl esters of PGE.sub.1 -type prostaglandins
    Patent number: 4012427
    Abstract: Substituted phenyl and naphthyl esters of PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1, and are also useful as a means for obtaining highly purified PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1 products.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: March 15, 1977
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • Process for preparing 5-oxa prostaglandin analogs
    Patent number: 4011257
    Abstract: Process for preparing 5-oxa phenyl- and phenoxy-substituted prostaglandin-type compounds. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 26, 1976
    Date of Patent: March 8, 1977
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Substituted keto and alkoxy carbonyl esters of 16-substituted PGE.sub.2 type compounds
    Patent number: 4011249
    Abstract: Substituted phenyl and naphthyl esters of PGE.sub.2 analogs, including the 16-alkyl, 16-fluoro, 16-phenoxy, and phenyl-substituted analogs, and their 15-epimers, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as these PGE.sub.2 analogs, and are also useful as a means for obtaining highly purified 16,16-dimethyl-PGE.sub.2, 16-phenoxy-17,18,19,20-tetranor-PGE.sub.2, and 17-phenyl-18,19,20-trinor-PGE.sub.2.
    Type: Grant
    Filed: November 21, 1975
    Date of Patent: March 8, 1977
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • 5-Oxa phenyl- and phenoxy-substituted prostaglandin A.sub.1 analogs
    Patent number: 4010194
    Abstract: 5-Oxa phenyl- and phenoxy-substituted prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer by inhibition of gastric secretion, reduction of blood pressure, and increase of blood flow.
    Type: Grant
    Filed: February 23, 1976
    Date of Patent: March 1, 1977
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 5-Oxa phenyl- and phenoxy-substituted prostaglandin E.sub.1 analogs
    Patent number: 4010192
    Abstract: 5-Oxa phenyl- and phenoxy-substituted prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 23, 1976
    Date of Patent: March 1, 1977
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson