Patents Represented by Attorney Morris L. Nielsen

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  • Substituted keto and alkoxy 16-phenoxy and 17-phenyl PGE.sub.2 -type compounds
    Patent number: 4010172
    Abstract: Substituted phenyl and naphthyl esters of PGE.sub.2 analogs, including the 16-alkyl, 16-fluoro, 16-phenoxy, and phenyl-substituted analogs, and their 15-epimers, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as these PGE.sub.2 analogs, and are also useful as a means for obtaining highly purified 16,16-dimethyl-PGE.sub.2, 16-phenoxy-17,18,19,20-tetranor-PGE.sub.2, and 17-phenyl-18,19,20-trinor-PGE.sub.2.
    Type: Grant
    Filed: November 21, 1975
    Date of Patent: March 1, 1977
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • 4,5-Cis-didehydro-PGF.sub.1 analogs
    Patent number: 4003946
    Abstract: This invention is a group of 4,5-didehydro PG.sub.1 (prostaglandin-type) analogs having variable chain length, branching and fluoro substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: November 7, 1975
    Date of Patent: January 18, 1977
    Assignee: The Upjohn Company
    Inventor: Barney J. Magerlein
  • 5-Oxa prostaglandin E.sub.1 analogs
    Patent number: 4001296
    Abstract: 5-Oxa prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: December 6, 1974
    Date of Patent: January 4, 1977
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Phenyl-substituted prostaglandin-.beta.-type anologs
    Patent number: 4001286
    Abstract: This invention is a group of phenyl-substituted PGE-type, PGF-type, PGA-type and PGB-type compounds, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: January 4, 1977
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • Prostaglandin F.sub..alpha. 15-monoacrylates
    Patent number: 4001306
    Abstract: Mono(carboxyacylates) of prostaglandins F.sub.1.sub..alpha., F.sub.2.sub..alpha., F.sub.3.sub..alpha., dihydro F.sub.1.sub..alpha., and their 15.beta. isomers, at the C-15 position, and processes for preparing them. These compounds are useful for a variety of pharmacological purposes, including inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and controlling blood pressure.
    Type: Grant
    Filed: January 30, 1975
    Date of Patent: January 4, 1977
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • Substituted anilide esters of 16-substituted PGE.sub.2
    Patent number: 3998869
    Abstract: Substituted phenyl and naphthyl esters of PGE.sub.2 analogs, including the 16-alkyl, 16-fluoro, 16-phenoxy, and phenyl-substituted analogs, and their 15-epimers, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as these PGE.sub.2 analogs, and are also useful as a means for obtaining highly purified 16,16-dimethyl-PGE.sub.2, 16-phenoxy-17,18,19,20-tetranor-PGE.sub.2, and 17-phenyl-18,19,20-trinor-PGE.sub.2.
    Type: Grant
    Filed: November 14, 1974
    Date of Patent: December 21, 1976
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • Tricyclic prostaglandin
    Patent number: 3997566
    Abstract: Process for preparing bicyclic diols of the formula ##STR1## wherein C.sub.p H.sub.2p is a valence bond or alkylene of one to 4 carbon atoms, inclusive, with one or 2 carbon atoms in the chain between the phenylene ring and --O--; wherein Y is a hydrocarbyl or substituted hydrocarbyl group; and wherein .about. indicates attachment to the cyclopropane ring in exo or endo configuration. These diols and the tricyclic prostaglandin intermediates prepared herein are useful intermediates in preparing prostaglandin analogs having pharmacological utility.
    Type: Grant
    Filed: August 13, 1975
    Date of Patent: December 14, 1976
    Assignee: The Upjohn Company
    Inventor: Douglas R. Morton, Jr.
  • 4-Oxa phenyl-substituted PGE compounds
    Patent number: 3996266
    Abstract: This invention is a group of 3-oxa and 4-oxa phenyl-substituted PGE type, PGF type, PGA type and PGB type compounds, and processes for making those. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: October 23, 1975
    Date of Patent: December 7, 1976
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • 3-Oxo phenyl-substituted PGF compounds
    Patent number: 3996267
    Abstract: This invention is a group of 3-oxa and 4-oxa phenyl-substituted PGE type, PGF type, PGA type and PGB type compounds, and processes for making those. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: October 23, 1975
    Date of Patent: December 7, 1976
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • Substituted anilide esters of 16-phenoxy and 17-phenyl PGE.sub.2 type compounds
    Patent number: 3994956
    Abstract: Substituted phenyl and naphthyl esters of PGE.sub.2 analogs, including the 16-alkyl, 16-fluoro, 16-phenoxy, and phenyl-substituted analogs, and their 15-epimers, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as these PGE.sub.2 analogs, and are also useful as a means for obtaining highly purified 16,16-dimethyl-PGE.sub.2, 16-phenoxy-17,18,19,20-tetranor-PGE.sub.2, and 17-phenyl-18,19,20-trinor-PGE.sub.2.
    Type: Grant
    Filed: November 21, 1975
    Date of Patent: November 30, 1976
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • Substituted tolyl esters of 16-phenoxy and 17-phenyl PGE.sub.2 type compounds
    Patent number: 3994957
    Abstract: Substituted phenyl and naphthyl esters of PGE.sub.2 analogs, including the 16-alkyl, 16-fluoro, 16-phenoxy, and phenyl-substituted analogs, and their 15-epimers, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as these PGE.sub.2 analogs, and are also useful as a means for obtaining highly purified 16,16-dimethyl-PGE.sub.2, 16-phenoxy-17,18,19,20-tetranor-PGE.sub.2, and 17-phenyl-18,19,20-trinor-PGE.sub.2.
    Type: Grant
    Filed: November 21, 1975
    Date of Patent: November 30, 1976
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • 4.5-Cis-didehydro-PGB.sub.1 analogs
    Patent number: 3989735
    Abstract: This invention is a group of 4,5-didehydro PG.sub.1 (prostaglandin-type) analogs having variable chain length, branching and fluoro substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: November 7, 1975
    Date of Patent: November 2, 1976
    Assignee: The Upjohn Company
    Inventor: Barney J. Magerlein
  • Substituted phenyl and naphthyl esters of PGE.sub.1
    Patent number: 3988355
    Abstract: Substituted phenyl and naphthyl esters of PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub. 1, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1, and are also useful as a means for obtaining highly purified PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1 products.
    Type: Grant
    Filed: December 12, 1974
    Date of Patent: October 26, 1976
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • 8.beta.,11.beta.,12.alpha.-PGF.sub.2.sub..alpha. compounds
    Patent number: 3987085
    Abstract: This invention is a group of 8-.beta., 12-.alpha.-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: October 19, 1976
    Assignee: The Upjohn Company
    Inventor: Ernest W. Yankee
  • Substituted aromatic esters of PGF.sub.2.sub..alpha.
    Patent number: 3987067
    Abstract: Substituted phenyl and naphthyl and 9-oxofluoren-4-yl esters of PGF.sub.2.sub..alpha., 15-alkyl-PGF.sub.2.sub..alpha., and 15(R)-15-alkyl-PGF.sub.2.sub..alpha., and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as PGF.sub.2.sub..alpha., 15-alkyl-PGF.sub.2.sub..alpha., and 15(R)-15-alkyl-PGF.sub.2.sub..alpha., and are also useful as a means for obtaining highly purified PGF.sub.2.sub..alpha., 15-alkyl-PGF.sub.2.sub..alpha., and 15(R)-15-alkyl-PGF.sub.2.sub..alpha. products.
    Type: Grant
    Filed: September 30, 1974
    Date of Patent: October 19, 1976
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • Phenyl-substituted prostaglandin-F type analogs
    Patent number: 3987087
    Abstract: This invention is a group of phenyl-substituted PGE-type, PGF-type, PGA-type and PGB-type compounds, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: January 7, 1974
    Date of Patent: October 19, 1976
    Assignee: The Upjohn Company
    Inventor: Gordon L. Bundy
  • Substituted phenyl esters of PGE.sub.1 - type prostaglandins
    Patent number: 3987084
    Abstract: Substituted phenyl and naphthyl esters of PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1, and are also useful as a means for obtaining highly purified PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1 products.
    Type: Grant
    Filed: December 12, 1974
    Date of Patent: October 19, 1976
    Assignee: The Upjohn Company
    Inventor: Walter Morozowich
  • 4,5-Cis-didehydro-PGA.sub.1 analogs
    Patent number: 3985787
    Abstract: This invention is a group of 4,5-didehydro PG.sub.1 (prostaglandin-type) analogs having variable chain length, branching and fluoro substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: November 7, 1975
    Date of Patent: October 12, 1976
    Assignee: The Upjohn Company
    Inventor: Barney J. Magerlein
  • 4,5-Cis-didehydro-PGA.sub.1 compounds
    Patent number: 3984457
    Abstract: This invention is a group of 4,5-didehydro and 4,5,17,18-tetradehydro PG.sub.1 (prostaglandin-type) compounds, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: September 9, 1975
    Date of Patent: October 5, 1976
    Assignee: The Upjohn Company
    Inventors: Bengt Samuelsson, Barney J. Magerlein
  • 4,5-Cis-didehydro-PGB.sub.1 compounds
    Patent number: 3984458
    Abstract: This invention is a group of 4,5-didehydro and 4,5,17,18-tetradehydro PG.sub.1 (prostaglandin-type) compounds, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: September 9, 1975
    Date of Patent: October 5, 1976
    Assignee: The Upjohn Company
    Inventors: Bengt Samuelsson, Barney J. Magerlein