Patents Represented by Attorney Morris L. Nielsen
  • Patent number: 4170598
    Abstract: Mercury derivatives of 5,6-dihydroprostacyclins are disclosed, illustrated for example by ##STR1## wherein G is nitrato, iodo, chloro, bromo, acetato, trifluoroacetato, or benzoato, and wherein .about. indicates alpha or beta configuration, said products having pharmacological activity.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: October 9, 1979
    Assignee: The Upjohn Company
    Inventor: Udo F. Axen
  • Patent number: 4169841
    Abstract: Processes for preparing prostacyclin analogs which are 9-deoxy-6,9-epoxymethano derivatives of prostaglandin F.sub.1.alpha. -type compounds, illustrated, for example, by a compound of the formula ##STR1## wherein .about. indicates alpha or beta configuration; including the products and intermediates produced therein, said products having pharmacological utility.
    Type: Grant
    Filed: September 11, 1978
    Date of Patent: October 2, 1979
    Assignee: The Upjohn Company
    Inventor: Robert C. Kelly
  • Patent number: 4150222
    Abstract: Prostaglandin (PG.sub.1) derivatives having a 9-deoxy-6,9-epoxy feature together with either a 5-halo or 5,6-didehydro feature are disclosed, for example ##STR1## including processes for preparing them and the appropriate intermediates; said derivatives having pharmacological activity.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: April 17, 1979
    Assignee: The Upjohn Company
    Inventor: Roy A. Johnson
  • Patent number: 4130569
    Abstract: Processes for preparing prostacyclin analogs which are 9-deoxy-6,9-epoxymethano derivatives of prostaglandin F.sub.1 .alpha. -type compounds, illustrated, for example, by a compound of the formula ##STR1## wherein .about. indicates alpha or beta configuration; including the products and intermediates produced therein, said products having pharmacological utility.
    Type: Grant
    Filed: April 19, 1977
    Date of Patent: December 19, 1978
    Assignee: The Upjohn Company
    Inventor: Robert C. Kelly
  • Patent number: 4130721
    Abstract: 11-Deoxyprostaglandin E and F type compounds, i.e. prostaglandin E and F type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: July 24, 1972
    Date of Patent: December 19, 1978
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • Patent number: 4125712
    Abstract: Processes for preparing 5,6-dihydro-prostacyclin analogs, which are 9-deoxy-6,9-cyclic ethers of prostaglandin F.sub.1.alpha. -type compounds, illustrated for example, by a compound of the formula ##STR1## wherein .about. indicates alpha or beta configuration; including the products and intermediates produced therein, said products having pharmacological utility.There are also provided mercury derivatives of these 5,6-dihydro-prostacyclins, illustrated, for example, by a compound of the formula ##STR2## wherein G is nitrato, iodo, chloro, bromo, acetato, trifluoroacetato, or benzoato, and wherein .about. indicates alpha or beta configuration, said products having pharmacological activity, and useful as intermediates in preparing the above compounds.
    Type: Grant
    Filed: December 5, 1977
    Date of Patent: November 14, 1978
    Assignee: The Upjohn Company
    Inventor: Udo F. Axen
  • Patent number: 4125713
    Abstract: Processes for preparing 5,6-dihydro-prostacyclin analogs, which are 9-deoxy-6,9-cyclic ethers of prostaglandin F.sub.1.alpha. -type compounds, illustrated, for example, by a compound of the formula ##STR1## wherein .about. indicates alpha or beta configuration; including the products and intermediates produced therein, said products having pharmacological utility.
    Type: Grant
    Filed: December 5, 1977
    Date of Patent: November 14, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4124599
    Abstract: Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, together with a 9-deoxy-9-hydroxymethyl feature for example ##STR1## or (2) a 9-deoxy-6,9-epoxymethano feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## or a 5,6-didehydro feature, for example in an enol ether of the formula ##STR3## said derivatives having pharmacological activity. Processess for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: July 28, 1977
    Date of Patent: November 7, 1978
    Assignee: The Upjohn Company
    Inventor: Robert C. Kelly
  • Patent number: 4124601
    Abstract: Prostaglandin E (PGE) - type derivatives and analogs having a 6-keto feature are disclosed, including processes for preparing them and the appropriate intermediates, said derivatives having pharmacological activity.A typical 6-keto compound is 6-keto-PGE.sub.
    Type: Grant
    Filed: September 2, 1977
    Date of Patent: November 7, 1978
    Assignee: The Upjohn Company
    Inventor: Herman W. Smith
  • Patent number: 4123441
    Abstract: Prostaglandin (PG.sub.1) derivatives having (1) a 5-keto feature, for example ##STR1## or (2) a 9-deoxy-5,9-epoxy feature together with a 4-halo or 5-hydroxy feature, for example ##STR2## or a 4,5-didehydro feature, for example in an enol ether of the formula ##STR3## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: July 28, 1977
    Date of Patent: October 31, 1978
    Assignee: The Upjohn Company
    Inventor: Roy A. Johnson
  • Patent number: 4118577
    Abstract: This invention is a group of 4,5,6-trinor-3,7-inter-m-phenylene prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including hypotensive control and inhibition of platelet aggregation.A typical formula for a PGA.sub.
    Type: Grant
    Filed: January 31, 1977
    Date of Patent: October 3, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4116988
    Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: September 26, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4116989
    Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: September 26, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4100355
    Abstract: This invention is a group of 8-beta, 12-alpha-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.
    Type: Grant
    Filed: June 28, 1973
    Date of Patent: July 11, 1978
    Assignee: The Upjohn Company
    Inventor: Ernest W. Yankee
  • Patent number: 4099013
    Abstract: This invention is a group of 4,5,6-trinor-3,7-inter-m-phenylene prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including hypotensive control and inhibition of platelet aggregation.A typical formula for a PGE.sub.
    Type: Grant
    Filed: January 31, 1977
    Date of Patent: July 4, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4096179
    Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 10, 1977
    Date of Patent: June 20, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4096335
    Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: June 20, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4096178
    Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 10, 1977
    Date of Patent: June 20, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4087616
    Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: May 2, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4084058
    Abstract: This invention is a group of 4,5,6-trinor-3,7-inter-m-phenylene prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including hypotensive control and inhibition of platelet aggregation.A typical formula for a PGF.sub.1.alpha.
    Type: Grant
    Filed: January 31, 1977
    Date of Patent: April 11, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson