Patents Represented by Law Firm Murray and Whisenhunt
  • Patent number: 4668514
    Abstract: This invention provides a penicillin derivative of the formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and represent hydrogen, C.sub.1-6 alkyl, C.sub.1-6 hydroxyalkyl, C.sub.3-9 acyloxyalkyl, C.sub.8-13 benzyloxyalkyl, C.sub.2-7 alkoxyalkyl, C.sub.2-7 alkoxycarbonyl, C.sub.3-8 alkenyloxycarbonyl, C.sub.3-8 alkynyloxycarbonyl, phenyl, amino, cyano, formyl, trifluoromethyl, C.sub.2-6 acyl, carbamoyl, C.sub.2-7 alkylcarbamoyl, benzyloxycarbonylamino, C.sub.2-7 alkoxycarbonylamino; and R.sub.3 is hydrogen, a group for forming a pharmaceutically acceptable salt, or a penicillin carboxyl protecting group, with the proviso that both of R.sub.1 and R.sub.2 are not hydrogen or C.sub.2-7 alkoxycarbonyl at the same time and that when one of R.sub.1 and R.sub.2 is hydrogen, the other is not C.sub.2-7 alkoxycarbonyl, or a pharmaceutically acceptable acid addition salt, process for preparing the derivative, and a pharmaceutical composition containing the derivative.
    Type: Grant
    Filed: October 5, 1984
    Date of Patent: May 26, 1987
    Assignee: Taiho Pharmaceutical Company Limited
    Inventors: Ronald G. Micetich, Shigeru Yamabe, Motoaki Tanaka, Tomio Yamazaki, Naobumi Ishida, Makoto Kajitani
  • Patent number: 4667088
    Abstract: A credit card size portable system comprises a bubble memory for storage serially of digital data, especially of sound analogue signal which has been digitally encoded including, a decoder means for converting the memory output into analogue form, preferably several decoders each for one sound band, a control register for controlling input and output of data from the memory and which is responsive to control data present in the input and output stream, and input and output for the data entering and leaving the card system. The memory can be of 8 megabyte size, which can record 31/2 minutes of music signal. Optical input can be used, with a photoelectric converter at the input. A card is readily programmed with the digital data and can readily be stored or transported for replay of sound signal as desired, in place of conventional discs or cassettes. The control data bits are detected by the control register and serve to control the recording and replay steps.
    Type: Grant
    Filed: September 22, 1986
    Date of Patent: May 19, 1987
    Inventors: Kane N. Kramer, James S. Campbell
  • Patent number: 4666911
    Abstract: An analgesic compositon containing as active ingredient an allophanoylpiperazine compound represented by the general formula ##STR1## wherein R.sup.1 represents a lower alkyl group or phenyl group; R.sup.2 and R.sup.3 each represents a hydrogen atom or a lower alkyl group; and R.sup.4 represents a phenyl group or a substituted phenyl group having as substituent a halogen atom or methyl, trifluoromethyl, hydroxyl, methoxy, methylenedioxy, nitro, or carboxyl group; pyridyl group, pyrimidyl group, thiazolyl group, benzyl group, cinnamyl group, cyclohexyl group, a lower alkyl group, a substituted lower alkyl group having chlorine atom or hydroxyl group as substituent; or a lower alkenyl group.
    Type: Grant
    Filed: July 8, 1981
    Date of Patent: May 19, 1987
    Assignee: Taiho Pharmaceutical Company Limited
    Inventors: Hajime Fujimura, Yasuzo Hiramatu, Takahiro Yabuuchi, Masakatu Hisaki, Katsuo Takikawa, Takaji Honna, Hidekazu Miyake, Makoto Kajitani
  • Patent number: 4664525
    Abstract: In a method for detecting an inferior container, wherein: light beams are projected in different two directions upon a side of a transparent or a semitransparent test container while the container is rotatably driven; both of a transmitted beam which is one of the above light beams, having penetrated through the container, and a refelected beam which is the other of the above light beams, having reflected from the container are simultaneously received by a common photo-receptive surface; a composite image constructed of both of the transmitted beam and the reflected beam is projected upon this photo-receptive surface; and an inferior container is detected by means of a shadow formed in this image.
    Type: Grant
    Filed: March 18, 1985
    Date of Patent: May 12, 1987
    Assignee: Eisai Co., Ltd.
    Inventor: Ryosaku Tagaya
  • Patent number: 4665084
    Abstract: The present invention relates to new condensed benzopyrone derivatives having a 5-tetrazolyl substituent thereon, and to pharmaceutical compositions containing them. The compounds are useful in the treatment of allergic conditions.
    Type: Grant
    Filed: January 14, 1986
    Date of Patent: May 12, 1987
    Assignee: Farmitalia Carlo Erba, S.p.A.
    Inventors: Gianfederico Doria, Carlo Passarotti, Ada Buttinoni
  • Patent number: 4663169
    Abstract: A method for automatic measurement and control in curd making process is provided wherein an electrical current is supplied to an electrical conductor thermally contactable with milk stored in a curd tank so as to be heated to result in sufficiently higher temperature of the said conductor than the surrounding milk, temperatures or electrical resistances of the electrical conductor are measured in relation to time lapse, an elapsed time starting from the commencement of curdling is measured on the basis of a change in temperature or electrical resistance of the electrical conductor, and the elapsed time is compared with a predetermined curdling progress time ranging from the commencement of curdling to curd cutting so as to automatically judge a curd cutting timing.
    Type: Grant
    Filed: February 19, 1986
    Date of Patent: May 5, 1987
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Tomoshige Hori, Kensuke Itoh
  • Patent number: 4662558
    Abstract: In welding of metals, spatter preventing effect can be enhanced by spreading on the metal surface a halogen-containing duodimensional polymer having a proper degree of affinity for metals and other materials, being thermoplastic and also having a restoring force and flame resistance as a pretreatment.
    Type: Grant
    Filed: October 7, 1985
    Date of Patent: May 5, 1987
    Inventor: Hiroyoshi Hamanaka
  • Patent number: 4660574
    Abstract: A reel attaching and detaching device which is to be employed in a cigarette rolling machine is disclosed.
    Type: Grant
    Filed: February 13, 1985
    Date of Patent: April 28, 1987
    Assignee: Japan Tobacco, Inc.
    Inventors: Hideki Kobayashi, Yutaka Okumoto, Mikio Komori
  • Patent number: 4659643
    Abstract: A heat-sensitive recording material comprising a substrate and a heat-sensitive recording layer thereon, the heat-sensitive recording layer containing a diazonium salt, coupler compound, heat-fusible basic compound and at least one of the compounds represented by the formula [I] below ##STR1## wherein X is --O-- or --CONH--, R.sub.1 and R.sub.2 are each hydrogen, halogen, alkyl having 1 to 8 carbon atoms, cycloalkyl, aryl, aralkyl or alkoxyl and n is an integer of 1 to 10.
    Type: Grant
    Filed: October 21, 1985
    Date of Patent: April 21, 1987
    Assignee: Kanzaki Paper Manufacturing Co. Ltd.
    Inventors: Katsuhiko Ishida, Masaharu Nojima, Tosaku Okamoto
  • Patent number: 4657711
    Abstract: A packing sheet for use in a device, e.g. a cooling tower wherein a film of liquid and a gas stream are brought into contact to effect heat exchange therebetween, the sheet being continuously corrugated to define a plurality of parallel depressions which are generally V-shaped in cross-section. Preferably the pair of walls which define each depression are disposed substantially at right angles with respect to one another and are disposed at an angle of around 45.degree. with respect to the plane of the sheet. Preferably the sheet is formed with transverse ribs which project from the walls of the depressions and which extend substantially continuously between the depressions to form channels which communicate between the depressions. Advantageously the sheet is formed in the walls of the depressions with angled projections, which preferably extend continuously between two adjacent crests of the depressions.
    Type: Grant
    Filed: September 17, 1984
    Date of Patent: April 14, 1987
    Inventor: Albert F. Wigley
  • Patent number: 4657871
    Abstract: A method of mixing polymers, especially rubber by (i) deforming the polymer until it is estimated to attain a first predetermined viscosity, (ii) adding filler and deforming the polymer-and-filler mixture until it is estimated to attain a second predetermined viscosity, (iii) adding oil or plasticiser, and deforming and resulting mixture until it is estimated to attain a third predetermined viscosity, and then (iv) discharging the resulting mixture from the process, where the estimating of each predetermined viscosity is attained by measuring: (1) the mixing torque applied by a mixer during the process at last twice at a fixed mixer-rotor speed and corrected by a reference batch temperature; (2) the rate of change of the torque and (3) the time, or the deforming energy, necessary to reach the torque characteristic of the respective predetermined viscosity. In addition, the ram pressure applied to the mixing chamber is monitored and increased or decreased in response to the cyclic ram movement during mixing.
    Type: Grant
    Filed: August 14, 1985
    Date of Patent: April 14, 1987
    Inventors: Philip K. Freakley, Bernard R. Matthews, Henry D. Giffin
  • Patent number: 4655885
    Abstract: In a bioelectrochemical process in which the electrons are transferred directly, without use of a mediator, such as a redox dye or cofactor, between an electrode and an electroactive biological material, such as an enzyme or a protein, in either direction, rapid electron transfer has previously been achieved between an electrode and the positively charged protein horse-heart cytochrome c by adding a surface-modifier such as 4,4'-bipyridyl or a derivative thereof.It has now been found possible to promote electron transfer to either a positively or a negatively charged protein using the same surface-modifier for either job, namely a compound of formula ##STR1## wherein: the pyridine ring shown is substituted in the 2-, 3- or 4-position by the (methylene)hydrazinecarbothioamide group shown;R.sup.1 represents hydrogen atom(s) or one or two methyl or ethyl groups in the 2-,3- or 4-position (when the said position is not substituted by the (methylene)hydrazinecarbothioamide group shown);R.sup.
    Type: Grant
    Filed: January 10, 1986
    Date of Patent: April 7, 1987
    Assignee: National Research Development Corporation
    Inventors: Hugh A. O. Hill, David J. Page, Nicholas J. Walton, David Whitford
  • Patent number: 4655967
    Abstract: An electrically conductive titanate derivative containing an element other than titanium is prepared by baking a mixture of a titanate and a compound containing an element other than titanium.
    Type: Grant
    Filed: June 12, 1985
    Date of Patent: April 7, 1987
    Assignee: Otsuka Kagaku Kabushiki Kaisha
    Inventors: Takuo Morimoto, Kihachiro Nishiuchi, Kenichi Wada, Masayoshi Suzue, Yukiya Hareyama
  • Patent number: 4652439
    Abstract: A process for preparing a fibrous alkali metal titanate which comprises baking a mixture of rutile and an oxygen-containing alkali metal compound, rutile being finely pulverized to a particle size such that an average particle passes through a 200-mesh sieve, and pulverizing the resulting agglomerate.
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: March 24, 1987
    Assignee: Otsuka Kagaku Kabushiki Kaisha
    Inventors: Kihachiro Nishiuchi, Masayoshi Suzue, Koji Sakane
  • Patent number: 4652570
    Abstract: An anti-cancer composition for treating cancers sensitive to 5-fluorouracil therapy in warm-blooded animals, comprising 5-fluorouracil and uracil.
    Type: Grant
    Filed: August 28, 1984
    Date of Patent: March 24, 1987
    Assignee: Taiho Pharmaceutical Company, Limited
    Inventors: Setsuro Fujii, Norio Unemi, Setsuo Takeda
  • Patent number: 4650801
    Abstract: An anti-cancer composition for delivering 5-fluorouracil to cancer tissues which comprises at least one 5-fluorouracil derivative, and a uracil derivative.
    Type: Grant
    Filed: November 16, 1983
    Date of Patent: March 17, 1987
    Assignee: Taiho Pharmaceutical Company, Ltd.
    Inventors: Setsuro Fujii, Norio Unemi, Setsuo Takeda
  • Patent number: 4649974
    Abstract: A handbag having a replaceable decorative cover is provided. The decorative cover has a laminated structure. A face sheet, a central core sheet and a back sheet are bonded to one another with the central core sheet between the face sheet and the back sheet. The central core sheet is a size smaller than the face and back sheets. The lamination is done by bonding the peripheral margins of the face and back sheets while the central core sheet is applied with adhesives at appropriate portions to be bonded to the face and back sheets. In this way, the peripheral marginal area of the laminated decorative cover is thinner than the central area thereof with the result that the marginal area can be inserted under the frame attached to the cover or body of the handbag without causing the frame to bulge. In addition, the laminated structure provides a wide range of alternatives in material selection.
    Type: Grant
    Filed: July 8, 1985
    Date of Patent: March 17, 1987
    Assignee: TR Co., Ltd.
    Inventor: Tadao Takanashi
  • Patent number: 4649134
    Abstract: The administration of the drug, containing defibrotide as the active ingredient, in the case of acute renal insufficiencies accompanied by a thrombotic microangiopathy, permits the evolution of the clinical situation towards the chronicity to be stopped and, in a number of cases, a complete remission to be obtained.
    Type: Grant
    Filed: September 10, 1984
    Date of Patent: March 10, 1987
    Assignee: Crinos Industria Farmacobiologica SpA
    Inventor: Vittorio Bonomini
  • Patent number: 4648947
    Abstract: To a conventional chromium electroplating bath containing 450 g/l chromic acid CrO.sub.3 and 4.5 g/l sulphuric acid H.sub.2 SO.sub.4 are added 10 g/l of potassium perchlorate or potassium bromate or potassium iodate or mixtures thereof. Higher current densities may be used in electrodepositing chromium without impairing the quality.
    Type: Grant
    Filed: May 1, 1985
    Date of Patent: March 10, 1987
    Assignee: National Research Development Corp.
    Inventors: John A. Naismith, Malcolm McCormick, David Howe, Malcolm A. Pate
  • Patent number: 4648962
    Abstract: Persistent chemisorption bonds of clay solids in clay-containing heavy oil and water emulsions, from oil sands, heavy oil or conventional oil wells, are broken down by mixing the emulsion with an aqueous mixture of coal particles so that the mixture has a suspension density in the range 1 to 50 weight % solids. The coal particles have a particle size in the range 5 to 100 .mu.m so that occluded hydrophilic, inorganic solids are separable from a substantial portion of the hydrophobic, carbonaceous substances of the coal. The mixing of the emulsion with the aqueous suspension of coal particles is continued until agglomerates are formed comprising essentially carbonaceous components of the coal and the heavy oil thereby breaking down the chemisorption bonds by interdependantly dissociating carbonaceous components of the coal and heavy oil from the clay solids and other hydrophilic, inorganic solids and water from the coal and heavy oil.
    Type: Grant
    Filed: February 18, 1986
    Date of Patent: March 10, 1987
    Assignee: Canadian Patents and Development Limited
    Inventors: Charles E. Capes, Richard D. Coleman, William L. Thayer, Ira E. Puddington