Patents Represented by Attorney Paul J. Cook

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  • Apparatus for effecting capillary electrophoresis
    Patent number: 5246577
    Abstract: An apparatus is provided for concentrating a solute sample which can be subsequently released for analysis by capillary electrophoresis. The apparatus comprises a tube containing a short length of packed particles or gel adapted to retain sample solutes which particles are retained in the tube by tube constrictions or porous plugs. The tube includes an inlet for introducing a sample into the tube and an outlet for introducing the retained sample into a capillary electrophoresis tube.
    Type: Grant
    Filed: July 10, 1992
    Date of Patent: September 21, 1993
    Assignee: Millipore Corporation
    Inventors: Martin Fuchs, Michael Merion
  • Document feeder apparatus utilizing driven belts
    Patent number: 5234208
    Abstract: A document feed apparatus is provided which feeds document sheets from a stack of sheets seriatum to a position remote from the stack. Two motor driven feed belts are pivotally mounted to contact or not contact a top sheet of the stack. The belts are driven by separate motors which are activated or deactivated depending upon the top sheet position.
    Type: Grant
    Filed: January 30, 1991
    Date of Patent: August 10, 1993
    Assignee: Production Lines, Inc.
    Inventors: Vitaly Bandura, Paul St. Cyr
  • Composite microporous membranes
    Patent number: 5228994
    Abstract: A composite microporous membrane is provided having a microporous nonretentive substrate and a retentive microporous layer coated directly to the substrate in the absence of an intermediate support layer.
    Type: Grant
    Filed: October 13, 1992
    Date of Patent: July 20, 1993
    Assignee: Millipore Corporation
    Inventors: Gabriel Tkacik, Andrew J. Bartlett
  • Gel electrophoresis cassette with removable strip
    Patent number: 5228970
    Abstract: A gel electrophoresis cassette is formed of two plates and two spacers between the plates which plates and spacers form a void volume for housing a gel. The spacers are positioned slightly inward of the edges of the plates to form a first and a second small space. A strip and an adhesive are positioned within the small space. When the strips are removed from the small spaces, the adhesive is torn and the plates can be opened manually.
    Type: Grant
    Filed: September 13, 1991
    Date of Patent: July 20, 1993
    Assignee: Millipore Corporation
    Inventor: Brian D. Foley
  • Tough polymer compositions
    Patent number: 5223574
    Abstract: Polymer blends are provided comprising a glassy thermoplastic polymer having a glass transition temperature above ambient conditions, e.g., normal room temperature and between 0.1 and 4.0 weight percent of a rubbery polymer having a glass transition temperature below ambient temperature conditions, e.g., normal room temperature based on the weight of the blend. The blends can be produced by solution casting or by coagulation from solution followed by flocculation.
    Type: Grant
    Filed: October 11, 1991
    Date of Patent: June 29, 1993
    Assignee: Massachusetts Institute of Technology
    Inventors: Osman S. Gebizlioglu, Robert E. Cohen, Ali S. Argon, Haskell W. Beckham, Jian Qin
  • Multi-filter analytical apparatus
    Patent number: 5223133
    Abstract: A filtration member transfer apparatus is provided for transferring one or a plurality of discrete reaction or isolation zones such as filtration membranes from a sample isolation step to an analytical apparatus. The transfer apparatus includes a template, preferably which is electrically conductive, having holes or depressions of a size, shape and position corresponding to the reaction or isolation zones. An electrically conductive adhesive is exposed in the holes or depressions of the template.
    Type: Grant
    Filed: November 21, 1991
    Date of Patent: June 29, 1993
    Assignee: Millipore Corporation
    Inventors: Phillip Clark, Frederick G. Bargoot, Yolanda Nieuwkerk, Aldo M. Pitt
  • Insulated needle for forming an electrospray
    Patent number: 5223226
    Abstract: An electrically insulated needle tip is provided for forming an electrospray from a solution containing a solute sample. The insulated needle tip is positioned between an upstream electrode and a downstream counterelectrode. The solution passes through the needle, emerges from the insulated tip and is converted to an electrospray under the influence of an electric field generated between the electrode and the counterelectrode.
    Type: Grant
    Filed: April 14, 1992
    Date of Patent: June 29, 1993
    Assignee: Millipore Corporation
    Inventors: Douglas P. Wittmer, Michael J. Tomany, Joseph A. Jarell
  • Hydrophobic polymeric membrane composites
    Patent number: 5217802
    Abstract: A composite porous membrane is formed from a porous polymeric substrate having its entire surface modified with a cross-linked polymer which results in a hydrophobic and oleophobic surface. The composite membrane retains substantially all of its other original properties. The cross-linked polymer is formed in situ on the polymeric substrate from a reactant system comprising an ethylenically unsaturated monomer having at least one fluoroalkyl group, a cross-linker, and, if needed, a polymerization initiator, dissolved in a nonpolar and or weakly polar solvent system. The membrane substrate saturated with the reactant system is exposed to a suitable energy source to effect polymerization and cross linking of the monomer.
    Type: Grant
    Filed: March 17, 1992
    Date of Patent: June 8, 1993
    Assignee: Millipore Corporation
    Inventor: Louis M. Scarmoutzos
  • Can construction with wall indentation
    Patent number: 5217133
    Abstract: A container is provided with a top to which is secured at least one strip. The strip or strips can be free of prestress bias or are provided with a prestress bias so that when the top is severed from the container, the strip or strips are lifted away from the top so that the strip can be grasped easily to provide a means for lifting the top away from the container. An indentation is provided in the container wall to prevent a severed container top from sinking into the contents of the container.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: June 8, 1993
    Assignee: Wellesley Research Associates, Inc.
    Inventors: William J. Timson, Paul R. Chalifoux
  • Process for purifying resins utilizing bipolar interface
    Patent number: 5211823
    Abstract: Purified ion exchange resin particles are provided in a bifunctional electrodeionization step having anion depletion compartments containing anion exchange resin particles which are purified and cation depletion compartments containing cation exchange resin particle which are purified as well as ion concentration compartments. The bifunctional electrodeionization step for purifying resin particles is conducted under conditions to disassociate water into hydrogen ions and hydroxyl ions. Purified water having a purity of at least 1 megohm-cm is introduced into the anion depletion compartment and cation depletion compartments and water for accepting ionic impurities is introduced into the ion concentration compartments. The purified water is produced in an initial purification step which also can be an electrodeionization step.
    Type: Grant
    Filed: June 19, 1991
    Date of Patent: May 18, 1993
    Assignee: Millipore Corporation
    Inventors: Anthony J. Giuffrida, Gary C. Ganzi
  • Can construction
    Patent number: 5209366
    Abstract: A container is provided with a top to which is secured at least one strip. The strip or strips are provided with a prestress bias so that when the top is severed from the container, the strip or strips are lifted away from the top and over the container rim so that the strip can be grasped easily to provide a means for lifting the top away from the container.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: May 11, 1993
    Assignee: Wellesley Research Associates, Inc.
    Inventor: William J. Timson
  • Degeneration-resistant solventogenic clostridia
    Patent number: 5210032
    Abstract: Butanol and acetone are major end products of a bacterial fermentation process carried out by anaerobic saccharolytic clostridia such as Clostridium acetobutylicum. However, these organisms degenerate upon repeated subculture of growing cells, thereby losing their capacity to produce solvents and to develop into spores. A novel class of degeneration-resistant mutants of C. acetobutylicum, generated by transposon insertion mutagenesis, has been produced employing a novel selection procedure. Upon subculture the mutant cells survive significantly longer than the parental cells without altered solventogenic characteristics. The mutant organism, the technique for its isolation and its use are provided.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: May 11, 1993
    Assignee: Trustees of the Boston University
    Inventor: Eva R. Kashket
  • Apparatus for microbiological testing of liquids
    Patent number: 5202262
    Abstract: Method and apparatus for the microbiological testing of liquids to identify and count living microorganisms contained therein includes a tubular sleeve for collecting the liquid sample to which there is attached at one end a microporous membrane filter. Each end of the sleeve has the shape of a female receptacle portion where into one end a container housing a culture medium can be nested by force for applying the medium to the underside of the filter and where into the other end a cover can be nested to provide a substantially tight sealing of the device. Preferably, the tubular sleeve is in the form of a bellows the convolutions of which can be either compressed or expanded to correspondingly alter the volume of the sleeve between minimum and maximum values.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: April 13, 1993
    Assignee: Millipore Corporation
    Inventor: Jean Lemonnier
  • Fish hook attachment for fish hook construction
    Patent number: 5199209
    Abstract: A fish hook attachment is provided which includes at least one (a) hydrofoil or (b) stabilizer and hydrofoil of unitary construction secured to a hollow shank having a slot which extends along the length of the hollow shank. Each unitary construction is secured to a hook shank so that the hydrofoil portion is positioned at an angle between 5.degree. to 85.degree. degrees from the hook shank. The hydrofoil portion of the the unitary construction is positioned substantially perpendicular to the plane defined by the hook shank and hook elbow.
    Type: Grant
    Filed: March 25, 1991
    Date of Patent: April 6, 1993
    Assignee: Wellesley Research Associates, Inc.
    Inventor: Russell Cook
  • Dental implant system and apparatus
    Patent number: 5197881
    Abstract: A dental implant is provided for insertion into the jawbone of a patient for the purpose of building a dental prostheses thereon. The implant includes a central hole for accommodating a dental post having wings. The dental post wings fit into mating slots in the implant hole in order to effect retention of the post in the implant while avoiding rotation of the positioned post.
    Type: Grant
    Filed: December 30, 1991
    Date of Patent: March 30, 1993
    Assignee: Wellesley Research Associates, Inc.
    Inventor: Paul R. Chalifoux
  • Photometric apparatus and process
    Patent number: 5194915
    Abstract: A photometric apparatus is provided for analyzing a sample liquid capable of fluorescing when exposed to excitation light. The sample liquid, surrounded by a sheath liquid under conditions of laminar flow to form an interface between the sample liquid and the sheath is passed through a cell conduit. An excitation light is directed axially into the sample liquid and is totally internally reflected at the interface with the sheath liquid. The sample fluoresces in response to the excitation light and fluorescent emission is observed through the sheath liquid.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: March 16, 1993
    Assignee: Millipore Corporation
    Inventor: Anthony C. Gilby
  • Process for effecting high efficiency separations by capillary electrophoresis
    Patent number: 5192405
    Abstract: Capillary electrophoresis is effected by introducing into a capillary a buffer solution a zwitterion composition comprised of substantially equal numbers of positive and negative charges when the negative charges are desired from sulfonate or sulfate groups and the positive charges are derived from quaternary amines, quaternary phosphines or quanternary arsines. A sample is introduced into the capillary and an electric field is established through the capillary to cause the sample to migrate through the capillary.
    Type: Grant
    Filed: September 9, 1991
    Date of Patent: March 9, 1993
    Assignee: Millipore Corporation
    Inventors: John S. Petersen, Michael Merion
  • Conduit plate for fluid delivery system
    Patent number: 5188148
    Abstract: A plate structure including conduit and reagent delivery means for a fluid delivery system is provided to deliver precise volumes of a plurality of fluids in sequence to a treatment reservoir. Fluid channels are formed in the plate structure to provide a means for delivering fluids from a plurality of fluid reservoirs attached to the plate structure to one or a plurality of treatment reservoirs attached to the plate structure. Each fluid is delivered by a system comprising a check valve in fluid communication with a fluid reservoirs, a positive displacement pump in fluid communication with the check valve and an injector in fluid communication with the positive displacement pump all of which are attached to the plate structure. A partition switch attached to the plate structure is provided to direct fluid to the desired treatment reservoirs or pressure reservoirs.
    Type: Grant
    Filed: February 14, 1991
    Date of Patent: February 23, 1993
    Assignee: Millipore Corporation
    Inventor: Brevard S. Garrison
  • Apparatus and process for effecting sequential peptide syntheses
    Patent number: 5188733
    Abstract: A chemically modified membrane is positioned between a first template having a first set of holes and a second set of holes aligned with the first set of holes to define a plurality of exposed portions of the membrane in such as manner as to prevent collapse of pores in the membrane during application of a differential pressure across the membrane.
    Type: Grant
    Filed: February 26, 1992
    Date of Patent: February 23, 1993
    Assignee: Trustees of Boston University
    Inventors: Zhengxin Wang, Richard A. Laursen
  • Photometric apparatus with a flow cell coated with an amorphous fluoropolymer
    Patent number: 5184192
    Abstract: A flow cell for optically analyzing a liquid sample is coated with a fluoropolymer having a refractive index less than the refractive index of water.
    Type: Grant
    Filed: July 17, 1991
    Date of Patent: February 2, 1993
    Assignee: Millipore Corporation
    Inventors: Anthony C. Gilby, William W. Carson