Abstract: Functions of sno gene are analyzed by constructing heterogenous or homogeneous mouse variants lacking sno gene to thereby provide heterogenous or homogeneous mouse variants lacking sno gene, cells of these animals and screening systems with the use of these animals or cells. Non-human animals, preferably mice, lacking sno gene and cells thereof. The above animals or cells thereof include both of heterogenous variants and homogeneous variants. A method for screening candidates for drugs by using the above animals or cells thereof.

Abstract: A semiconductor package with a heat-dissipating structure and a method for making the same are proposed. The heat-dissipating structure includes a heat sink and a plurality of solder columns, wherein the solder columns are attached at ends thereof to the heat sink and to a substrate, so as to support the heat sink to be positioned above a semiconductor chip mounted on the substrate. A reflow process performed after the attachment of the heat-dissipating structure to the substrate allows the self-alignment of the solder columns with respect to predetermined positions on the substrate, which helps precisely control the positioning of the heat-dissipating structure fixed on the substrate. Moreover, the solder columns can protect the substrate from being damaged or deformed during a molding process. In addition, the heat-dissipating structure is simple in structure, which simplifies the manufacturing process and reduces the cost.

Abstract: The invention provides new light absorbing crosslinking compositions suitable for use as an antireflective composition (ARC), particularly suitable for short wavelength imaging applications such as 193 nm. The ARCs of the invention are preferably used with an overcoated resist layer (i.e. bottom layer ARCs) and in general comprise novel ARC resin binders that can effectively absorb reflected sub-200 nm exposure radiation.

Abstract: The invention is drawn to novel bis-aromatic a,&bgr;-unsaturated ketones. The compounds are useful in the treatment and prophylaxis of diseases caused by parasites or bacteria.

Abstract: An advanced flip-chip packaging technology is proposed, which is characterized in the forming of a metal dam over the substrate to serve three different utilization purposes. First, the metal dam can help provide a specific fillet width to the underfilled material under the flip chip so as to allow the joint between the flip chip and the substrate to have increased robustness against thermal stress. Second, the metal dam can serve as a mechanical reinforcement to the substrate to prevent package warpage. Third, the metal dam can additionally serve as a heat-dissipation structure to help the heat dissipation from the flip chip. These benefits allow the finished package product to be highly assured in quality and reliability.

Abstract: An oral pharmaceutical modified release multiple-units composition for the administration of a therapeutically and/or prophylactically effective amount of a non-steroid anti-inflammatory drug substance to obtain both a relatively fast onset of the therapeutic effect and the maintenance of a therapeutically active plasma concentration for a relatively long period of time is disclosed.

Abstract: A disk-cloning method and system is provided for cloning computer data from a source disk to a target disk. This disk-cloning method and system can be utilized, for example, in the computer assembly line to clone a preselected set of software programs to the main hard disk of each computer unit, or as a backup to a hard disk. This disk-cloning method and system is characterized in that the source data are read from the source disk and written onto the target disk in a sector-by-sector manner rather than in a file-by-file manner as the prior art. This feature allows the cloning procedure to be more efficiently carried out than the prior art. Moreover, it allows the disk-cloning procedure to be performed without having to make modifications to the existing FDT (File Directory Table) and FAT (File Allocation Table) on the target disk, thus ensuring the system security of the target disk. This disk-cloning method and system is therefore more reliable and efficient to use than the prior art.

Abstract: An artificial tube for a nerve is disclosed that has a controlled rate of decomposition in the body such that the tube remains in the body until the nerve regenerates, which induces axons regenerated from severed nerve stumps to extend in the proper direction without pressing on the regenerated nerve following nerve regeneration and causes rapid restoration of blood flow by promoting infiltration of blood capillaries from the body to promote regeneration of the nerve, and which comprises a tube (10) or (20) having a coating layer (13) or (23) that is composed of gelatin or collagen on at least the outer surface of tube (11) or (21) that is composed of a material that is biodegradable and absorbable in vivo, wherein a pre-thermal dehydration crosslinking treated collagen fiber bundle (referring to a bundle fibers (31) composed of collagen) is inserted in its lumen along the axis of the tube (10) or (20), and wherein the fibers composed of collagen are coated with laminin.

Abstract: A QFN semiconductor package and a fabrication method thereof are proposed, wherein a lead frame having a plurality of leads is adopted, and each lead is formed at its inner end with a protruding portion. A wire bonding region and a bump attach region are respectively defined on opposite surfaces of the protruding portion, and staggered in position. This allows a force applied from a wire bonder to the wire bonding regions not to adversely affect solder bumps implanted on the bump attach regions, so that the solder bumps can be structurally assured without cracking. Moreover, the wire bonding regions spaced apart from the bump attach regions can be prevented from being contaminated by an etching solution used in solder bump implantation, so that wire bonding quality can be well maintained.

Abstract: A method and device for the quantification of muscle tone, particularly the wrist, wherein non-sinusoidal and non ramp trajectories are used to drive the wrist. Equation 1 is utilized determine the stiffness, viscosity and inertial parameters. &tgr;s(t)=KH&thgr;(t)+BH&thgr;(t)+JT&thgr;(t)+&tgr;off  [Eq. 1] wherein where &tgr;s is the total torque, &tgr;off is the offset torque, KH and BH are the angular stiffness and viscosity of the combined flexor and extensor muscle groups that act on the joint, JT is the combined inertia of the oscillating appendage, &thgr; is the angular displacement of the system, and θ . ⁢   ⁢ and ⁢   ⁢ θ ¨ are the velocity and acceleration.

Abstract: A dual-chip integrated circuit package and a method for manufacturing such a dual-chip integrated circuit package are proposed, which can help prevent the occurrence of cracking and delamination in the chips and the occurrence of voids in the encapsulant during the manufacture process. The dual-chip integrated circuit package is constructed on a leadframe having a plurality of first leads and a plurality of second leads and at least a pair of support members between the first and second leads. Further, the dual-chip integrated circuit package includes at least one support member attached to the front side of the first integrated circuit chip for providing a support to the bonding pads on the second integrated circuit chip; the support member being not smaller in dimension than the area where the bonding pads on the second integrated circuit chip are located.

Abstract: The present invention relates to novel yeast cells with increased permeability to compounds, such as small organic compounds. In particular, the invention provides genetically modified yeast cells carrying functional, preferably conditionally regulated, copies of HXT9 and HXT11 genes integrated in the chromosome at the PDR1 and PDR3 loci, thereby disrupting the PDR1 and PDR3 gene activity. The invention further relates to methods and compositions for the use of these hyperpermeable yeast cells for screening for compounds that modulate macromolecular interactions. The invention is exemplified by the use of the hyperpermeable yeast cells in such a screening system. In addition, the invention further provides methods of producing the yeast cells of the invention, as well as polynucleotides, vectors, and kits for use of the hyperpermeable yeast cells and the screening methods of the invention.

Abstract: A novel, cost effective optical filter is employed for photosensors used in ultraviolet-based water purification systems. Optically tuned to specifically eliminate the non-germicidal wavelength polychromatic emissions from mercury lamps, this unique optical filter approach significantly reduces the cost in manufacturing reliable water purification systems employing ultraviolet light.

Abstract: The present invention relates to methods for identifying a compound capable of modulating mitochondrial function, comprising contacting a eukaryotic cell with one or more candidate compounds, and detecting a change in the mitochondrial redox state of the cell. The methods further relates to such methods wherein endogenous fluorescence of the cell mitochondria is indicative of a change of redox state.

Abstract: A system and method are provided for oxygenating infusion/irrigation fluid, and for providing the hyperoxic infusion/irrigation fluid so formed to an ophthalmic surgical site.

Abstract: A structure for fixing a roller on a base is disclosed. The structure includes a sheet-like elastomer having a guiding hole for trapping a shaft of the roller, and two fixing elements respectively disposed at two opposite sides of the base, which is located at two lateral sides of the roller, for receiving two ends of the sheet-like elastomer to provide a deformation of the sheet-like elastomer for providing a suppress power for the roller.

Abstract: Ceramic igniter compositions are provided that contain components of conductive material and insulating material, where the insulating material component includes a relatively high concentration of metal oxide. Ceramic igniters of the invention are particularly effective for high voltage use, including throughout the range of from about 187 to 264 volts.

Abstract: A low-profile multi-chip module is provided, wherein two or more chips are integrated in a package unit connected to a printed circuit board (PCB), to provide a manifold level of functionality and data storage capacity. The multi-chip module includes at least a first chip and a second chip connected to a predetermined position on an active surface of the first chip by chip-on-chip technology, allowing the active surface of the first chip to be further mounted to a substrate by flip-chip technology. The substrate is attached to the PCB by surface-mount technology, and interposed between the first chip and the PCB. At least a passive component is mounted on the PCB at a position beside the substrate and underneath the second chip. This structure allows the use of a PCB having a smaller layout area for implementing the multi-chip module, thereby desirably reducing the overall structural profile.

Abstract: The present invention provides preparations for efficaciously administering ginsenoside Rb1 or its salt useful as cytoprotective agents. More particularly, the present invention provides pharmaceutical compositions comprising ginsenoside Rb1 or its salt for inhibiting apoptosis or apoptosis-like cell death or pharmaceutical compositions comprising ginsenoside Rb1 or its salt for promoting the expression of a cell death-inhibitory gene product Bcl-xL. Further, the present invention provides preparations for intravenous administration comprising ginsenoside Rb1 or its salt. The above pharmaceutical compositions contain ginsenoside Rb1 or its salt at low extracellular concentrations in lesion, preferably at 1 ng/ml or less and still preferably at 1 to 100 fg/ml. These compositions promote the expression of the cell death-inhibitory gene product Bcl-xL and inhibit apoptosis or apoptosis-like cell death.

Abstract: The present invention provides a human c-Ha-ras proto-oncogene transgenic rat and the methods of the screening of many carcinogens and the screenings of promoters of carcinogenesis and preventive and inhibitory agents of tumors, and additionally enables the analysis of the carcinogenesis mechanism of a number of tumors.