Patents Represented by Attorney Robert L. Stone

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  • Inactivation of bacterial endotoxins using peroxy-diphosphate compoounds
    Patent number: 5034383
    Abstract: Bacterial endotoxins are inhibited by a non-toxic, water-soluble, pharmaceutically acceptable peroxydiphosphate compound in contact with bacterial endotoxin.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: July 23, 1991
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Edward J. Coleman
  • Antiplaque antibacterial oral composition
    Patent number: 5032386
    Abstract: An oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, about 0.25-0.35% by weight of a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxy diphenyl ether (triclosan) and an antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
    Type: Grant
    Filed: August 25, 1989
    Date of Patent: July 16, 1991
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer
  • Inhibition of parathyroid hormone secretion
    Patent number: 5028439
    Abstract: Parathyroid Hormone, when excessively synthesized, induces pathologic bone resorption and demineralization and results in hypocalcemia which produces toxic effects in soft tissues. Non-toxic water-soluble pharmaceutically acceptable compound derivative of peroxydiphosphoric acid, administered orally or systemically, inhibits parathyroid hormone induced bone resorption in vitro and in vivo in warm blooded animals.
    Type: Grant
    Filed: January 9, 1989
    Date of Patent: July 2, 1991
    Assignee: Colgate Palmolive Company
    Inventor: Abdul Gaffar
  • Stabilized amine fluoride dental cream
    Patent number: 5023074
    Abstract: Dental cream effective in promoting oral hygiene containing an amine fluoride, insoluble alkali metal metaphosphate polishing material, an aqueous humectant phase including at least one of glycerine and sorbitol and a solid phase containing non-ionic cellulosic gelling agent, wherein polyethylene glycol of average molecular weight of about 200-1000 is present to stabilize the dental cream against phase separation.
    Type: Grant
    Filed: May 7, 1990
    Date of Patent: June 11, 1991
    Assignee: Colgate-Palmolive Company
    Inventors: Anthony J. Morton, Ian W. Stewart, Kenneth Harvey
  • Anticalculus oral composition
    Patent number: 5017362
    Abstract: An oral composition such as a toothpaste (including gel or cream), mouthwash, lozenge, chewing gum or tooth powder containing a calculus-inhibiting amount of a linear molecularly dehydrated polyphosphate salt and, to inhibit enzymatic hydrolysis of said polyphosphate salt in saliva, a combination of a fluoride ion-providing source and a synthetic linear polymeric polycarboxylate.
    Type: Grant
    Filed: December 8, 1989
    Date of Patent: May 21, 1991
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Thomas G. Polefka
  • Composition for treating osteoporosis and hormonal imbalance
    Patent number: 5013728
    Abstract: A medication for providing fluoride ion for the prevention and treatment of bone loss disease, together with an estrogen-containing substance for not only treating hormonal imbalance but to obtain more advantageous use of the fluoride ion within the body. The dosage is a lozenge, tablet or capsule containing from 20 to 100 milligrams of sodium monofluorophosphate and further including an estrogen-containing substance and a slow release mechanism for controlling release of the fluoride ion and estrogen over a period of from four to eight hours after swallowing. Up to ten percent of sodium fluoride and/or calcium can be added.
    Type: Grant
    Filed: May 4, 1990
    Date of Patent: May 7, 1991
    Assignee: Colgate - Palmolive Company
    Inventor: Marcus G. Grodberg
  • Zinc-containing oral products with reduced astringency
    Patent number: 5000944
    Abstract: A zinc-containing antitartar oral product substantially free of astringency, containing as the essential agent, a zinc/polyphosphate complex having at least about a 50% water solubility, formed by the reaction or interaction of a zinc compound with a potassium or sodium polyphosphate by dissolving a zinc salt in a polyphosphate solution such as pyrophosphate, tripolyphosphate, hexametaphosphate and combinations thereof.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: March 19, 1991
    Assignee: Colgate-Palmolive Company
    Inventors: Michael Prencipe, Shamsul K. Bakar
  • Dentrifice composition
    Patent number: 4992258
    Abstract: A dentifrice for treatment of hypersensitive dentine containing montmorrolinite clay.
    Type: Grant
    Filed: October 23, 1989
    Date of Patent: February 12, 1991
    Assignee: Colgate-Palmolive Company
    Inventor: Stephen C. Mason
  • Plaque disclosing compositions
    Patent number: 4992256
    Abstract: Dental plaque-disclosing compositions comprising FD&C Red No. 40 which selectively stain plaque formed on tooth surfaces, making plaque easily observable to the naked eye at visible light wave-lengths.
    Type: Grant
    Filed: September 27, 1989
    Date of Patent: February 12, 1991
    Assignee: Colgate-Palmolive Company
    Inventors: J. Michael Skaggs, Robert E. Dickson, James H. Bowers, Edward A. Tavss
  • Inhibition of tumor development
    Patent number: 4975423
    Abstract: Non-toxic water-soluble pharmaceutically acceptable compound derivative of peroxydiphosphoric acid when administered orally or systemically supplements inhibition of malignant myeloma carcinoma tumor development of tumor cells in vitro and actual tumor development in vivo in warm blooded animals.
    Type: Grant
    Filed: May 3, 1989
    Date of Patent: December 4, 1990
    Assignee: Colgate-Palmolive Company
    Inventor: Abdul Gaffar
  • Anticalculus oral composition
    Patent number: 4966777
    Abstract: An oral dentifrice composition such as a toothpaste, dental gel, toothpowder, dental tablet or lozenge containing as anticalculus agent about 4.3% to about 7% of alkali metal pyrophosphates comprising at least 4.3% of tetrapotassium pyrophosphate alone or admixed with up to 2.7% of tetrasodium pyrophosphate, and as inhibitors against enzymatic hydrolysis of such agent in saliva, a fluoride and preferably up to about 3% of a synthetic anionic polymeric polycarboxylate, and use of such composition in a program of oral hygiene and/or for inhibiting dental calculus.
    Type: Grant
    Filed: December 21, 1989
    Date of Patent: October 30, 1990
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffab, Thomas G. Polefka, Robert J. Ferlauto, Jr., Rosemarie M. Crisafulli
  • Anticalculus oral composition
    Patent number: 4931273
    Abstract: An oral dentifrice composition such as a toothpaste, dental gel, toothpowder, dental tablet or lozenge containing as anticalculus agent about 4.3% to about 7% of alkali metal pyrophosphates comprising at least 4.3% of tetrapotassium pyrophosphate alone or admixed with up to 2.7% of tetrasodium pyrophoshpate, and as inhibitors against enzymatic hydrolysis of such agent in saliva, a fluoride and preferably up to about 3% of a synthetic anionic polymeric polycarboxylate, and use of such composition in a program of oral hygiene and/or for inhibiting dental calculus.
    Type: Grant
    Filed: November 16, 1989
    Date of Patent: June 5, 1990
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Thomas G. Polefka, Robert J. Ferlauto, Jr., Rosemarie M. Crisafulli
  • Animal trap
    Patent number: 4926581
    Abstract: A T-shaped animal trap having entry ports and sliding doors at opposite ends of its head portion and a platform resting on a dowel in its leg portion. A magnet is on each end of the dowel outside of the trap which can magnetically hold to each magnet a flexible metal wire when the entry ports are open, which wire extends into the head portion and is attached to one sliding door. When the platform is moved over the dowel, the dowel partially rotates and the wires are released from the magnets, thereby permitting the sliding doors to close the entry ports. Atlernatively, the animal trap may be tunned shaped with entry ports and sliding doors at opposite ends and a platform resting on a dowel near the middle of the tunnel.
    Type: Grant
    Filed: July 6, 1989
    Date of Patent: May 22, 1990
    Inventor: August Grivas
  • Anticalculus oral composition
    Patent number: 4925654
    Abstract: An oral dentifrice composition such as a toothpaste, dental gel, toothpowder, dental tablet or lozenge containing as anticalculus agent about 4.3% to about 7% of alkali metal pyrophosphates comprising at least 4.3% of tetrapotassium pyrophosphate alone or admixed with up to 2.7% of tetrasodium pyrophosphate, and as inhibitors against enzymatic hydrolysis of such agent in saliva, a fluoride and preferably up to about 3% of a synthetic anionic polymeric polycarboxylate, and use of such composition in a program of oral hygiene and/or for inhibiting dental calculus.
    Type: Grant
    Filed: February 8, 1989
    Date of Patent: May 15, 1990
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Thomas G. Polefka, Robert J. Ferlauto, Jr., Rosemarie M. Crisafulli
  • Anticalculus oral composition
    Patent number: 4921692
    Abstract: An oral composition such as a toothpaste (including gel or cream), mouthwash, lozenge, chewing gum or tooth powder containing a calculus-inhibiting amount of a linear molecularly dehydrated polyphosphate salt and, to inhibit enzymatic hydrolysis of said polyphosphate salt in saliva, a combination of a fluoride ion-providing source and a synthetic linear polymeric polycarboxylate.
    Type: Grant
    Filed: February 8, 1989
    Date of Patent: May 1, 1990
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Thomas G. Polefka
  • Anticalculus oral composition
    Patent number: 4921693
    Abstract: An oral composition such as a toothpaste (including gel or cream), mouthwash, lozenge, chewing gum or tooth powder containing a calculus-inhibiting amount of a linear molecularly dehydrated polyphosphate salt and, to inhibit enzymatic hydrolysis of said polyphosphate salt in saliva, a combination of a fluoride ion-providing source and a synthetic linear polymeric polycarboxylate.
    Type: Grant
    Filed: February 8, 1989
    Date of Patent: May 1, 1990
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Thomas G. Polefka
  • Appetite suppressant dentifrice
    Patent number: 4913894
    Abstract: An appetite suppressant oral composition containing Benzocaine, high impact flavor and a sweetening agent, in the form of a dental cream or a mouthspray. A novel method of reducing appetite and thereby intended for controlling weight of consumers, which comprises applying to the oral cavity a high impact flavor in a dentrifrice or mouthspray.
    Type: Grant
    Filed: May 1, 1989
    Date of Patent: April 3, 1990
    Assignee: Colgate-Palmolive Company
    Inventors: John P. Curtis, Susan E. Wieckowski, Karen J. De Pierro
  • Anticalculus oral composition
    Patent number: 4906456
    Abstract: An oral dentifrice composition such as a toothpaste, dental gel, toothpowder, dental tablet or lozenge containing as anticalculus agent about 4.3% to about 7% of alkali metal pyrophosphates comprising at least 4.3% of tetrapotassium pyrophosphate alone or admixed with up to 2.7% of tetrasodium pyrophosphate, and as inhibitors against enzymatic hydrolysis of such agent in saliva, a fluoride and preferably up to about 3% of a synthetic anionic polymeric polycarboxylate, and use of such composition in a program of oral hygiene and/or for inhibiting dental calculus.
    Type: Grant
    Filed: February 17, 1989
    Date of Patent: March 6, 1990
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Thomas G. Polefka, Robert J. Ferlauto, Jr., Rosemarie M. Crisafulli
  • Antibacterial antiplaque oral composition
    Patent number: 4894220
    Abstract: An oral composition such as a dentifrice or mouthwash, containing an aqueous phase of water and as solubilizing agent propylene glycol, dipropylene glycol, methyl cellosolve, ethyl cellosolve, olive oil, castor oil, amyl acetate, ethyl acetate, glyceryl tristearate or benzyl benzoate mixed with at least one of glycerine and sorbitol, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2.sup.1 -hydroxydiphenyl ether (triclosan), and a synthetic anionic linear polymeric polycarboxylate having a molecular weight of about 1,000 to about 1,000,000.
    Type: Grant
    Filed: December 29, 1988
    Date of Patent: January 16, 1990
    Assignee: Colgate-Palmolive Company
    Inventors: Nuran Nabi, Abdul Gaffar
  • Non-aqueous, nonionic heavy duty laundry detergent with improved stability
    Patent number: 4892673
    Abstract: A non-aqueous liquid heavy duty laundry detergent composition in the form of a suspension of builder salt in liquid nonionic surfactant is stabilized against phase separation by the incorporation of gas bubbles having an average particle size diameter of 10 to 100 microns. The gas bubbles are incorporated in an amount to equalize the densities of the continuous liquid phase and the dispersed phase. The gas bubbles are stabilized by incorporation of a stabilizer having the formula ##STR1## wherein R is a hydrocarbon group of about 5 to 21 carbon atoms,Q is a hydrogen atom, a Group IA metal, a Group IIA metal, a group having the formula --CH.sub.2 --CH(R.sup.1)--CH.sub.2 (R.sup.2), or a mixture thereof, wherein R.sup.1 and R.sup.2 are, independently, --OH or R-C(O)O-- (R being as defined above); anda is 1 or 2, with the proviso that a=2 only when Q is a Group IIA metal.
    Type: Grant
    Filed: May 2, 1988
    Date of Patent: January 9, 1990
    Assignee: Colgate-Palmolive Company
    Inventors: Nagaraj S. Dixit, Robert J. Rhinesmith, James J. Sullivan, Cynthia A. Barone, Richard P. Adams, Kuo-Yann Lai