Patents Represented by Attorney Steven F. Stone

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  • Drug delivery device for programmed delivery of beneficial drug
    Patent number: 4624847
    Abstract: An osmotic dispensing device is disclosed for delivering a medicine to a biological environment of use. The device comprises a semipermeable wall surrounding a compartment with an osmotic passageway in the semipermeable wall connecting the outside of the device with the compartment. The compartment houses a medicine releasable carrier by a means for increasing in size for delivering the beneficial medicine from the device over time.
    Type: Grant
    Filed: April 22, 1985
    Date of Patent: November 25, 1986
    Assignee: ALZA Corporation
    Inventors: Atul D. Ayer, Brian Barclay
  • Dispensing system with means for increasing delivery of beneficial agent from the system
    Patent number: 4624945
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) heat responsive means containing a beneficial agent in the space, (3) means for increasing the amount of beneficial agent delivered from the device in the space, (4) expandable means in the space, (5) an optional dense means in the space, and (6) means in the housing for delivering the beneficial agent from the dispensing device.
    Type: Grant
    Filed: August 9, 1985
    Date of Patent: November 25, 1986
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Richard Cortese, Felix A. Landrau
  • Dosage form for use in a body mounted pump
    Patent number: 4619652
    Abstract: A self-contained body mounted pump assembly for continuously administering a therapeutic agent parenterally. The pump has a transparent top through which the contents can be seen and outwardly flaring sides to provide for comfort, stability and other useful features. The pump assembly is driven by a fluid imbibing, preferably osmotic pump and contains its own source of actuating fluid. Means for superimposing a pulse dose on the tonic flow are also described.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: October 28, 1986
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, John R. Peery, Felix A. Landrau
  • Device for administering calcium ascorbate
    Patent number: 4618487
    Abstract: A dispensing device is disclosed for delivering calcium ascorbate to a biological environment of use over time.
    Type: Grant
    Filed: August 9, 1985
    Date of Patent: October 21, 1986
    Assignee: ALZA Corporation
    Inventors: Mark DuBois, Felix Theeuwes, Patrick S. L. Wong
  • Total agent osmotic delivery system
    Patent number: 4615698
    Abstract: An osmotic device is disclosed for delivering a beneficial agent formulation to the stomach and small intestine. The device delivers substantially all of the beneficial agent in the stomach and small intestine, collapses and is easily eliminated from a host.
    Type: Grant
    Filed: March 23, 1984
    Date of Patent: October 7, 1986
    Assignee: ALZA Corporation
    Inventors: George V. Guittard, Patrick S. L. Wong, Felix Theeuwes
  • Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes
    Patent number: 4615699
    Abstract: A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 .mu.g/cm.sup.2 hr and preferably in the range of 50-150 .mu.g/cm.sup.2 hr. Ethanol delivered at a rate of from 250-500 .mu.g/cm.sup.2 hr is employed as a permeation enhancer for the nitroglycerin and a rate controlling membrane formed from ethylene vinyl acetate having a vinyl acetate content greater than 11% and preferably between 12-18% provides the appropriate rate control for both the drug and the permeation enhancer. This system is suitable for use in treatment of angina pectoris and congestive heart failure.
    Type: Grant
    Filed: May 3, 1985
    Date of Patent: October 7, 1986
    Assignee: ALZA Corporation
    Inventors: Robert M. Gale, Randall G. Berggren
  • Osmotic device with dual thermodynamic activity
    Patent number: 4612008
    Abstract: An osmotic system is disclosed comprising a wall formed in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial agent, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: September 16, 1986
    Assignee: Alza Corporation
    Inventors: Patrick S. L. Wong, Brian Barclay, Joseph C. Deters, Felix Theeuwes
  • Method for establishing blood levels of biocide in animals
    Patent number: 4612186
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a semipermeable housing defining an internal space, (2) a dense member in the space, (3) a heat responsive composition containing a beneficial agent in the space, (4) an expandable member in the space, and (5) a passageway in the semipermeable housing for delivering the beneficial agent from the dispensing device.
    Type: Grant
    Filed: September 27, 1985
    Date of Patent: September 16, 1986
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Richard Cortese, Felix A. Landrau
  • Controlled delivery of haloperidol by an osmotic delivery system
    Patent number: 4610686
    Abstract: An osmotic system is disclosed for the delivery of haloperidol at a controlled rate over a prolonged period of time.
    Type: Grant
    Filed: November 2, 1983
    Date of Patent: September 9, 1986
    Assignee: ALZA Corporation
    Inventors: Atul Ayer, Felix Theeuwes, Patrick S. L. Wong
  • Osmotic device comprising means for governing initial time of agent release therefrom
    Patent number: 4609374
    Abstract: An osmotic dispensing device is disclosed for delivering a medicine to a biological environment of use. The device comprises a semipermeable wall surrounding a compartment with an osmotic passageway in the semipermeable wall connecting the outside of the device with the compartment. The compartment house a medicine releasably held on a carrier member selected from the group consisting of cellulose esters, cellulose ethers and cellulose ester-ethers.
    Type: Grant
    Filed: April 22, 1985
    Date of Patent: September 2, 1986
    Assignee: ALZA Corporation
    Inventor: Atul D. Ayer
  • Dispensing device with drug delivery patterns
    Patent number: 4608048
    Abstract: An osmotic device is disclosed for delivering an agent to a selected environment. The device comprises a semipermeable wall surrounding a first and second compartment for containing the agent, and the device is provided with means for delivering the agent from both compartments through a single osmotic passageway.
    Type: Grant
    Filed: December 6, 1984
    Date of Patent: August 26, 1986
    Assignee: ALZA Corporation
    Inventors: Richard Cortese, Felix Theeuwes
  • Urine container with biocidal activity
    Patent number: 4601880
    Abstract: A patient-care system is disclosed comprising a container housing a device that delivers an agent for controlling the presence of pathogens. Also, the device and a method are disclosed using the device for preventing pathogenic infections.
    Type: Grant
    Filed: April 11, 1985
    Date of Patent: July 22, 1986
    Assignee: ALZA Corporation
    Inventors: Patrick S. L. Wong, Jimmy B. Langston, Harold M. Leeper
  • Parenteral delivery system utilizing a hollow fiber cellular unit
    Patent number: 4596555
    Abstract: A formulation cell consisting essentially of a hollow fiber surrounded by a beneficial agent is disclosed for use in an intravenous delivery system. An intravenous system is disclosed that uses the formulation cell.
    Type: Grant
    Filed: January 28, 1985
    Date of Patent: June 24, 1986
    Assignee: ALZA Corporation
    Inventor: Felix Theeuwes
  • Delivery system controlled administration of beneficial agent to ruminants
    Patent number: 4595583
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a semipermeable housing defining an internal space, (2) a dense member in the space, (3) a heat responsive composition containing a beneficial agent in the space, (4) an expandable member in the space, and (5) a passageway in the semipermeable housing for delivering the beneficial agent from the dispensing device.
    Type: Grant
    Filed: March 19, 1984
    Date of Patent: June 17, 1986
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Richard Cortese, Felix A. Landrau
  • Constant pressure end burning gas generator
    Patent number: 4590860
    Abstract: End burning gas generators for use either as propulsion systems or means for generating large volume of gases for various purposes such as the generation of the fuel for a ducted rocket engine, the rapid inflation of air bags for personal protection or recovery of submersed items or the expulsion of projectiles from subsurface launch tubes are currently widely utilized. End burning gas generator grains are ignited at one end of a generally cylindrical charge mounted within a combustion chamber which is fixed with a suitable exhaust means. For many of the applications described above, it is desirable that the gas generator burn in a uniform manner such that a constant volume of gas is generated per unit of time so that the chamber pressure and the mass flow rate of gas remain constant.
    Type: Grant
    Filed: January 11, 1984
    Date of Patent: May 27, 1986
    Assignee: United Technologies Corporation
    Inventor: Robert V. Kromrey
  • Transdermal administration of fentanyl and device therefor
    Patent number: 4588580
    Abstract: Transdermal delivery systems for delivery of fentanyl and its analgetically effective derivatives for extended periods of time are disclosed which deliver the base form of the drug at a rate of from 0.5 to 10 .mu.g/cm.sup.2 /hr for a substantial portion of their useful life. The systems can be from 5-100 cm.sup.2 in releasing surface and preferably employ an in-line amine resistant adhesive. Preferred rate controlled systems utilize an aqueous ethanolic gel to minimize drug content.
    Type: Grant
    Filed: July 23, 1984
    Date of Patent: May 13, 1986
    Assignee: Alza Corporation
    Inventors: Robert M. Gale, Victor Goetz, Eun S. Lee, Lina T. Taskovich, Su I. Yum
  • Medical device for delivering drug to pH environments greater than 3.5
    Patent number: 4587117
    Abstract: An osmotic device is disclosed for delivering a beneficial agent to a first environment having a pH of 1.0 to 3.5 inclusive and to a second environment having a pH of greater than 3.5 to 8.0. The device maintains its integrity in the first environment and loses its integrity in the second environment.
    Type: Grant
    Filed: January 22, 1985
    Date of Patent: May 6, 1986
    Assignee: Alza Corporation
    Inventors: David Edgren, Patrick S. L. Wong, Felix Theeuwes
  • Intravenous system for delivering a beneficial agent
    Patent number: 4586922
    Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
    Type: Grant
    Filed: February 15, 1985
    Date of Patent: May 6, 1986
    Assignee: ALZA Corporation
    Inventor: Felix Theeuwes
  • Parenteral controlled therapy
    Patent number: 4579553
    Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
    Type: Grant
    Filed: January 7, 1985
    Date of Patent: April 1, 1986
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Delivery system housing a plurality of delivery devices
    Patent number: 4578075
    Abstract: A delivery system is disclosed comprising a wall surrounding a lumen containing a plurality of osmotic delivery devices. The wall is formed of an environment sensitive material that releases the tiny osmotic devices into the environment. The osmotic devices comprise a semipermeable wall surrounding a compartment containing drug. A passageway through the semipermeable wall releases drug from the device to the environment.
    Type: Grant
    Filed: December 20, 1982
    Date of Patent: March 25, 1986
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes