Patents Represented by Attorney Steven F. Stone

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  • Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes
    Patent number: 4681584
    Abstract: A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 .mu.g/cm.sup.2 hr and preferably in the range of 50-150 .mu.g/cm.sup.2 hr. Ethanol delivered at a rate of from 250-500 .mu.g/cm.sup.2 hr is employed as a permeation enhancer for the nitroglycerin and a rate controlling membrane formed from ethylene vinyl acetate having a vinyl acetate content greater than 11% and preferably between 12-18% provides the appropriate rate control for both the drug and the permeation enhancer. This system is suitable for use in treatment of angina pectoris and congestive heart failure.
    Type: Grant
    Filed: June 2, 1986
    Date of Patent: July 21, 1987
    Assignee: ALZA Corporation
    Inventors: Robert M. Gale, Randall G. Berggren
  • Dispenser comprising capsule with volume displacing member
    Patent number: 4678467
    Abstract: A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
    Type: Grant
    Filed: February 13, 1986
    Date of Patent: July 7, 1987
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Felix Theeuwes, Joseph C. Deters
  • Veterinary dispenser delivering beneficial agent by gas power generated in situ
    Patent number: 4675174
    Abstract: A dispensing system is disclosed for delivering a beneficial agent. The dispensing system comprises (1) a housing defining an internal space, (2) a gas-generating composition in the space, (3) a dense member in the space, (4) a composition comprising a beneficial agent and a non-toxic heat responsive carrier in the space, and (5) a passageway in the housing for delivering the beneficial agent for the dispensing system.
    Type: Grant
    Filed: August 16, 1985
    Date of Patent: June 23, 1987
    Assignee: Alza Corporation
    Inventor: James B. Eckenhoff
  • Osmotic system with instant drug availability
    Patent number: 4673405
    Abstract: An osmotic device is disclosed for delivering a beneficial agent. The device comprises a wall surrounding a compartment containing drug, a passageway in the wall connecting the exterior of the device with the compartment, and drug in the wall. The device delivers the drug from the compartment and the wall.
    Type: Grant
    Filed: January 8, 1986
    Date of Patent: June 16, 1987
    Assignee: Alza Corporation
    Inventors: George V. Guittard, Joseph C. Deters, Felix Theeuwes, Richard Cortese
  • Apparatus for parenteral infusion of fluid containing beneficial agent
    Patent number: 4664650
    Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to a recipient. The system comprises (a) a primary container of a medical fluid; (b) a primary drip chamber in fluid communication with the primary container; (c) a primary formulation chamber in fluid communication with the primary drip chamber and housing an agent dispensing device or a beneficial agent; (d) a secondary container of a medical fluid; (e) a secondary drip chamber in fluid communication with the secondary container; (f) a secondary formulation chamber in fluid communication with the secondary drip chamber and housing an agent dispensing device or a beneficial agent; and (g) a common tubing in communication with the primary formulation chamber and the secondary formulation chamber for communicating the system with the recipient.
    Type: Grant
    Filed: October 31, 1983
    Date of Patent: May 12, 1987
    Assignee: Alza Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Dispenser comprising inner and outer walls functioning as cooperative unit
    Patent number: 4663149
    Abstract: A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: May 5, 1987
    Assignee: Alza Corporation
    Inventors: James B. Eckenhoff, Felix Theeuwes, Joseph C. Deters
  • Pseudoephedrine, brompheniramine therapy
    Patent number: 4662880
    Abstract: A dosage form is disclosed for delivering the beneficial drugs pseudoephedrine and brompheniramine to a biological environment of use.
    Type: Grant
    Filed: March 14, 1986
    Date of Patent: May 5, 1987
    Assignee: Alza Corporation
    Inventors: L. G. Hamel, Felix A. Landrau, Patrick S. L. Wong, George V. Guittard
  • Dispenser comprising telescopically engaging members
    Patent number: 4663148
    Abstract: A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: May 5, 1987
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Felix Theeuwes, Joseph C. Deters
  • Medical bandage for administering vasodilator drug
    Patent number: 4661105
    Abstract: A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
    Type: Grant
    Filed: June 9, 1986
    Date of Patent: April 28, 1987
    Assignee: ALZA Corporation
    Inventor: Robert M. Gale
  • Oral delivery system comprising a plurality of tiny pills for delivering drug in the stomach and intestine
    Patent number: 4659558
    Abstract: A delivery device is disclosed for delivering a beneficial drug to a biological environment of use. The device comprises a hydrogel reservoir containing tiny pills. The tiny pills comprise a wall surrounding a drug core.
    Type: Grant
    Filed: January 17, 1984
    Date of Patent: April 21, 1987
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Fluid imbibing pump with self-regulating skin patch
    Patent number: 4655766
    Abstract: A medical device comprising a fluid imbibing, self-regulating, skin patch drug delivery system is disclosed which includes a fluid imbibing, preferably osmotic, pump comprising a reservoir for a drug or, drug formulation or other fluid to be dispensed to the skin, 10 at least one wall of the reservoir comprising a fluid permeable membrane which is permeable to an external activating fluid. The external fluid is imbibed through the membrane at a predetermined rate thereby causing the drug to be pumped through one or more passages provided in the reservoir structure and 15 into contact with the skin. The device includes an impermeable exterior wall member which covers and extends outwardly from the fluid imbibing pump terminating in an edge portion adapted to be secured, as by adhesion, to the skin.
    Type: Grant
    Filed: April 17, 1986
    Date of Patent: April 7, 1987
    Assignee: ALZA Corporation
    Inventors: Felix Theeuwes, James B. Eckenhoff
  • Method for treating ischemic conditions
    Patent number: 4650484
    Abstract: A method is disclosed for treating an ischemic condition. The method comprises coadministering topically and internally a vasodilator to a patient having the condition for treating said condition.
    Type: Grant
    Filed: February 3, 1983
    Date of Patent: March 17, 1987
    Assignee: ALZA Corporation
    Inventors: Jane Shaw, Robert M. Gale
  • Drug delivery system for delivering a plurality of tiny pills in the gastrointestinal tract
    Patent number: 4649043
    Abstract: A delivery device is disclosed for delivering a beneficial drug to a biological environment of use. The device comprises a hydrogel reservoir containing tiny pills. The tiny pills comprise a wall surrounding a drug core.
    Type: Grant
    Filed: January 16, 1984
    Date of Patent: March 10, 1987
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Transdermal delivery of highly ionized fat insoluble drugs
    Patent number: 4645502
    Abstract: A medical device for the transdermal delivery of highly ionized, fat insoluble drugs comprises an aqueous drug reservoir having a physiological pH, said reservoir preferably being a gel maintained in an impermeable receptacle by a highly permeable support member disposed between the gel and a permeable contact adhesive. A permeation enhancer reservoir delivers a permeation enhancer to the skin through the aqueous reservoir and through a permeation enhancer release rate controlling membrane which is permeable to the permeation enhancer and impermeable to the drug and water. In a preferred embodiment the permeation enhancer release rate controlling membrane forms at least a portion of said receptacle.
    Type: Grant
    Filed: May 3, 1985
    Date of Patent: February 24, 1987
    Assignee: ALZA Corporation
    Inventors: Robert M. Gale, David J. Enscore
  • Means for providing instant agent from agent dispensing system
    Patent number: 4643731
    Abstract: A dispensing system is disclosed for delivering a beneficial agent formulation instantly and continuously over time to an environment of use. The dispensing system comprises an outer housing surrounding at least a part of a dispensing device. The dispensing device comprises a wall surrounding a compartment with a passageway in the wall connecting the compartment with the interior of the dispensing device. A beneficial agent formulation is present in the housing for instant delivery and a beneficial agent formulation is present in the compartment for continuous delivery.
    Type: Grant
    Filed: August 16, 1985
    Date of Patent: February 17, 1987
    Assignee: ALZA Corporation
    Inventor: James B. Eckenhoff
  • Gastrointestinal drug delivery system comprising a hydrogel reservoir containing a plurality of tiny pills
    Patent number: 4642233
    Abstract: A delivery device is disclosed for delivering a beneficial drug to a biological environment of use. The device comprises a hydrogel reservoir containing tiny pills. The tiny pills comprise a wall surrounding a drug core.
    Type: Grant
    Filed: January 16, 1984
    Date of Patent: February 10, 1987
    Assignee: Alza Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Vaginal dispenser for dispensing beneficial hormone
    Patent number: 4629449
    Abstract: The invention is for a method of treating a decrease in estrogen secretion in a woman after the cessation of cyclic ovulation using a vaginal dispenser comprising a wall surrounding an internal lumen and having a pair of ends with one end placed inside the other end to form a closed dispenser. A vaginally administrable beneficial agent is housed in the lumen for release by the dispenser over time.
    Type: Grant
    Filed: March 21, 1985
    Date of Patent: December 16, 1986
    Assignee: ALZA Corporation
    Inventor: Patrick S. Wong
  • Osmotic device with self-sealing passageway
    Patent number: 4627971
    Abstract: An osmotic dispensing device is disclosed for delivering a medicine to a biological environment of use. The device comprises a semipermeable wall surrounding a compartment comprising a first layer comprising a beneficial agent formulation and a first passageway in the wall for delivering the beneficial agent formulation from the device, and a second layer of a composition comprising a hydrogel and a means for closing a second passageway formed during the manufacture of the device.
    Type: Grant
    Filed: April 22, 1985
    Date of Patent: December 9, 1986
    Assignee: ALZA Corporation
    Inventor: Atul D. Ayer
  • Osmotic capsule
    Patent number: 4627850
    Abstract: An osmotic capsule is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic capsule comprises an outer semipermeable wall surrounding and laminating an inner capsule wall formed of a different polymeric composition than the outer wall. The walls define an interior space containing the beneficial agent formulation. A passageway through the walls connects the exterior of the osmotic capsule with the interior of the osmotic capsule.
    Type: Grant
    Filed: November 2, 1983
    Date of Patent: December 9, 1986
    Assignee: ALZA Corporation
    Inventors: Joseph C. Deters, Felix Theeuwes, Kevin J. Mullins, James B. Eckenhoff
  • Colonic-therapeutic delivery system
    Patent number: 4627851
    Abstract: An osmotic device is disclosed for delivering a drug to the colon. The device comprises a laminated wall surrounding a compartment containing a drug with a passageway through the wall for dispensing the drug from the device. The laminated wall comprises three laminae, an inner semipermeable lamina, a middle lamina containing a salt of a fatty acid and an outer enteric lamina.
    Type: Grant
    Filed: October 26, 1984
    Date of Patent: December 9, 1986
    Assignee: ALZA Corporation
    Inventors: Patrick S. L. Wong, Felix Theeuwes